{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:37:41Z","timestamp":1770885461411,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s11626-016-0001-9","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T20:29:33Z","timestamp":1454099373000},"page":"466-472","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Methyl viologen induces neural differentiation on murine P19 cells"],"prefix":"10.1007","volume":"52","author":[{"given":"Eriko","family":"Shimada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohisa","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Tsutsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Tsuruwaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,29]]},"reference":[{"key":"1_CR1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10059-011-0276-3","volume":"32","author":"YS Bae","year":"2011","unstructured":"Bae YS, Oh H, Rhee SG, Yoo YD (2011) Regulation of reactive oxygen species generation in cell signaling. Mol Cells 32:491\u2013509","journal-title":"Mol Cells"},{"key":"1_CR2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/bies.950160509","volume":"16","author":"G Bain","year":"1994","unstructured":"Bain G, Ray WJ, Yao M, Gottlieb DI (1994) From embryonal carcinoma cells to neurons: the P19 pathway. BioEssays 16:343\u2013348","journal-title":"BioEssays"},{"key":"1_CR3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1289\/ehp.7616139","volume":"16","author":"JS Bus","year":"1976","unstructured":"Bus JS, Aust SD, Gibson JE (1976) Paraquat toxicity: proposed mechanism of action involving lipid peroxidation. Environ Health Perspect 16:139\u2013146","journal-title":"Environ Health Perspect"},{"key":"1_CR4","doi-asserted-by":"crossref","first-page":"14186","DOI":"10.1074\/jbc.M700827200","volume":"282","author":"PR Castello","year":"2007","unstructured":"Castello PR, Drechsel DA, Patel M (2007) Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain. J Biol Chem 282:14186\u201314193","journal-title":"J Biol Chem"},{"key":"1_CR5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1182\/blood-2006-08-039883","volume":"110","author":"SM Chan","year":"2007","unstructured":"Chan SM, Weng AP, Tibshirani R, Aster JC, Utz PJ (2007) Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia. Blood 110:278\u2013286","journal-title":"Blood"},{"key":"1_CR6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","volume":"410","author":"L Chang","year":"2001","unstructured":"Chang L, Karin M (2001) Mammalian MAP kinase signaling cascades. Nature 410:37\u201340","journal-title":"Nature"},{"key":"1_CR7","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1096\/fj.08-112375","volume":"22","author":"HJ Chiu","year":"2008","unstructured":"Chiu HJ, Fischman DA, Hammerling U (2008) Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation. FASEB J 22:3878\u20133887","journal-title":"FASEB J"},{"key":"1_CR8","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/bdra.20118","volume":"73","author":"DA Cory-Slechta","year":"2005","unstructured":"Cory-Slechta DA, Thiruchelvam M, Richfield EK, Barlow BK, Brooks AI (2005) Developmental pesticide exposures and the Parkinson\u2019s disease phenotype. Birth Defects Res A Clin Mol Teratol 73:136\u2013139","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"1_CR9","first-page":"247","volume":"14","author":"M Djukic","year":"2007","unstructured":"Djukic M, Jovanovic MC, Ninkovic M, Vasiljevic I, Jovanovic M (2007) The role of nitric oxide in paraquat-induced oxidative stress in rat striatum. Ann Agric Environ Med 14:247\u2013252","journal-title":"Ann Agric Environ Med"},{"key":"1_CR10","first-page":"3783","volume":"6","author":"HC Ha","year":"2000","unstructured":"Ha HC, Thiagalingam A, Nelkin BD, Casero RA Jr (2000) Reactive oxygen species are critical for the growth and differentiation of medullary thyroid carcinoma cells. Clin Cancer Res 6:3783\u20133787","journal-title":"Clin Cancer Res"},{"key":"1_CR11","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1002\/ana.10483","volume":"53","author":"P Jenner","year":"2003","unstructured":"Jenner P (2003) Oxidative stress in Parkinson\u2019s disease. Ann Neurol 53:S26\u2013S36","journal-title":"Ann Neurol"},{"key":"1_CR12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1083\/jcb.94.2.253","volume":"94","author":"EMV Jones-Villeneuve","year":"1982","unstructured":"Jones-Villeneuve EMV, McBurney MW, Rogers KA, Kalnins VI (1982) Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells. J Cell Biol 94:253\u2013262","journal-title":"J Cell Biol"},{"key":"1_CR13","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1128\/MCB.3.12.2271","volume":"3","author":"EMV Jones-Villeneuve","year":"1983","unstructured":"Jones-Villeneuve EMV, Rudnicki MA, Harris JF, McBurney MW (1983) Retinoic acid-induced neural differentiation of embryonal carcinoma cells. Mol Cell Biol 3:2271\u20132279","journal-title":"Mol Cell Biol"},{"key":"1_CR14","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1096\/fj.06-7859rev","volume":"22","author":"MR Junttila","year":"2008","unstructured":"Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22:954\u2013965","journal-title":"FASEB J"},{"key":"1_CR15","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y (2013) Investigation of the freely-available easy-to-use software \u201cEZR\u201d (Easy R) for medical statistics. Bone Marrow Transplant 48:452\u2013458","journal-title":"Bone Marrow Transplant"},{"key":"1_CR16","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1074\/jbc.M607630200","volume":"282","author":"K Kondoh","year":"2007","unstructured":"Kondoh K, Sunadome K, Nishida E (2007) Notch signaling suppresses p38 MAPK activity via induction of MKP-1 in myogenesis. J Biol Chem 282:3058\u20133065","journal-title":"J Biol Chem"},{"key":"1_CR17","doi-asserted-by":"crossref","first-page":"7066","DOI":"10.1074\/jbc.273.12.7066","volume":"273","author":"HY Lee","year":"1998","unstructured":"Lee HY, Walsh GL, Dawson MI, Hong WK, Kurie JM (1998) All-trans-retinoic acid inhibits Jun N-terminal kinase-dependent signaling pathways. J Biol Chem 273:7066\u20137071","journal-title":"J Biol Chem"},{"key":"1_CR18","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1128\/MCB.19.3.1973","volume":"19","author":"HY Lee","year":"1999","unstructured":"Lee HY, Sueoka N, Hong WK, Mangelsdorf DJ, Claret FX, Kurie JM (1999) All-trans-retinoic acid inhibits Jun N-terminal kinase by increasing dual-specificity phosphatase activity. Mol Cell Biol 19:1973\u20131980","journal-title":"Mol Cell Biol"},{"key":"1_CR19","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/j.cellsig.2011.07.006","volume":"23","author":"YE Leem","year":"2011","unstructured":"Leem YE, Choi HK, Jung SY, Kim BJ, Lee KY, Yoon K, Qin J, Kang JS, Kim ST (2011) Esco2 promotes neuronal differentiation by repressing Notch signaling. Cell Signal 23:1876\u20131884","journal-title":"Cell Signal"},{"key":"1_CR20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/dbio.2001.0203","volume":"232","author":"J Li","year":"2001","unstructured":"Li J, Molkentin JD, Colbert MC (2001) Retinoic acid inhibits cardiac neural crest migration by blocking c-Jun N-terminal kinase activation. Dev Biol 232:351\u2013361","journal-title":"Dev Biol"},{"key":"1_CR21","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1212\/WNL.48.6.1583","volume":"48","author":"HH Liou","year":"1997","unstructured":"Liou HH, Tsai MC, Chen CJ, Jeng JS, Chang YC, Chen SY, Chen RC (1997) Environmental risk factors and Parkinson\u2019s disease: a case\u2013control study in Taiwan. Neurology 48:1583\u20131588","journal-title":"Neurology"},{"key":"1_CR22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0304-4165(00)00167-7","volume":"1524","author":"AS Margolis","year":"2000","unstructured":"Margolis AS, Porasuphatana S, Rosen GM (2000) Role of paraquat in the uncoupling of nitric oxide synthase. Biochim Biophys Acta 1524:253\u2013257","journal-title":"Biochim Biophys Acta"},{"key":"1_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.10119","volume":"192","author":"JL Martindale","year":"2002","unstructured":"Martindale JL, Holbrook NJ (2002) Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192:1\u201315","journal-title":"J Cell Physiol"},{"key":"1_CR24","unstructured":"McBurney MW (1993) P19 embryonal carcinoma cells. Int J Dev Biol 37:135\u2013140"},{"key":"1_CR25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/299165a0","volume":"299","author":"MW McBurney","year":"1982","unstructured":"McBurney MW, Jones-Villeneuve EM, Edwards MK, Anderson PJ (1982) Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line. Nature 299:165\u2013167","journal-title":"Nature"},{"key":"1_CR26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.taap.2004.04.019","volume":"201","author":"S McCarthy","year":"2004","unstructured":"McCarthy S, Somayajulu M, Sikorska M, Borowy-Borowski H, Pandey S (2004) Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble coenzyme Q10. Toxicol Appl Pharmacol 201:21\u201331","journal-title":"Toxicol Appl Pharmacol"},{"key":"1_CR27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0891-5849(96)00051-2","volume":"21","author":"HP Monteiro","year":"1996","unstructured":"Monteiro HP, Stern A (1996) Redox modulation of tyrosine phosphorylation-dependent signal transduction pathways. Free Radic Biol Med 21:323\u2013333","journal-title":"Free Radic Biol Med"},{"key":"1_CR28","doi-asserted-by":"crossref","first-page":"175909141557871","DOI":"10.1177\/1759091415578712","volume":"7","author":"M Olgu\u00edn-Albuerne","year":"2015","unstructured":"Olgu\u00edn-Albuerne M, Mor\u00e1n J (2015) ROS produced by NOX2 control in vitro development of cerebellar granule neurons development. ASN Neuro 7:1759091415578712. doi: 10.1177\/1759091415578712","journal-title":"ASN Neuro"},{"key":"1_CR29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jchromb.2007.11.002","volume":"862","author":"NC Posecion","year":"2008","unstructured":"Posecion NC, Ostrea EM, Bielawski DM (2008) Quantitative determination of paraquat in meconium by sodium borohydride-nickel chloride chemical reduction and gas chromatography\/mass spectrometry (GC\/MS). J Chromatogr B Analyt Technol Biomed Life Sci 862:93\u201399","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"1_CR30","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1042\/bj3520701","volume":"352","author":"S Reffas","year":"2000","unstructured":"Reffas S, Schlegel W (2000) Compartment-specific regulation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs) by ERK-dependent and non-ERK-dependent inductions of MAPK phosphatase (MKP)-3 and MKP-1 in differentiating P19 cells. Biochem J 352:701\u2013708","journal-title":"Biochem J"},{"key":"1_CR31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11064-007-9400-3","volume":"33","author":"J Sagara","year":"2008","unstructured":"Sagara J, Makino N (2008) Glutathione induces neuronal differentiation in rat bone marrow stromal cells. Neurochem Res 33:16\u201321","journal-title":"Neurochem Res"},{"key":"1_CR32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000047804","volume":"11","author":"H Sauer","year":"2001","unstructured":"Sauer H, Wartenberg M, Hescheler J (2001) Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem 11:173\u2013186","journal-title":"Cell Physiol Biochem"},{"key":"1_CR33","first-page":"792639","volume":"2011","author":"Y Son","year":"2011","unstructured":"Son Y, Cheong YK, Kim NH, Chung HT, Kang DG, Pae HO (2011) Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways? J Signal Transduct 2011:792639","journal-title":"J Signal Transduct"},{"key":"1_CR34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0891-5849(96)00109-8","volume":"21","author":"Y Sun","year":"1996","unstructured":"Sun Y, Oberley LW (1996) Redox regulation of transcriptional activators. Free Radi Biol Med 21:335\u2013348","journal-title":"Free Radi Biol Med"},{"key":"1_CR35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0300-483X(02)00382-7","volume":"180","author":"ZE Suntres","year":"2002","unstructured":"Suntres ZE (2002) Role of antioxidants in paraquat toxicity. Toxicology 180:65\u201377","journal-title":"Toxicology"},{"key":"1_CR36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0891-5849(96)00275-4","volume":"22","author":"YJ Suzuki","year":"1997","unstructured":"Suzuki YJ, Forman HJ, Sevanian A (1997) Oxidants as stimulators of signal transduction. Free Radic Biol Med 22:269\u2013285","journal-title":"Free Radic Biol Med"},{"key":"1_CR37","first-page":"12","volume":"30","author":"AR Talbot","year":"1988","unstructured":"Talbot AR, Fu CC, Hsieh MF (1988) Paraquat intoxication during pregnancy: a report of 9 cases. Vet Hum Toxicol 30:12\u201317","journal-title":"Vet Hum Toxicol"},{"key":"1_CR38","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1289\/ehp.1002839","volume":"119","author":"CM Tanner","year":"2011","unstructured":"Tanner CM, Kamel F, Ross GW, Hoppin JA, Goldman SM, Korell M, Marras C, Bhudhikanok GS, Kasten M, Chade AR, Comyns K, Richards MB, Meng C, Priestley B, Fernandez HH, Cambi F, Umbach DM, Blair A, Sandler DP, Langston JW (2011) Rotenone, paraquat, and Parkinson\u2019s disease. Environ Health Perspect 119:866\u2013872","journal-title":"Environ Health Perspect"},{"key":"1_CR39","first-page":"113","volume":"38","author":"AM Tsatsakis","year":"1996","unstructured":"Tsatsakis AM, Perakis K, Koumantakis E (1996) Experience with acute paraquat poisoning in Crete. Vet Human Toxicol 38:113\u2013117","journal-title":"Vet Human Toxicol"},{"key":"1_CR40","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1006\/taap.2001.9325","volume":"178","author":"M Tsukamoto","year":"2002","unstructured":"Tsukamoto M, Tampo Y, Sawada M, Yonaha M (2002) Paraquat-induced oxidative stress and dysfunction of the glutathione redox cycle in pulmonary microvascular endothelial cells. Toxicol Appl Pharmacol 178:82\u201392","journal-title":"Toxicol Appl Pharmacol"},{"key":"1_CR41","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.mad.2009.07.005","volume":"130","author":"P Wu","year":"2009","unstructured":"Wu P, Jiang C, Shen Q, Hu Y (2009) Systematic gene expression profile of hypothalamus in calorie-restricted mice implicates the involvement of mTOR signaling in neuroprotective activity. Mech Ageing Dev 130:602\u2013610","journal-title":"Mech Ageing Dev"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-016-0001-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11626-016-0001-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-016-0001-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T18:27:15Z","timestamp":1559413635000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11626-016-0001-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,29]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["1"],"URL":"https:\/\/doi.org\/10.1007\/s11626-016-0001-9","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,29]]}}}