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The area under the receiver operating characteristic curve (AUC) was calculated using an internal validation set (33% of the HCA cohort), and external validation was performed using similar data from six academic centers associated with a hospital medicine research network (HOMERuN).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key Results<\/jats:title>\n                <jats:p>The final HCA cohort included 62,195 patients (mean age 61.9\u00a0years, 51.9% male), of whom 4704 (7.6%) were readmitted or died within 30\u00a0days of discharge. Independent risk factors for death or readmission included fever within 72\u00a0h of discharge; tachypnea, tachycardia, or lack of improvement in oxygen requirement in the last 24\u00a0h; lymphopenia or thrombocytopenia at the time of discharge; being\u2009\u2264\u20097\u00a0days since first positive test for SARS-CoV-2; HOSPITAL readmission risk score\u2009\u2265\u20095; and several comorbidities. Inpatient treatment with remdesivir or anticoagulation were associated with lower odds. The model\u2019s AUC for the internal validation set was 0.73 (95% CI 0.71\u20130.74) and 0.66 (95% CI 0.64 to 0.67) for the external validation set.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This large retrospective study identified several factors associated with post-discharge readmission or death in models which performed with good discrimination. Patients 7 or fewer days since test positivity and who demonstrate potentially reversible risk factors may benefit from delaying discharge until those risk factors resolve.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11606-024-08856-x","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T20:24:09Z","timestamp":1719519849000},"page":"2649-2661","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of Clinical Criteria for Discharge Among Patients Hospitalized for COVID-19: Development and Validation of a Risk Prediction Model"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7072-0781","authenticated-orcid":false,"given":"Jeffrey L.","family":"Schnipper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Oreper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin C.","family":"Hubbard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dax","family":"Kurbegov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanna A. 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