{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:33:46Z","timestamp":1744155226693},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1007\/s11626-014-9859-6","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T21:08:36Z","timestamp":1420060116000},"page":"441-446","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular characterization of E2 glycoprotein of classical swine fever virus: adaptation and propagation in porcine kidney cells"],"prefix":"10.1007","volume":"51","author":[{"given":"Rakesh","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagendra N.","family":"Barman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Khatoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gitika","family":"Rajbongshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nipu","family":"Deka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir","family":"Morla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"issue":"2","key":"9859_CR1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.20506\/rst.21.2.1332","volume":"21","author":"M Artois","year":"2002","unstructured":"Artois M, Depner KR, Guberti V, Hars J, Rossi S, Rutili D (2002) Classical swine fever (hog cholera) in wild boar in Europe. Rev Sci Tech 21(2):287\u2013303","journal-title":"Rev Sci Tech"},{"issue":"1","key":"9859_CR2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s13337-010-0006-z","volume":"21","author":"NN Barman","year":"2010","unstructured":"Barman NN, Gupt RS, Bora DP, Kataria RS, Tiwari AK, Roychoudhury P (2010) Molecular characterization of classical swine fever virus involved in the outbreak in Mizoram. Indian J Virol 21(1):76\u201381","journal-title":"Indian J Virol"},{"issue":"3","key":"9859_CR3","doi-asserted-by":"crossref","first-page":"919","DOI":"10.20506\/rst.31.3.2170","volume":"31","author":"NN Barman","year":"2012","unstructured":"Barman NN, Bora DP, Tiwari AK, Kataria RS, Desai GS, Deka PJ (2012) Classical swine fever in the pygmy hog. Rev Sci Tech 31(3):919\u2013930","journal-title":"Rev Sci Tech"},{"issue":"2","key":"9859_CR4","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1006\/viro.1994.1065","volume":"198","author":"P Becher","year":"1994","unstructured":"Becher P, Shannon AD, Tautz N, Thiel HJ (1994) Molecular characterization of border disease virus, a pestivirus from sheep. Virology 198(2):542\u2013551","journal-title":"Virology"},{"issue":"2","key":"9859_CR5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0378-1135(99)00003-6","volume":"66","author":"A Bouma","year":"1999","unstructured":"Bouma A, de Smit AJ, de Kluijver EP, Terpstra C, Moormann RJ (1999) Efficacy and stability of a subunit vaccine based on glycoprotein E2 of classical swine fever virus. Vet Microbiol 66(2):101\u2013114","journal-title":"Vet Microbiol"},{"key":"9859_CR6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/1743-422X-7-378","volume":"7","author":"N Chen","year":"2010","unstructured":"Chen N, Tong C, Li D, Wan J, Yuan X, Li X, Peng J, Fang W (2010) Antigenic analysis of classical swine fever virus E2 glycoprotein using pig antibodies identifies residues contributing to antigenic variation of the vaccine C-strain and group 2 strains circulating in China. Virol J 7:378","journal-title":"Virol J"},{"issue":"3","key":"9859_CR7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0147-9571(92)90093-7","volume":"15","author":"J Dahle","year":"1992","unstructured":"Dahle J, Liess B (1992) A review on classical swine fever infections in pigs: epizootiology, clinical disease and pathology. Comp Immunol Microbiol Infect Dis 15(3):203\u2013211","journal-title":"Comp Immunol Microbiol Infect Dis"},{"issue":"3","key":"9859_CR8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/01652176.2000.9695045","volume":"22","author":"AJ Smit de","year":"2000","unstructured":"de Smit AJ, Bouma A, de Kluijver EP, Terpstra C, Moormann RJ (2000) Prevention of transplacental transmission of moderate-virulent classical swine fever virus after single or double vaccination with an E2 subunit vaccine. Vet Q 22(3):150\u2013153","journal-title":"Vet Q"},{"issue":"13","key":"9859_CR9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/vr.149.13.377","volume":"149","author":"AR Elbers","year":"2001","unstructured":"Elbers AR, Stegeman JA, de Jong MC (2001) Factors associated with the introduction of classical swine fever virus into pig herds in the central area of the 1997\/98 epidemic in The Netherlands. Vet Rec 149(13):377\u2013382","journal-title":"Vet Rec"},{"key":"9859_CR10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.virol.2014.08.021","volume":"468-470C","author":"U Fahnoe","year":"2014","unstructured":"Fahnoe U, Pedersen AG, Risager PC, Nielsen J, Belsham GJ, Hoper D, Beer M, Rasmussen TB (2014) Rescue of the highly virulent classical swine fever virus strain \u201cKoslov\u201d from cloned cDNA and first insights into genome variations relevant for virulence. Virology 468-470C:379\u2013387","journal-title":"Virology"},{"issue":"Pt 6","key":"9859_CR11","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1099\/0022-1317-77-6-1295","volume":"77","author":"EF Flores","year":"1996","unstructured":"Flores EF, Kreutz LC, Donis RO (1996) Swine and ruminant pestiviruses require the same cellular factor to enter bovine cells. J Gen Virol 77(Pt 6):1295\u20131303","journal-title":"J Gen Virol"},{"key":"9859_CR12","doi-asserted-by":"crossref","unstructured":"Hierholzer JC, Killington R (eds) (1996) Virus isolation and quantitation. In: Mahy BW, Kangro H (eds) Virology methods manual. Academic, London","DOI":"10.1016\/B978-012465330-6\/50003-8"},{"issue":"Pt 11","key":"9859_CR13","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1099\/0022-1317-78-11-2779","volume":"78","author":"MM Hulst","year":"1997","unstructured":"Hulst MM, Moormann RJ (1997) Inhibition of pestivirus infection in cell culture by envelope proteins E(rns) and E2 of classical swine fever virus: E(rns) and E2 interact with different receptors. J Gen Virol 78(Pt 11):2779\u20132787","journal-title":"J Gen Virol"},{"issue":"3","key":"9859_CR14","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/nar\/gkm1051","volume":"36","author":"R Ivanyi-Nagy","year":"2008","unstructured":"Ivanyi-Nagy R, Lavergne JP, Gabus C, Ficheux D, Darlix JL (2008) RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae. Nucleic Acids Res 36(3):712\u2013725","journal-title":"Nucleic Acids Res"},{"key":"9859_CR15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.meegid.2014.04.008","volume":"25","author":"W Ji","year":"2014","unstructured":"Ji W, Niu DD, Si HL, Ding NZ, He CQ (2014) Vaccination influences the evolution of classical swine fever virus. Infect Genet Evol 25:69\u201377","journal-title":"Infect Genet Evol"},{"issue":"2","key":"9859_CR16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.mbs.2003.08.005","volume":"186","author":"D Klinkenberg","year":"2003","unstructured":"Klinkenberg D, Everts-van der Wind A, Graat EA, de Jong MC (2003) Quantification of the effect of control strategies on classical swine fever epidemics. Math Biosci 186(2):145\u2013173","journal-title":"Math Biosci"},{"issue":"7","key":"9859_CR17","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1128\/JVI.79.7.4191-4200.2005","volume":"79","author":"T Krey","year":"2005","unstructured":"Krey T, Thiel HJ, Rumenapf T (2005) Acid-resistant bovine pestivirus requires activation for pH-triggered fusion during entry. J Virol 79(7):4191\u20134200","journal-title":"J Virol"},{"issue":"4","key":"9859_CR18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/bib\/bbn017","volume":"9","author":"S Kumar","year":"2008","unstructured":"Kumar S, Nei M, Dudley J, Tamura K (2008) MEGA: a biologist-centric software for evolutionary analysis of DNA and protein sequences. Brief Bioinform 9(4):299\u2013306","journal-title":"Brief Bioinform"},{"issue":"3\u20134","key":"9859_CR19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0378-1135(92)90151-I","volume":"32","author":"J Kwang","year":"1992","unstructured":"Kwang J, Littledike ET, Donis RO, Dubovi EJ (1992) Recombinant polypeptide from the gp48 region of the bovine viral diarrhea virus (BVDV) detects serum antibodies in vaccinated and infected cattle. Vet Microbiol 32(3\u20134):281\u2013292","journal-title":"Vet Microbiol"},{"key":"9859_CR20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1297-9716-43-33","volume":"43","author":"I Leifer","year":"2012","unstructured":"Leifer I, Blome S, Blohm U, Konig P, Kuster H, Lange B, Beer M (2012) Characterization of C-strain \u201cRiems\u201d TAV-epitope escape variants obtained through selective antibody pressure in cell culture. Vet Res 43:33","journal-title":"Vet Res"},{"issue":"Pt 5","key":"9859_CR21","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1099\/vir.0.18557-0","volume":"84","author":"D Liang","year":"2003","unstructured":"Liang D, Sainz IF, Ansari IH, Gil LH, Vassilev V, Donis RO (2003) The envelope glycoprotein E2 is a determinant of cell culture tropism in ruminant pestiviruses. J Gen Virol 84(Pt 5):1269\u20131274","journal-title":"J Gen Virol"},{"issue":"24","key":"9859_CR22","doi-asserted-by":"crossref","first-page":"11619","DOI":"10.1128\/JVI.74.24.11619-11625.2000","volume":"74","author":"M Lin","year":"2000","unstructured":"Lin M, Lin F, Mallory M, Clavijo A (2000) Deletions of structural glycoprotein E2 of classical swine fever virus strain alfort\/187 resolve a linear epitope of monoclonal antibody WH303 and the minimal N-terminal domain essential for binding immunoglobulin G antibodies of a pig hyperimmune serum. J Virol 74(24):11619\u201311625","journal-title":"J Virol"},{"issue":"4","key":"9859_CR23","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1128\/JVI.78.4.1792-1799.2004","volume":"78","author":"K Maurer","year":"2004","unstructured":"Maurer K, Krey T, Moennig V, Thiel HJ, Rumenapf T (2004) CD46 is a cellular receptor for bovine viral diarrhea virus. J Virol 78(4):1792\u20131799","journal-title":"J Virol"},{"issue":"2","key":"9859_CR24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.virusres.2003.08.020","volume":"98","author":"D Mayer","year":"2003","unstructured":"Mayer D, Thayer TM, Hofmann MA, Tratschin JD (2003) Establishment and characterisation of two cDNA-derived strains of classical swine fever virus, one highly virulent and one avirulent. Virus Res 98(2):105\u2013116","journal-title":"Virus Res"},{"issue":"2","key":"9859_CR25","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0042-6822(89)90625-9","volume":"171","author":"G Meyers","year":"1989","unstructured":"Meyers G, Rumenapf T, Thiel HJ (1989) Molecular cloning and nucleotide sequence of the genome of hog cholera virus. Virology 171(2):555\u2013567","journal-title":"Virology"},{"issue":"3","key":"9859_CR26","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1128\/JVI.01815-07","volume":"82","author":"CL Murray","year":"2008","unstructured":"Murray CL, Marcotrigiano J, Rice CM (2008) Bovine viral diarrhea virus core is an intrinsically disordered protein that binds RNA. J Virol 82(3):1294\u20131304","journal-title":"J Virol"},{"key":"9859_CR27","unstructured":"Project directorate on animal disease monitoring and surveillance, 2011. Livestock disease scenario in India. Rahman H. July 6th"},{"issue":"8","key":"9859_CR28","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s00705-008-0147-1","volume":"153","author":"Y Qi","year":"2008","unstructured":"Qi Y, Liu LC, Zhang BQ, Shen Z, Wang J, Chen YH (2008) Characterization of antibody responses against a neutralizing epitope on the glycoprotein E2 of classical swine fever virus. Arch Virol 153(8):1593\u20131598","journal-title":"Arch Virol"},{"issue":"3","key":"9859_CR29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1089\/vim.2009.0007","volume":"22","author":"Y Qi","year":"2009","unstructured":"Qi Y, Zhang BQ, Shen Z, Chen YH (2009) Candidate vaccine focused on a classical Swine Fever virus epitope induced antibodies with neutralizing activity. Viral Immunol 22(3):205\u2013213","journal-title":"Viral Immunol"},{"issue":"6","key":"9859_CR30","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1128\/JVI.79.6.3787-3796.2005","volume":"79","author":"GR Risatti","year":"2005","unstructured":"Risatti GR, Borca MV, Kutish GF, Lu Z, Holinka LG, French RA, Tulman ER, Rock DL (2005) The E2 glycoprotein of classical swine fever virus is a virulence determinant in swine. J Virol 79(6):3787\u20133796","journal-title":"J Virol"},{"issue":"2","key":"9859_CR31","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0034-5288(94)90059-0","volume":"57","author":"PM Roehe","year":"1994","unstructured":"Roehe PM, Edwards S (1994) Comparison of pestivirus multiplication in cells of different species. Res Vet Sci 57(2):210\u2013214","journal-title":"Res Vet Sci"},{"key":"9859_CR32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/978-3-7091-9153-8_2","volume":"3","author":"T Rumenapf","year":"1991","unstructured":"Rumenapf T, Meyers G, Stark R, Thiel HJ (1991) Molecular characterization of hog cholera virus. Arch Virol Suppl 3:7\u201318","journal-title":"Arch Virol Suppl"},{"issue":"1","key":"9859_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1702(00)00159-3","volume":"68","author":"C Schelp","year":"2000","unstructured":"Schelp C, Greiser-Wilke I, Moennig V (2000) An actin-binding protein is involved in pestivirus entry into bovine cells. Virus Res 68(1):1\u20135","journal-title":"Virus Res"},{"issue":"1\u20132","key":"9859_CR34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0378-1135(02)00357-7","volume":"92","author":"S Suradhat","year":"2003","unstructured":"Suradhat S, Damrongwatanapokin S (2003) The influence of maternal immunity on the efficacy of a classical swine fever vaccine against classical swine fever virus, genogroup 2.2, infection. Vet Microbiol 92(1\u20132):187\u2013194","journal-title":"Vet Microbiol"},{"issue":"16","key":"9859_CR35","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1128\/JVI.00551-12","volume":"86","author":"T Tamura","year":"2012","unstructured":"Tamura T, Sakoda Y, Yoshino F, Nomura T, Yamamoto N, Sato Y, Okamatsu M, Ruggli N, Kida H (2012) Selection of classical swine fever virus with enhanced pathogenicity reveals synergistic virulence determinants in E2 and NS4B. J Virol 86(16):8602\u20138613","journal-title":"J Virol"},{"issue":"45","key":"9859_CR36","doi-asserted-by":"crossref","first-page":"32730","DOI":"10.1074\/jbc.M706803200","volume":"282","author":"BA Tews","year":"2007","unstructured":"Tews BA, Meyers G (2007) The pestivirus glycoprotein Erns is anchored in plane in the membrane via an amphipathic helix. J Biol Chem 282(45):32730\u201332741","journal-title":"J Biol Chem"},{"issue":"9","key":"9859_CR37","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1128\/JVI.65.9.4705-4712.1991","volume":"65","author":"HJ Thiel","year":"1991","unstructured":"Thiel HJ, Stark R, Weiland E, Rumenapf T, Meyers G (1991) Hog cholera virus: molecular composition of virions from a pestivirus. J Virol 65(9):4705\u20134712","journal-title":"J Virol"},{"key":"9859_CR38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-3-7091-9300-6_4","volume":"7","author":"HJ Thiel","year":"1993","unstructured":"Thiel HJ, Meyers G, Stark R, Tautz N, Rumenapf T, Unger G, Conzelmann KK (1993) Molecular characterization of positive-strand RNA viruses: pestiviruses and the porcine reproductive and respiratory syndrome virus (PRRSV). Arch Virol Suppl 7:41\u201352","journal-title":"Arch Virol Suppl"},{"issue":"1\u20132","key":"9859_CR39","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.vetmic.2007.05.001","volume":"125","author":"PA Rijn van","year":"2007","unstructured":"van Rijn PA (2007) A common neutralizing epitope on envelope glycoprotein E2 of different pestiviruses: implications for improvement of vaccines and diagnostics for classical swine fever (CSF). Vet Microbiol 125(1\u20132):150\u2013156","journal-title":"Vet Microbiol"},{"issue":"Pt 11","key":"9859_CR40","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1099\/0022-1317-77-11-2737","volume":"77","author":"PA Rijn van","year":"1996","unstructured":"van Rijn PA, Bossers A, Wensvoort G, Moormann RJ (1996) Classical swine fever virus (CSFV) envelope glycoprotein E2 containing one structural antigenic unit protects pigs from lethal CSFV challenge. J Gen Virol 77(Pt 11):2737\u20132745","journal-title":"J Gen Virol"},{"issue":"1","key":"9859_CR41","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.virol.2004.09.023","volume":"330","author":"Z Wang","year":"2004","unstructured":"Wang Z, Nie Y, Wang P, Ding M, Deng H (2004) Characterization of classical swine fever virus entry by using pseudotyped viruses: E1 and E2 are sufficient to mediate viral entry. Virology 330(1):332\u2013341","journal-title":"Virology"},{"issue":"Pt 8","key":"9859_CR42","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1099\/vir.0.82798-0","volume":"88","author":"F Wehrle","year":"2007","unstructured":"Wehrle F, Renzullo S, Faust A, Beer M, Kaden V, Hofmann MA (2007) Chimeric pestiviruses: candidates for live-attenuated classical swine fever marker vaccines. J Gen Virol 88(Pt 8):2247\u20132258","journal-title":"J Gen Virol"},{"issue":"Pt 11","key":"9859_CR43","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1099\/0022-1317-70-11-2865","volume":"70","author":"G Wensvoort","year":"1989","unstructured":"Wensvoort G (1989) Topographical and functional mapping of epitopes on hog cholera virus with monoclonal antibodies. J Gen Virol 70(Pt 11):2865\u20132876","journal-title":"J Gen Virol"},{"issue":"2","key":"9859_CR44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0378-1135(86)90072-6","volume":"12","author":"G Wensvoort","year":"1986","unstructured":"Wensvoort G, Terpstra C, Boonstra J, Bloemraad M, Van Zaane D (1986) Production of monoclonal antibodies against swine fever virus and their use in laboratory diagnosis. Vet Microbiol 12(2):101\u2013108","journal-title":"Vet Microbiol"},{"issue":"Pt 3","key":"9859_CR45","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1099\/0022-1317-71-3-531","volume":"71","author":"G Wensvoort","year":"1990","unstructured":"Wensvoort G, Boonstra J, Bodzinga BG (1990) Immunoaffinity purification and characterization of the envelope protein E1 of hog cholera virus. J Gen Virol 71(Pt 3):531\u2013540","journal-title":"J Gen Virol"},{"issue":"1","key":"9859_CR46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00705-005-0623-9","volume":"151","author":"F Zhang","year":"2006","unstructured":"Zhang F, Yu M, Weiland E, Morrissy C, Zhang N, Westbury H, Wang LF (2006) Characterization of epitopes for neutralizing monoclonal antibodies to classical swine fever virus E2 and Erns using phage-displayed random peptide library. Arch Virol 151(1):37\u201354","journal-title":"Arch Virol"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-014-9859-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11626-014-9859-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-014-9859-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T14:32:07Z","timestamp":1598625127000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11626-014-9859-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["9859"],"URL":"https:\/\/doi.org\/10.1007\/s11626-014-9859-6","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}