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This study aims to synthesize the effectiveness of VBA for smoking cessation and summarize the implementation strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched randomized controlled trials aiming at tobacco abstinence and comparing VBA versus no smoking advice or no contact from Medline, Embase, CINAHL, Cochrane Library, PsycInfo databases, six Chinese databases, two trial registries ClinicalTrials.gov and WHO-ICTRP from inception to September 30, 2023. Grading of Recommendations, Assessment, Development, and Evaluations framework was used to assess the certainty of the evidence of the meta-analytic findings. The outcomes were self-reported long-term tobacco abstinence at least 6\u00a0months after treatment initiation, earlier than 6\u00a0months after treatment initiation, and quit attempts. Effect sizes were computed as risk ratio (RR) with 95% CI using frequentist random-effect models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis<\/jats:title>\n                    <jats:p>\n                      Thirteen randomized controlled trials from 15 articles (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926,437) were included. There was moderate-certainty evidence that VBA significantly increased self-reported tobacco abstinence at\u2009\u2265\u20096\u00a0months in the adjusted model (adjusted risk ratio ARR 1.17, 95% CI: 1.07\u20131.27) compared with controls. The sensitivity analysis showed similar results when abstinence was verified by biochemical validation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096 studies, RR 1.53, 95% CI 0.98\u20132.40). There was high-certainty evidence that VBA significantly increased abstinence at\u2009&lt;\u20096\u00a0months (ARR 1.22, 95% CI: 1.01\u20131.47). Evidence of effect on quit attempts (ARR 1.03, 95% CI 0.97\u20131.08) was of very low certainty.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>VBA delivered in a clinical setting is effective in increasing self-reported tobacco abstinence, which provides support for wider adoption in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11606-024-08786-8","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T11:01:32Z","timestamp":1714647692000},"page":"1721-1734","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Effectiveness of Very Brief Advice on Tobacco Cessation: A Systematic Review and Meta-Analysis"],"prefix":"10.1007","volume":"39","author":[{"given":"Christopher Chi Wai","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Jia Aaron","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebe","family":"Gouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu Tsun","family":"Luk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai Hing","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia Siu Chee","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-5349","authenticated-orcid":false,"given":"Yee Tak Derek","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"8786_CR1","unstructured":"Smoking Cessation: A Report of the Surgeon General. 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