{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:04:37Z","timestamp":1775214277325,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Project of Fujian Provincial Department of Education","award":["JA15717"],"award-info":[{"award-number":["JA15717"]}]},{"DOI":"10.13039\/501100018623","name":"Quanzhou Science and Technology Project","doi-asserted-by":"crossref","award":["2015Z98"],"award-info":[{"award-number":["2015Z98"]}],"id":[{"id":"10.13039\/501100018623","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s11626-020-00441-w","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T21:02:46Z","timestamp":1588798966000},"page":"286-295","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["DSCAM-AS1 mediates pro-hypertrophy role of GRK2 in cardiac hypertrophy aggravation via absorbing miR-188-5p"],"prefix":"10.1007","volume":"56","author":[{"given":"Huiqin","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kefeng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"441_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1080\/14728222.2018.1406925","volume":"22","author":"A Cannavo","year":"2018","unstructured":"Cannavo A, Komici K, Bencivenga L, D'Amico ML, Gambino G, Liccardo D, Ferrara N, Rengo G (2018) GRK2 as a therapeutic target for heart failure. Expert Opin Ther Targets 22:75\u201383","journal-title":"Expert Opin Ther Targets"},{"key":"441_CR2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/jnc.13761","volume":"139","author":"M Deng","year":"2016","unstructured":"Deng M, Tufan T, Raza MU, Jones TC, Zhu MY (2016) MicroRNAs 29b and 181a down-regulate the expression of the norepinephrine transporter and glucocorticoid receptors in PC12 cells. J Neurochem 139:197\u2013207","journal-title":"J Neurochem"},{"key":"441_CR3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","volume":"65","author":"N Frey","year":"2003","unstructured":"Frey N, Olson EN (2003) Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol 65:45\u201379","journal-title":"Annu Rev Physiol"},{"key":"441_CR4","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.cellsig.2014.11.018","volume":"27","author":"Q Fu","year":"2015","unstructured":"Fu Q, Xu B, Parikh D, Cervantes D, Xiang YK (2015) Insulin induces IRS2-dependent and GRK2-mediated beta2AR internalization to attenuate betaAR signaling in cardiomyocytes. Cell Signal 27:707\u2013715","journal-title":"Cell Signal"},{"key":"441_CR5","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12943-019-0993-3","volume":"18","author":"S Jin","year":"2019","unstructured":"Jin S, Yang X, Li J, Yang W, Ma H, Zhang Z (2019) p53-targeted lincRNA-p21 acts as a tumor suppressor by inhibiting JAK2\/STAT3 signaling pathways in head and neck squamous cell carcinoma. Mol Cancer 18:38","journal-title":"Mol Cancer"},{"key":"441_CR6","doi-asserted-by":"publisher","first-page":"e0160961","DOI":"10.1371\/journal.pone.0160961","volume":"11","author":"MR Kang","year":"2016","unstructured":"Kang MR, Park KH, Yang JO, Lee CW, Oh SJ, Yun J, Lee MY, Han SB, Kang JS (2016) miR-6734 up-regulates p21 gene expression and induces cell cycle arrest and apoptosis in colon cancer cells. PLoS One 11:e0160961","journal-title":"PLoS One"},{"key":"441_CR7","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1158\/2159-8290.CD-13-0202","volume":"3","author":"FA Karreth","year":"2013","unstructured":"Karreth FA, Pandolfi PP (2013) ceRNA cross-talk in cancer: when ce-bling rivalries go awry. Cancer Discov 3:1113\u20131121","journal-title":"Cancer Discov"},{"key":"441_CR8","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1093\/cvr\/cvw050","volume":"110","author":"V Kooij","year":"2016","unstructured":"Kooij V, Viswanathan MC, Lee DI, Rainer PP, Schmidt W, Kronert WA, Harding SE, Kass DA, Bernstein SI, Van Eyk JE, Cammarato A (2016) Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy. Cardiovasc Res 110:238\u2013248","journal-title":"Cardiovasc Res"},{"key":"441_CR9","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ijcard.2014.02.035","volume":"173","author":"C Li","year":"2014","unstructured":"Li C, Li X, Gao X, Zhang R, Zhang Y, Liang H, Xu C, Du W, Zhang Y, Liu X, Ma N, Xu Z, Wang L, Chen X, Lu Y, Ju J, Yang B, Shan H (2014) MicroRNA-328 as a regulator of cardiac hypertrophy. Int J Cardiol 173:268\u2013276","journal-title":"Int J Cardiol"},{"key":"441_CR10","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1186\/s12885-019-5731-0","volume":"19","author":"Y Li","year":"2019","unstructured":"Li Y, Yan X, Shi J, He Y, Xu J, Lin L, Chen W, Lin X, Lin X (2019) Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt\/beta-catenin signaling. BMC Cancer 19:505","journal-title":"BMC Cancer"},{"key":"441_CR11","first-page":"1265","volume":"42","author":"Z Li","year":"2018","unstructured":"Li Z, Liu Y, Guo X, Sun G, Ma Q, Dai Y, Zhu G, Sun Y (2018) Long noncoding RNA myocardial infarction-associated transcript is associated with the microRNA-150-5p\/P300 pathway in cardiac hypertrophy. Int J Mol Med 42:1265\u20131272","journal-title":"Int J Mol Med"},{"key":"441_CR12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s12943-018-0870-5","volume":"17","author":"H Liang","year":"2018","unstructured":"Liang H, Yu T, Han Y, Jiang H, Wang C, You T, Zhao X, Shan H, Yang R, Yang L, Shan H, Gu Y (2018) LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression. Mol Cancer 17:119","journal-title":"Mol Cancer"},{"key":"441_CR13","first-page":"1087","volume":"23","author":"J Liao","year":"2019","unstructured":"Liao J, Xie N (2019) Long noncoding RNA DSCAM-AS1 functions as an oncogene in non-small cell lung cancer by targeting BCL11A. Eur Rev Med Pharmacol Sci 23:1087\u20131092","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"441_CR14","doi-asserted-by":"crossref","unstructured":"Liu H, Xu D, Zhong X, Xu D, Chen G, Ge J, Li H (2019) LncRNA-mRNA competing endogenous RNA network depicts transcriptional regulation in ischaemia reperfusion injury 23:2272\u20132276","DOI":"10.1111\/jcmm.14163"},{"key":"441_CR15","doi-asserted-by":"crossref","unstructured":"Liu T, Han Z, Li H, Zhu Y, Sun Z, Zhu A (2018) LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3. Mol Cancer 17:118","DOI":"10.1186\/s12943-018-0873-2"},{"key":"441_CR16","doi-asserted-by":"crossref","unstructured":"Lv L, Li T, Li X, Xu C, Liu Q, Jiang H, Li Y, Liu Y, Yan H, Huang Q, Zhou Y, Zhang M, Shan H, Liang H (2018) The lncRNA Plscr4 controls cardiac hypertrophy by regulating miR-214. Mol Ther Nucleic Acids 10:387\u2013397","DOI":"10.1016\/j.omtn.2017.12.018"},{"key":"441_CR17","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1186\/s13287-019-1522-4","volume":"10","author":"Q Mao","year":"2019","unstructured":"Mao Q, Liang XL, Zhang CL, Pang YH, Lu YX (2019) LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p\/Sirt1 axis. Stem Cell Res Ther 10:393","journal-title":"Stem Cell Res Ther"},{"key":"441_CR18","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1161\/01.HYP.19.6.708","volume":"19","author":"M Nagano","year":"1992","unstructured":"Nagano M, Higaki J, Nakamura F, Higashimori K, Nagano N, Mikami H, Ogihara T (1992) Role of cardiac angiotensin II in isoproterenol-induced left ventricular hypertrophy. Hypertension 19:708\u2013712","journal-title":"Hypertension"},{"key":"441_CR19","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1158\/1535-7163.MCT-19-0051","volume":"18","author":"ZY Nie","year":"2019","unstructured":"Nie ZY, Yang L, Liu XJ, Yang Z, Yang GS, Zhou J, Qin Y, Yu J, Jiang LL, Wen JK, Luo JM (2019) Morin inhibits proliferation and induces apoptosis by modulating the miR-188-5p\/PTEN\/AKT regulatory pathway in CML cells. Mol Cancer Ther 18:2296\u20132307","journal-title":"Mol Cancer Ther"},{"key":"441_CR20","doi-asserted-by":"publisher","first-page":"12791","DOI":"10.1038\/ncomms12791","volume":"7","author":"YS Niknafs","year":"2016","unstructured":"Niknafs YS, Han S, Ma T, Speers C, Zhang C, Wilder-Romans K, Iyer MK, Pitchiaya S, Malik R, Hosono Y, Prensner JR, Poliakov A, Singhal U, Xiao L, Kregel S, Siebenaler RF, Zhao SG, Uhl M, Gawronski A, Hayes DF, Pierce LJ, Cao X, Collins C, Backofen R, Sahinalp CS, Rae JM, Chinnaiyan AM, Feng FY (2016) The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. Nat Commun 7:12791","journal-title":"Nat Commun"},{"key":"441_CR21","doi-asserted-by":"publisher","first-page":"6656","DOI":"10.1038\/ncomms7656","volume":"6","author":"VB Pillai","year":"2015","unstructured":"Pillai VB, Samant S, Sundaresan NR, Raghuraman H, Kim G, Bonner MY, Arbiser JL, Walker DI, Jones DP, Gius D, Gupta MP (2015) Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. Nat Commun 6:6656","journal-title":"Nat Commun"},{"key":"441_CR22","first-page":"6607","volume":"8","author":"A Ruedel","year":"2015","unstructured":"Ruedel A, Dietrich P, Schubert T, Hofmeister S, Hellerbrand C, Bosserhoff AK (2015) Expression and function of microRNA-188-5p in activated rheumatoid arthritis synovial fibroblasts. Int J Clin Exp Pathol 8:6607\u20136616","journal-title":"Int J Clin Exp Pathol"},{"key":"441_CR23","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.yjmcc.2015.10.002","volume":"89","author":"PY Sato","year":"2015","unstructured":"Sato PY, Chuprun JK, Ibetti J, Cannavo A, Drosatos K, Elrod JW, Koch WJ (2015) GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels. J Mol Cell Cardiol 89:360\u2013364","journal-title":"J Mol Cell Cardiol"},{"key":"441_CR24","doi-asserted-by":"publisher","first-page":"e0182110","DOI":"10.1371\/journal.pone.0182110","volume":"12","author":"P Schlegel","year":"2017","unstructured":"Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW (2017) G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. PLoS One 12:e0182110","journal-title":"PLoS One"},{"key":"441_CR25","doi-asserted-by":"publisher","first-page":"ra30","DOI":"10.1126\/scisignal.aae0549","volume":"9","author":"SM Schumacher","year":"2016","unstructured":"Schumacher SM, Gao E, Cohen M, Lieu M, Chuprun JK, Koch WJ (2016) A peptide of the RGS domain of GRK2 binds and inhibits Galpha(q) to suppress pathological cardiac hypertrophy and dysfunction. Sci Signal 9:ra30","journal-title":"Sci Signal"},{"key":"441_CR26","doi-asserted-by":"crossref","unstructured":"Schumacher SM, Gao E, Zhu W, Chen X, Chuprun JK, Feldman AM, Tesmer JJ, Koch WJ (2015) Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction. Sci Transl Med 7:277ra231","DOI":"10.1126\/scitranslmed.aaa0154"},{"key":"441_CR27","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.5114\/aoms.2018.75535","volume":"14","author":"S Shao","year":"2018","unstructured":"Shao S, Tian J, Zhang H, Wang S (2018) LncRNA myocardial infarction-associated transcript promotes cell proliferation and inhibits cell apoptosis by targeting miR-330-5p in epithelial ovarian cancer cells. Arch Med Sci 14:1263\u20131270","journal-title":"Arch Med Sci"},{"key":"441_CR28","doi-asserted-by":"publisher","first-page":"9561","DOI":"10.3892\/mmr.2017.7775","volume":"16","author":"J Shi","year":"2017","unstructured":"Shi J, Zhang W, Tian H, Zhang Q, Men T (2017) lncRNA ROR promotes the proliferation of renal cancer and is negatively associated with favorable prognosis. Mol Med Rep 16:9561\u20139566","journal-title":"Mol Med Rep"},{"key":"441_CR29","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nature12986","volume":"505","author":"Y Tay","year":"2014","unstructured":"Tay Y, Rinn J, Pandolfi PP (2014) The multilayered complexity of ceRNA crosstalk and competition. Nature 505:344\u2013352","journal-title":"Nature"},{"key":"441_CR30","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1007\/s00204-015-1477-x","volume":"89","author":"YK Tham","year":"2015","unstructured":"Tham YK, Bernardo BC, Ooi JY, Weeks KL, McMullen JR (2015) Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets. Arch Toxicol 89:1401\u20131438","journal-title":"Arch Toxicol"},{"key":"441_CR31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cell.2013.06.020","volume":"154","author":"I Ulitsky","year":"2013","unstructured":"Ulitsky I, Bartel DP (2013) lincRNAs: genomics, evolution, and mechanisms. Cell 154:26\u201346","journal-title":"Cell"},{"key":"441_CR32","doi-asserted-by":"publisher","unstructured":"Wang J, Zhang X, Chen W, Hu X, Li J, Liu C (2019) Regulatory roles of long non-coding RNAs implicated in cancer hallmarks. Int J Cancer. https:\/\/doi.org\/10.1002\/ijc.32277","DOI":"10.1002\/ijc.32277"},{"key":"441_CR33","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/s41434-018-0045-4","volume":"25","author":"H Wu","year":"2018","unstructured":"Wu H, Zhao ZA, Liu J, Hao K, Yu Y, Han X, Li J, Wang Y, Lei W, Dong N, Shen Z, Hu S (2018) Long noncoding RNA Meg3 regulates cardiomyocyte apoptosis in myocardial infarction. Gene Ther 25:511\u2013523","journal-title":"Gene Ther"},{"key":"441_CR34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12943-019-0984-4","volume":"18","author":"Y Xie","year":"2019","unstructured":"Xie Y, Dang W, Zhang S, Yue W, Yang L, Zhai X, Yan Q, Lu J (2019) The role of exosomal noncoding RNAs in cancer. Mol Cancer 18:37","journal-title":"Mol Cancer"},{"key":"441_CR35","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12943-017-0696-6","volume":"16","author":"S Xu","year":"2017","unstructured":"Xu S, Kong D, Chen Q, Ping Y, Pang D (2017) Oncogenic long noncoding RNA landscape in breast cancer. Mol Cancer 16:129","journal-title":"Mol Cancer"},{"key":"441_CR36","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1038\/s41418-018-0236-y","volume":"26","author":"TP Xu","year":"2019","unstructured":"Xu TP, Ma P, Wang WY, Shuai Y, Wang YF, Yu T, Xia R, Shu YQ (2019) KLF5 and MYC modulated LINC00346 contributes to gastric cancer progression through acting as a competing endogeous RNA and indicates poor outcome. Cell Death Differ 26:2179\u20132193. https:\/\/doi.org\/10.1038\/s41418-018-0236-y","journal-title":"Cell Death Differ"},{"key":"441_CR37","doi-asserted-by":"publisher","first-page":"6092","DOI":"10.18632\/oncotarget.3341","volume":"6","author":"H Zhang","year":"2015","unstructured":"Zhang H, Qi S, Zhang T, Wang A, Liu R, Guo J, Wang Y, Xu Y (2015) miR-188-5p inhibits tumour growth and metastasis in prostate cancer by repressing LAPTM4B expression. Oncotarget 6:6092\u20136104","journal-title":"Oncotarget"},{"key":"441_CR38","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/jcp.28964","volume":"235","author":"Q Zhang","year":"2020","unstructured":"Zhang Q, Wang F, Wang F, Wu N (2020) Long noncoding RNA MAGI1-IT1 regulates cardiac hypertrophy by modulating miR-302e\/DKK1\/Wnt\/beta-catenin signaling pathway. J Cell Physiol 235:245\u2013253","journal-title":"J Cell Physiol"},{"key":"441_CR39","doi-asserted-by":"publisher","first-page":"e13066","DOI":"10.1097\/MD.0000000000013066","volume":"97","author":"Z Zhong","year":"2018","unstructured":"Zhong Z, Hou J, Zhang Q, Li B, Li C, Liu Z, Yang M, Zhong W, Zhao P (2018) Differential expression of circulating long non-coding RNAs in patients with acute myocardial infarction. Medicine (Baltimore) 97:e13066","journal-title":"Medicine (Baltimore)"},{"key":"441_CR40","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1159\/000487204","volume":"8","author":"G Zhou","year":"2018","unstructured":"Zhou G, Li C, Feng J, Zhang J, Fang Y (2018) lncRNA UCA1 is a novel regulator in cardiomyocyte hypertrophy through targeting the miR-184\/HOXA9 axis. Cardiorenal Med 8:130\u2013139","journal-title":"Cardiorenal Med"},{"key":"441_CR41","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/abbs\/gmy165","volume":"51","author":"W Zhu","year":"2019","unstructured":"Zhu W, Wu X, Yang B, Yao X, Cui X, Xu P, Chen X (2019) miR-188-5p regulates proliferation and invasion via PI3K\/Akt\/MMP-2\/9 signaling in keloids. Acta Biochim Biophys Sin Shanghai 51:185\u2013196","journal-title":"Acta Biochim Biophys Sin Shanghai"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-020-00441-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-020-00441-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-020-00441-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T01:25:42Z","timestamp":1620264342000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-020-00441-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["441"],"URL":"https:\/\/doi.org\/10.1007\/s11626-020-00441-w","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"31 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}