{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:50:07Z","timestamp":1760215807078},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s11626-014-9844-0","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T20:54:02Z","timestamp":1417726442000},"page":"353-360","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Melatonin protects against myocardial hypertrophy induced by lipopolysaccharide"],"prefix":"10.1007","volume":"51","author":[{"given":"Qi","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,12,5]]},"reference":[{"key":"9844_CR1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.yjmcc.2011.01.012","volume":"51","author":"ME Anderson","year":"2011","unstructured":"Anderson ME, Brown JH, Bers DM (2011) CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol 51:468\u2013473","journal-title":"J Mol Cell Cardiol"},{"key":"9844_CR2","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0002-9149(99)00112-5","volume":"83","author":"S Arangino","year":"1999","unstructured":"Arangino S, Cagnacci A, Angiolucci M, Vacca AM, Longu G, Volpe A, Melis GB (1999) Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. Am J Cardiol 83:1417\u20131419","journal-title":"Am J Cardiol"},{"key":"9844_CR3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s004410050618","volume":"285","author":"M Arras","year":"1996","unstructured":"Arras M, Hoche A, Bohle R, Eckert P, Riedel W, Schaper J (1996) Tumor necrosis factor-alpha in macrophages of heart, liver, kidney, and in the pituitary gland. Cell Tissue Res 285:39\u201349","journal-title":"Cell Tissue Res"},{"key":"9844_CR4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/01.CIR.89.1.151","volume":"89","author":"CA Beltrami","year":"1994","unstructured":"Beltrami CA, Finato N, Rocco M, Feruglio GA, Puricelli C, Cigola E, Quaini F, Sonnenblick EH, Olivetti G, Anversa P (1994) Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circ 89:151\u2013163","journal-title":"Circ"},{"key":"9844_CR5","doi-asserted-by":"crossref","first-page":"H8","DOI":"10.1152\/ajpheart.01303.2004","volume":"289","author":"K Berenji","year":"2005","unstructured":"Berenji K, Drazner MH, Rothermel BA, Hill JA (2005) Does load-induced ventricular hypertrophy progress to systolic heart failure? Am J Physiol Heart Circ Physiol 289:H8\u2013H16","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"Pt 1","key":"9844_CR6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1042\/bj3140115","volume":"314","author":"MA Bogoyevitch","year":"1996","unstructured":"Bogoyevitch MA, Andersson MB, Gillespie-Brown J, Clerk A, Glennon PE, Fuller SJ, Sugden PH (1996) Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy. Biochem J 314(Pt 1):115\u2013121","journal-title":"Biochem J"},{"key":"9844_CR7","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1161\/01.CIR.97.14.1382","volume":"97","author":"B Bozkurt","year":"1998","unstructured":"Bozkurt B, Kribbs SB, Clubb FJ Jr, Michael LH, Didenko VV, Hornsby PJ, Seta Y, Oral H, Spinale FG, Mann DL (1998) Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats. Circ 97:1382\u20131391","journal-title":"Circ"},{"key":"9844_CR8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1600-079X.2010.00808.x","volume":"50","author":"CF Chen","year":"2011","unstructured":"Chen CF, Wang D, Reiter RJ, Yeh DY (2011) Oral melatonin attenuates lung inflammation and airway hyperreactivity induced by inhalation of aerosolized pancreatic fluid in rats. J Pineal Res 50:46\u201353","journal-title":"J Pineal Res"},{"key":"9844_CR9","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1074\/jbc.274.16.10689","volume":"274","author":"JC Chow","year":"1999","unstructured":"Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F (1999) Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274:10689\u201310692","journal-title":"J Biol Chem"},{"key":"9844_CR10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-079X.1999.tb00591.x","volume":"27","author":"S Cuzzocrea","year":"1999","unstructured":"Cuzzocrea S, Costantino G, Mazzon E, Caputi AP (1999) Regulation of prostaglandin production in carrageenan-induced pleurisy by melatonin. J Pineal Res 27:9\u201314","journal-title":"J Pineal Res"},{"key":"9844_CR11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2174\/1566524033361537","volume":"3","author":"A Diwan","year":"2003","unstructured":"Diwan A, Tran T, Misra A, Mann DL (2003) Inflammatory mediators and the failing heart: a translational approach. Curr Mol Med 3:161\u2013182","journal-title":"Curr Mol Med"},{"key":"9844_CR12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ijcard.2012.04.110","volume":"158","author":"A Dominguez-Rodriguez","year":"2012","unstructured":"Dominguez-Rodriguez A, Abreu-Gonzalez P, Reiter RJ (2012) Melatonin and cardioprotection in the acute myocardial infarction: a promising cardioprotective agent. Int J Cardiol 158:309\u2013310","journal-title":"Int J Cardiol"},{"key":"9844_CR13","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","volume":"133","author":"JR Erickson","year":"2008","unstructured":"Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O\u2019Donnell SE, Aykin-Burns N et al (2008) A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell 133:462\u2013474","journal-title":"Cell"},{"key":"9844_CR14","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","volume":"109","author":"N Frey","year":"2004","unstructured":"Frey N, Katus HA, Olson EN, Hill JA (2004) Hypertrophy of the heart: a new therapeutic target? Circ 109:1580\u20131589","journal-title":"Circ"},{"key":"9844_CR15","first-page":"1","volume":"16","author":"M Fu","year":"2001","unstructured":"Fu M, Zhang J, Xu S, Pang Y, Liu N, Tang C (2001) Role of calcineurin in angiotensin II-induced cardiac myocyte hypertrophy of rats. Chin Med Sci J 16:1\u20134","journal-title":"Chin Med Sci J"},{"key":"9844_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2011.00916.x","volume":"51","author":"A Galano","year":"2011","unstructured":"Galano A, Tan DX, Reiter RJ (2011) Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res 51:1\u201316","journal-title":"J Pineal Res"},{"key":"9844_CR17","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","volume":"260","author":"G Grynkiewicz","year":"1985","unstructured":"Grynkiewicz G, Poenie M, Tsien RY (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440\u20133450","journal-title":"J Biol Chem"},{"key":"9844_CR18","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/01.CIR.59.4.679","volume":"59","author":"S Gunther","year":"1979","unstructured":"Gunther S, Grossman W (1979) Determinants of ventricular function in pressure-overload hypertrophy in man. Circ 59:679\u2013688","journal-title":"Circ"},{"key":"9844_CR19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1600-079X.2009.00701.x","volume":"47","author":"R Hardeland","year":"2009","unstructured":"Hardeland R, Tan DX, Reiter RJ (2009) Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 47:109\u2013126","journal-title":"J Pineal Res"},{"key":"9844_CR20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurjhf\/hfn043","volume":"11","author":"S Heymans","year":"2009","unstructured":"Heymans S, Hirsch E, Anker SD, Aukrust P, Balligand JL, Cohen-Tervaert JW, Drexler H, Filippatos G, Felix SB, Gullestad L et al (2009) Inflammation as a therapeutic target in heart failure? A scientific statement from the translational research committee of the heart failure association of the european society of cardiology. Eur J Heart Fail 11:119\u2013129","journal-title":"Eur J Heart Fail"},{"key":"9844_CR21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2119\/molmed.2008.00117","volume":"15","author":"A Korkmaz","year":"2009","unstructured":"Korkmaz A, Reiter RJ, Topal T, Manchester LC, Oter S, Tan DX (2009) Melatonin: an established antioxidant worthy of use in clinical trials. Mol Med 15:43\u201350","journal-title":"Mol Med"},{"key":"9844_CR22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11010-008-9754-0","volume":"313","author":"CJ Liu","year":"2008","unstructured":"Liu CJ, Cheng YC, Lee KW, Hsu HH, Chu CH, Tsai FJ, Tsai CH, Chu CY, Liu JY, Kuo WW et al (2008) Lipopolysaccharide induces cellular hypertrophy through calcineurin\/NFAT-3 signaling pathway in H9c2 myocardiac cells. Mol Cell Biochem 313:167\u2013178","journal-title":"Mol Cell Biochem"},{"key":"9844_CR23","doi-asserted-by":"crossref","unstructured":"Lu M, Wang H, Wang J, Zhang J, Yang J, Liang L, Maslov LN (2013) Astragaloside IV protects against cardiac hypertrophy via inhibiting the Ca2+\/CaN signaling pathway. Planta Med 80(1):63\u201369. doi:10.1055\/s-0033-1360129","DOI":"10.1055\/s-0033-1360129"},{"key":"9844_CR24","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1600-079X.2007.00432.x","volume":"42","author":"K Manda","year":"2007","unstructured":"Manda K, Ueno M, Anzai K (2007) AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res 42:386\u2013393","journal-title":"J Pineal Res"},{"key":"9844_CR25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-079X.1993.tb00511.x","volume":"15","author":"A Menendez-Pelaez","year":"1993","unstructured":"Menendez-Pelaez A, Reiter RJ (1993) Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization. J Pineal Res 15:59\u201369","journal-title":"J Pineal Res"},{"key":"9844_CR26","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1161\/01.CIR.98.8.794","volume":"98","author":"K Nakamura","year":"1998","unstructured":"Nakamura K, Fushimi K, Kouchi H, Mihara K, Miyazaki M, Ohe T, Namba M (1998) Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II. Circ 98:794\u2013799","journal-title":"Circ"},{"key":"9844_CR27","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.actatropica.2013.09.014","volume":"128","author":"LG Oliveira","year":"2013","unstructured":"Oliveira LG, Kuehn CC, dos Santos CD, Miranda MA, da Costa CM, Mendonca VJ, do Prado Junior JC (2013) Protective actions of melatonin against heart damage during chronic Chagas disease. Acta Trop 128:652\u2013658","journal-title":"Acta Trop"},{"key":"9844_CR28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/jpi.12099","volume":"56","author":"F Ortiz","year":"2014","unstructured":"Ortiz F, Garcia JA, Acuna-Castroviejo D, Doerrier C, Lopez A, Venegas C, Volt H, Luna-Sanchez M, Lopez LC, Escames G (2014) The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS. J Pineal Res 56:71\u201381","journal-title":"J Pineal Res"},{"key":"9844_CR29","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1600-079X.2007.00453.x","volume":"43","author":"MJ Perez","year":"2007","unstructured":"Perez MJ, Castano B, Gonzalez-Buitrago JM, Marin JJ (2007) Multiple protective effects of melatonin against maternal cholestasis-induced oxidative stress and apoptosis in the rat fetal liver-placenta-maternal liver trio. J Pineal Res 43:130\u2013139","journal-title":"J Pineal Res"},{"key":"9844_CR30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1034\/j.1600-079X.2003.2e114.x","volume":"34","author":"RJ Reiter","year":"2003","unstructured":"Reiter RJ, Tan DX (2003) What constitutes a physiological concentration of melatonin? J Pineal Res 34:79\u201380","journal-title":"J Pineal Res"},{"key":"9844_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.1995.tb00133.x","volume":"18","author":"RJ Reiter","year":"1995","unstructured":"Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden L, Chuang J, Ortiz GG, Acuna-Castroviejo D (1995) A review of the evidence supporting melatonin\u2019s role as an antioxidant. J Pineal Res 18:1\u201311","journal-title":"J Pineal Res"},{"key":"9844_CR32","first-page":"11","volume":"52","author":"RJ Reiter","year":"2007","unstructured":"Reiter RJ, Tan DX, Manchester LC, Pilar Terron M, Flores LJ, Koppisepi S (2007) Medical implications of melatonin: receptor-mediated and receptor-independent actions. Adv Med Sci 52:11\u201328","journal-title":"Adv Med Sci"},{"key":"9844_CR33","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/01.hjh.0000388488.51083.2b","volume":"28","author":"RJ Reiter","year":"2010","unstructured":"Reiter RJ, Manchester LC, Fuentes-Broto L, Tan D-X (2010) Cardiac hypertrophy and remodelling: pathophysiological consequences and protective effects of melatonin. J Hypertens 28:S7\u2013S12","journal-title":"J Hypertens"},{"key":"9844_CR34","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S0022-2828(03)00234-7","volume":"35","author":"T Saito","year":"2003","unstructured":"Saito T, Fukuzawa J, Osaki J, Sakuragi H, Yao N, Haneda T, Fujino T, Wakamiya N, Kikuchi K, Hasebe N (2003) Roles of calcineurin and calcium\/calmodulin-dependent protein kinase II in pressure overload-induced cardiac hypertrophy. J Mol Cell Cardiol 35:1153\u20131160","journal-title":"J Mol Cell Cardiol"},{"key":"9844_CR35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cardiores.2004.02.005","volume":"63","author":"K Sekiguchi","year":"2004","unstructured":"Sekiguchi K, Li X, Coker M, Flesch M, Barger PM, Sivasubramanian N, Mann DL (2004) Cross-regulation between the renin-angiotensin system and inflammatory mediators in cardiac hypertrophy and failure. Cardiovasc Res 63:433\u2013442","journal-title":"Cardiovasc Res"},{"key":"9844_CR36","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/01.RES.81.5.664","volume":"81","author":"T Shioi","year":"1997","unstructured":"Shioi T, Matsumori A, Kihara Y, Inoko M, Ono K, Iwanaga Y, Yamada T, Iwasaki A, Matsushima K, Sasayama S (1997) Increased expression of interleukin-1 beta and monocyte chemotactic and activating factor\/monocyte chemoattractant protein-1 in the hypertrophied and failing heart with pressure overload. Circ Res 81:664\u2013671","journal-title":"Circ Res"},{"key":"9844_CR37","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1016\/j.ijcard.2013.03.139","volume":"168","author":"F Simko","year":"2013","unstructured":"Simko F, Paulis L (2013) Antifibrotic effect of melatonin\u2014perspective protection in hypertensive heart disease. Int J Cardiol 168:2876\u20132877","journal-title":"Int J Cardiol"},{"issue":"Suppl 1","key":"9844_CR38","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1097\/01.hjh.0000388489.28213.08","volume":"28","author":"F Simko","year":"2010","unstructured":"Simko F, Pechanova O, Pelouch V, Krajcirovicova K, Celec P, Palffy R, Bednarova K, Vrankova S, Adamcova M, Paulis L (2010) Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril. J Hypertens 28(Suppl 1):S13\u2013S18","journal-title":"J Hypertens"},{"key":"9844_CR39","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/01.RES.56.6.884","volume":"56","author":"P Simpson","year":"1985","unstructured":"Simpson P (1985) Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating. Circ Res 56:884\u2013894","journal-title":"Circ Res"},{"key":"9844_CR40","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1172\/JCI35541","volume":"119","author":"MV Singh","year":"2009","unstructured":"Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS et al (2009) Ca2+\/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J Clin Invest 119:986\u2013996","journal-title":"J Clin Invest"},{"key":"9844_CR41","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.yjmcc.2012.01.021","volume":"52","author":"MV Singh","year":"2012","unstructured":"Singh MV, Swaminathan PD, Luczak ED, Kutschke W, Weiss RM, Anderson ME (2012) MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction. J Mol Cell Cardiol 52:1135\u20131144","journal-title":"J Mol Cell Cardiol"},{"key":"9844_CR42","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1590\/S0100-879X2012007500121","volume":"45","author":"GJ Wang","year":"2012","unstructured":"Wang GJ, Wang HX, Yao YS, Guo LY, Liu P et al (2012) The role of Ca2+\/calmodulin-dependent protein kinase II and calcineurin in TNF-alpha-induced myocardial hypertrophy. Braz J Med Biol Res 45:1045\u20131051","journal-title":"Braz J Med Biol Res"},{"key":"9844_CR43","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/26239","volume":"395","author":"RB Yang","year":"1998","unstructured":"Yang RB, Mark MR, Gray A, Huang A, Xie MH, Zhang M, Goddard A, Wood WI, Gurney AL, Godowski PJ (1998) Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nat 395:284\u2013288","journal-title":"Nat"},{"key":"9844_CR44","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1161\/01.CIR.95.5.1247","volume":"95","author":"T Yokoyama","year":"1997","unstructured":"Yokoyama T, Nakano M, Bednarczyk JL, McIntyre BW, Entman M, Mann DL (1997) Tumor necrosis factor-alpha provokes a hypertrophic growth response in adult cardiac myocytes. Circ 95:1247\u20131252","journal-title":"Circ"},{"key":"9844_CR45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jpi.12033","volume":"55","author":"H Zhang","year":"2013","unstructured":"Zhang H, Liu D, Wang X, Chen X, Long Y, Chai W, Zhou X, Rui X, Zhang Q, Wang H et al (2013) Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury. J Pineal Res 55:1\u20136","journal-title":"J Pineal Res"},{"key":"9844_CR46","doi-asserted-by":"crossref","first-page":"15239","DOI":"10.1074\/jbc.275.20.15239","volume":"275","author":"W Zhu","year":"2000","unstructured":"Zhu W, Zou Y, Shiojima I, Kudoh S, Aikawa R, Hayashi D, Mizukami M, Toko H, Shibasaki F, Yazaki Y et al (2000) Ca2+\/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy. J Biol Chem 275:15239\u201315245","journal-title":"J Biol Chem"}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-014-9844-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11626-014-9844-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-014-9844-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T22:06:39Z","timestamp":1650751599000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11626-014-9844-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,5]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["9844"],"URL":"https:\/\/doi.org\/10.1007\/s11626-014-9844-0","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,5]]}}}