{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:47:04Z","timestamp":1789447624764,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technology Project of the Changzhou Health Committee of Jiangsu Province","award":["ZD201761"],"award-info":[{"award-number":["ZD201761"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81273267"],"award-info":[{"award-number":["81273267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aberrant expression of B cell\u2013activating factor belonging to TNF superfamily\u00a0(BAFF) and its receptors results in abnormal biological activities in hematopoietic and non-hematopoietic cells and is closely associated with the occurrence and development of various diseases. However, the biological significance and potential mechanisms underlying BAFF signaling in renal tubular epithelial cells (RTECs) remain unknown. This study aimed to investigate the biological role of BAFF signaling in RTECs. Mice primary RTECs were applied. The proliferation status and apoptotic rates were examined by MTS assay and flow cytometry, respectively. The expression of BAFF and its receptors was analyzed via flow cytometry and sodium ion transport function, and cytokeratin-18 expression was detected through immunofluorescence staining. In addition, Pin1 was knocked down via siRNA and its expression was assessed through reverse transcription PCR. Lastly, western blotting was performed to analyze E-cadherin, \u0251-SMA, and Pin1 expression. Results suggested that BAFF-R was significantly upregulated upon IFN-\u03b3 stimulation, and enhancement of BAFF signaling promoted cell survival and reduced their apoptotic rate, while simultaneously reducing the epithelial phenotype and promoting the interstitial transformation of cells. Furthermore, Pin1 was significantly increased, along with the upregulation of BAFF signaling in the RTECs, and participated in interstitial transformation induced by BAFF signaling. Collectively, the present results elucidate the potential mechanism of loss of normal function of RTECs under long-term high dose of BAFF stimulation provides a potential therapeutic target for renal interstitial fibrosis, and underlining mechanisms of shortening of long-term outcomes of kidney allografts via augmenting of BAFF signaling.<\/jats:p>","DOI":"10.1007\/s11626-021-00598-y","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T17:02:32Z","timestamp":1623690152000},"page":"649-659","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["BAFF signaling drives interstitial transformation of mouse renal tubular epithelial cells in a Pin1-dependent manner"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1339-4638","authenticated-orcid":false,"given":"Haiyan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renfang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhou","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"issue":"10","key":"598_CR1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/nrneph.2015.133","volume":"11","author":"SJ Allison","year":"2015","unstructured":"Allison SJ (2015) Fibrosis: targeting EMT to reverse renal fibrosis. Nat Rev Nephrol 11(10):565. https:\/\/doi.org\/10.1038\/nrneph.2015.133","journal-title":"Nat Rev Nephrol"},{"key":"598_CR2","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cyto.2018.01.014","volume":"110","author":"W Alturaiki","year":"2018","unstructured":"Alturaiki W, McFarlane AJ, Rose K, Corkhill R, McNamara PS, Schwarze J, Flanagan BF (2018) Expression of the B cell differentiation factor BAFF and chemokine CXCL13 in a murine model of respiratory syncytial virus infection. Cytokine 110:267\u2013271. https:\/\/doi.org\/10.1016\/j.cyto.2018.01.014","journal-title":"Cytokine"},{"issue":"4","key":"598_CR3","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1111\/ajt.13180","volume":"15","author":"P Boor","year":"2015","unstructured":"Boor P, Floege J (2015) Renal allograft fibrosis: biology and therapeutic targets. Am J Transplant 15(4):863\u2013886. https:\/\/doi.org\/10.1111\/ajt.13180","journal-title":"Am J Transplant"},{"issue":"9","key":"598_CR4","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/s41419-018-0844-y","volume":"9","author":"Y Chen","year":"2018","unstructured":"Chen Y, Wu YR, Yang HY, Li XZ, Jie MM, Hu CJ, Wu YY, Yang SM, Yang YB (2018) Prolyl isomerase Pin1: a promoter of cancer and a target for therapy. Cell Death Dis 9(9):883. https:\/\/doi.org\/10.1038\/s41419-018-0844-y","journal-title":"Cell Death Dis"},{"key":"598_CR5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/J.trim.2017.12.004","volume":"47","author":"J Friebus-Kardash","year":"2018","unstructured":"Friebus-Kardash J, Wilde B, Keles D, Heinold A, Kribben A, Witzke O, Heinemann FM, Eisenberger U (2018) Pretransplant serum BAFF levels are associated with pretransplant HLA immunization and renal allograft survival. Transpl Immunol 47:10\u201317. https:\/\/doi.org\/10.1016\/J.trim.2017.12.004","journal-title":"Transpl Immunol"},{"issue":"9","key":"598_CR6","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/nm.3901","volume":"21","author":"MT Grande","year":"2015","unstructured":"Grande MT, S\u00e1nchez-Laorden B, L\u00f3pez-Blau C, De Frutos CA, Boutet A, Ar\u00e9valo M, Rowe RG, Weiss SJ, L\u00f3pez-Novoa JM, Nieto MA (2015) Snail 1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. Nat Med 21(9):989\u2013997. https:\/\/doi.org\/10.1038\/nm.3901","journal-title":"Nat Med"},{"issue":"12","key":"598_CR7","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.3390\/cells8121545","volume":"8","author":"MK Inoue","year":"2019","unstructured":"Inoue MK, Nakatsu Y, Yamamotoya T, Hasei S, Kanamoto M, Naitou M, Matsunaga Y, Sakoda H, Fujishiro M, Ono H, Kushiyama A, Asano T (2019) Pin1 plays essential roles in NASH development by modulating multiple target proteins. Cells 8(12):1545. https:\/\/doi.org\/10.3390\/cells8121545","journal-title":"Cells"},{"issue":"4","key":"598_CR8","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1002\/eji.200738013","volume":"38","author":"M Ittah","year":"2008","unstructured":"Ittah M, Miceli-Richard C, Gottenberg JE, Sellam J, Eid P, Lebon P, Pallier C, Lepajolec C, Mariette X (2008) Viruses induce high expression of BAFF by salivary gland epithelial cells through TLR- and type-1 IFN-dependent and independent pathways. Eur J Immunol 38(4):1058\u20131064. https:\/\/doi.org\/10.1002\/eji.200738013","journal-title":"Eur J Immunol"},{"issue":"5","key":"598_CR9","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1002\/eji.200839086","volume":"39","author":"M Ittah","year":"2009","unstructured":"Ittah M, Miceli-Richard C, Gottenberg JE, Sellam J, Lepajolec C, Mariette X (2009) B-cell-activating factor expressions in salivary epithelial cells after dsRNA virus infection depends on RNA-activated protein kinase activation. Eur J Immunol 39(5):1271\u20131279. https:\/\/doi.org\/10.1002\/eji.200839086","journal-title":"Eur J Immunol"},{"issue":"1","key":"598_CR10","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/imr.12810","volume":"292","author":"SW Jackson","year":"2019","unstructured":"Jackson SW, Davidson A (2019) BAFF inhibition in SLE-is tolerance restored? Immunol Rev 292(1):102\u2013119. https:\/\/doi.org\/10.1111\/imr.12810","journal-title":"Immunol Rev"},{"issue":"10","key":"598_CR11","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1111\/j.1349-7006.2009.01260.x","volume":"100","author":"MR Kim","year":"2009","unstructured":"Kim MR, Choi HK, Cho KB, Kim HS, Kang KW (2009) Involvement of Pin1 induction in epithelial-mesenchymal transition of tamoxifen-resistant breast cancer cells. Cancer Sci 100(10):1834\u20131841. https:\/\/doi.org\/10.1111\/j.1349-7006.2009.01260.x","journal-title":"Cancer Sci"},{"issue":"1","key":"598_CR12","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12865-017-0236-6","volume":"18","author":"L K\u00fchne","year":"2017","unstructured":"K\u00fchne L, Jung B, Poth H, Schuster A, Wurm S, Ruemmele P, Banas B, Bergler T (2017) Renal allograft rejection, lymphocyte infiltration, and de novo donor-specific antibodies in a novel model of non-adherence to immunosuppressive therapy. BMC Immunol 18(1):52. https:\/\/doi.org\/10.1186\/s12865-017-0236-6","journal-title":"BMC Immunol"},{"key":"598_CR13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jaut.2014.02.004","volume":"51","author":"A Lahiri","year":"2014","unstructured":"Lahiri A, Varin MM, le Pottier L, Pochard P, Bendaoud B, Youinou P, Pers JO (2014) Specific forms of BAFF favor BAFF receptor-mediated epithelial cell survival. J Autoimmun 51:30\u201337. https:\/\/doi.org\/10.1016\/j.jaut.2014.02.004","journal-title":"J Autoimmun"},{"issue":"26","key":"598_CR14","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1056\/NEJMc1813976","volume":"379","author":"C Lefaucheur","year":"2018","unstructured":"Lefaucheur C, Loupy A (2018) Antibody-mediated rejection of solid-organ allografts. N Engl J Med 379(26):2580\u20132582. https:\/\/doi.org\/10.1056\/NEJMc1813976","journal-title":"N Engl J Med"},{"key":"598_CR15","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/978-981-13-8871-2_11","volume":"1165","author":"BC Liu","year":"2019","unstructured":"Liu BC, Tang TT, Lv LL (2019) How tubular epithelial cell injury contributes to renal fibrosis. Adv Exp Med Biol 1165:233\u2013252. https:\/\/doi.org\/10.1007\/978-981-13-8871-2_11","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"598_CR16","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.bbrc.2016.09.050","volume":"479","author":"X Liu","year":"2016","unstructured":"Liu X, Liang E, Song X, Du Z, Zhang Y, Zhao Y (2016) Inhibition of Pin1 alleviates myocardial fibrosis and dysfunction in STZ-induced diabetic mice. Biochem Biophys Res Commun 479(1):109\u2013115. https:\/\/doi.org\/10.1016\/j.bbrc.2016.09.050","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"598_CR17","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1038\/nm.3902","volume":"21","author":"S Lovisa","year":"2015","unstructured":"Lovisa S, LeBleu VS, Tampe B, Sugimoto H, Vadnagara K, Carstens JL, Wu CC, Hagos Y, Burckhardt BC, Pentcheva-Hoang T, Nischal H, Allison JP, Zeisberg M, Kalluri R (2015) Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. Nat Med 21(9):998\u20131009. https:\/\/doi.org\/10.1038\/nm.3902","journal-title":"Nat Med"},{"issue":"3","key":"598_CR18","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/cbin.11100","volume":"43","author":"X Lu","year":"2019","unstructured":"Lu X, Chen M, Shen J, Xu Y, Wu H (2019) IL-1\u03b2 functionally attenuates ABCG2 and PDZK1 expression in HK-2 cells partially through NF-\u03baB activation. Cell Biol Int 43(3):279\u2013289. https:\/\/doi.org\/10.1002\/cbin.11100","journal-title":"Cell Biol Int"},{"issue":"7","key":"598_CR19","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nri2572","volume":"9","author":"F Mackay","year":"2009","unstructured":"Mackay F, Schneider P (2009) Cracking the BAFF code. Nat Rev Immunol 9(7):491\u2013502. https:\/\/doi.org\/10.1038\/nri2572","journal-title":"Nat Rev Immunol"},{"key":"598_CR20","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.coph.2019.09.009","volume":"49","author":"J Majo","year":"2019","unstructured":"Majo J, Klinkhammer BM, Boor P, Tiniakos D (2019) Pathology and natural history of organ fibrosis. Curr Opin Pharmacol 49:82\u201389. https:\/\/doi.org\/10.1016\/j.coph.2019.09.009","journal-title":"Curr Opin Pharmacol"},{"issue":"3","key":"598_CR21","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1074\/jbc.M109.063826","volume":"285","author":"I Matsuura","year":"2010","unstructured":"Matsuura I, Chiang KN, Lai CY, He D, Wang G, Ramkumar R, Uchida T, Ryo A, Lu K, Liu F (2010) Pin1 promotes transforming growth factor-beta-induced migration and invasion. J Biol Chem 285(3):1754\u20131764. https:\/\/doi.org\/10.1074\/jbc.M109.063826","journal-title":"J Biol Chem"},{"issue":"1","key":"598_CR22","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1136\/thoraxjnl-2012-202288","volume":"68","author":"PS McNamara","year":"2013","unstructured":"McNamara PS, Fonceca AM, Howarth D, Correia JB, Slupsky JR, Trinick RE, Al Turaiki W, Smyth RL, Flanagan BF (2013) Respiratory syncytial virus infection of airway epithelial cells, in vivo and in vitro, supports pulmonary antibody responses by inducing expression of the B cell differentiation factor BAFF. Thorax 68(1):76\u201381. https:\/\/doi.org\/10.1136\/thoraxjnl-2012-202288","journal-title":"Thorax"},{"key":"598_CR23","doi-asserted-by":"publisher","unstructured":"Nakada S, Kuboki S, Nojima H, Yoshitomi H, Furukawa K, Takayashiki T, Takano S, Miyazaki M, Ohtsuka M (2019) Roles of Pin1 as a key molecule for EMT induction by activation of STAT3 and NF-\u03baB in human gallbladder cancer. Ann Surg Oncol 26(3):907\u2013917. https:\/\/doi.org\/10.1245\/s10434-018-07132-7","DOI":"10.1245\/s10434-018-07132-7"},{"issue":"20","key":"598_CR24","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.2174\/0929867325666181105120911","volume":"27","author":"Y Nakatsu","year":"2020","unstructured":"Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK, Mizuno Y, Kushiyama A, Ono H, Fujishiro M, Ito H, Okabe T, Asano T (2020) Development of Pin1 inhibitors and their potential as therapeutic agents. Curr Med Chem 27(20):3314\u20133329. https:\/\/doi.org\/10.2174\/0929867325666181105120911","journal-title":"Curr Med Chem"},{"issue":"9","key":"598_CR25","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.3390\/ijms17091495","volume":"17","author":"Y Nakatsu","year":"2016","unstructured":"Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mori K, Sakoda H, Fujishiro M, Ono H, Kushiyama A, Asano T (2016) Physiological and pathogenic roles of prolyl isomerase Pin1 in metabolic regulations via multiple signal transduction pathway modulations. Int J Mol Sci 17(9):1495. https:\/\/doi.org\/10.3390\/ijms17091495","journal-title":"Int J Mol Sci"},{"issue":"3","key":"598_CR26","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.trre.2009.02.003","volume":"23","author":"CY Nguan","year":"2009","unstructured":"Nguan CY, Du C (2009) Renal tubular epithelial cells as immunoregulatory cells in renal allograft rejection. Transplant Rev (Orlando) 23(3):129\u2013138. https:\/\/doi.org\/10.1016\/j.trre.2009.02.003","journal-title":"Transplant Rev (Orlando)"},{"issue":"1","key":"598_CR27","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1097\/TP.0000000000002993","volume":"104","author":"SE Panzer","year":"2020","unstructured":"Panzer SE (2020) Anti-BAFF therapy: a new tool to target B cells in antibody-mediated rejection? Transplantation 104(1):e3\u2013e4. https:\/\/doi.org\/10.1097\/TP.0000000000002993","journal-title":"Transplantation"},{"key":"598_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.taap.2018.03.006","volume":"345","author":"F Qiu","year":"2018","unstructured":"Qiu F, Dong C, Liu Y, Shao X, Huang D, Han Y, Wang B, Liu Y, Huo R, Paulo P, Zhang ZR, Zhao D, Chu WF (2018) Pharmacological inhibition of SUMO-1 with ginkgolic acid alleviates cardiac fibrosis induced by myocardial infarction in mice. Toxicol Appl Pharmacol 345:1\u20139. https:\/\/doi.org\/10.1016\/j.taap.2018.03.006","journal-title":"Toxicol Appl Pharmacol"},{"issue":"11","key":"598_CR29","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1084\/jem.189.11.1747","volume":"189","author":"P Schneider","year":"1999","unstructured":"Schneider P, Mackay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, Bixler S, Acha-Orbea H, Valmori D, Romero P, Werner-Favre C, Zubler RH, Browning JL, Tschopp J (1999) BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 189(11):1747\u20131756. https:\/\/doi.org\/10.1084\/jem.189.11.1747","journal-title":"J Exp Med"},{"issue":"2","key":"598_CR30","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1177\/0961203317717083","volume":"27","author":"A Schwarting","year":"2018","unstructured":"Schwarting A, Relle M, Meineck M, F\u00f6hr B, Triantafyllias K, Weinmann A, Roth W, Weinmann-Menke J (2018) Renal tubular epithelial cell-derived BAFF expression mediates kidney damage and correlates with activity of proliferative lupus nephritis in mouse and men. Lupus 27(2):243\u2013256. https:\/\/doi.org\/10.1177\/0961203317717083","journal-title":"Lupus"},{"issue":"8","key":"598_CR31","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.3109\/10428194.2013.862619","volume":"55","author":"F Secreto","year":"2014","unstructured":"Secreto F, Manske M, Price-Troska T, Ziesmer S, Hodge LS, Ansell SM, Cerhan JR, Novak AJ (2014) B-cell activating factor-receptor specific activation of tumor necrosis factor receptor associated factor 6 and the phosphatidyl inositol 3-kinase pathway in lymphoma B cells. Leuk Lymphoma 55(8):1884\u20131892. https:\/\/doi.org\/10.3109\/10428194.2013.862619","journal-title":"Leuk Lymphoma"},{"issue":"28","key":"598_CR32","doi-asserted-by":"publisher","first-page":"23294","DOI":"10.1074\/jbc.M111.313684","volume":"287","author":"ZJ Shen","year":"2012","unstructured":"Shen ZJ, Braun RK, Hu J, Xie Q, Chu H, Love RB, Stodola LA, Rosenthal LA, Szakaly RJ, Sorkness RL, Malter JS (2012) Pin1 protein regulates Smad protein signaling and pulmonary fibrosis. J Biol Chem 287(28):23294\u201323305. https:\/\/doi.org\/10.1074\/jbc.M111.313684","journal-title":"J Biol Chem"},{"issue":"12","key":"598_CR33","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1038\/ni1266","volume":"6","author":"ZJ Shen","year":"2005","unstructured":"Shen ZJ, Esnault S, Malter JS (2005) The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils. Nat Immunol 6(12):1280\u20131287. https:\/\/doi.org\/10.1038\/ni1266","journal-title":"Nat Immunol"},{"issue":"2","key":"598_CR34","doi-asserted-by":"publisher","first-page":"e0150093","DOI":"10.1371\/journal.pone.0150093","volume":"11","author":"ZJ Shen","year":"2016","unstructured":"Shen ZJ, Hu J, Shiizaki K, Kuro-o M, Malter JS (2016) Phosphate-induced renal fibrosis requires the prolyl isomerase Pin1. PLoS One 11(2):e0150093. https:\/\/doi.org\/10.1371\/journal.pone.0150093","journal-title":"PLoS One"},{"issue":"5","key":"598_CR35","doi-asserted-by":"publisher","first-page":"e19337","DOI":"10.1371\/journal.pone.0019337","volume":"6","author":"MJ Valente","year":"2011","unstructured":"Valente MJ, Henrique R, Costa VL, Jer\u00f3nimo C, Carvalho F, Bastos M, de Pinho PG, Carvalho M (2011) A rapid and simple procedure for the establishment of human normal and cancer renal primary cell cultures from surgical specimens. PLoS One 6(5):e19337","journal-title":"PLoS One"},{"issue":"8","key":"598_CR36","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/77929","volume":"7","author":"MA Verdecia","year":"2000","unstructured":"Verdecia MA, Bowman ME, Lu KP, Hunter T, Noel JP (2000) Structural basis for phosphoserine-proline recognition by group IV WW domains. Nat Struct Biol 7(8):639\u2013643. https:\/\/doi.org\/10.1038\/77929","journal-title":"Nat Struct Biol"},{"issue":"1","key":"598_CR37","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/cbin.11231","volume":"44","author":"R Wang","year":"2019","unstructured":"Wang R, Yan Y, Li C (2019) LINC00462 is involved in high glucose-induced apoptosis of renal tubular epithelial cells via AKT pathway. Cell Biol Int 44(1):286\u2013294. https:\/\/doi.org\/10.1002\/cbin.11231","journal-title":"Cell Biol Int"},{"issue":"5","key":"598_CR38","doi-asserted-by":"publisher","first-page":"6263","DOI":"10.1002\/jcp.27357","volume":"234","author":"D Wu","year":"2019","unstructured":"Wu D, Huang D, Li LL, Ni P, Li XX, Wang B, Han YN, Shao XQ, Zhao D, Chu WF, Li BY (2019) TGF-\u03b21-PML SUMOylation-peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) form a positive feedback loop to regulate cardiac fibrosis. J Cell Physiol 234(5):6263\u20136273. https:\/\/doi.org\/10.1002\/jcp.27357","journal-title":"J Cell Physiol"},{"issue":"1","key":"598_CR39","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.transproceed.2008.10.037","volume":"41","author":"H Xu","year":"2009","unstructured":"Xu H, He X, Sun J, Shi D, Zhu Y, Zhang X (2009) The expression of B-cell activating factor belonging to tumor necrosis factor superfamily (BAFF) significantly correlated with C4d in kidney allograft rejection. Transplant Proc 41(1):112\u2013116. https:\/\/doi.org\/10.1016\/j.transproceed.2008.10.037","journal-title":"Transplant Proc"},{"issue":"5-6","key":"598_CR40","first-page":"411","volume":"58","author":"H Xu","year":"2012","unstructured":"Xu H, He X, Zhao W, Guo H, Shi Q, Zhu Y, Zhang X (2012) CD256 can be found in antibody-mediated renal allograft rejection tissues. Clin Lab 58(5-6):411\u2013418","journal-title":"Clin Lab"},{"issue":"1","key":"598_CR41","doi-asserted-by":"publisher","first-page":"276","DOI":"10.4049\/jimmunol.181.1.276","volume":"181","author":"W Xu","year":"2008","unstructured":"Xu W, Santini PA, Matthews AJ, Chiu A, Plebani A, He B, Chen K, Cerutti A (2008) Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF. J Immunol 181(1):276\u2013287. https:\/\/doi.org\/10.4049\/jimmunol.181.1.276","journal-title":"J Immunol"},{"issue":"6","key":"598_CR42","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.jhep.2014.02.004","volume":"60","author":"JW Yang","year":"2014","unstructured":"Yang JW, Hien TT, Lim SC, Jun DW, Choi HS, Yoon JH, Cho IJ, Kang KW (2014) Pin1 induction in the fibrotic liver and its roles in TGF-beta1 expression and Smad2\/3 phosphorylation. J Hepatol 60(6):1235\u20131241. https:\/\/doi.org\/10.1016\/j.jhep.2014.02.004","journal-title":"J Hepatol"},{"issue":"4","key":"598_CR43","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.3892\/mmr.2017.6190","volume":"15","author":"N Zheng","year":"2017","unstructured":"Zheng N, Fan J, Wang B, Wang D, Feng P, Yang Q, Yu X (2017) Expression profile of BAFF in peripheral blood from patients of IgA nephropathy: correlation with clinical features and streptococcus pyogenes infection. Mol Med rep 15(4):1925\u20131935. https:\/\/doi.org\/10.3892\/mmr.2017.6190","journal-title":"Mol Med rep"}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-021-00598-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-021-00598-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-021-00598-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T15:40:12Z","timestamp":1627400412000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-021-00598-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["598"],"URL":"https:\/\/doi.org\/10.1007\/s11626-021-00598-y","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"25 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}