{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:15:20Z","timestamp":1789398920170,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J GEN INTERN MED"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Major osteoporotic fracture (MOF) is associated with increased mortality; however, few studies in postmenopausal women have examined racial and ethnic differences in 1-year and 5-year mortality following MOF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>To assess 1-year and 5-year mortality following MOF by race and ethnicity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Design<\/jats:title>\n            <jats:p>This prospective cohort study included postmenopausal women enrolled in the Women\u2019s Health Initiative (WHI), a population-based, multisite US study. Participants were followed from September 1994 to February 2023. Data were analyzed between August 2023 and November 2023.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Participants<\/jats:title>\n            <jats:p>Postmenopausal women aged 50 to 79\u00a0years old who experienced a MOF (<jats:italic>N<\/jats:italic>\u2009=\u200932,675 in 1\u00a0year and 29,506 in 5\u00a0years following MOF).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Main Measures<\/jats:title>\n            <jats:p>Self-reported race and ethnicity. All-cause mortality was determined by death certificates, reports of surrogates, and the National Death Index Search.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Key Results<\/jats:title>\n            <jats:p>The baseline mean age of participants was 77.0 [SD\u2009=\u20098.5] years with 31,223 [95.6%] White participants in the 1-year mortality analysis, and 76.3 [SD\u2009=\u20098.5] years with 28,212 [95.6%] White participants in the 5-year mortality analysis. In fully adjusted models, compared to White women, Black women had a higher risk of mortality (adjusted odds ratio (aOR)\u2009=\u20091.42, 95% CI [1.06, 1.90], while Asian women had a lower risk of mortality (aOR\u2009=\u20090.48 95% CI [0.27, 0.88]), within 1\u00a0year following MOF. Compared to White women, the mortality risk within 5\u00a0years after MOF was significantly higher among American Indian\/Alaska Native (aOR\u2009=\u20093.30, 95% CI [1.65, 6.60]) and lower among Asian (aOR\u2009=\u20090.58, 95% CI [0.42,0.80]) women. While there were no mortality differences by ethnicity 1\u00a0year following MOF, Hispanic\/Latina women were less likely to die 5\u00a0years following MOF (aOR\u2009=\u20090.74, [95% CI 0.57\u20130.96]) compared to Non-Hispanic\/Latina women.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>In this large prospective study, mortality following MOF differed by race. Future research is needed to delineate the mechanism behind these associations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11606-025-09506-6","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T11:38:45Z","timestamp":1745494725000},"page":"2583-2592","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Race, Ethnicity, and Mortality Following Major Osteoporotic Fracture: Results from the Women\u2019s Health Initiative Study"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5626-8332","authenticated-orcid":false,"given":"Michaela","family":"Juels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine E.","family":"Ensrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia L.","family":"Stefanick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladdin H.","family":"Shadyab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Nassir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Schnatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn J.","family":"Crandall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"issue":"8","key":"9506_CR1","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","volume":"9","author":"JA Kanis","year":"1994","unstructured":"Kanis JA, Melton LJ 3rd, Christiansen C, Johnston CC, Khaltaev N. 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