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Whole-body magnetic resonance imaging (WBMRI) is marketed as a multi-disease screening modality. The diagnostic yield and clinical utility of WBMRI for population-based disease screening are uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our systematic review and meta-analysis aimed to synthesize and critically appraise the available literature on WBMRI without an evidence-based indication. Our objective was to evaluate the diagnostic yield of WBMRI and assess the scope of findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We conducted a systematic review and meta-analysis searching MEDLINE, Embase, and CENTRAL from inception through August 2025. This review was registered with PROSPERO (No.: CRD42024554848). Prespecified criteria for study inclusion included literature that reported WBMRI findings in a population without an evidence-based indication for WBMRI. Data appraisal was performed by two independent reviewers with summary data extracted from published reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Measures<\/jats:title>\n                    <jats:p>Outcomes evaluated included pooled proportions of individuals with no clinical findings reported, any clinical finding, non-malignant actionable findings that required subsequent diagnostic workup, and new cancer diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>In a pooled cohort of 18,043 individuals from 17 heterogeneous low-quality studies who underwent WBMRI, 16.9% (95% CI 5.1; 43.7) had no findings reported, while 78.0% (95% CI 44.9; 93.9) had a finding reported. Clinically actionable non-malignant findings were reported in 14.8% (95% CI 6.6\u201330.0%); 58.2% (95% CI 36.0; 77.5) of these individuals pursued additional laboratory work and\/or imaging, and 20.8% (95% CI 9.7; 39.2) pursued a subsequent procedure. The prevalence of malignancy was 1.4% (95% CI 0.9\u20132.2%). Clinical outcomes associated with discovery of lesions could not be determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The majority of WBMRIs performed in a population without an evidence-based indication result in findings that are normal or do not require follow-up. Clinical outcomes associated with discovery of actionable lesions are unknown. High-quality observational data or randomized trials are needed to inform the efficacy of WBMRI for multi-disease screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Number<\/jats:title>\n                    <jats:p>Not applicable<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11606-026-10802-y","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:02:54Z","timestamp":1790884974000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Diagnostic Yield of Whole-Body MRI as a Multi-disease Screening Modality: A Systematic Review and Meta-analysis"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8633-8931","authenticated-orcid":false,"given":"Muhammad Danyal","family":"Ahsan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Frontera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Gurram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Sharaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murtaza","family":"Qazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruv","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siena","family":"Gioia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel R.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rylee","family":"McGonigle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preethi","family":"Guniganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Dodelzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea S.","family":"Kierans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa C.","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra","family":"Godwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mert","family":"Sabuncu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Lantos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith D.","family":"Hentel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa K.","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi N.","family":"Sharaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"10802_CR1","unstructured":"Force USPT. 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