{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:45:26Z","timestamp":1790253926350,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31572430"],"award-info":[{"award-number":["31572430"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"China Agriculture Research System","award":["CARS-36"],"award-info":[{"award-number":["CARS-36"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s11626-017-0226-2","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T09:38:19Z","timestamp":1520847499000},"page":"311-320","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effect of short-chain fatty acids on the expression of genes involved in short-chain fatty acid transporters and inflammatory response in goat jejunum epithelial cells"],"prefix":"10.1007","volume":"54","author":[{"given":"Kang","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MaoCheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GuoQi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"key":"226_CR1","doi-asserted-by":"crossref","unstructured":"Albrecht E, Kolisek M, Viergutz T, Zitnan R, Schweigel M (2008) Molecular identification, immunolocalization, and functional activity of a vacuolar-type H(+)-ATPase in bovine rumen epithelium. J Comp Physiol B 178(3):285\u2013295","DOI":"10.1007\/s00360-007-0221-0"},{"issue":"4","key":"226_CR2","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.2527\/jas.2010-3301","volume":"89","author":"JR Aschenbach","year":"2011","unstructured":"Aschenbach JR, Penner GB, Stumpff F, G\u00e4bel G (2011) Ruminant nutrition symposium: role of fermentation acid absorption in the regulation of ruminal pH. J Anim Sci 89(4):1092\u20131107. https:\/\/doi.org\/10.2527\/jas.2010-3301","journal-title":"J Anim Sci"},{"issue":"1","key":"226_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1046\/j.1365-2249.2003.02056.x","volume":"131","author":"U B\u00f6cker","year":"2003","unstructured":"B\u00f6cker U, Nebe T, Herweck F, Holt L, Panja A, Jobin C, Rossol S, Sartor R B, Singer MV (2003) Butyrate modulates intestinal epithelial cell-mediated neutrophil migration. Clin Exp Immunol 131(1):53\u201360. https:\/\/doi.org\/10.1046\/j.1365-2249.2003.02056.x","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"226_CR4","doi-asserted-by":"publisher","first-page":"G260","DOI":"10.1152\/ajpgi.00304.2010","volume":"301","author":"A Bondzio","year":"2011","unstructured":"Bondzio A, Gabler C, Badewien-Rentzsch B, Schulze P, Martens H, Einspanier R (2011) Identification of differentially expressed proteins in ruminal epithelium in response to a concentrate supplemented diet. Am J Physiol Gastrointest Liver Physiol 301(2):G260\u2013G268. https:\/\/doi.org\/10.1152\/ajpgi.00304.2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"226_CR5","doi-asserted-by":"crossref","unstructured":"Erwin ES, Marco GJ, Emery EM (1961) Volatile fatty acid analyses of blood and rumen fluid by gas chromatography. J Dairy Sci 44(9):1768\u20131771","DOI":"10.3168\/jds.S0022-0302(61)89956-6"},{"key":"226_CR6","doi-asserted-by":"crossref","unstructured":"Etschmann B, Heipertz KS, von der Schulenburg A, Schweigel M (2006) A vH+-ATPase is present in cultured sheep ruminal epithelial cells. Am J Physiol Gastrointest Liver Physiol 291(6):G1171\u20139","DOI":"10.1152\/ajpgi.00099.2006"},{"key":"226_CR7","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0083-6729(06)74011-0","volume":"74","author":"K Dagmar","year":"2006","unstructured":"Dagmar K, Thomas S (2006) NF-\u03baB and cytokines. Vitam Horm 74:283\u2013300","journal-title":"Vitam Horm"},{"issue":"36","key":"226_CR8","doi-asserted-by":"publisher","first-page":"26528","DOI":"10.1074\/jbc.M703617200","volume":"282","author":"SP George","year":"2007","unstructured":"George SP, Wang Y, Mathew S, Srinivasan K, Khurana S (2007) Dimerization and actin-bundling properties of villin and its role in the assembly of epithelial cell brush borders. J Biol Chem 282(36):26528\u201326265. https:\/\/doi.org\/10.1074\/jbc.M703617200","journal-title":"J Biol Chem"},{"issue":"4","key":"226_CR9","doi-asserted-by":"publisher","first-page":"G775","DOI":"10.1152\/ajpgi.2000.279.4.G775","volume":"279","author":"C Hadjiagapiou","year":"2000","unstructured":"Hadjiagapiou C, Schmidt L, Dudeja PK, Layden TJ, Ramaswamy K (2000) Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1. Am J Physiol Gastrointest Liver Physiol 279(4):G775\u2013G780. https:\/\/doi.org\/10.1152\/ajpgi.2000.279.4.G775","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"226_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/ajpgi.00048.2011","volume":"302","author":"HM Hamer","year":"2012","unstructured":"Hamer HM, De Preter V, Windey K, Verbeke K (2012) Functional analysis of colonic bacterial metabolism: relevant to health? Am J Physiol Gastrointest Liver Physiol 302:1\u20139","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"226_CR11","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1053\/gast.1997.v112.pm9041249","volume":"112","author":"R Hass","year":"1997","unstructured":"Hass R, Busche R, Luciano L, Reale E, Engelhardt WV (1997) Lack of butyrate is associated with induction of BAX and subsequent apoptosis in the proximal colon of guinea pig. Gastroenterology 112(3):875\u2013881. https:\/\/doi.org\/10.1053\/gast.1997.v112.pm9041249","journal-title":"Gastroenterology"},{"issue":"1","key":"226_CR12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000007736","volume":"61","author":"T Ihara","year":"2000","unstructured":"Ihara T, Tsujikawa T, Fujiyama Y, Bamba T (2000) Regulation of PepT1 transporter expression in the rat small intestine under malnourished condition. Digestion 61(1):59\u201367. https:\/\/doi.org\/10.1159\/000007736","journal-title":"Digestion"},{"issue":"4","key":"226_CR13","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/S0016-5085(00)70142-9","volume":"118","author":"MS Inan","year":"2000","unstructured":"Inan MS, Rasoulpour RJ, Yin L, Hubbard AK, Rosenberg DW, Giardina C (2000) The luminal short-chain fatty acid butyrate modulates NF-B activity in a human colonic epithelial cell line. Gastroenterology 118(4):724\u2013734. https:\/\/doi.org\/10.1016\/S0016-5085(00)70142-9","journal-title":"Gastroenterology"},{"issue":"2","key":"226_CR14","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1053\/j.gastro.2013.04.056","volume":"145","author":"MH Kim","year":"2013","unstructured":"Kim MH, Kang SG, Park JH, Yanagisawa M, Kim CH (2013) Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology 145(2):396\u2013406. https:\/\/doi.org\/10.1053\/j.gastro.2013.04.056","journal-title":"Gastroenterology"},{"issue":"2","key":"226_CR15","doi-asserted-by":"publisher","first-page":"S100","DOI":"10.1053\/j.gastro.2005.11.048","volume":"130","author":"KA Kles","year":"2006","unstructured":"Kles KA, Chang EB (2006) Short-chain fatty acids impact on intestinal adaptation, inflammation, carcinoma, and failure. Gastroenterology 130(2):S100\u2013S105. https:\/\/doi.org\/10.1053\/j.gastro.2005.11.048","journal-title":"Gastroenterology"},{"issue":"28","key":"226_CR16","doi-asserted-by":"publisher","first-page":"25481","DOI":"10.1074\/jbc.M301403200","volume":"278","author":"PE Le","year":"2003","unstructured":"Le PE, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, Brezillon S, Dupriez V, Vassart G, Van Damme J, Parmentier M, Detheux M (2003) Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 278(28):25481\u201325489. https:\/\/doi.org\/10.1074\/jbc.M301403200","journal-title":"J Biol Chem"},{"issue":"07","key":"226_CR17","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1017\/S1751731110000261","volume":"4","author":"S Leonhard-Marek","year":"2010","unstructured":"Leonhard-Marek S, Stumpff F, Martens H (2010) Transport of cations and anions across forestomach epithelia: conclusions from in vitro studies. Animal 4(07):1037\u20131056. https:\/\/doi.org\/10.1017\/S1751731110000261","journal-title":"Animal"},{"issue":"1","key":"226_CR18","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3168\/jds.2015-9605","volume":"99","author":"Z Lu","year":"2016","unstructured":"Lu Z, Yao L, Jiang Z, Aschenbach JR, Martens H, Shen Z (2016) Acidic pH and short-chain fatty acids activate Na+ transport but differentially modulate expression of Na+\/H+ exchanger isoforms 1, 2, and 3 in omasal epithelium. J Dairy Sci 99(1):733\u2013745. https:\/\/doi.org\/10.3168\/jds.2015-9605","journal-title":"J Dairy Sci"},{"issue":"1","key":"226_CR19","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1600-065X.2011.01080.x","volume":"245","author":"L Macia","year":"2012","unstructured":"Macia L, Thorburn AN, Binge LC, Marino E, Rogers KE, Maslowski KM, Vieira AT, Kranich J, Mackay CR (2012) Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. Immunol Rev 245(1):164\u2013176. https:\/\/doi.org\/10.1111\/j.1600-065X.2011.01080.x","journal-title":"Immunol Rev"},{"issue":"1","key":"226_CR20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/ni0111-5","volume":"12","author":"KM Maslowski","year":"2011","unstructured":"Maslowski KM, Mackay CR (2011) Diet, gut microbiota and immune responses. Nat Immunol 12(1):5\u20139. https:\/\/doi.org\/10.1038\/ni0111-5","journal-title":"Nat Immunol"},{"issue":"7268","key":"226_CR21","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1038\/nature08530","volume":"461","author":"KM Maslowski","year":"2009","unstructured":"Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, Schilter HC, Rolph MS, Mackay F, Artis D, Xavier RJ, Teixeira MM, Mackay CR (2009) Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461(7268):1282\u20131286. https:\/\/doi.org\/10.1038\/nature08530","journal-title":"Nature"},{"issue":"9","key":"226_CR22","doi-asserted-by":"publisher","first-page":"4256","DOI":"10.2527\/jas.2012-5570","volume":"91","author":"BU Metzler-Zebeli","year":"2013","unstructured":"Metzler-Zebeli BU, Hollmann M, Sabitzer S, Podstatzky-Lichtenstein L, Klein D, Zebeli Q (2013) Epithelial response to high-grain diets involves alteration in nutrient transporters and Na+\/K+-ATPase mRNA expression in rumen and colon of goats. J Anim Sci 91(9):4256\u20134266. https:\/\/doi.org\/10.2527\/jas.2012-5570","journal-title":"J Anim Sci"},{"issue":"1","key":"226_CR23","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00418-009-0648-3","volume":"133","author":"K Miyazawa","year":"2010","unstructured":"Miyazawa K, Hondo T, Kanaya T, Tanaka S, Takakura I, Itani W, Rose MT, Kitazawa H, Yamaguchi T, Aso H (2010) Characterization of newly established bovine intestinal epithelial cell line. Histochem Cell Biol 133(1):125\u2013134. https:\/\/doi.org\/10.1007\/s00418-009-0648-3","journal-title":"Histochem Cell Biol"},{"issue":"5","key":"226_CR24","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","volume":"142","author":"DY Oh","year":"2010","unstructured":"Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky JM (2010) Gpr120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142(5):687\u2013698. https:\/\/doi.org\/10.1016\/j.cell.2010.07.041","journal-title":"Cell"},{"issue":"51","key":"226_CR25","doi-asserted-by":"publisher","first-page":"6685","DOI":"10.1038\/sj.onc.1209934","volume":"25","author":"C Scheidereit","year":"2006","unstructured":"Scheidereit C (2006) IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene 25(51):6685\u20136705. https:\/\/doi.org\/10.1038\/sj.onc.1209934","journal-title":"Oncogene"},{"issue":"11","key":"226_CR26","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1007\/BF02071409","volume":"41","author":"W Scheppach","year":"1996","unstructured":"Scheppach W (1996) Treatment of distal ulcerative colitis with short-chain fatty acid enemas. A placebo-controlled trial. German-Austrian SCFA Study Group. Dig Dis Sci 41(11):2254\u20132259. https:\/\/doi.org\/10.1007\/BF02071409","journal-title":"Dig Dis Sci"},{"issue":"6","key":"226_CR27","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1152\/physiolgenomics.00117.2010","volume":"43","author":"MA Steele","year":"2011","unstructured":"Steele MA, Vandervoort G, AlZahal O, Hook SE, Matthews JC, McBride BW (2011) Rumen epithelial adaptation to high-grain diets involves the coordinated regulation of genes involved in cholesterol homeostasis. Physiol Genomics 43(6):308\u2013316. https:\/\/doi.org\/10.1152\/physiolgenomics.00117.2010","journal-title":"Physiol Genomics"},{"key":"226_CR28","doi-asserted-by":"crossref","unstructured":"Somers J, Smith C, Donnison M, Wells DN, Henderson H, McLeay L, Pfeffer PL (2006) Gene expression profiling of individual bovine nuclear transfer blastocysts. Reproduction 131(6):1073\u20131084","DOI":"10.1530\/rep.1.00967"},{"issue":"20","key":"226_CR29","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.3748\/wjg.v13.i20.2826","volume":"13","author":"S Tedelind","year":"2007","unstructured":"Tedelind S, Westberg F, Kjerrulf M, Vidal A (2007) Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease. World J Gastroenterol 13(20):2826\u20132832. https:\/\/doi.org\/10.3748\/wjg.v13.i20.2826","journal-title":"World J Gastroenterol"},{"issue":"4","key":"226_CR30","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1113\/expphysiol.2005.029959","volume":"92","author":"DT Thwaites","year":"2007","unstructured":"Thwaites DT, Anderson CM (2007) H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol 92(4):603\u2013619. https:\/\/doi.org\/10.1113\/expphysiol.2005.029959","journal-title":"Exp Physiol"},{"issue":"8","key":"226_CR31","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.jgg.2012.05.008","volume":"39","author":"J Wu","year":"2012","unstructured":"Wu J, Zhou Z, Hu Y, Dong S (2012) Butyrate-induced GPR41 activation inhibits histone acetylation and cell growth. J Genet Genomics 39(8):375\u2013384. https:\/\/doi.org\/10.1016\/j.jgg.2012.05.008","journal-title":"J Genet Genomics"},{"issue":"9","key":"226_CR32","doi-asserted-by":"publisher","first-page":"5668","DOI":"10.3168\/jds.2013-7807","volume":"97","author":"L Yan","year":"2014","unstructured":"Yan L, Zhang B, Shen Z (2014) Dietary modulation of the expression of genes involved in short-chain fatty acid absorption in the rumen epithelium is related to short-chain fatty acid concentration and pH in the rumen of goats. J Dairy Sci 97(9):5668\u20135675. https:\/\/doi.org\/10.3168\/jds.2013-7807","journal-title":"J Dairy Sci"},{"issue":"1","key":"226_CR33","doi-asserted-by":"publisher","first-page":"307","DOI":"10.2527\/jas.2011-3854","volume":"90","author":"W Yang","year":"2012","unstructured":"Yang W, Shen Z, Martens H (2012) An energy-rich diet enhances expression of Na+\/H+ exchanger isoform 1 and 3 messenger RNA in rumen epithelium of goat. J Anim Sci 90(1):307\u2013317. https:\/\/doi.org\/10.2527\/jas.2011-3854","journal-title":"J Anim Sci"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11626-017-0226-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-017-0226-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-017-0226-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T14:13:52Z","timestamp":1570889632000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11626-017-0226-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,12]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["226"],"URL":"https:\/\/doi.org\/10.1007\/s11626-017-0226-2","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,12]]},"assertion":[{"value":"27 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Animal slaughter followed the Ethics Committee of the Institute of Yangzhou University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}