{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:36:49Z","timestamp":1787639809580,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/20910-5"],"award-info":[{"award-number":["2018\/20910-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/21646-9"],"award-info":[{"award-number":["2014\/21646-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/22102-2"],"award-info":[{"award-number":["2014\/22102-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/17368-0"],"award-info":[{"award-number":["2013\/17368-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/19678-1"],"award-info":[{"award-number":["2011\/19678-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Brazilian Center for Research in Energy and Materials-Brasilizan Biosciences National Laboratory","award":["20992"],"award-info":[{"award-number":["20992"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s11626-020-00497-8","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T16:17:41Z","timestamp":1599754661000},"page":"604-613","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Discriminating aspects of global metabolism of neonatal cardiomyocytes from wild type and KO-CSRP3 rats using proton magnetic resonance spectroscopy of culture media samples"],"prefix":"10.1007","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8529-1577","authenticated-orcid":false,"given":"Antonio Carlos","family":"Bloise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Adriane","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis Vasconcelos","family":"de Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius","family":"Bassaneze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia Ferreira","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano Mesquita","family":"Alencar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"issue":"24","key":"497_CR1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.21037\/atm.2018.12.12","volume":"6","author":"E Aliu","year":"2018","unstructured":"Aliu E, Kanungo S, Arnold GL (2018) Amino acid disorders. Ann Transl Med 6(24):471\u2013471. https:\/\/doi.org\/10.21037\/atm.2018.12.12","journal-title":"Ann Transl Med"},{"key":"497_CR2","doi-asserted-by":"publisher","unstructured":"Arber S, Hunter JJ, Ross J, Hongo M, Sansig G, Borg J et al (1997) MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell 88(3):393\u2013403. Retrieved from https:\/\/doi.org\/10.1186\/2193-1801-3-470","DOI":"10.1186\/2193-1801-3-470"},{"key":"497_CR3","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1186\/2193-1801-3-470","volume":"3","author":"PS Bacchi","year":"2014","unstructured":"Bacchi PS, Bloise AC, Bustos SO, Zimmermann L, Chammas R, Rabbani SR (2014) Metabolism under hypoxia in Tm1 murine melanoma cells is affected by the presence of galectin-3, a metabolomics approach. SpringerPlus 3:470","journal-title":"SpringerPlus"},{"issue":"4","key":"497_CR4","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.yjmcc.2009.04.006","volume":"47","author":"SY Boateng","year":"2009","unstructured":"Boateng SY, Senyo SE, Qi L, Goldspink PH, Russell B (2009) Myocyte remodeling in response to hypertrophic stimuli requires nucleocytoplasmic shuttling of muscle LIM protein. J Mol Cell Cardiol 47(4):426\u2013435. https:\/\/doi.org\/10.1016\/j.yjmcc.2009.04.006","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"497_CR5","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1042\/cs20171601","volume":"132","author":"LCG Campos","year":"2018","unstructured":"Campos LCG, Ribeiro-Silva JC, Menegon AS, Barauna VG, Miyakawa AA, Krieger JE (2018) Cyclic stretch-induced Crp3 sensitizes vascular smooth muscle cells to apoptosis during vein arterialization remodeling. Clin Sci 132(4):449\u2013459. https:\/\/doi.org\/10.1042\/cs20171601","journal-title":"Clin Sci"},{"issue":"12","key":"497_CR6","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1007\/s00726-017-2419-0","volume":"49","author":"U Chaudhari","year":"2017","unstructured":"Chaudhari U, Ellis JK, Wagh V, Nemade H, Hescheler J, Keun HC, Sachinidis A (2017) Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes. Amino Acids 49(12):1955\u20131963. https:\/\/doi.org\/10.1007\/s00726-017-2419-0","journal-title":"Amino Acids"},{"key":"497_CR7","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.yjmcc.2018.07.248","volume":"121","author":"M Ehsan","year":"2018","unstructured":"Ehsan M, Kelly M, Hooper C, Yavari A, Beglov J, Bellahcene M et al (2018) Mutant muscle LIM protein C58G causes cardiomyopathy through protein depletion. J Mol Cell Cardiol 121:287\u2013296. https:\/\/doi.org\/10.1016\/j.yjmcc.2018.07.248","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"497_CR8","doi-asserted-by":"publisher","first-page":"28","DOI":"10.2174\/2213235x11301010028","volume":"1","author":"JJ Ellinger","year":"2013","unstructured":"Ellinger JJ, Chylla RA, Ulrich EL, Markley JL (2013) Databases and software for NMR-based metabolomics. Curr Metabolomics 1(1):28\u201340. https:\/\/doi.org\/10.2174\/2213235x11301010028","journal-title":"Curr Metabolomics"},{"key":"497_CR9","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/978-1-4939-2377-9_13","volume":"1277","author":"AHM Emwas","year":"2015","unstructured":"Emwas AHM (2015) The strengths and weaknesses of NMR spectroscopy and mass spectrometry with particular focus on metabolomics research. Methods Mol Biol 1277:161\u2013193. https:\/\/doi.org\/10.1007\/978-1-4939-2377-9_13","journal-title":"Methods Mol Biol"},{"issue":"Suppl 1","key":"497_CR10","doi-asserted-by":"publisher","first-page":"S33","DOI":"10.1097\/01.hjh.0000388492.73954.0b","volume":"28","author":"P Finckenberg","year":"2010","unstructured":"Finckenberg P, Mervaala E (2010) Novel regulators and drug targets of cardiac hypertrophy. J Hypertens 28(Suppl 1):S33\u2013S38. https:\/\/doi.org\/10.1097\/01.hjh.0000388492.73954.0b","journal-title":"J Hypertens"},{"issue":"10","key":"497_CR11","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1161\/01.CIR.0000056522.82563.5F","volume":"107","author":"C Geier","year":"2003","unstructured":"Geier C, Perrot A, \u00d6zcelik C, Binner P, Counsell D, Hoffmann K et al (2003) Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy. Circulation 107(10):1390\u20131395. https:\/\/doi.org\/10.1161\/01.CIR.0000056522.82563.5F","journal-title":"Circulation"},{"issue":"7","key":"497_CR12","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nrc1390","volume":"4","author":"JL Griffin","year":"2004","unstructured":"Griffin JL, Shockcor JP (2004) Metabolic profiles of cancer cells. Nat Rev Cancer 4(7):551","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"497_CR13","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1198\/tech.2005.s319","volume":"47","author":"CE Heckler","year":"2005","unstructured":"Heckler CE (2005) Applied multivariate statistical analysis: applied multivariate statistical analysis. Technometrics 47(4):517\u2013517. https:\/\/doi.org\/10.1198\/tech.2005.s319","journal-title":"Technometrics"},{"issue":"2","key":"497_CR14","doi-asserted-by":"publisher","first-page":"E267","DOI":"10.1152\/ajpendo.00435.2017","volume":"315","author":"A Hernandez-Carretero","year":"2018","unstructured":"Hernandez-Carretero A, Weber N, LaBarge SA, Peterka V, Doan NYT, Schenk S, Osborn O (2018) Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle. Am J Physiol-Endocrinol Metab 315(2):E267\u2013E278. https:\/\/doi.org\/10.1152\/ajpendo.00435.2017","journal-title":"Am J Physiol-Endocrinol Metab"},{"key":"497_CR15","doi-asserted-by":"publisher","unstructured":"Jensen L, Neri E, Bassaneze V, De Almeida Oliveira NC, Dariolli R, Tura\u00e7a LT, \u2026 Krieger JE (2018) Integrated molecular, biochemical, and physiological assessment unravels key extraction method mediated influences on rat neonatal cardiomyocytes. J Cell Physiol 233(7):5420\u20135430. https:\/\/doi.org\/10.1002\/jcp.26380","DOI":"10.1002\/jcp.26380"},{"key":"497_CR16","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1146\/annurev.pharmtox.48.113006.094715","volume":"48","author":"R Kaddurah-Daouk","year":"2008","unstructured":"Kaddurah-Daouk R, Kristal BS, Weinshilboum RM (2008) Metabolomics: a global biochemical approach to drug response and disease. Annu Rev Pharmacol Toxicol 48:653\u2013683. https:\/\/doi.org\/10.1146\/annurev.pharmtox.48.113006.094715","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"497_CR17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/J.ABB.2018.11.027","volume":"662","author":"M Klos","year":"2019","unstructured":"Klos M, Morgenstern S, Hicks K, Suresh S, Devaney EJ (2019) The effects of the ketone body \u03b2-hydroxybutyrate on isolated rat ventricular myocyte excitation-contraction coupling. Arch Biochem Biophys 662:143\u2013150. https:\/\/doi.org\/10.1016\/J.ABB.2018.11.027","journal-title":"Arch Biochem Biophys"},{"key":"497_CR18","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/978-1-4939-7592-1_25","volume":"1730","author":"S Kostidis","year":"2018","unstructured":"Kostidis S (2018) Quantitative analysis of central energy metabolism in cell culture samples. Methods Mol Biol 1730:329\u2013342. https:\/\/doi.org\/10.1007\/978-1-4939-7592-1_25","journal-title":"Methods Mol Biol"},{"issue":"1","key":"497_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12120","volume":"7","author":"S Lange","year":"2016","unstructured":"Lange S, Gehmlich K, Lun AS, Blondelle J, Hooper C, Dalton ND et al (2016) MLP and CARP are linked to chronic PKC\u03b1 signaling in dilated cardiomyopathy. Nat Commun 7(1):12120. https:\/\/doi.org\/10.1038\/ncomms12120","journal-title":"Nat Commun"},{"key":"497_CR20","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1016\/j.febslet.2013.04.018","volume":"587","author":"R Li","year":"2013","unstructured":"Li R, Yan G, Zhang Q, Jiang Y, Sun H, Hu Y et al (2013) miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. FEBS Lett 587:1754\u20131761","journal-title":"FEBS Lett"},{"key":"497_CR21","doi-asserted-by":"publisher","unstructured":"Li X, Lu WJ, Li Y, Wu F, Bai R, Ma S et al (2019) MLP-deficient human pluripotent stem cell derived cardiomyocytes develop hypertrophic cardiomyopathy and heart failure phenotypes due to abnormal calcium handling. Cell Death Dis 10(8). https:\/\/doi.org\/10.1038\/s41419-019-1826-4","DOI":"10.1038\/s41419-019-1826-4"},{"issue":"6","key":"497_CR22","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s11095-006-0025-z","volume":"23","author":"JC Lindon","year":"2006","unstructured":"Lindon JC, Holmes E, Nicholson JK (2006) Metabonomics techniques and applications to pharmaceutical research & development. Pharm Res 23(6):1075\u20131088. https:\/\/doi.org\/10.1007\/s11095-006-0025-z","journal-title":"Pharm Res"},{"key":"497_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52841-4.X5000-0","volume-title":"The Handbook of Metabonomics and Metabolomics","author":"JC Lindon","year":"2007","unstructured":"Lindon JC, Nicholson JK, Holmes E (2007) The Handbook of Metabonomics and Metabolomics. In: The Handbook of Metabonomics and Metabolomics. https:\/\/doi.org\/10.1016\/B978-0-444-52841-4.X5000-0"},{"issue":"2","key":"497_CR24","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s10334-014-0458-z","volume":"28","author":"B Madhu","year":"2015","unstructured":"Madhu B, Dadulescu M, Griffiths J (2015) Artifacts in 1H NMR-based metabolomic studies on cell cultures. MAGMA 28(2):161\u2013171. https:\/\/doi.org\/10.1007\/s10334-014-0458-z","journal-title":"MAGMA"},{"key":"497_CR25","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.aca.2009.11.042","volume":"659","author":"R Madsen","year":"2010","unstructured":"Madsen R, Lundstedt T, Trygg J (2010) Chemometrics in metabolomics - a review in human disease diagnosis. Anal Chim Acta 659:23\u201333","journal-title":"Anal Chim Acta"},{"issue":"3","key":"497_CR26","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/jat.1663","volume":"31","author":"C-F Mandenius","year":"2011","unstructured":"Mandenius C-F, Steel D, Noor F, Meyer T, Heinzle E, Asp J et al (2011) Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review. J Appl Toxicol 31(3):191\u2013205. https:\/\/doi.org\/10.1002\/jat.1663","journal-title":"J Appl Toxicol"},{"key":"497_CR27","doi-asserted-by":"publisher","unstructured":"Mart\u00ednez MS, Garc\u00eda A, Luzardo E, Ch\u00e1vez-Castillo M, Olivar LC, Salazar J et al (2017) Energetic metabolism in cardiomyocytes: molecular basis of heart ischemia and arrhythmogenesis. Vessel Plus 1(12). https:\/\/doi.org\/10.20517\/2574-1209.2017.34","DOI":"10.20517\/2574-1209.2017.34"},{"key":"497_CR28","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.mri.2012.04.003","volume":"30","author":"AB Martins-Bach","year":"2012","unstructured":"Martins-Bach AB, Bloise AC, Vainzof M, Rabbani SR (2012) Metabolic profile of dystrophic mdx mouse muscles analyzed with in vitro magnetic resonance spectroscopy (MRS). Magn Reson Imaging 30:1167\u20131176","journal-title":"Magn Reson Imaging"},{"key":"497_CR29","unstructured":"Massad E, de Menezes RX, Silveira PSP, Ortega NRS (2004) M\u00e9todos Quantitativos em Medicina. Manole"},{"issue":"4","key":"497_CR30","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s10616-012-9508-4","volume":"65","author":"SE Mohmad-Saberi","year":"2013","unstructured":"Mohmad-Saberi SE, Hashim YZH-Y, Mel M, Amid A, Ahmad-Raus R, Packeer-Mohamed V (2013) Metabolomics profiling of extracellular metabolites in CHO-K1 cells cultured in different types of growth media. Cytotechnology 65(4):577\u2013586. https:\/\/doi.org\/10.1007\/s10616-012-9508-4","journal-title":"Cytotechnology"},{"issue":"4","key":"497_CR31","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/biology5040038","volume":"5","author":"M Nalbandian","year":"2016","unstructured":"Nalbandian M, Takeda M (2016) Lactate as a signaling molecule that regulates exercise-induced adaptations. Biology 5(4):38. https:\/\/doi.org\/10.3390\/biology5040038","journal-title":"Biology"},{"issue":"7277","key":"497_CR32","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/463026a","volume":"463","author":"JK Nicholson","year":"2010","unstructured":"Nicholson JK (2010) 2020 visions. Nature 463(7277):26\u201332. https:\/\/doi.org\/10.1038\/463026a","journal-title":"Nature"},{"issue":"11","key":"497_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113769","volume":"9","author":"T Pereira","year":"2014","unstructured":"Pereira T, Ivanova G, Caseiro AR, Barbosa P, B\u00e1rtolo PJ, Santos JD et al (2014) MSCs conditioned media and umbilical cord blood plasma metabolomics and composition. PLoS ONE 9(11):e113769. https:\/\/doi.org\/10.1371\/journal.pone.0113769","journal-title":"PLoS ONE"},{"key":"497_CR34","doi-asserted-by":"publisher","unstructured":"Saborano R, Eraslan Z, Roberts J, Khanim FL, Lalor PF, Reed MAC, G\u00fcnther UL (2019) A framework for tracer-based metabolism in mammalian cells by NMR. Sci Rep 9(1). https:\/\/doi.org\/10.1038\/s41598-018-37525-3","DOI":"10.1038\/s41598-018-37525-3"},{"key":"497_CR35","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1002\/nbm.1516","volume":"23","author":"MN Triba","year":"2010","unstructured":"Triba MN, Starzec A, Bouchemal N, Guenin E, Perret GY, Le Moyec L (2010) Metabolomic profiling with NMR discriminates between biphosphonate and doxorubicin effects on B16 melanoma cells. NMR Biomed 23:1009\u20131016. https:\/\/doi.org\/10.1002\/nbm.1516","journal-title":"NMR Biomed"},{"key":"497_CR36","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1093\/nar\/gks1065","volume":"41","author":"DS Wishart","year":"2013","unstructured":"Wishart DS, Jewison T, Guo AC, Wilson M, Knox C (2013) HMDB 3.0 - The human metabolome database in 2013. Nucleic Acids Res 41:801\u2013807","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"497_CR37","doi-asserted-by":"publisher","first-page":"92","DOI":"10.2174\/221323X11301010092","volume":"1","author":"B Worley","year":"2013","unstructured":"Worley B, Powers R (2013) Multivariate analysis in metabolomics. Curr Metabolomics 1(1):92\u2013107. https:\/\/doi.org\/10.2174\/221323X11301010092","journal-title":"Curr Metabolomics"},{"key":"497_CR38","doi-asserted-by":"publisher","first-page":"14.10.1","DOI":"10.1002\/cpbi.11","volume":"55","author":"J Xia","year":"2016","unstructured":"Xia J, Wishart DS (2016) Using MetaboAnalyst 3.0 for comprehensive metabolomics data analysis. Curr Protoc Bioinformatics 55:14.10.1\u201314.10.91","journal-title":"Curr Protoc Bioinformatics"},{"key":"497_CR39","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.pbiomolbio.2008.02.017","volume":"97","author":"Y Zhang","year":"2008","unstructured":"Zhang Y, Sekar RB, McCulloch AD, Tung L (2008) Cell cultures as models of cardiac mechanoelectrical feedback. Prog Biophys Mol 97:367\u2013382","journal-title":"Prog Biophys Mol"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-020-00497-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-020-00497-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-020-00497-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T22:32:11Z","timestamp":1631226731000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-020-00497-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["497"],"URL":"https:\/\/doi.org\/10.1007\/s11626-020-00497-8","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"30 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Approval was obtained from the institutional review board from the University of Sao Paulo, School of Medicine, Brazil (#340\/12).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}