{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:09:02Z","timestamp":1791281342169,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T00:00:00Z","timestamp":1289952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1007\/s11626-010-9368-1","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T21:27:05Z","timestamp":1289942825000},"page":"125-131","source":"Crossref","is-referenced-by-count":351,"title":["The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro"],"prefix":"10.1007","volume":"47","author":[{"given":"Sarah J.","family":"Watkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian M.","family":"Borthwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Arthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,17]]},"reference":[{"issue":"Pt 2","key":"9368_CR1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1042\/bj3090437","volume":"309","author":"MA Bogoyevitch","year":"1995","unstructured":"Bogoyevitch M. A.; Clerk A.; Sugden P. H. Activation of the mitogen-activated protein kinase cascade by pertussis toxin-sensitive and -insensitive pathways in cultured ventricular cardiomyocytes. Biochem J 309(Pt 2): 437\u2013443; 1995.","journal-title":"Biochem J"},{"key":"9368_CR2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1006\/dbio.2001.0313","volume":"235","author":"EW Brunskill","year":"2001","unstructured":"Brunskill E. W.; Witte D. P.; Yutzey K. E.; Potter S. S. Novel cell lines promote the discovery of genes involved in early heart development. Dev Biol 235: 507\u2013520; 2001.","journal-title":"Dev Biol"},{"key":"9368_CR3","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1096\/fasebj.5.15.1835945","volume":"5","author":"KR Chien","year":"1991","unstructured":"Chien K. R.; Knowlton K. U.; Zhu H.; Chien S. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J 5: 3037\u20133046; 1991.","journal-title":"FASEB J"},{"key":"9368_CR4","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1073\/pnas.95.6.2979","volume":"95","author":"WC Claycomb","year":"1998","unstructured":"Claycomb W. C.; Lanson Jr. N. A.; Stallworth B. S.; Egeland D. B.; Delcarpio J. B.; Bahinski A. et al. HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci USA 95: 2979\u20132984; 1998.","journal-title":"Proc Natl Acad Sci USA"},{"key":"9368_CR5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yjmcc.2005.03.003","volume":"39","author":"MM Davidson","year":"2005","unstructured":"Davidson M. M.; Nesti C.; Palenzuela L.; Walker W. F.; Hernandez E.; Protas L. et al. Novel cell lines derived from adult human ventricular cardiomyocytes. J Mol Cell Cardiol 39: 133\u2013147; 2005.","journal-title":"J Mol Cell Cardiol"},{"key":"9368_CR6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1042\/BST0381037","volume":"38","author":"E Dick","year":"2010","unstructured":"Dick E.; Rajamohan D.; Ronksley J.; Denning C. Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening. Biochem. Soc. Trans. 38: 1037\u20131045; 2010.","journal-title":"Biochem. Soc. Trans."},{"key":"9368_CR7","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1161\/CIRCULATIONAHA.107.711317","volume":"116","author":"D Frank","year":"2007","unstructured":"Frank D.; Kuhn C.; van Eickels M.; Gehring D.; Hanselmann C.; Lippl S. et al. Calsarcin-1 protects against angiotensin II-induced cardiac hypertrophy. Circulation 116: 2587\u20132596; 2007.","journal-title":"Circulation"},{"key":"9368_CR8","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/jcb.22164","volume":"107","author":"C Freund","year":"2009","unstructured":"Freund C.; Mummery C. L. Prospects for pluripotent stem cell-derived cardiomyocytes in cardiac cell therapy and as disease models. J Cell Biochem 107: 592\u2013599; 2009.","journal-title":"J Cell Biochem"},{"key":"9368_CR9","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1079\/IVP2006787","volume":"42","author":"BI Goldman","year":"2006","unstructured":"Goldman B. I.; Amin K. M.; Kubo H.; Singhal A.; Wurzel J. Human myocardial cell lines generated with SV40 temperature-sensitive mutant tsA58. In Vitro Cell Dev Biol Anim 42: 324\u2013331; 2006.","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"9368_CR10","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1161\/01.RES.69.6.1476","volume":"69","author":"J Hescheler","year":"1991","unstructured":"Hescheler J.; Meyer R.; Plant S.; Krautwurst D.; Rosenthal W.; Schultz G. Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart. Circ Res 69: 1476\u20131486; 1991.","journal-title":"Circ Res"},{"key":"9368_CR11","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.bbrc.2004.09.156","volume":"324","author":"CY Huang","year":"2004","unstructured":"Huang C. Y.; Chueh P. J.; Tseng C. T.; Liu K. Y.; Tsai H. Y.; Kuo W. W. et al. ZAK reprograms atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells. Biochem Biophys Res Commun 324: 973\u2013980; 2004a.","journal-title":"Biochem Biophys Res Commun"},{"key":"9368_CR12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.bbrc.2004.09.067","volume":"324","author":"CY Huang","year":"2004","unstructured":"Huang C. Y.; Kuo W. W.; Chueh P. J.; Tseng C. T.; Chou M. Y.; Yang J. J. Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK. Biochem Biophys Res Commun 324: 424\u2013431; 2004b.","journal-title":"Biochem Biophys Res Commun"},{"key":"9368_CR13","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1056\/NEJM199910213411706","volume":"341","author":"JJ Hunter","year":"1999","unstructured":"Hunter J. J.; Chien K. R. Signaling pathways for cardiac hypertrophy and failure. N Engl J Med 341: 1276\u20131283; 1999.","journal-title":"N Engl J Med"},{"key":"9368_CR14","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1172\/JCI116579","volume":"92","author":"H Ito","year":"1993","unstructured":"Ito H.; Hirata Y.; Adachi S.; Tanaka M.; Tsujino M.; Koike A. et al. Endothelin-1 is an autocrine\/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest 92: 398\u2013403; 1993.","journal-title":"J Clin Invest"},{"key":"9368_CR15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0014-4827(76)90447-X","volume":"98","author":"BW Kimes","year":"1976","unstructured":"Kimes B. W.; Brandt B. L. Properties of a clonal muscle cell line from rat heart. Exp Cell Res 98: 367\u2013381; 1976.","journal-title":"Exp Cell Res"},{"key":"9368_CR16","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1016\/j.febslet.2009.08.011","volume":"583","author":"AL Koekemoer","year":"2009","unstructured":"Koekemoer A. L.; Chong N. W.; Goodall A. H.; Samani N. J. Myocyte stress 1 plays an important role in cellular hypertrophy and protection against apoptosis. FEBS Lett 583: 2964\u20132967; 2009.","journal-title":"FEBS Lett"},{"key":"9368_CR17","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cardiores.2007.03.003","volume":"75","author":"M Padmasekar","year":"2007","unstructured":"Padmasekar M.; Nandigama R.; Wartenberg M.; Schluter K. D.; Sauer H. The acute phase protein alpha2-macroglobulin induces rat ventricular cardiomyocyte hypertrophy via ERK1, 2 and PI3-kinase\/Akt pathways. Cardiovasc Res 75: 118\u2013128; 2007.","journal-title":"Cardiovasc Res"},{"key":"9368_CR18","doi-asserted-by":"crossref","first-page":"26339","DOI":"10.1074\/jbc.M414409200","volume":"280","author":"A Pedram","year":"2005","unstructured":"Pedram A.; Razandi M.; Aitkenhead M.; Levin E. R. Estrogen inhibits cardiomyocyte hypertrophy in vitro. Antagonism of calcineurin-related hypertrophy through induction of MCIP1. J Biol Chem 280: 26339\u201326348; 2005.","journal-title":"J Biol Chem"},{"key":"9368_CR19","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.yjmcc.2009.08.030","volume":"47","author":"F Rao","year":"2009","unstructured":"Rao F.; Deng C. Y.; Wu S. L.; Xiao D. Z.; Yu X. Y.; Kuang S. J. et al. Involvement of Src in L-type Ca2+ channel depression induced by macrophage migration inhibitory factor in atrial myocytes. J Mol Cell Cardiol 47: 586\u2013594; 2009.","journal-title":"J Mol Cell Cardiol"},{"key":"9368_CR20","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cardiores.2004.04.030","volume":"63","author":"S Rosenkranz","year":"2004","unstructured":"Rosenkranz S. TGF-beta1 and angiotensin networking in cardiac remodeling. Cardiovasc Res 63: 423\u2013432; 2004.","journal-title":"Cardiovasc Res"},{"key":"9368_CR21","doi-asserted-by":"crossref","first-page":"H835","DOI":"10.1152\/ajpheart.01365.2005","volume":"291","author":"N Shimojo","year":"2006","unstructured":"Shimojo N.; Jesmin S.; Zaedi S.; Maeda S.; Soma M.; Aonuma K. et al. Eicosapentaenoic acid prevents endothelin-1-induced cardiomyocyte hypertrophy in vitro through the suppression of TGF-beta 1 and phosphorylated JNK. Am J Physiol Heart Circ Physiol 291: H835\u2013H845; 2006.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"9368_CR22","doi-asserted-by":"crossref","first-page":"20555","DOI":"10.1016\/S0021-9258(17)30538-0","volume":"265","author":"HE Shubeita","year":"1990","unstructured":"Shubeita H. E.; McDonough P. M.; Harris A. N.; Knowlton K. U.; Glembotski C. C.; Brown J. H. et al. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. J Biol Chem 265: 20555\u201320562; 1990.","journal-title":"J Biol Chem"},{"key":"9368_CR23","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/01.RES.69.6.1487","volume":"69","author":"KR Sipido","year":"1991","unstructured":"Sipido K. R.; Marban E. L-type calcium channels, potassium channels, and novel nonspecific cation channels in a clonal muscle cell line derived from embryonic rat ventricle. Circ Res 69: 1487\u20131499; 1991.","journal-title":"Circ Res"},{"key":"9368_CR24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11626-007-9079-4","volume":"44","author":"P Sreejit","year":"2008","unstructured":"Sreejit P.; Kumar S.; Verma R. S. An improved protocol for primary culture of cardiomyocyte from neonatal mice. In Vitro Cell Dev Biol Anim 44: 45\u201350; 2008.","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"9368_CR25","first-page":"H1826","volume":"259","author":"ME Steinhelper","year":"1990","unstructured":"Steinhelper M. E.; Lanson Jr. N. A.; Dresdner K. P.; Delcarpio J. B.; Wit A. L.; Claycomb W. C. et al. Proliferation in vivo and in culture of differentiated adult atrial cardiomyocytes from transgenic mice. Am J Physiol 259: H1826\u2013H1834; 1990.","journal-title":"Am J Physiol"},{"key":"9368_CR26","doi-asserted-by":"crossref","first-page":"S359","DOI":"10.1054\/jcaf.2002.129282","volume":"8","author":"PH Sugden","year":"2002","unstructured":"Sugden P. H. Signaling pathways activated by vasoactive peptides in the cardiac myocyte and their role in myocardial pathologies. J Card Fail 8: S359\u2013S369; 2002.","journal-title":"J Card Fail"},{"key":"9368_CR27","doi-asserted-by":"crossref","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","volume":"3","author":"J Vandesompele","year":"2002","unstructured":"Vandesompele J.; De Preter K.; Pattyn F.; Poppe B.; Van Roy N.; De Paepe A. et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3: RESEARCH0034; 2002.","journal-title":"Genome Biol"},{"key":"9368_CR28","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.bbrc.2009.12.001","volume":"391","author":"C Vindis","year":"2010","unstructured":"Vindis C.; D'Angelo R.; Mucher E.; Negre-Salvayre A.; Parini A.; Mialet-Perez J. Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT2A serotonin receptors. Biochem Biophys Res Commun 391: 979\u2013983; 2010.","journal-title":"Biochem Biophys Res Commun"},{"key":"9368_CR29","first-page":"755","volume":"64","author":"Z Wang","year":"2009","unstructured":"Wang Z.; Cao Y.; Shen X.; Bu X.; Bao Y.; Le K. et al. Inhibition of endothelin converting enzyme-1 activity or expression ameliorates angiotensin II-induced myocardial hypertrophy in cultured cardiomyocytes. Pharmazie 64: 755\u2013759; 2009.","journal-title":"Pharmazie"},{"key":"9368_CR30","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.cardiores.2005.11.007","volume":"69","author":"SJ Watkins","year":"2006","unstructured":"Watkins S. J.; Jonker L.; Arthur H. M. A direct interaction between TGFbeta activated kinase 1 and the TGFbeta type II receptor: implications for TGFbeta signalling and cardiac hypertrophy. Cardiovasc Res 69: 432\u2013439; 2006.","journal-title":"Cardiovasc Res"},{"key":"9368_CR31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3181\/00379727-232-2320385","volume":"232","author":"Y Zhou","year":"2007","unstructured":"Zhou Y.; Jiang Y.; Kang Y. J. Copper inhibition of hydrogen peroxide-induced hypertrophy in embryonic rat cardiac H9c2 cells. Exp Biol Med (Maywood) 232: 385\u2013389; 2007.","journal-title":"Exp Biol Med (Maywood)"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-010-9368-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11626-010-9368-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-010-9368-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T08:14:14Z","timestamp":1711959254000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11626-010-9368-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,17]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["9368"],"URL":"https:\/\/doi.org\/10.1007\/s11626-010-9368-1","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,17]]}}}