{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:26:07Z","timestamp":1791897967189,"version":"4.3.4"},"reference-count":144,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s11626-021-00548-8","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T03:07:04Z","timestamp":1613704024000},"page":"133-147","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Human reconstructed kidney models"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6205-1661","authenticated-orcid":false,"given":"Seiji","family":"Kishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaharu","family":"Ichimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig R.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"issue":"3","key":"548_CR1","doi-asserted-by":"publisher","first-page":"5517","DOI":"10.3390\/ijms16035517","volume":"16","author":"D Antoni","year":"2015","unstructured":"Antoni D, Burckel H, Josset E, Noel G (2015) Three-dimensional cell culture: a breakthrough in vivo. Int J Mol Sci 16(3):5517\u20135527","journal-title":"Int J Mol Sci"},{"issue":"1","key":"548_CR2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084881","volume":"9","author":"T Araoka","year":"2014","unstructured":"Araoka T, Mae S, Kurose Y, Uesugi M, Ohta A, Yamanaka S, Osafune K (2014) Efficient and rapid induction of human iPSCs\/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods. PLoS One 9(1):e84881","journal-title":"PLoS One"},{"issue":"3","key":"548_CR3","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.kint.2015.10.019","volume":"89","author":"E Arif","year":"2016","unstructured":"Arif E, Solanki AK, Nihalani D (2016) Adriamycin susceptibility among C57BL\/6 substrains. Kidney Int 89(3):721\u2013723","journal-title":"Kidney Int"},{"issue":"2","key":"548_CR4","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/0014-4827(58)90039-9","volume":"15","author":"R Auerbach","year":"1958","unstructured":"Auerbach R, Grobstein C (1958) Inductive interaction of embryonic tissues after dissociation and reaggregation. Exp Cell Res 15(2):384\u2013397","journal-title":"Exp Cell Res"},{"issue":"11","key":"548_CR5","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1124\/dmd.118.082958","volume":"46","author":"P Bajaj","year":"2018","unstructured":"Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G (2018) Emerging kidney models to investigate metabolism, transport, and toxicity of drugs and xenobiotics. Drug Metab Dispos 46(11):1692\u20131702","journal-title":"Drug Metab Dispos"},{"issue":"4","key":"548_CR6","doi-asserted-by":"publisher","first-page":"Fso63","DOI":"10.4155\/fso.15.63","volume":"1","author":"F Barr\u00e9-Sinoussi","year":"2015","unstructured":"Barr\u00e9-Sinoussi F, Montagutelli X (2015) Animal models are essential to biological research: issues and perspectives. Future Sci OA 1(4):Fso63","journal-title":"Future Sci OA"},{"key":"548_CR7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.tiv.2017.11.016","volume":"47","author":"SM Bell","year":"2018","unstructured":"Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes NS, Sprankle CS, Strickland J, Troutman J, Wetmore BA, Kleinstreuer NC (2018) In vitro to in vivo extrapolation for high throughput prioritization and decision making. Toxicol in Vitro 47:213\u2013227","journal-title":"Toxicol in Vitro"},{"issue":"8","key":"548_CR8","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/nbt.2989","volume":"32","author":"SN Bhatia","year":"2014","unstructured":"Bhatia SN, Ingber DE (2014) Microfluidic organs-on-chips. Nat Biotechnol 32(8):760\u2013772","journal-title":"Nat Biotechnol"},{"issue":"22","key":"548_CR9","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.1101\/gad.240102","volume":"16","author":"M Bouchard","year":"2002","unstructured":"Bouchard M, Souabni A, Mandler M, Neubuser A, Busslinger M (2002) Nephric lineage specification by Pax2 and Pax8. Genes Dev 16(22):2958\u20132970","journal-title":"Genes Dev"},{"issue":"5","key":"548_CR10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.1432-0436.2006.00149.x","volume":"75","author":"SJ Bruce","year":"2007","unstructured":"Bruce SJ, Rea RW, Steptoe AL, Busslinger M, Bertram JF, Perkins AC (2007) In vitro differentiation of murine embryonic stem cells toward a renal lineage. Differentiation 75(5):337\u2013349","journal-title":"Differentiation"},{"issue":"5","key":"548_CR11","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1097\/00007890-200003150-00065","volume":"69","author":"MJ Burne","year":"2000","unstructured":"Burne MJ, Haq M, Matsuse H, Mohapatra S, Rabb H (2000) Genetic susceptibility to renal ischemia reperfusion injury revealed in a murine model. Transplantation 69(5):1023\u20131025","journal-title":"Transplantation"},{"key":"548_CR12","doi-asserted-by":"crossref","unstructured":"Canaud G, Brooks CR, Kishi S, Taguchi K, Nishimura K, Magassa S, Scott A, Hsiao LL, Ichimura T, Terzi F et al (2019) Cyclin G1 and TASCC regulate kidney epithelial cell G2-M arrest and fibrotic maladaptive repair. Sci Transl Med 11(476)","DOI":"10.1126\/scitranslmed.aav4754"},{"issue":"1","key":"548_CR13","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3109\/08977194.2014.975799","volume":"33","author":"MC Caroleo","year":"2015","unstructured":"Caroleo MC, Carito V, Pingitore A, Perrotta ID, Perri M, Mancuso D, Russo A, Cione E (2015) Human kidney podocyte cell population as a novel biological target of nerve growth factor. Growth Factors 33(1):14\u201322","journal-title":"Growth Factors"},{"key":"548_CR14","doi-asserted-by":"crossref","unstructured":"Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA et al (2017) Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. JCI Insight 2(22)","DOI":"10.1172\/jci.insight.95978"},{"issue":"7","key":"548_CR15","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1016\/j.cell.2016.05.082","volume":"165","author":"H Clevers","year":"2016","unstructured":"Clevers H (2016) Modeling development and disease with organoids. Cell 165(7):1586\u20131597","journal-title":"Cell"},{"issue":"1","key":"548_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13073-019-0615-0","volume":"11","author":"AN Combes","year":"2019","unstructured":"Combes AN, Zappia L, Er PX, Oshlack A, Little MH (2019) Single-cell analysis reveals congruence between kidney organoids and human fetal kidney. Genome Med 11(1):3","journal-title":"Genome Med"},{"issue":"6121","key":"548_CR17","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1126\/science.1231143","volume":"339","author":"L Cong","year":"2013","unstructured":"Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F (2013) Multiplex genome engineering using CRISPR\/Cas systems. Science 339(6121):819\u2013823","journal-title":"Science"},{"issue":"7","key":"548_CR18","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/j.1432-0436.2006.00106.x","volume":"74","author":"F Costantini","year":"2006","unstructured":"Costantini F (2006) Renal branching morphogenesis: concepts, questions, and recent advances. Differentiation 74(7):402\u2013421","journal-title":"Differentiation"},{"issue":"11","key":"548_CR19","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/nmat4994","volume":"16","author":"NM Cruz","year":"2017","unstructured":"Cruz NM, Song X, Czerniecki SM, Gulieva RE, Churchill AJ, Kim YK, Winston K, Tran LM, Diaz MA, Fu H, Finn LS, Pei Y, Himmelfarb J, Freedman BS (2017) Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease. Nat Mater 16(11):1112\u20131119","journal-title":"Nat Mater"},{"issue":"6","key":"548_CR20","doi-asserted-by":"publisher","first-page":"929\u2013940.e924","DOI":"10.1016\/j.stem.2018.04.022","volume":"22","author":"SM Czerniecki","year":"2018","unstructured":"Czerniecki SM, Cruz NM, Harder JL, Menon R, Annis J, Otto EA, Gulieva RE, Islas LV, Kim YK, Tran LM et al (2018) High-throughput screening enhances kidney organoid differentiation from human pluripotent stem cells and enables automated multidimensional phenotyping. Cell Stem Cell 22(6):929\u2013940.e924","journal-title":"Cell Stem Cell"},{"issue":"12","key":"548_CR21","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1681\/ASN.2015070832","volume":"26","author":"M de Caestecker","year":"2015","unstructured":"de Caestecker M, Humphreys BD, Liu KD, Fissell WH, Cerda J, Nolin TD, Askenazi D, Mour G, Harrell FE Jr, Pullen N et al (2015) Bridging translation by improving preclinical study design in AKI. J Am Soc Nephrol 26(12):2905\u20132916","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"548_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059219","volume":"8","author":"TM DesRochers","year":"2013","unstructured":"DesRochers TM, Suter L, Roth A, Kaplan DL (2013) Bioengineered 3D human kidney tissue, a platform for the determination of nephrotoxicity. PLoS One 8(3):e59219","journal-title":"PLoS One"},{"issue":"9931","key":"548_CR23","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1016\/S0140-6736(14)60659-0","volume":"383","author":"O Devuyst","year":"2014","unstructured":"Devuyst O, Knoers NV, Remuzzi G, Schaefer F (2014) Rare inherited kidney diseases: challenges, opportunities, and perspectives. Lancet 383(9931):1844\u20131859","journal-title":"Lancet"},{"issue":"6","key":"548_CR24","doi-asserted-by":"publisher","first-page":"1586\u20131598.e1512","DOI":"10.1016\/j.cell.2018.07.009","volume":"174","author":"KK Dijkstra","year":"2018","unstructured":"Dijkstra KK, Cattaneo CM, Weeber F, Chalabi M, van de Haar J, Fanchi LF, Slagter M, van der Velden DL, Kaing S, Kelderman S et al (2018) Generation of tumor-reactive T cells by co-culture of peripheral blood lymphocytes and tumor organoids. Cell 174(6):1586\u20131598.e1512","journal-title":"Cell"},{"key":"548_CR25","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1146\/annurev.cellbio.22.010305.104340","volume":"22","author":"GR Dressler","year":"2006","unstructured":"Dressler GR (2006) The cellular basis of kidney development. Annu Rev Cell Dev Biol 22:509\u2013529","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"3","key":"548_CR26","doi-asserted-by":"publisher","first-page":"521\u2013535.e523","DOI":"10.1016\/j.cell.2019.07.002","volume":"178","author":"M Dvela-Levitt","year":"2019","unstructured":"Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G et al (2019) Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell 178(3):521\u2013535.e523","journal-title":"Cell"},{"issue":"4","key":"548_CR27","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1089\/adt.2014.573","volume":"12","author":"R Edmondson","year":"2014","unstructured":"Edmondson R, Broglie JJ, Adcock AF, Yang L (2014) Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors. Assay Drug Dev Technol 12(4):207\u2013218","journal-title":"Assay Drug Dev Technol"},{"issue":"6","key":"548_CR28","first-page":"1375","volume":"16","author":"RL Ehrmann","year":"1956","unstructured":"Ehrmann RL, Gey GO (1956) The growth of cells on a transparent gel of reconstituted rat-tail collagen. J Natl Cancer Inst 16(6):1375\u20131403","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"548_CR29","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.coph.2012.08.005","volume":"13","author":"C Ergorul","year":"2013","unstructured":"Ergorul C, Levin LA (2013) Solving the lost in translation problem: improving the effectiveness of translational research. Curr Opin Pharmacol 13(1):108\u2013114","journal-title":"Curr Opin Pharmacol"},{"key":"548_CR30","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1146\/annurev-bioeng-071910-124629","volume":"13","author":"MB Esch","year":"2011","unstructured":"Esch MB, King TL, Shuler ML (2011) The role of body-on-a-chip devices in drug and toxicity studies. Annu Rev Biomed Eng 13:55\u201372","journal-title":"Annu Rev Biomed Eng"},{"issue":"5819","key":"548_CR31","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/292154a0","volume":"292","author":"MJ Evans","year":"1981","unstructured":"Evans MJ, Kaufman MH (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292(5819):154\u2013156","journal-title":"Nature"},{"issue":"12","key":"548_CR32","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1007\/s00204-019-02598-0","volume":"93","author":"J Faria","year":"2019","unstructured":"Faria J, Ahmed S, Gerritsen KGF, Mihaila SM, Masereeuw R (2019) Kidney-based in vitro models for drug-induced toxicity testing. Arch Toxicol 93(12):3397\u20133418","journal-title":"Arch Toxicol"},{"issue":"5","key":"548_CR33","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.ajhg.2018.03.014","volume":"102","author":"TA Forbes","year":"2018","unstructured":"Forbes TA, Howden SE, Lawlor K, Phipson B, Maksimovic J, Hale L, Wilson S, Quinlan C, Ho G, Holman K, Bennetts B, Crawford J, Trnka P, Oshlack A, Patel C, Mallett A, Simons C, Little MH (2018) Patient-iPSC-derived kidney organoids show functional validation of a ciliopathic renal phenotype and reveal underlying pathogenetic mechanisms. Am J Hum Genet 102(5):816\u2013831","journal-title":"Am J Hum Genet"},{"key":"548_CR34","doi-asserted-by":"publisher","first-page":"8715","DOI":"10.1038\/ncomms9715","volume":"6","author":"BS Freedman","year":"2015","unstructured":"Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV (2015) Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat Commun 6:8715","journal-title":"Nat Commun"},{"key":"548_CR35","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41536-020-0093-4","volume":"5","author":"T Geuens","year":"2020","unstructured":"Geuens T, van Blitterswijk CA, LaPointe VLS (2020) Overcoming kidney organoid challenges for regenerative medicine. NPJ Regen Med 5:8","journal-title":"NPJ Regen Med"},{"key":"548_CR36","doi-asserted-by":"publisher","unstructured":"GBD Chronic Kidney Disease Collaboration (2020) Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 395(10225):709\u2013733. https:\/\/doi.org\/10.1016\/S0140-6736(20)30045-3","DOI":"10.1016\/S0140-6736(20)30045-3"},{"issue":"21","key":"548_CR37","doi-asserted-by":"publisher","first-page":"8685","DOI":"10.1073\/pnas.0701361104","volume":"104","author":"KI Goh","year":"2007","unstructured":"Goh KI, Cusick ME, Valle D, Childs B, Vidal M, Barabasi AL (2007) The human disease network. Proc Natl Acad Sci U S A 104(21):8685\u20138690","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"548_CR38","doi-asserted-by":"publisher","first-page":"5167","DOI":"10.1038\/s41467-018-07594-z","volume":"9","author":"LJ Hale","year":"2018","unstructured":"Hale LJ, Howden SE, Phipson B, Lonsdale A, Er PX, Ghobrial I, Hosawi S, Wilson S, Lawlor KT, Khan S, Oshlack A, Quinlan C, Lennon R, Little MH (2018) 3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening. Nat Commun 9(1):5167","journal-title":"Nat Commun"},{"issue":"2","key":"548_CR39","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1124\/jpet.118.250142","volume":"367","author":"JM Haynes","year":"2018","unstructured":"Haynes JM, Selby JN, Vandekolk TH, Abad IPL, Ho JK, Lieuw WL, Leach K, Savige J, Saini S, Fisher CL, Ricardo SD (2018) Induced pluripotent stem cell-derived podocyte-like cells as models for assessing mechanisms underlying heritable disease phenotype: initial studies using two Alport syndrome patient lines indicate impaired potassium channel activity. J Pharmacol Exp Ther 367(2):335\u2013347","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"548_CR40","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/s41598-018-37485-8","volume":"9","author":"K Hiratsuka","year":"2019","unstructured":"Hiratsuka K, Monkawa T, Akiyama T, Nakatake Y, Oda M, Goparaju SK, Kimura H, Chikazawa-Nohtomi N, Sato S, Ishiguro K, Yamaguchi S, Suzuki S, Morizane R, Ko SBH, Itoh H, Ko MSH (2019) Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors. Sci Rep 9(1):913","journal-title":"Sci Rep"},{"issue":"3","key":"548_CR41","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41592-019-0325-y","volume":"16","author":"KA Homan","year":"2019","unstructured":"Homan KA, Gupta N, Kroll KT, Kolesky DB, Skylar-Scott M, Miyoshi T, Mau D, Valerius MT, Ferrante T, Bonventre JV, Lewis JA, Morizane R (2019) Flow-enhanced vascularization and maturation of kidney organoids in vitro. Nat Methods 16(3):255\u2013262","journal-title":"Nat Methods"},{"issue":"6","key":"548_CR42","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1242\/dev.150201","volume":"144","author":"M Huch","year":"2017","unstructured":"Huch M, Knoblich JA, Lutolf MP, Martinez-Arias A (2017) The hope and the hype of organoid research. Development 144(6):938\u2013941","journal-title":"Development"},{"issue":"5986","key":"548_CR43","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1126\/science.1188302","volume":"328","author":"D Huh","year":"2010","unstructured":"Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE (2010) Reconstituting organ-level lung functions on a chip. Science 328(5986):1662\u20131668","journal-title":"Science"},{"issue":"1","key":"548_CR44","doi-asserted-by":"publisher","first-page":"85","DOI":"10.2353\/ajpath.2010.090517","volume":"176","author":"BD Humphreys","year":"2010","unstructured":"Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, Valerius MT, McMahon AP, Duffield JS (2010) Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 176(1):85\u201397","journal-title":"Am J Pathol"},{"issue":"4","key":"548_CR45","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nrclinonc.2011.34","volume":"8","author":"L Hutchinson","year":"2011","unstructured":"Hutchinson L, Kirk R (2011) High drug attrition rates\u2014where are we going wrong? Nat Rev Clin Oncol 8(4):189\u2013190","journal-title":"Nat Rev Clin Oncol"},{"issue":"7102","key":"548_CR46","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/nature04838","volume":"442","author":"T Iimura","year":"2006","unstructured":"Iimura T, Pourquie O (2006) Collinear activation of Hoxb genes during gastrulation is linked to mesoderm cell ingression. Nature 442(7102):568\u2013571","journal-title":"Nature"},{"key":"548_CR47","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.biomaterials.2016.07.038","volume":"106","author":"W Jia","year":"2016","unstructured":"Jia W, Gungor-Ozkerim PS, Zhang YS, Yue K, Zhu K, Liu W, Pi Q, Byambaa B, Dokmeci MR, Shin SR, Khademhosseini A (2016) Direct 3D bioprinting of perfusable vascular constructs using a blend bioink. Biomaterials 106:58\u201368","journal-title":"Biomaterials"},{"issue":"12","key":"548_CR48","doi-asserted-by":"publisher","first-page":"3527","DOI":"10.1681\/ASN.2005050544","volume":"16","author":"D Kim","year":"2005","unstructured":"Kim D, Dressler GR (2005) Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia. J Am Soc Nephrol 16(12):3527\u20133534","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"548_CR49","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/s41580-020-0259-3","volume":"21","author":"J Kim","year":"2020","unstructured":"Kim J, Koo BK, Knoblich JA (2020) Human organoids: model systems for human biology and medicine. Nat Rev Mol Cell Biol 21(10):571\u2013584","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"548_CR50","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1177\/2211068214557812","volume":"20","author":"H Kimura","year":"2015","unstructured":"Kimura H, Ikeda T, Nakayama H, Sakai Y, Fujii T (2015) An on-chip small intestine-liver model for pharmacokinetic studies. Journal of laboratory automation 20(3):265\u2013273","journal-title":"Journal of laboratory automation"},{"issue":"1","key":"548_CR51","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.dmpk.2017.11.003","volume":"33","author":"H Kimura","year":"2018","unstructured":"Kimura H, Sakai Y, Fujii T (2018) Organ\/body-on-a-chip based on microfluidic technology for drug discovery. Drug Metab Pharmacokinet 33(1):43\u201348","journal-title":"Drug Metab Pharmacokinet"},{"issue":"11","key":"548_CR52","doi-asserted-by":"publisher","first-page":"4797","DOI":"10.1172\/JCI122313","volume":"129","author":"S Kishi","year":"2019","unstructured":"Kishi S, Brooks CR, Taguchi K, Ichimura T, Mori Y, Akinfolarin A, Gupta N, Galichon P, Elias BC, Suzuki T, Wang Q, Gewin L, Morizane R, Bonventre JV (2019) Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses. J Clin Invest 129(11):4797\u20134816","journal-title":"J Clin Invest"},{"issue":"4","key":"548_CR53","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.stemcr.2014.08.008","volume":"3","author":"A Kobayashi","year":"2014","unstructured":"Kobayashi A, Mugford JW, Krautzberger AM, Naiman N, Liao J, McMahon AP (2014) Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis. Stem Cell Reports 3(4):650\u2013662","journal-title":"Stem Cell Reports"},{"key":"548_CR54","doi-asserted-by":"crossref","unstructured":"Kobayashi A, Valerius MT, Mugford JW, Carroll TJ, Self M, Oliver G, McMahon AP (2008) Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 3(2):169\u2013181","DOI":"10.1016\/j.stem.2008.05.020"},{"issue":"2","key":"548_CR55","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bbrc.2005.08.136","volume":"336","author":"T Kobayashi","year":"2005","unstructured":"Kobayashi T, Tanaka H, Kuwana H, Inoshita S, Teraoka H, Sasaki S, Terada Y (2005) Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells. Biochem Biophys Res Commun 336(2):585\u2013595","journal-title":"Biochem Biophys Res Commun"},{"key":"548_CR56","doi-asserted-by":"crossref","unstructured":"Koning M, van den Berg CW, Rabelink TJ (2019) Stem cell-derived kidney organoids: engineering the vasculature. Cell Mol Life Sci","DOI":"10.1007\/s00018-019-03401-0"},{"key":"548_CR57","doi-asserted-by":"crossref","unstructured":"Kramann R, Machado F, Wu H, Kusaba T, Hoeft K, Schneider RK, Humphreys BD (2018) Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis. JCI Insight 3(9)","DOI":"10.1172\/jci.insight.99561"},{"issue":"10","key":"548_CR58","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/psp4.12134","volume":"5","author":"L Kuepfer","year":"2016","unstructured":"Kuepfer L, Niederalt C, Wendl T, Schlender JF, Willmann S, Lippert J, Block M, Eissing T, Teutonico D (2016) Applied concepts in PBPK modeling: how to build a PBPK\/PD model. CPT Pharmacometrics Syst Pharmacol 5(10):516\u2013531","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"548_CR59","doi-asserted-by":"crossref","unstructured":"Kumar SV, Er PX, Lawlor KT, Motazedian A, Scurr M, Ghobrial I, Combes AN, Zappia L, Oshlack A, Stanley EG et al (2019) Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells. Development 146(5)","DOI":"10.1242\/dev.172361"},{"key":"548_CR60","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1007\/s40620-020-00793-2","volume":"33","author":"JT Kurzhagen","year":"2020","unstructured":"Kurzhagen JT, Dellepiane S, Cantaluppi V, Rabb H (2020) AKI: an increasingly recognized risk factor for CKD development and progression. J Nephrol 33:1171\u20131187","journal-title":"J Nephrol"},{"issue":"6","key":"548_CR61","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1681\/ASN.2013080831","volume":"25","author":"AQ Lam","year":"2014","unstructured":"Lam AQ, Freedman BS, Morizane R, Lerou PH, Valerius MT, Bonventre JV (2014) Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol 25(6):1211\u20131225","journal-title":"J Am Soc Nephrol"},{"issue":"6194","key":"548_CR62","doi-asserted-by":"publisher","first-page":"1247125","DOI":"10.1126\/science.1247125","volume":"345","author":"MA Lancaster","year":"2014","unstructured":"Lancaster MA, Knoblich JA (2014) Organogenesis in a dish: modeling development and disease using organoid technologies. Science 345(6194):1247125","journal-title":"Science"},{"issue":"6","key":"548_CR63","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1681\/ASN.2017121283","volume":"29","author":"DR Lemos","year":"2018","unstructured":"Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, Miyoshi T, Susa K, Johnson BG, Soliman K, Wang G, Morizane R, Bonventre JV, Duffield JS (2018) Interleukin-1beta activates a MYC-dependent metabolic switch in kidney stromal cells necessary for progressive tubulointerstitial fibrosis. J Am Soc Nephrol 29(6):1690\u20131705","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"548_CR64","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1002\/path.4484","volume":"235","author":"M Li","year":"2015","unstructured":"Li M, Armelloni S, Zennaro C, Wei C, Corbelli A, Ikehata M, Berra S, Giardino L, Mattinzoli D, Watanabe S, Agostoni C, Edefonti A, Reiser J, Messa P, Rastaldi MP (2015) BDNF repairs podocyte damage by microRNA-mediated increase of actin polymerization. J Pathol 235(5):731\u2013744","journal-title":"J Pathol"},{"issue":"10","key":"548_CR65","first-page":"1008","volume":"23","author":"JH Lin","year":"1995","unstructured":"Lin JH (1995) Species similarities and differences in pharmacokinetics. Drug Metab Dispos 23(10):1008\u20131021","journal-title":"Drug Metab Dispos"},{"key":"548_CR66","doi-asserted-by":"crossref","unstructured":"Lin S, Lin Y, Nery JR, Urich MA, Breschi A, Davis CA, Dobin A, Zaleski C, Beer MA, Chapman WC, Gingeras TR, Ecker JR, Snyder MP (2014) Comparison of the transcriptional landscapes between human and mouse tissues. Proc Natl Acad Sci U S A 111(48):17224\u201317229","DOI":"10.1073\/pnas.1413624111"},{"issue":"10","key":"548_CR67","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1089\/scd.2010.0017","volume":"19","author":"SA Lin","year":"2010","unstructured":"Lin SA, Kolle G, Grimmond SM, Zhou Q, Doust E, Little MH, Aronow B, Ricardo SD, Pera MF, Bertram JF, Laslett AL (2010) Subfractionation of differentiating human embryonic stem cell populations allows the isolation of a mesodermal population enriched for intermediate mesoderm and putative renal progenitors. Stem Cells Dev 19(10):1637\u20131648","journal-title":"Stem Cells Dev"},{"issue":"3","key":"548_CR68","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1681\/ASN.2017080890","volume":"29","author":"NO Lindstrom","year":"2018","unstructured":"Lindstrom NO, Guo J, Kim AD, Tran T, Guo Q, De Sena BG, Ransick A, Parvez RK, Thornton ME, Baskin L et al (2018) Conserved and divergent features of mesenchymal progenitor cell types within the cortical nephrogenic niche of the human and mouse kidney. J Am Soc Nephrol 29(3):806\u2013824","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"548_CR69","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1681\/ASN.2017080887","volume":"29","author":"NO Lindstrom","year":"2018","unstructured":"Lindstrom NO, McMahon JA, Guo J, Tran T, Guo Q, Rutledge E, Parvez RK, Saribekyan G, Schuler RE, Liao C et al (2018) Conserved and divergent features of human and mouse kidney organogenesis. J Am Soc Nephrol 29(3):785\u2013805","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"548_CR70","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1681\/ASN.2017091036","volume":"29","author":"NO Lindstrom","year":"2018","unstructured":"Lindstrom NO, Tran T, Guo J, Rutledge E, Parvez RK, Thornton ME, Grubbs B, McMahon JA, McMahon AP (2018) Conserved and divergent molecular and anatomic features of human and mouse nephron patterning. J Am Soc Nephrol 29(3):825\u2013840","journal-title":"J Am Soc Nephrol"},{"issue":"19\u201320","key":"548_CR71","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1101\/gad.329573.119","volume":"33","author":"MH Little","year":"2019","unstructured":"Little MH, Combes AN (2019) Kidney organoids: accurate models or fortunate accidents. Genes Dev 33(19\u201320):1319\u20131345","journal-title":"Genes Dev"},{"key":"548_CR72","doi-asserted-by":"crossref","unstructured":"Little MH, McMahon AP (2012) Mammalian kidney development: principles, progress, and projections. Cold Spring Harb Perspect Biol 4(5)","DOI":"10.1101\/cshperspect.a008300"},{"issue":"2","key":"548_CR73","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/sj.ki.5000054","volume":"69","author":"Y Liu","year":"2006","unstructured":"Liu Y (2006) Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int 69(2):213\u2013217","journal-title":"Kidney Int"},{"issue":"3","key":"548_CR74","doi-asserted-by":"publisher","first-page":"373\u2013387.e379","DOI":"10.1016\/j.stem.2019.06.009","volume":"25","author":"JH Low","year":"2019","unstructured":"Low JH, Li P, Chew EGY, Zhou B, Suzuki K, Zhang T, Lian MM, Liu M, Aizawa E, Rodriguez Esteban C et al (2019) Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network. Cell Stem Cell 25(3):373\u2013387.e379","journal-title":"Cell Stem Cell"},{"issue":"3","key":"548_CR75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059689","volume":"8","author":"AC Luca","year":"2013","unstructured":"Luca AC, Mersch S, Deenen R, Schmidt S, Messner I, Sch\u00e4fer KL, Baldus SE, Huckenbeck W, Piekorz RP, Knoefel WT, Krieg A, Stoecklein NH (2013) Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines. PLoS One 8(3):e59689","journal-title":"PLoS One"},{"issue":"4","key":"548_CR76","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.bbrc.2010.02.111","volume":"393","author":"S Mae","year":"2010","unstructured":"Mae S, Shirasawa S, Yoshie S, Sato F, Kanoh Y, Ichikawa H, Yokoyama T, Yue F, Tomotsune D, Sasaki K (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem Biophys Res Commun 393(4):877\u2013882","journal-title":"Biochem Biophys Res Commun"},{"key":"548_CR77","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/ncomms2378","volume":"4","author":"SI Mae","year":"2013","unstructured":"Mae SI, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda-Nishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K, Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP, Yamanaka S, Osafune K (2013) Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun 4:1367","journal-title":"Nat Commun"},{"issue":"6","key":"548_CR78","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1242\/dev.140731","volume":"144","author":"HA McCauley","year":"2017","unstructured":"McCauley HA, Wells JM (2017) Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish. Development 144(6):958\u2013962","journal-title":"Development"},{"issue":"4","key":"548_CR79","first-page":"3","volume":"10","author":"WW McCrory","year":"1974","unstructured":"McCrory WW (1974) The normal embryologic development of the kidney: a basis for understanding structural abnormalities. Birth Defects Orig Artic Ser 10(4):3\u201311","journal-title":"Birth Defects Orig Artic Ser"},{"issue":"8","key":"548_CR80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006709","volume":"4","author":"S Metsuyanim","year":"2009","unstructured":"Metsuyanim S, Harari-Steinberg O, Buzhor E, Omer D, Pode-Shakked N, Ben-Hur H, Halperin R, Schneider D, Dekel B (2009) Expression of stem cell markers in the human fetal kidney. PLoS One 4(8):e6709","journal-title":"PLoS One"},{"issue":"1","key":"548_CR81","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0014-4827(75)90532-7","volume":"94","author":"G Michalopoulos","year":"1975","unstructured":"Michalopoulos G, Pitot HC (1975) Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations. Exp Cell Res 94(1):70\u201378","journal-title":"Exp Cell Res"},{"issue":"1","key":"548_CR82","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/dvdy.22","volume":"249","author":"T Miyoshi","year":"2020","unstructured":"Miyoshi T, Hiratsuka K, Saiz EG, Morizane R (2020) Kidney organoids in translational medicine: disease modeling and regenerative medicine. Dev Dyn 249(1):34\u201345","journal-title":"Dev Dyn"},{"issue":"3","key":"548_CR83","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.molmed.2017.01.001","volume":"23","author":"R Morizane","year":"2017","unstructured":"Morizane R, Bonventre JV (2017) Kidney organoids: a translational journey. Trends Mol Med 23(3):246\u2013263","journal-title":"Trends Mol Med"},{"issue":"11","key":"548_CR84","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1038\/nbt.3392","volume":"33","author":"R Morizane","year":"2015","unstructured":"Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT, Bonventre JV (2015) Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat Biotechnol 33(11):1193\u20131200","journal-title":"Nat Biotechnol"},{"issue":"6","key":"548_CR85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064843","volume":"8","author":"R Morizane","year":"2014","unstructured":"Morizane R, Monkawa T, Fujii S, Yamaguchi S, Homma K, Matsuzaki Y, Okano H, Itoh H (2014) Kidney specific protein-positive cells derived from embryonic stem cells reproduce tubular structures in vitro and differentiate into renal tubular cells. PLoS One 8(6):e64843","journal-title":"PLoS One"},{"issue":"4","key":"548_CR86","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1016\/j.bbrc.2009.10.148","volume":"390","author":"R Morizane","year":"2009","unstructured":"Morizane R, Monkawa T, Itoh H (2009) Differentiation of murine embryonic stem and induced pluripotent stem cells to renal lineage in vitro. Biochem Biophys Res Commun 390(4):1334\u20131339","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"548_CR87","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.ydbio.2008.03.044","volume":"319","author":"JW Mugford","year":"2008","unstructured":"Mugford JW, Sipila P, Kobayashi A, Behringer RR, McMahon AP (2008) Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev Biol 319(2):396\u2013405","journal-title":"Dev Biol"},{"issue":"4","key":"548_CR88","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/ki.2012.442","volume":"83","author":"K Narayanan","year":"2013","unstructured":"Narayanan K, Schumacher KM, Tasnim F, Kandasamy K, Schumacher A, Ni M, Gao S, Gopalan B, Zink D, Ying JY (2013) Human embryonic stem cells differentiate into functional renal proximal tubular-like cells. Kidney Int 83(4):593\u2013603","journal-title":"Kidney Int"},{"issue":"6032","key":"548_CR89","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1126\/science.1205407","volume":"332","author":"M Narita","year":"2011","unstructured":"Narita M, Young AR, Arakawa S, Samarajiwa SA, Nakashima T, Yoshida S, Hong S, Berry LS, Reichelt S, Ferreira M et al (2011) Spatial coupling of mTOR and autophagy augments secretory phenotypes. Science 332(6032):966\u2013970","journal-title":"Science"},{"issue":"7","key":"548_CR90","doi-asserted-by":"publisher","first-page":"1972\u20131988.e1916","DOI":"10.1016\/j.cell.2018.11.021","volume":"175","author":"JT Neal","year":"2018","unstructured":"Neal JT, Li X, Zhu J, Giangarra V, Grzeskowiak CL, Ju J, Liu IH, Chiou SH, Salahudeen AA, Smith AR et al (2018) Organoid modeling of the tumor immune microenvironment. Cell 175(7):1972\u20131988.e1916","journal-title":"Cell"},{"issue":"2","key":"548_CR91","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.bbrc.2011.12.071","volume":"417","author":"M Nishikawa","year":"2012","unstructured":"Nishikawa M, Yanagawa N, Kojima N, Yuri S, Hauser PV, Jo OD, Yanagawa N (2012) Stepwise renal lineage differentiation of mouse embryonic stem cells tracing in vivo development. Biochem Biophys Res Commun 417(2):897\u2013902","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"548_CR92","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/s41581-019-0176-x","volume":"15","author":"R Nishinakamura","year":"2019","unstructured":"Nishinakamura R (2019) Human kidney organoids: progress and remaining challenges. Nat Rev Nephrol 15(10):613\u2013624","journal-title":"Nat Rev Nephrol"},{"issue":"6","key":"548_CR93","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/ng2047","volume":"39","author":"DT Odom","year":"2007","unstructured":"Odom DT, Dowell RD, Jacobsen ES, Gordon W, Danford TW, MacIsaac KD, Rolfe PA, Conboy CM, Gifford DK, Fraenkel E (2007) Tissue-specific transcriptional regulation has diverged significantly between human and mouse. Nat Genet 39(6):730\u2013732","journal-title":"Nat Genet"},{"issue":"9981","key":"548_CR94","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1016\/S0140-6736(15)60907-2","volume":"385","author":"AC Ong","year":"2015","unstructured":"Ong AC, Devuyst O, Knebelmann B, Walz G (2015) Autosomal dominant polycystic kidney disease: the changing face of clinical management. Lancet 385(9981):1993\u20132002","journal-title":"Lancet"},{"issue":"1","key":"548_CR95","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1084\/jem.145.1.204","volume":"145","author":"RW Orkin","year":"1977","unstructured":"Orkin RW, Gehron P, McGoodwin EB, Martin GR, Valentine T, Swarm R (1977) A murine tumor producing a matrix of basement membrane. J Exp Med 145(1):204\u2013220","journal-title":"J Exp Med"},{"issue":"1","key":"548_CR96","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1242\/dev.02174","volume":"133","author":"K Osafune","year":"2006","unstructured":"Osafune K, Takasato M, Kispert A, Asashima M, Nishinakamura R (2006) Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development 133(1):151\u2013161","journal-title":"Development"},{"issue":"1","key":"548_CR97","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41592-018-0253-2","volume":"16","author":"B Phipson","year":"2019","unstructured":"Phipson B, Er PX, Combes AN, Forbes TA, Howden SE, Zappia L, Yen HJ, Lawlor KT, Hale LJ, Sun J, Wolvetang E, Takasato M, Oshlack A, Little MH (2019) Evaluation of variability in human kidney organoids. Nat Methods 16(1):79\u201387","journal-title":"Nat Methods"},{"issue":"2","key":"548_CR98","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.stemcr.2018.06.018","volume":"11","author":"A Przepiorski","year":"2018","unstructured":"Przepiorski A, Sander V, Tran T, Hollywood JA, Sorrenson B, Shih JH, Wolvetang EJ, McMahon AP, Holm TM, Davidson AJ (2018) A simple bioreactor-based method to generate kidney organoids from pluripotent stem cells. Stem Cell Reports 11(2):470\u2013484","journal-title":"Stem Cell Reports"},{"issue":"9","key":"548_CR99","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.2337\/diabetes.54.9.2628","volume":"54","author":"Z Qi","year":"2005","unstructured":"Qi Z, Fujita H, Jin J, Davis LS, Wang Y, Fogo AB, Breyer MD (2005) Characterization of susceptibility of inbred mouse strains to diabetic nephropathy. Diabetes 54(9):2628\u20132637","journal-title":"Diabetes"},{"key":"548_CR100","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.biomaterials.2017.11.010","volume":"155","author":"Y Qu","year":"2018","unstructured":"Qu Y, An F, Luo Y, Lu Y, Liu T, Zhao W, Lin B (2018) A nephron model for study of drug-induced acute kidney injury and assessment of drug-induced nephrotoxicity. Biomaterials 155:41\u201353","journal-title":"Biomaterials"},{"issue":"6212","key":"548_CR101","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1126\/science.1259595","volume":"346","author":"AL Rasmussen","year":"2014","unstructured":"Rasmussen AL, Okumura A, Ferris MT, Green R, Feldmann F, Kelly SM, Scott DP, Safronetz D, Haddock E, LaCasse R, Thomas MJ, Sova P, Carter VS, Weiss JM, Miller DR, Shaw GD, Korth MJ, Heise MT, Baric RS, de Villena FPM, Feldmann H, Katze MG (2014) Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance. Science 346(6212):987\u2013991","journal-title":"Science"},{"issue":"11","key":"548_CR102","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/s41576-018-0051-9","volume":"19","author":"G Rossi","year":"2018","unstructured":"Rossi G, Manfrin A, Lutolf MP (2018) Progress and potential in organoid research. Nat Rev Genet 19(11):671\u2013687","journal-title":"Nat Rev Genet"},{"issue":"1","key":"548_CR103","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/clpt.2012.65","volume":"92","author":"A Rostami-Hodjegan","year":"2012","unstructured":"Rostami-Hodjegan A (2012) Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology. Clin Pharmacol Ther 92(1):50\u201361","journal-title":"Clin Pharmacol Ther"},{"issue":"7244","key":"548_CR104","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/nature07935","volume":"459","author":"T Sato","year":"2009","unstructured":"Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H (2009) Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459(7244):262\u2013265","journal-title":"Nature"},{"issue":"10","key":"548_CR105","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/nrg2205","volume":"8","author":"A Schedl","year":"2007","unstructured":"Schedl A (2007) Renal abnormalities and their developmental origin. Nat Rev Genet 8(10):791\u2013802","journal-title":"Nat Rev Genet"},{"issue":"5981","key":"548_CR106","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1126\/science.1186176","volume":"328","author":"D Schmidt","year":"2010","unstructured":"Schmidt D, Wilson MD, Ballester B, Schwalie PC, Brown GD, Marshall A, Kutter C, Watt S, Martinez-Jimenez CP, Mackay S, Talianidis I, Flicek P, Odom DT (2010) Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding. Science 328(5981):1036\u20131040","journal-title":"Science"},{"issue":"2","key":"548_CR107","doi-asserted-by":"publisher","first-page":"223","DOI":"10.14573\/altex.1710181","volume":"35","author":"PF Secker","year":"2018","unstructured":"Secker PF, Luks L, Schlichenmaier N, Dietrich DR (2018) RPTEC\/TERT1 cells form highly differentiated tubules when cultured in a 3D matrix. Altex 35(2):223\u2013234","journal-title":"Altex"},{"issue":"6","key":"548_CR108","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1681\/ASN.2015010096","volume":"27","author":"S Sharmin","year":"2016","unstructured":"Sharmin S, Taguchi A, Kaku Y, Yoshimura Y, Ohmori T, Sakuma T, Mukoyama M, Yamamoto T, Kurihara H, Nishinakamura R (2016) Human induced pluripotent stem cell-derived podocytes mature into vascularized glomeruli upon experimental transplantation. J Am Soc Nephrol 27(6):1778\u20131791","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"548_CR109","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nmeth.2857","volume":"11","author":"B Shen","year":"2014","unstructured":"Shen B, Zhang W, Zhang J, Zhou J, Wang J, Chen L, Wang L, Hodgkins A, Iyer V, Huang X, Skarnes WC (2014) Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nat Methods 11(4):399\u2013402","journal-title":"Nat Methods"},{"issue":"3","key":"548_CR110","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1002\/stem.3131","volume":"38","author":"MF Sobral-Reyes","year":"2020","unstructured":"Sobral-Reyes MF, Lemos DR (2020) Recapitulating human tissue damage, repair, and fibrosis with human pluripotent stem cell-derived organoids. Stem Cells 38(3):318\u2013329","journal-title":"Stem Cells"},{"issue":"9","key":"548_CR111","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046453","volume":"7","author":"B Song","year":"2012","unstructured":"Song B, Smink AM, Jones CV, Callaghan JM, Firth SD, Bernard CA, Laslett AL, Kerr PG, Ricardo SD (2012) The directed differentiation of human iPS cells into kidney podocytes. PLoS One 7(9):e46453","journal-title":"PLoS One"},{"issue":"1","key":"548_CR112","doi-asserted-by":"publisher","first-page":"5462","DOI":"10.1038\/s41467-019-13382-0","volume":"10","author":"A Subramanian","year":"2019","unstructured":"Subramanian A, Sidhom EH, Emani M, Vernon K, Sahakian N, Zhou Y, Kost-Alimova M, Slyper M, Waldman J, Dionne D, Nguyen LT, Weins A, Marshall JL, Rosenblatt-Rosen O, Regev A, Greka A (2019) Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation. Nat Commun 10(1):5462","journal-title":"Nat Commun"},{"issue":"7","key":"548_CR113","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1039\/c3lc41017j","volume":"13","author":"JH Sung","year":"2013","unstructured":"Sung JH, Esch MB, Prot JM, Long CJ, Smith A, Hickman JJ, Shuler ML (2013) Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab Chip 13(7):1201\u20131212","journal-title":"Lab Chip"},{"issue":"1","key":"548_CR114","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.stem.2013.11.010","volume":"14","author":"A Taguchi","year":"2014","unstructured":"Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, Nishinakamura R (2014) Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14(1):53\u201367","journal-title":"Cell Stem Cell"},{"issue":"6","key":"548_CR115","doi-asserted-by":"publisher","first-page":"730\u2013746.e736","DOI":"10.1016\/j.stem.2017.10.011","volume":"21","author":"A Taguchi","year":"2017","unstructured":"Taguchi A, Nishinakamura R (2017) Higher-order kidney organogenesis from pluripotent stem cells. Cell Stem Cell 21(6):730\u2013746.e736","journal-title":"Cell Stem Cell"},{"issue":"5","key":"548_CR116","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","volume":"131","author":"K Takahashi","year":"2007","unstructured":"Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5):861\u2013872","journal-title":"Cell"},{"issue":"4","key":"548_CR117","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663\u2013676","journal-title":"Cell"},{"issue":"1","key":"548_CR118","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/ncb2894","volume":"16","author":"M Takasato","year":"2014","unstructured":"Takasato M, Er PX, Becroft M, Vanslambrouck JM, Stanley EG, Elefanty AG, Little MH (2014) Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney. Nat Cell Biol 16(1):118\u2013126","journal-title":"Nat Cell Biol"},{"issue":"7574","key":"548_CR119","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nature15695","volume":"526","author":"M Takasato","year":"2015","unstructured":"Takasato M, Er PX, Chiu HS, Maier B, Baillie GJ, Ferguson C, Parton RG, Wolvetang EJ, Roost MS, Chuva de Sousa Lopes SM et al (2015) Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 526(7574):564\u2013568","journal-title":"Nature"},{"issue":"7459","key":"548_CR120","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature12271","volume":"499","author":"T Takebe","year":"2013","unstructured":"Takebe T, Sekine K, Enomura M, Koike H, Kimura M, Ogaeri T, Zhang RR, Ueno Y, Zheng YW, Koike N, Aoyama S, Adachi Y, Taniguchi H (2013) Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 499(7459):481\u2013484","journal-title":"Nature"},{"issue":"6444","key":"548_CR121","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1126\/science.aaw7567","volume":"364","author":"T Takebe","year":"2019","unstructured":"Takebe T, Wells JM (2019) Organoids by design. Science 364(6444):956\u2013959","journal-title":"Science"},{"issue":"3","key":"548_CR122","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.stem.2017.08.016","volume":"21","author":"T Takebe","year":"2017","unstructured":"Takebe T, Zhang B, Radisic M (2017) Synergistic engineering: organoids meet organs-on-a-chip. Cell Stem Cell 21(3):297\u2013300","journal-title":"Cell Stem Cell"},{"issue":"3","key":"548_CR123","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.stemcr.2018.08.003","volume":"11","author":"S Tanigawa","year":"2018","unstructured":"Tanigawa S, Islam M, Sharmin S, Naganuma H, Yoshimura Y, Haque F, Era T, Nakazato H, Nakanishi K, Sakuma T, Yamamoto T, Kurihara H, Taguchi A, Nishinakamura R (2018) Organoids from nephrotic disease-derived iPSCs identify impaired NEPHRIN localization and slit diaphragm formation in kidney podocytes. Stem Cell Reports 11(3):727\u2013740","journal-title":"Stem Cell Reports"},{"issue":"5391","key":"548_CR124","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","volume":"282","author":"JA Thomson","year":"1998","unstructured":"Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM (1998) Embryonic stem cell lines derived from human blastocysts. Science 282(5391):1145\u20131147","journal-title":"Science"},{"issue":"3","key":"548_CR125","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/MNH.0000000000000498","volume":"28","author":"P Tian","year":"2019","unstructured":"Tian P, Lennon R (2019) The myriad possibility of kidney organoids. Curr Opin Nephrol Hypertens 28(3):211\u2013218","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"25","key":"548_CR126","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1056\/NEJMoa1205511","volume":"367","author":"VE Torres","year":"2012","unstructured":"Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Grantham JJ, Higashihara E, Perrone RD, Krasa HB, Ouyang J, Czerwiec FS (2012) Tolvaptan in patients with autosomal dominant polycystic kidney disease. N Engl J Med 367(25):2407\u20132418","journal-title":"N Engl J Med"},{"issue":"1","key":"548_CR127","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1006\/dbio.2000.9733","volume":"223","author":"TE Tsang","year":"2000","unstructured":"Tsang TE, Shawlot W, Kinder SJ, Kobayashi A, Kwan KM, Schughart K, Kania A, Jessell TM, Behringer RR, Tam PP (2000) Lim1 activity is required for intermediate mesoderm differentiation in the mouse embryo. Dev Biol 223(1):77\u201390","journal-title":"Dev Biol"},{"key":"548_CR128","first-page":"2020","volume-title":"Annual data report","author":"USRDS","year":"2020","unstructured":"USRDS (2020) Annual data report, p 2020"},{"key":"548_CR129","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1146\/annurev.pharmtox.48.113006.094615","volume":"48","author":"VS Vaidya","year":"2008","unstructured":"Vaidya VS, Ferguson MA, Bonventre JV (2008) Biomarkers of acute kidney injury. Annu Rev Pharmacol Toxicol 48:463\u2013493","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"3","key":"548_CR130","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.stemcr.2018.01.041","volume":"10","author":"CW van den Berg","year":"2018","unstructured":"van den Berg CW, Ritsma L, Avramut MC, Wiersma LE, van den Berg BM, Leuning DG, Lievers E, Koning M, Vanslambrouck JM, Koster AJ, Howden SE, Takasato M, Little MH, Rabelink TJ (2018) Renal subcapsular transplantation of PSC-derived kidney organoids induces neo-vasculogenesis and significant glomerular and tubular maturation in vivo. Stem Cell Reports 10(3):751\u2013765","journal-title":"Stem Cell Reports"},{"issue":"6","key":"548_CR131","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1681\/ASN.2006101078","volume":"18","author":"C Vigneau","year":"2007","unstructured":"Vigneau C, Polgar K, Striker G, Elliott J, Hyink D, Weber O, Fehling HJ, Keller G, Burrow C, Wilson P (2007) Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo. J Am Soc Nephrol 18(6):1709\u20131720","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"548_CR132","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1039\/C7LC00134G","volume":"17","author":"L Wang","year":"2017","unstructured":"Wang L, Tao T, Su W, Yu H, Yu Y, Qin J (2017) A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice. Lab Chip 17(10):1749\u20131760","journal-title":"Lab Chip"},{"issue":"1","key":"548_CR133","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1681\/ASN.2007060688","volume":"19","author":"X Wang","year":"2008","unstructured":"Wang X, Wu Y, Ward CJ, Harris PC, Torres VE (2008) Vasopressin directly regulates cyst growth in polycystic kidney disease. J Am Soc Nephrol 19(1):102\u2013108","journal-title":"J Am Soc Nephrol"},{"issue":"11","key":"548_CR134","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1038\/nm.3737","volume":"20","author":"CL Watson","year":"2014","unstructured":"Watson CL, Mahe MM, Munera J, Howell JC, Sundaram N, Poling HM, Schweitzer JI, Vallance JE, Mayhew CN, Sun Y et al (2014) An in vivo model of human small intestine using pluripotent stem cells. Nat Med 20(11):1310\u20131314","journal-title":"Nat Med"},{"issue":"3","key":"548_CR135","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.kint.2016.06.011","volume":"90","author":"EJ Weber","year":"2016","unstructured":"Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ (2016) Development of a microphysiological model of human kidney proximal tubule function. Kidney Int 90(3):627\u2013637","journal-title":"Kidney Int"},{"issue":"1","key":"548_CR136","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nm.4233","volume":"23","author":"MJ Workman","year":"2017","unstructured":"Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM (2017) Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Nat Med 23(1):49\u201359","journal-title":"Nat Med"},{"key":"548_CR137","doi-asserted-by":"publisher","first-page":"550","DOI":"10.2215\/CJN.07470619","volume":"15","author":"H Wu","year":"2020","unstructured":"Wu H, Humphreys BD (2020) Single cell sequencing and kidney organoids generated from pluripotent stem cells. Clin J Am Soc Nephrol 15:550\u2013556","journal-title":"Clin J Am Soc Nephrol"},{"issue":"6","key":"548_CR138","doi-asserted-by":"publisher","first-page":"869\u2013881.e868","DOI":"10.1016\/j.stem.2018.10.010","volume":"23","author":"H Wu","year":"2018","unstructured":"Wu H, Uchimura K, Donnelly EL, Kirita Y, Morris SA, Humphreys BD (2018) Comparative analysis and refinement of human PSC-derived kidney organoid differentiation with single-cell transcriptomics. Cell Stem Cell 23(6):869\u2013881.e868","journal-title":"Cell Stem Cell"},{"issue":"11","key":"548_CR139","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1038\/nprot.2014.182","volume":"9","author":"Y Xia","year":"2014","unstructured":"Xia Y, Sancho-Martinez I, Nivet E, Rodriguez Esteban C, Campistol JM, Izpisua Belmonte JC (2014) The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells. Nat Protoc 9(11):2693\u20132704","journal-title":"Nat Protoc"},{"issue":"1","key":"548_CR140","doi-asserted-by":"publisher","first-page":"F52","DOI":"10.1152\/ajprenal.00001.2004","volume":"290","author":"M Yamamoto","year":"2006","unstructured":"Yamamoto M, Cui L, Johkura K, Asanuma K, Okouchi Y, Ogiwara N, Sasaki K (2006) Branching ducts similar to mesonephric ducts or ureteric buds in teratomas originating from mouse embryonic stem cells. Am J Physiol Renal Physiol 290(1):F52\u2013F60","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"548_CR141","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nm.2144","volume":"16","author":"L Yang","year":"2010","unstructured":"Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV (2010) Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury. Nat Med 16(5):535\u2013543 531p following 143","journal-title":"Nat Med"},{"issue":"5858","key":"548_CR142","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1126\/science.1151526","volume":"318","author":"J Yu","year":"2007","unstructured":"Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318(5858):1917\u20131920","journal-title":"Science"},{"issue":"2","key":"548_CR143","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/clpt.2010.298","volume":"89","author":"P Zhao","year":"2011","unstructured":"Zhao P, Zhang L, Grillo JA, Liu Q, Bullock JM, Moon YJ, Song P, Brar SS, Madabushi R, Wu TC, Booth BP, Rahman NA, Reynolds KS, Gil Berglund E, Lesko LJ, Huang SM (2011) Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review. Clin Pharmacol Ther 89(2):259\u2013267","journal-title":"Clin Pharmacol Ther"},{"key":"548_CR144","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.biomaterials.2017.01.042","volume":"124","author":"W Zhu","year":"2017","unstructured":"Zhu W, Qu X, Zhu J, Ma X, Patel S, Liu J, Wang P, Lai CS, Gou M, Xu Y et al (2017) Direct 3D bioprinting of prevascularized tissue constructs with complex microarchitecture. Biomaterials 124:106\u2013115","journal-title":"Biomaterials"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-021-00548-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11626-021-00548-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-021-00548-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T19:27:55Z","timestamp":1615404475000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11626-021-00548-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":144,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["548"],"URL":"https:\/\/doi.org\/10.1007\/s11626-021-00548-8","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"19 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}