{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:59:29Z","timestamp":1780473569404,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T00:00:00Z","timestamp":1228435200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1007\/s11626-008-9158-1","type":"journal-article","created":{"date-parts":[[2008,12,4]],"date-time":"2008-12-04T21:15:50Z","timestamp":1228425350000},"page":"194-200","source":"Crossref","is-referenced-by-count":44,"title":["Cissus quadrangularis extract enhances biomineralization through up-regulation of MAPK-dependent alkaline phosphatase activity in osteoblasts"],"prefix":"10.1007","volume":"45","author":[{"given":"Duenpim","family":"Parisuthiman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weerachai","family":"Singhatanadgit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaweephol","family":"Dechatiwongse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitthichai","family":"Koontongkaew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,12,5]]},"reference":[{"key":"9158_CR1","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1634\/stemcells.2006-0612","volume":"25","author":"B. Binetruy","year":"2007","unstructured":"Binetruy B.; Heasley L.; Bost F.; Caron L.; Aouadi M. Concise review: regulation of embryonic stem cell lineage commitment by mitogen-activated protein kinases. Stem Cells 25: 1090\u20131095; 2007. doi: 10.1634\/stemcells.2006-0612 .","journal-title":"Stem Cells"},{"key":"9158_CR2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.bone.2003.11.014","volume":"34","author":"L. R. Chaudhary","year":"2004","unstructured":"Chaudhary L. R.; Hofmeister A. M.; Hruska K. A. Differential growth factor control of bone formation through osteoprogenitor differentiation. Bone 34: 402\u2013411; 2004. doi: 10.1016\/j.bone.2003.11.014 .","journal-title":"Bone"},{"key":"9158_CR3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1089\/109662003322233495","volume":"6","author":"K. N. Chidambara Murthy","year":"2003","unstructured":"Chidambara Murthy K. N.; Vanitha A.; Mahadeva Swamy M.; Ravishankar G. A. Antioxidant and antimicrobial activity of Cissus quadrangularis L. J. Med. Food 6: 99\u2013105; 2003. doi: 10.1089\/109662003322233495 .","journal-title":"J. Med. Food"},{"key":"9158_CR4","first-page":"44","volume":"26","author":"D. K. Deka","year":"1994","unstructured":"Deka D. K.; Lahon D. C.; Saikia J.; Mukit A. Effect of Cissus quadrangularis in accelerating healing process of experimentally fractured radius-ulna of dog, a preliminary study. Indian J. Pharm. 26: 44\u201345; 1994.","journal-title":"Indian J. Pharm."},{"key":"9158_CR5","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0092-8674(00)80257-3","volume":"89","author":"P. Ducy","year":"1997","unstructured":"Ducy P.; Zhang R.; Geoffroy V.; Ridall A. L.; Karsenty G. Osf2\/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89: 747\u2013754; 1997. doi: 10.1016\/S0092-8674(00)80257-3 .","journal-title":"Cell"},{"key":"9158_CR6","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1196\/annals.1402.081","volume":"1116","author":"R. T. Franceschi","year":"2007","unstructured":"Franceschi R. T.; Ge C.; Xiao G.; Roca H.; Jiang D. I. Transcriptional regulation of osteoblasts. Ann. N. Y. Acad. Sci. 1116: 196\u2013207; 2007. doi: 10.1196\/annals.1402.081 .","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"9158_CR7","first-page":"446","volume":"88","author":"R. T. Franceschi","year":"2003","unstructured":"Franceschi R. T.; Xiao G. Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways. J. Cell Biol. 88: 446\u2013454; 2003.","journal-title":"J. Cell Biol."},{"key":"9158_CR8","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1359\/jbmr.2003.18.11.2060","volume":"18","author":"J. Guicheux","year":"2003","unstructured":"Guicheux J.; Lemonnier J.; Ghayor C.; Suzuki A.; Palmer G.; Caverzasio J. Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation. J. Bone Miner. Res. 18: 2060\u20132068; 2003. doi: 10.1359\/jbmr.2003.18.11.2060 .","journal-title":"J. Bone Miner. Res."},{"key":"9158_CR9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature01660","volume":"423","author":"S. Harada","year":"2003","unstructured":"Harada S.; Rodan G. A. Control of osteoblast function and regulation of bone mass. Nature 423: 349\u2013355; 2003. doi: 10.1038\/nature01660 .","journal-title":"Nature"},{"key":"9158_CR10","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1210\/en.2002-220863","volume":"144","author":"Y. Hu","year":"2003","unstructured":"Hu Y.; Chan E.; Wang S. X.; Li B. Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation. Endocrinology 144: 2068\u20132074; 2003. doi: 10.1210\/en.2002-220863 .","journal-title":"Endocrinology"},{"key":"9158_CR11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cbi.2006.04.011","volume":"161","author":"M. Jainu","year":"2006","unstructured":"Jainu M.; Devi C. S. Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: role of proinflammatory cytokines and oxidative damage. Chem. Biol. Interact. 161: 262\u2013270; 2006. doi: 10.1016\/j.cbi.2006.04.011 .","journal-title":"Chem. Biol. Interact."},{"key":"9158_CR12","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jep.2005.08.076","volume":"104","author":"M. Jainu","year":"2006","unstructured":"Jainu M.; Mohan K. V.; Devi C. S. Protective effect of Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats. J. Ethnopharmacol. 104: 302\u2013305; 2006. doi: 10.1016\/j.jep.2005.08.076 .","journal-title":"J. Ethnopharmacol."},{"key":"9158_CR13","doi-asserted-by":"crossref","first-page":"14443","DOI":"10.1074\/jbc.M010021200","volume":"276","author":"C.-F. Lai","year":"2001","unstructured":"Lai C.-F.; Chaudhary L.; Fausto A.; Halstead L. R.; Ory D. S.; Avioli L. V.; Cheng S.-L. Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells. J. Biol. Chem. 276: 14443\u201314450; 2001.","journal-title":"J. Biol. Chem."},{"key":"9158_CR14","first-page":"14","volume-title":"Primer on the metabolic bone diseases and disorders of mineral metabolism","author":"J. B. Lian","year":"1999","unstructured":"Lian J. B.; Stein G. S.; Canalis E.; Gehron Robey P.; Boskey A. L. Bone formation: osteoblast lineage cells, growth factors, matrix protein and the mineralization process. In: Favus; M. J. (eds) Primer on the metabolic bone diseases and disorders of mineral metabolism. Lippincott Williums & Wilkins, Philadelphia, PA, pp 14\u201329; 1999."},{"key":"9158_CR15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/pca.569","volume":"12","author":"M. Mehta","year":"2001","unstructured":"Mehta M.; Kaur N.; Bhutani K. K. Determination of marker constituents from Cissus quadrangularis Linn. and their quantitation by HPTLC and HPLC. Phytochem. Anal. 12: 91\u201395; 2001. doi: 10.1002\/pca.569 .","journal-title":"Phytochem. Anal."},{"key":"9158_CR16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00622-5","volume":"108","author":"K. Nakashima","year":"2002","unstructured":"Nakashima K.; Zhou X.; Kunkel G.; Zhang Z.; Deng J. M.; Behringer R. R.; de Crombrugghe B. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108: 17\u201329; 2002. doi: 10.1016\/S0092-8674(01)00622-5 .","journal-title":"Cell"},{"key":"9158_CR17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0014-4827(03)00386-0","volume":"291","author":"U. Noth","year":"2003","unstructured":"Noth U.; Tuli R.; Seghatoleslami R.; Howard M.; Shah A.; Hall D. J.; Hickok N. J.; Tuan R. S. Activation of p38 and Smads mediates BMP-2 effects on human trabecular bone-derived osteoblasts. Exp. Cell Res. 291: 201\u2013211; 2003. doi: 10.1016\/S0014-4827(03)00386-0 .","journal-title":"Exp. Cell Res."},{"key":"9158_CR18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-511X-5-24","volume":"5","author":"J. Oben","year":"2006","unstructured":"Oben J.; Kuate D.; Agbor G.; Momo C.; Talla X. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis. 5: 24; 2006. doi: 10.1186\/1476-511X-5-24 .","journal-title":"Lipids Health Dis."},{"key":"9158_CR19","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jep.2006.09.018","volume":"110","author":"A. Panthong","year":"2007","unstructured":"Panthong A.; Supraditaporn W.; Kanjanapothi D.; Taesotikul T.; Reutrakul V. Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn. J. Ethnopharmacol. 110: 264\u2013270; 2007. doi: 10.1016\/j.jep.2006.09.018 .","journal-title":"J. Ethnopharmacol."},{"key":"9158_CR20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1359\/JBMR.041026","volume":"20","author":"S. Pornprasertsuk","year":"2005","unstructured":"Pornprasertsuk S.; Duarte W. R.; Mochida Y.; Yamauchi M. Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization. J. Bone Miner. Res. 20: 81\u201387; 2005. doi: 10.1359\/JBMR.041026 .","journal-title":"J. Bone Miner. Res."},{"key":"9158_CR21","first-page":"667","volume":"51","author":"G. C. Prasad","year":"1963","unstructured":"Prasad G. C.; Udupa K. N. Effect of Cissus quadrangularis on the healing of cortisone treated fractures. Indian J. Med. Res. 51: 667\u2013676; 1963.","journal-title":"Indian J. Med. Res."},{"key":"9158_CR22","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.bcp.2003.11.009","volume":"67","author":"C. Prouillet","year":"2004","unstructured":"Prouillet C.; Maziere J.-C.; Maziere C.; Wattel A.; Brazier M.; Kamel S. Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Biochem. Pharmacol. 67: 1307\u20131313; 2004. doi: 10.1016\/j.bcp.2003.11.009 .","journal-title":"Biochem. Pharmacol."},{"key":"9158_CR23","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1172\/JCI27071","volume":"115","author":"L. G. Raisz","year":"2005","unstructured":"Raisz L. G. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J. Clin. Invest. 115: 3318\u20133325; 2005. doi: 10.1172\/JCI27071 .","journal-title":"J. Clin. Invest."},{"key":"9158_CR24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bone.2007.02.031","volume":"41","author":"A. Rey","year":"2007","unstructured":"Rey A.; Manen D.; Rizzoli R.; Ferrari S. L.; Caverzasio J. Evidences for a role of p38 MAP kinase in the stimulation of alkaline phosphatase and matrix mineralization induced by parathyroid hormone in osteoblastic cells. Bone 41: 59\u201367; 2007. doi: 10.1016\/j.bone.2007.02.031 .","journal-title":"Bone"},{"key":"9158_CR25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jep.2003.08.004","volume":"89","author":"A. Shirwaikar","year":"2003","unstructured":"Shirwaikar A.; Khan S.; Malini S. Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat. J Ethnopharmacol. 89: 245\u2013250; 2003. doi: 10.1016\/j.jep.2003.08.004 .","journal-title":"J Ethnopharmacol."},{"key":"9158_CR26","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/14786410601130471","volume":"21","author":"G. Singh","year":"2007","unstructured":"Singh G.; Rawat P.; Maurya R. Constituents of Cissus quadrangularis. Nat. Prod. Res. 21: 522\u2013528; 2007. doi: 10.1080\/14786410601130471 .","journal-title":"Nat. Prod. Res."},{"key":"9158_CR27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S8756-3282(01)00660-3","volume":"30","author":"A. Suzuki","year":"2002","unstructured":"Suzuki A.; Guicheux J.; Palmer G.; Miura Y.; Oiso Y.; Bonjour J. P.; Caverzasio J. Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation. Bone 30: 91\u201398; 2002. doi: 10.1016\/S8756-3282(01)00660-3 .","journal-title":"Bone"},{"key":"9158_CR28","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1210\/endo.140.7.6857","volume":"140","author":"A. Suzuki","year":"1999","unstructured":"Suzuki A.; Palmer G.; Bonjour J. P.; Caverzasio J. Regulation of alkaline phosphatase activity by p38 MAP kinase in response to activation of Gi protein-coupled receptors by epinephrine in osteoblast-like cells. Endocrinology 140: 3177\u20133182; 1999. doi: 10.1210\/en.140.7.3177 .","journal-title":"Endocrinology"},{"key":"9158_CR29","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1038\/sj.onc.1210415","volume":"26","author":"A. G. Turjanski","year":"2007","unstructured":"Turjanski A. G.; Vaque J. P.; Gutkind J. S. MAP kinases and the control of nuclear events. Oncogene 26: 3240\u20133253; 2007. doi: 10.1038\/sj.onc.1210415 .","journal-title":"Oncogene"},{"key":"9158_CR30","first-page":"480","volume":"52","author":"K. N. Udupa","year":"1964","unstructured":"Udupa K. N.; Prasad G. Biomechanical and calcium-45 studies on the effect of Cissus quadrangularis in fracture repair. Indian J. Med. Res. 52: 480\u2013487; 1964a.","journal-title":"Indian J. Med. Res."},{"key":"9158_CR31","first-page":"26","volume":"52","author":"K. N. Udupa","year":"1964","unstructured":"Udupa K. N.; Prasad G. C. Further studies on the effect of Cissus quadrangularis in accelerating fracture healing. Indian J. Med. Res. 52: 26\u201335; 1964b.","journal-title":"Indian J. Med. Res."},{"key":"9158_CR32","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1359\/jbmr.1999.14.6.893","volume":"14","author":"D. Wang","year":"1999","unstructured":"Wang D.; Christensen K.; Chawla K.; Xiao G.; Krebsbach P. H.; Franceschi R. T. Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation\/mineralization potential. J. Bone Miner. Res. 14: 893\u2013903; 1999. doi: 10.1359\/jbmr.1999.14.6.893 .","journal-title":"J. Bone Miner. Res."},{"key":"9158_CR33","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1359\/jbmr.2000.15.10.1879","volume":"15","author":"C. Wennberg","year":"2000","unstructured":"Wennberg C.; Hessle L.; Lundberg P.; Mauro S.; Narisawa S.; Lerner U. H.; Millan J. L. Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice. J. Bone Miner. Res. 15: 1879\u20131888; 2000. doi: 10.1359\/jbmr.2000.15.10.1879 .","journal-title":"J. Bone Miner. Res."},{"key":"9158_CR34","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1359\/jbmr.2002.17.1.101","volume":"17","author":"G. Xiao","year":"2002","unstructured":"Xiao G.; Gopalakrishnan R.; Jiang D.; Reith E.; Benson M. D.; Franceschi R. T. Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J. Bone Miner. Res. 17: 101\u2013110; 2002. doi: 10.1359\/jbmr.2002.17.1.101 .","journal-title":"J. Bone Miner. Res."},{"key":"9158_CR35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.phymed.2007.04.002","volume":"15","author":"D. W. Zhang","year":"2008","unstructured":"Zhang D. W.; Cheng Y.; Wang N. L.; Zhang J. C.; Yang M. S.; Yao X. S. Effects of total flavonoids and flavonol glycosides from Epimedium koreanum Nakai on the proliferation and differentiation of primary osteoblasts. Phytomedicine 15: 55\u201361; 2008. doi: 10.1016\/j.phymed.2007.04.002 .","journal-title":"Phytomedicine"}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-008-9158-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11626-008-9158-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-008-9158-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T18:26:49Z","timestamp":1559413609000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11626-008-9158-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,5]]},"references-count":35,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["9158"],"URL":"https:\/\/doi.org\/10.1007\/s11626-008-9158-1","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,5]]}}}