{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:43:16Z","timestamp":1790473396132,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T00:00:00Z","timestamp":1428710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s11626-014-9841-3","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T03:00:19Z","timestamp":1428721219000},"page":"630-643","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["In vitro antioxidant and hepatoprotective potential of Azolla microphylla phytochemically synthesized gold nanoparticles on acetaminophen \u2013 induced hepatocyte damage in Cyprinus carpio L."],"prefix":"10.1007","volume":"51","author":[{"given":"Selvaraj","family":"Kunjiappan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiranjib","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,11]]},"reference":[{"key":"9841_CR1","doi-asserted-by":"crossref","first-page":"S1392","DOI":"10.1016\/S2221-1691(12)60423-7","volume":"2","author":"G Abraham","year":"2012","unstructured":"Abraham G, Vidhu A (2012) A preliminary examination of the phytochemical profile of Azolla microphylla with respect to seasons. Asian Pac J Trop Biomed 2:S1392\u2013S1395","journal-title":"Asian Pac J Trop Biomed"},{"key":"9841_CR2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.freeradbiomed.2005.04.017","volume":"39","author":"ML Alexandrova","year":"2005","unstructured":"Alexandrova ML, Bochev PG (2005) Oxidative stress during the chronic phase of stroke. Free Radic Biol Med 39:297\u2013316","journal-title":"Free Radic Biol Med"},{"key":"9841_CR3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/01480548109066370","volume":"4","author":"WA Al-Turk","year":"1981","unstructured":"Al-Turk WA, Stohs SJ (1981) Hepatic glutathione content and aryl hydrocarbon hydroxylase activity of acetaminophen treated mice as a function of age. Drug Chem Toxicol 4:37\u201348","journal-title":"Drug Chem Toxicol"},{"key":"9841_CR4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.aquatox.2009.07.006","volume":"94","author":"LK Bickley","year":"2009","unstructured":"Bickley LK, Lange A, Winter MJ, Tyler CR (2009) Evaluation of a carp primary hepatocyte culture system for screening chemicals for oestrogenic activity. Aquat Toxicol 94:195\u2013203","journal-title":"Aquat Toxicol"},{"key":"9841_CR5","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1139\/z92-173","volume":"70","author":"LT Buck","year":"2001","unstructured":"Buck LT, Brill RW, Hocharchkp AW (2001) Gluconeogenesis in hepatocytes isolated from the skipjack tuna (Kutsuwonus pelamis). Can J Zool 70:1254\u20131257","journal-title":"Can J Zool"},{"key":"9841_CR6","first-page":"317","volume":"31","author":"A Castano","year":"2003","unstructured":"Castano A, Bols N, Braunbeck T, Dierickx P, Halder MB, Kawahara K, Lee LEJ, Mothersill C, Part P, Repetto G, Sintes JR, Rufli H, Smith R, Wood C, Segner H (2003) The use of fish cells in ecotoxicology. ATLA 31:317\u2013351","journal-title":"ATLA"},{"key":"9841_CR7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jep.2003.08.006","volume":"89","author":"RR Chattopadhyay","year":"2003","unstructured":"Chattopadhyay RR (2003) Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: part II. J Ethnopharmacol 89:217\u2013219","journal-title":"J Ethnopharmacol"},{"key":"9841_CR8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1475-2891-5-31","volume":"5","author":"H Chen","year":"2006","unstructured":"Chen H, Yan X, Zhu P, Lin J (2006) Antioxidant activity and hepatoprotective potential of agaro-oligosaccharides in vitro and in vivo. Nutr J 5:31","journal-title":"Nutr J"},{"key":"9841_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4077\/CJP.2012.AMM056","volume":"55","author":"Y-P Chen","year":"2012","unstructured":"Chen Y-P, Dai Z-H, Liu P-C, Chuu J-J, Lee K-Y, Lee S-L, Chen Y-J (2012) Effects of nanogold on the alleviation of carbon tetrachloride-induced hepatic injury in rats. Chin J Physiol 55:1\u20135","journal-title":"Chin J Physiol"},{"key":"9841_CR10","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1073\/pnas.81.5.1327","volume":"81","author":"DC Dahlin","year":"1984","unstructured":"Dahlin DC, Miwa GT, Lu AY, Nelson SD (1984) N-Acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc Natl Acad Sci 81:1327\u20131331","journal-title":"Proc Natl Acad Sci"},{"key":"9841_CR11","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/S0022-3565(25)12225-8","volume":"275","author":"Y Dai","year":"1995","unstructured":"Dai Y, Cederbaum AI (1995) Inactivation and degradation of human cytochrome P4502E1 by CC14 in a transfected hepg2 cell line. J Pharmacol Exp Ther 275:1614\u20131622","journal-title":"J Pharmacol Exp Ther"},{"key":"9841_CR12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0378-8741(98)00229-3","volume":"66","author":"C Gadgoli","year":"1999","unstructured":"Gadgoli C, Mishra SH (1999) Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa. J Ethnopharmacol 66:187\u2013192","journal-title":"J Ethnopharmacol"},{"key":"9841_CR13","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.addr.2008.03.016","volume":"60","author":"P Ghosh","year":"2008","unstructured":"Ghosh P, Han G, De M, Kim CK, Rotello VM (2008) Gold nanoparticles in delivery applications. Adv Drug Deliv Rev 60:1307\u20131315","journal-title":"Adv Drug Deliv Rev"},{"key":"9841_CR14","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/35104607","volume":"414","author":"M Gratzel","year":"2001","unstructured":"Gratzel M (2001) Photoelectrochemical cells. Nature 414:338\u2013344","journal-title":"Nature"},{"key":"9841_CR15","first-page":"307","volume":"57","author":"SS Handa","year":"1986","unstructured":"Handa SS, Sharma A, Chakraborti KK (1986) Natural products and plants as liver protecting drugs. Fitoterpia 57:307\u2013351","journal-title":"Fitoterpia"},{"key":"9841_CR16","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0955-2863(02)00208-5","volume":"13","author":"KE Heim","year":"2002","unstructured":"Heim KE, Tagliaferro AR, Bobilya DJ (2002) Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem 13:572\u2013584","journal-title":"J Nutr Biochem"},{"key":"9841_CR17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/65.2.166","volume":"65","author":"H Jaeschke","year":"2002","unstructured":"Jaeschke H, Gores GJ, Cederbaum AI, Jack A, Hinson JA, Pessayre D, Lemasters JJ (2002) FORUM mechanisms of hepatotoxicity. Toxicol Sci 65:166\u2013176","journal-title":"Toxicol Sci"},{"key":"9841_CR18","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.3748\/wjg.v16.i19.2448","volume":"16","author":"H Jaeschke","year":"2010","unstructured":"Jaeschke H, Williams CD, Mcgill MR, Farhood A (2010) Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity. World J Gastroenterol 16:2448\u20132450","journal-title":"World J Gastroenterol"},{"key":"9841_CR19","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1124\/dmd.31.12.1499","volume":"31","author":"LP James","year":"2003","unstructured":"James LP, Mayeux PR, Hinson JA (2003) Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 31:1499\u20131506","journal-title":"Drug Metab Dispos"},{"key":"9841_CR20","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s10695-011-9575-z","volume":"38","author":"R Jia","year":"2012","unstructured":"Jia R, Cao L, Xu P, Jeney G, Yin G (2012) In vitro and in vivo hepatoprotective and antioxidant effects of Astragalus polysaccharides against carbon tetrachloride-induced hepatocyte damage in common carp (Cyprinus carpio). Fish Physiol Biochem 38:871\u2013881","journal-title":"Fish Physiol Biochem"},{"key":"9841_CR21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrd1750","volume":"4","author":"N Kaplowitz","year":"2005","unstructured":"Kaplowitz N (2005) Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov 4:489\u2013499","journal-title":"Nat Rev Drug Discov"},{"issue":"7","key":"9841_CR22","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/ceat.200900046","volume":"32","author":"N Krumov","year":"2009","unstructured":"Krumov N, Perner-Nochta I, Oder S, Gotcheva V, Angelov A, Posten C (2009) Biological synthesis of inorganic nanoparticles by microorganisms. Chem Eng Technol 32(7):1026\u20131035","journal-title":"Chem Eng Technol"},{"key":"9841_CR23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jep.2003.12.009","volume":"92","author":"G Kumar","year":"2004","unstructured":"Kumar G, Sharmila Banu G, Vanitha Pappa P, Sundararajan M, Rajasekara Pandian M (2004) Hepatoprotective activity of Trianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats. J Ethnopharmacol 92:37\u201340","journal-title":"J Ethnopharmacol"},{"key":"9841_CR24","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1142\/S0192415X06004004","volume":"34","author":"C-Y Lee","year":"2006","unstructured":"Lee C-Y, Peng W-H, Cheng H-Y, Chen F-N, Lai M-T, Chiu T-H (2006) Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride. Am J Chin Med 34:471\u2013482","journal-title":"Am J Chin Med"},{"key":"9841_CR25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0891-5849(95)00023-Q","volume":"19","author":"S Lores Arnaiz","year":"1995","unstructured":"Lores Arnaiz S, Llesuy S, Cutrin JC, Boveris A (1995) Oxidative stress by acute acetaminophen administration in mouse liver. Free Radic Biol Med 19:303\u2013310","journal-title":"Free Radic Biol Med"},{"key":"9841_CR26","first-page":"213","volume-title":"Clinical enzymology, a case-oriented approach","author":"JA Lott","year":"1987","unstructured":"Lott JA, Nemensanszky E (1987) Lactate dehydrogenase. In: Lott JA, Wolf PL (eds) Clinical enzymology, a case-oriented approach. Yearbook Medical, New York, pp 213\u2013244"},{"key":"9841_CR27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/BF03160941","volume":"4","author":"M Mazer","year":"2008","unstructured":"Mazer M, Perrone J (2008) Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. J Med Toxicol 4:2\u20136","journal-title":"J Med Toxicol"},{"key":"9841_CR28","doi-asserted-by":"crossref","first-page":"1285T","DOI":"10.1096\/fasebj.8.15.8001741","volume":"8","author":"HM Mehendale","year":"1994","unstructured":"Mehendale HM, Roth RA, Gandolfi AJ, Klaunig JE, Lemasters JJ, Curtis LR (1994) Novel mechanisms in chemically induced hepatotoxicity. FASEB J 8:1285T\u20131295T","journal-title":"FASEB J"},{"key":"9841_CR29","first-page":"951","volume":"1","author":"DK Mittal","year":"2010","unstructured":"Mittal DK, Joshi D, Shukla S (2010) Protective effects of Polygonum bistort (Linn.) and its active principle against acetaminophen-induced toxicity in rats. Asian J Exp Biol Sci 1:951\u2013958","journal-title":"Asian J Exp Biol Sci"},{"key":"9841_CR30","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1523-1755.2005.67111.x","volume":"67","author":"AJ Nauta","year":"2005","unstructured":"Nauta AJ, De Haij S, Bottazzi B, Mantovani A, Borrias MC, Aten J, Rastaldi MP, Daha MR, Van Kooten C, Roos A (2005) Human renal epithelial cells produce the long pentraxin PTX3. Kidney Int 67:543\u2013553","journal-title":"Kidney Int"},{"key":"9841_CR31","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1021\/tx00034a019","volume":"6","author":"CJ Patten","year":"1993","unstructured":"Patten CJ, Thomas PE, Guy RL, Lee M, Gonzales FJ, Guengerich FP, Yang CS (1993) Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. Chem Res Toxicol 6:511\u2013518","journal-title":"Chem Res Toxicol"},{"issue":"5","key":"9841_CR32","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.physe.2009.11.081","volume":"42","author":"D Philip","year":"2010","unstructured":"Philip D (2010) Green synthesis of gold and silver nanoparticles using Hibiscus rosasinensis. Phys E Low Dimens Syst Nanostruct 42(5):1417\u20131424","journal-title":"Phys E Low Dimens Syst Nanostruct"},{"key":"9841_CR33","first-page":"110","volume":"29","author":"KS Rao","year":"1997","unstructured":"Rao KS, Mishra SH (1997) Anti-inflammatory and hepatoprotective activities of Sida rhombifolia Linn. Indian J Pharmacol 29:110\u2013116","journal-title":"Indian J Pharmacol"},{"key":"9841_CR34","volume-title":"The isolated hepatocytes. Use in toxicology and Xenobiotic biotransformation. Cell biology\u2014a series of monographs","year":"1987","unstructured":"Raukman EJ, Padilla GM (eds) (1987) The isolated hepatocytes. Use in toxicology and Xenobiotic biotransformation. Cell biology\u2014a series of monographs. Academic, New York"},{"key":"9841_CR35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0378-8741(01)00191-X","volume":"75","author":"RK Reen","year":"2001","unstructured":"Reen RK, Karan M, Singh K, Karan V, Johri RK, Singh J (2001) Screening of various Swerita species extracts in primary monolayer cultures of rat hepatocyte against carbon tetrachloride- and paracetamol-induced toxicity. J Ethanopharmacol 75:239\u2013247","journal-title":"J Ethanopharmacol"},{"key":"9841_CR36","doi-asserted-by":"crossref","unstructured":"Roy P, Das S, Auddy RG, Saha A, Mukherjee A (2012) Engineered andrographolide nanoparticles mitigate paracetamol hepatotoxicity in mice. Pharm Res 30(5):1252\u22121262","DOI":"10.1007\/s11095-012-0964-5"},{"key":"9841_CR37","first-page":"1","volume":"5","author":"K Selvaraj","year":"2013","unstructured":"Selvaraj K, Chowdhury R, Bhattacharjee C (2013) Isolation and structural elucidation of flavonoids from aquatic fern Azolla microphylla and evaluation of free radical scavenging activity. Int J Pharm Pharm Sci 5:1\u201312","journal-title":"Int J Pharm Pharm Sci"},{"issue":"2","key":"9841_CR38","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jcis.2004.03.003","volume":"275","author":"SS Shankar","year":"2004","unstructured":"Shankar SS, Rai A, Ahmad A, Sastry M (2004) Rapid synthesis of Au, Ag, and bimetallic Au core\u2013Ag shell nanoparticles using neem (Azadirachta indica) leaf broth. J Colloid Interface Sci 275(2):496\u2013502","journal-title":"J Colloid Interface Sci"},{"key":"9841_CR39","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1021\/nl102184c","volume":"10","author":"J Shi","year":"2010","unstructured":"Shi J, Votruba AR, Farokhzad OC, Langer R (2010) Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett 10:3223\u20133230","journal-title":"Nano Lett"},{"key":"9841_CR40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0944-7113(97)80024-4","volume":"4","author":"MF Souza","year":"1997","unstructured":"Souza MF, Rao VSN, Silveira ER (1997) Inhibition of lipid peroxidation by ter-natin, a tetramethoxyflavone from Egletes viscosa L. Phytomed 4:27\u201331","journal-title":"Phytomed"},{"key":"9841_CR41","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.3748\/wjg.15.2817","volume":"15","author":"G Tarantino","year":"2009","unstructured":"Tarantino G, Di Minno MN, Capane D (2009) Drug induced liver injury: is it somehow foreseeable? World J Gastroenterol 15:2817\u20132833","journal-title":"World J Gastroenterol"},{"key":"9841_CR42","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s12098-007-0118-7","volume":"74","author":"BR Thapa","year":"2007","unstructured":"Thapa BR, Walia A (2007) Liver function tests and their interpretation. Indian J Pediatr 74:663\u2013671","journal-title":"Indian J Pediatr"},{"key":"9841_CR43","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1039\/df9511100055","volume":"11","author":"J Turkevitch","year":"1951","unstructured":"Turkevitch J, Stevenson PC, Hillier JA (1951) Study of the nucleation and growth process in the synthesis of colloidal gold. Faraday Soc 11:55\u201375","journal-title":"Faraday Soc"},{"key":"9841_CR44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02857915","volume":"63","author":"GM Wagner","year":"1997","unstructured":"Wagner GM (1997) Azolla: a review of its biology and utilization. Bot Rev 63:1\u201326","journal-title":"Bot Rev"},{"key":"9841_CR45","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ecoenv.2004.01.005","volume":"58","author":"X Wan","year":"2004","unstructured":"Wan X, Ma T, Wu W, Wang Z (2004) EROD activities in a primary cell culture of grass carp (Ctenopharyngodon idellus) hepatocytes exposed to polychlorinated aromatic hydrocarbons. Ecotoxicol Environ Saf 58:84\u201389","journal-title":"Ecotoxicol Environ Saf"},{"key":"9841_CR46","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/adma.200390087","volume":"15","author":"Y Xia","year":"2003","unstructured":"Xia Y, Yang P, Sun Y, Wu Y, Mayers B, Gates B, Yin Y, Kim F, Yan H (2003) One-dimensional nanostructures: synthesis, characterization, and applications. Adv Mater 15:353\u2013389","journal-title":"Adv Mater"},{"key":"9841_CR47","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10616-008-9169-5","volume":"58","author":"F Yanhong","year":"2008","unstructured":"Yanhong F, Chenghua H, Guofang L, Haibin Z (2008) Optimization of the isolation and cultivation of Cyprinus carpio primary hepatocytes. Cytotechnology 58:85\u201392","journal-title":"Cytotechnology"},{"key":"9841_CR48","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11626-010-9359-2","volume":"47","author":"G Yin","year":"2011","unstructured":"Yin G, Cao L, Xu P, Jeney G, Nakao M (2011) Hepatoprotective and antioxidant effects of Hibiscus sabdariffa extract against carbon tetrachloride-induced hepatocyte damage in Cyprinus carpio. In Vitro Cell Dev Biol Anim 47:10\u201315","journal-title":"In Vitro Cell Dev Biol Anim"}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-014-9841-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11626-014-9841-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-014-9841-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T08:59:18Z","timestamp":1747904358000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11626-014-9841-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,11]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["9841"],"URL":"https:\/\/doi.org\/10.1007\/s11626-014-9841-3","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,11]]}}}