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We examined whether more reported barriers to medication adherence could signal the presence of MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We developed a count of barriers (0, 1, 2, and\u2009\u22653) and determined the independent association between a greater number of barriers and odds of MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Rural primary care practices in Alabama and North Carolina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>One thousand two hundred seventy-nine participants of the Southeastern Collaboration to Improve Blood Pressure Control trial; all were African Americans with persistently uncontrolled hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Measure<\/jats:title>\n                    <jats:p>Presence of mild cognitive impairment (MCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants reporting\u2009\u2265\u20092 barriers had 2.40 (95% CI 1.03\u20135.75) times higher adjusted odds of MCI compared to those reporting none; those reporting\u2009\u2265\u20093 barriers had 3.80 (95% CI 1.74\u20138.31) higher odds. As the number of barriers increased, odds of MCI increased (\n                      <jats:italic>p<\/jats:italic>\n                      for trend\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Barriers to medication adherence may signal MCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11606-026-10477-5","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:19:21Z","timestamp":1777915161000},"page":"3434-3440","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Barriers to Medication Adherence and Mild Cognitive Impairment Among African Americans with Persistently Uncontrolled Hypertension: A Cross-sectional Analysis from the Southeastern Collaboration Trial"],"prefix":"10.1007","volume":"41","author":[{"given":"Sunidhi","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna Bryan","family":"Ringel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Baquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doyle M.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Halladay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Cherrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Andreae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-0563","authenticated-orcid":false,"given":"Monika","family":"Safford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"10477_CR1","doi-asserted-by":"publisher","unstructured":"Thomas SJ, Booth JN, 3rd, Dai C, et al. 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The study protocol was approved by the Weill Cornell Medicine Institutional Review Board (protocol 1609017600).","order":1,"name":"Ethics","label":"Ethics Approval and Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Dr. Safford is a consultant for Merck and Amgen. None to disclose for the other authors.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The views expressed in this article are my own and not an official position of the affiliated institution(s) nor any sources of funding.","order":3,"name":"Ethics","label":"Disclaimer","group":{"name":"EthicsHeading","label":"Declarations"}}]}}