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Routine integration of deprescribing recommendations into guidelines may enhance their reach, adoption, and impact.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To elicit the perspectives of Australian healthcare professionals on the preferred content, language, and format of deprescribing recommendations for inclusion in clinical guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A qualitative study using semi-structured interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Twenty-four medical doctors, pharmacists, and registered nurses were interviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach<\/jats:title>\n                    <jats:p>Open-ended questions on what constitutes a complete, clear, and implementable deprescribing recommendation were posed. Participants were asked to identify features of example deprescribing recommendations that they found to be useful or not, justifying their reasoning. A thematic framework analysis was conducted using the Guideline Language and Format Instrument (GLAFI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Three overarching themes were generated. Theme 1\u2014\n                      <jats:italic>a higher content and evidentiary threshold for deprescribing recommendations compared to prescribing recommendations<\/jats:italic>\n                      \u2014reflected participants\u2019 perceptions that deprescribing is more complex than medication initiation. Consequently, a higher standard for what constitutes an acceptable, feasible, and clinically useful deprescribing recommendation was described. Theme 2\u2014\n                      <jats:italic>balancing clarity and comprehensiveness<\/jats:italic>\n                      \u2014explored the tension between participants\u2019 desire for succinct and uncomplicated recommendations, and their want for detailed and comprehensive deprescribing instruction. Theme 3\u2014\n                      <jats:italic>optimizing the location of deprescribing recommendations<\/jats:italic>\n                      \u2014explored differing preferences on the location of deprescribing recommendations, with some participants favoring co-location with prescribing recommendations to promote proactive deprescribing, and others preferring a standalone section to enable inclusion of broader deprescribing principles and strategies, beyond medication-specific advice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Healthcare professionals considered the content, language, and format of deprescribing recommendations to be intrinsic to implementability. Deprescribing-specific factors, particularly the operational complexity of\n                      <jats:italic>how<\/jats:italic>\n                      to deprescribe and risk-framing considerations, extended beyond GLAFI\u2019s principles. These findings highlight opportunities to improve future deprescribing recommendations and to strengthen implementability frameworks for de-implementation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11606-026-10679-x","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:46:42Z","timestamp":1786373202000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Designing Implementable Deprescribing Recommendations: A Qualitative Study of Healthcare Professional Perspectives"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0509-5136","authenticated-orcid":false,"given":"Aili V.","family":"Langford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin J.","family":"Liau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryn","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Farrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Pollock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Moriarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijela","family":"Gnjidic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagham J.","family":"Ailabouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Reeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"10679_CR1","unstructured":"Institute of Medicine (US) Committee on Standards for Developing Trustworthy Clinical Practice Guidelines, Graham R, Mancher M, Miller Wolman D, Greenfield S, Steinberg E, eds.\u00a0Clinical Practice Guidelines We Can Trust. 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Dr Emily Reeve receives\u00a0royalties\u00a0from UpToDate for co-authoring a chapter on deprescribing. Dr Barbara Farrell has received consulting fees from the United States Deprescribing Research Network and honorarium from the Canadian Medication Appropriateness and Deprescribing Network. No other authors have any conflicts to declare.","order":3,"name":"Ethics","label":"<b>Conflict of interest<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}}]}}