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Subgroup analyses were conducted by use of anti-obesity medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>KEY RESULTS<\/jats:title>\n                    <jats:p>A total of 5056 patients enrolled between November 2022 and October 2023, and 4511 (89.2%) completed registration for RestoreHealth. At six months, mean absolute and percent weight change among all enrolled patients were -5.7 pounds and -2.5%, respectively (p\u2009&lt;\u20090.0001 for both), and 27.7% of patients lost\u2009\u2265\u20095% of their body weight. There was greater weight loss among patients using anti-obesity medications (mean absolute and percent weight change\u2009=\u2009-12.5 pounds and -5.5%, respectively). Among registered patients, 91.8% engaged in the program, although engagement decreased over time. Older age, greater weight at enrollment, and longer duration of engagement were associated with greater weight loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>We rapidly enrolled a large, diverse population of patients in PROPS 2.0. Patients lost weight at six months, with greater weight loss among those using anti-obesity medications. This program has the potential to be scaled and implemented at other institutions in the future.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ClinicalTrials.gov registration number<\/jats:title>\n                    <jats:p>NCT05553925 (initial release date August 18, 2022).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11606-026-10493-5","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:01:20Z","timestamp":1780498880000},"page":"3757-3767","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engagement and Weight Change in an Online Weight Management Program in Clinical Settings: An Implementation Project"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7273-5602","authenticated-orcid":false,"given":"Heather J.","family":"Baer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Fay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Apovian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley C.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Blood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipika","family":"Samal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi D. 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Dr. Apovian has participated on advisory boards for AbbVie Inc., Altimmune, Inc., Arrowhead Pharmaceuticals, Inc., BioAge, Biolinq Incorporated, Caribou Biosciences, Inc., CinFina Pharma, Inc., Covidien LP, Cowen and Company, LLC, Currax Pharmaceuticals, LLC, EPG Communication Holdings Ltd., Form Health, Inc., Fractyl Health, Inc., Keros Therapeutics, Inc., L-Nutra, Inc., Lilly USA, LLC, Mediflix Inc., NeuroBo Pharmaceuticals, Inc., Neurocrine Biosciences, Inc., NodThera Limited, Novo Nordisk, Nutrisystem, OptumRx, Inc., Pain Script Corporation, Palatin Technologies, Inc., Pursuit By You, Redesign Health Inc., ReShape Lifesciences Inc., Riverview School, Roman Health Ventures Inc., Scholar Rock, Inc., Terns, Inc., Verily Life Sciences LLC, Veru Inc., Vida Health, Inc., Wave Life Sciences, Wondr Health, Xeno Biosciences and Zyversa Therapeutics, Inc. Dr. Apovian has received research funding from PCORI and GI Dynamics, Inc. Dr. Fisher reported research funding from Recor Medical; she received consulting fees from Aktiia, Alnylam, Astra Zeneca, and Recor Medical. Dr. Plutzky reported research grants from Boehringer Ingelheim and Novo Nordisk, as well as consulting fees from Altimmune, Amgen, Esperion, Merck, Novo Nordisk, and MJH Health. Dr. Rozenblum reported having equity in Hospitech Respiration, TRI-O, AEYE Health, RxE2, OtheReality, Co-Patient Support, and Medyx.ai. He also has received research funding from Boston Scientific Corporation, Telem, Calosense Health, Breath of Health, Merative, and BriefCam. Mr. Oates reported institutional research grants to Brigham and Women\u2019s Hospital from Better Therapeutics, Boehringer Ingelheim, Lilly USA, Foresite Labs, Milestone Pharmaceuticals, and NovoNordisk. Dr. Scirica reported institutional research grants to Brigham and Women\u2019s Hospital from Better Therapeutics, Boehringer Ingelheim, Merck, NovoNordisk, and Pfizer; he also has received consulting fees from Abbvie (DSMB), AstraZeneca (DSMB), Boehringer Ingelheim, Better Therapeutics, Bristol Myers-Squibb, Elsevier Practice Update Cardiology, Esperion, Hanmi (DSMB), Lexeo (DSMB), Lexicon, NovoNordisk, and has equity in Health [at] Scale and Doximity. Dr. Bates reported grants and personal fees from EarlySense, personal fees from CDI Negev, equity from ValeraHealth, equity from Clew, equity from MDClone, personal fees and equity from AESOP, personal fees and equity from FeelBetter, personal fees and equity from Guided Clinical Solutions, and grants from IBM Watson Health.","order":3,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}