{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:42:36Z","timestamp":1791895356573,"version":"4.3.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s11626-022-00657-y","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T18:02:42Z","timestamp":1649959362000},"page":"295-306","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["LncRNA HOTAIR promotes proliferation and suppresses apoptosis of mouse spermatogonium GC-1 cells by sponging miR-761 to modulate NANOS2 expression"],"prefix":"10.1007","volume":"58","author":[{"given":"Xiangbin","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjin","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengshuang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyuan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiujia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honggang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"657_CR1","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1242\/jcs.057968","volume":"123","author":"F Barrios","year":"2010","unstructured":"Barrios F, Filipponi D, Pellegrini M, Paronetto MP, Siena SD, Geremia R, Rossi P, Felici MD, Jannini EA, Dolci S (2010) Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells. J Cell Sci 123:871\u2013880","journal-title":"J Cell Sci"},{"key":"657_CR2","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1159\/000493408","volume":"49","author":"L Chang","year":"2018","unstructured":"Chang L, Guo R, Yuan Z, Shi HR, Zhanget DY (2018) LncRNA HOTAIR regulates CCND1 and CCND2 expression by sponging miR-206 in ovarian cancer. Cell Physiol Biochem 49:1289\u20131303","journal-title":"Cell Physiol Biochem"},{"key":"657_CR3","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3389\/fcell.2020.00409","volume":"8","author":"PJ Dexheimer","year":"2020","unstructured":"Dexheimer PJ, Cochella L (2020) MicroRNAs: from mechanism to organism. Front Cell Dev Biol 8:409","journal-title":"Front Cell Dev Biol"},{"key":"657_CR4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s40781-018-0183-7","volume":"60","author":"JK Dhanoa","year":"2018","unstructured":"Dhanoa JK, Sethi RS, Verma R, Arora JS, Mukhopadhyay CS (2018) Long non-coding RNA: its evolutionary relics and biological implications in mammals: a review. J Anim Sci Technol 60:25","journal-title":"J Anim Sci Technol"},{"key":"657_CR5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1074\/mcp.M113.035600","volume":"13","author":"L Fagerberg","year":"2014","unstructured":"Fagerberg L, Hallstr\u00f6m BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, Habuka M, Tahmasebpoor S, Danielsson A, Edlund K et al (2014) Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics 13:397\u2013406","journal-title":"Mol Cell Proteomics"},{"key":"657_CR6","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1101\/gr.082701.108","volume":"19","author":"RC Friedman","year":"2009","unstructured":"Friedman RC, Farh KK, Burge CB, Bartel DP (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19:92\u2013105","journal-title":"Genome Res"},{"key":"657_CR7","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ncrna.2017.03.003","volume":"2","author":"TJM Gon\u00e7alves","year":"2017","unstructured":"Gon\u00e7alves TJM, Armand AS (2017) Non-coding RNAs in skeletal muscle regeneration. Noncoding RNA Res 2:56\u201367","journal-title":"Noncoding RNA Res"},{"key":"657_CR8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","volume":"27","author":"A Grimson","year":"2007","unstructured":"Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP, Bartel DP (2007) MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell 27:91\u2013105","journal-title":"Mol Cell"},{"key":"657_CR9","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/nature08975","volume":"464","author":"RA Gupta","year":"2010","unstructured":"Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL et al (2010) Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464:1071\u20131076","journal-title":"Nature"},{"key":"657_CR10","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s12032-013-0670-0","volume":"30","author":"M Hajjari","year":"2013","unstructured":"Hajjari M, Behmanesh M, Sadeghizadeh M, Zeinoddini M (2013) Up-regulation of HOTAIR long noncoding RNA in human gastric adenocarcinoma tissues. Med Oncol 30:670","journal-title":"Med Oncol"},{"key":"657_CR11","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1126\/science.1064023","volume":"293","author":"SM Hammond","year":"2001","unstructured":"Hammond SM, Boettcher S, Caudy AA, Kobayashi R, Hannon GJ (2001) Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293:1146\u20131150","journal-title":"Science"},{"key":"657_CR12","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1126\/science.1073827","volume":"297","author":"G Hutvagner","year":"2002","unstructured":"Hutvagner G, Zamore PD (2002) A microRNA in a multiple turnover RNAi enzyme complex. Science 297:2056\u20132060","journal-title":"Science"},{"key":"657_CR13","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.cell.2007.05.016","volume":"129","author":"M Kiriakidou","year":"2007","unstructured":"Kiriakidou M, Tan GS, Lamprinaki S, De Planell-Saguer M, Nelson PT, Mourelatos Z (2007) An mRNA m7G cap binding-like motif within human Ago2 represses translation. Cell 129:1141\u20131151","journal-title":"Cell"},{"key":"657_CR14","doi-asserted-by":"publisher","first-page":"6320","DOI":"10.1158\/0008-5472.CAN-11-1021","volume":"71","author":"R Kogo","year":"2011","unstructured":"Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S et al (2011) Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res 71:6320\u20136326","journal-title":"Cancer Res"},{"key":"657_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"BP Lewis","year":"2005","unstructured":"Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15\u201320","journal-title":"Cell"},{"key":"657_CR16","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","volume":"115","author":"BP Lewis","year":"2003","unstructured":"Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB (2003) Prediction of mammalian microRNA targets. Cell 115:787\u2013798","journal-title":"Cell"},{"key":"657_CR17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4161\/epi.27472","volume":"9","author":"FP Marchese","year":"2014","unstructured":"Marchese FP, Huarte M (2014) Long non-coding RNAs and chromatin modifiers: their place in the epigenetic code. Epigenetics 9:21\u201326","journal-title":"Epigenetics"},{"key":"657_CR18","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nature05519","volume":"445","author":"I Martianov","year":"2007","unstructured":"Martianov I, Ramadass A, Serra Barros A, Chow N, Akoulitchev A (2007) Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript. Nature 445:666\u2013670","journal-title":"Nature"},{"key":"657_CR19","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S0092-8674(02)00908-X","volume":"110","author":"J Martinez","year":"2002","unstructured":"Martinez J, Patkaniowska A, Urlaub H, Luhrmann R, Tuschl T (2002) Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 110:563\u2013574","journal-title":"Cell"},{"key":"657_CR20","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1126\/science.287.5457.1489","volume":"287","author":"X Meng","year":"2000","unstructured":"Meng X, Lindahl M, Hyvonen ME, Parvinen M, de Rooij DG, Hess MW, Raatikainen-Ahokas A, Sainio K, Rauvala H, Lakso M et al (2000) Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Science 287:1489\u20131493","journal-title":"Science"},{"key":"657_CR21","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1261\/rna.768207","volume":"13","author":"CB Nielsen","year":"2007","unstructured":"Nielsen CB, Shomron N, Sandberg R, Hornstein E, Kitzman J, Burge CB (2007) Determinants of targeting by endogenous and exogenous microRNAs and siRNAs. RNA 13:1894\u20131910","journal-title":"RNA"},{"key":"657_CR22","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1017\/S0967199419000066","volume":"27","author":"V Pandey","year":"2019","unstructured":"Pandey V, Tripathi A, Dubey PK (2019) Expression and intracellular localization of Nanos2-homologue protein in primordial germ cells and spermatogonial stem cells. Zygote 27:82\u201388","journal-title":"Zygote"},{"key":"657_CR23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fgene.2014.00023","volume":"5","author":"SM Peterson","year":"2014","unstructured":"Peterson SM, Thompson JA, Ufkin ML, Sathyanarayana P, Liaw L, Congdon CB (2014) Common features of microRNA target prediction tools. Front Genet 5:23","journal-title":"Front Genet"},{"key":"657_CR24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.mod.2018.01.001","volume":"149","author":"HP Pui","year":"2018","unstructured":"Pui HP, Saga Y (2018) NANOS2 acts as an intrinsic regulator of gonocytes-to-spermatogonia transition in the murine testes. Mech Dev 149:27\u201340","journal-title":"Mech Dev"},{"key":"657_CR25","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ydbio.2013.10.018","volume":"385","author":"R Saba","year":"2014","unstructured":"Saba R, Kato Y, Saga Y (2014) NANOS2 promotes male germ cell development independent of meiosis suppression. Dev Biol 385:32\u201340","journal-title":"Dev Biol"},{"key":"657_CR26","doi-asserted-by":"publisher","first-page":"3815","DOI":"10.1007\/s00018-010-0456-x","volume":"67","author":"Y Saga","year":"2010","unstructured":"Saga Y (2010) Function of Nanos2 in the male germ cell lineage in mice. Cell Mol Life Sci 67:3815\u20133822","journal-title":"Cell Mol Life Sci"},{"key":"657_CR27","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","volume":"146","author":"L Salmena","year":"2011","unstructured":"Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP (2011) A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell 146:353\u2013358","journal-title":"Cell"},{"key":"657_CR28","doi-asserted-by":"publisher","first-page":"e1002071","DOI":"10.1371\/journal.pgen.1002071","volume":"7","author":"P Schorderet","year":"2011","unstructured":"Schorderet P, Duboule D (2011) Structural and functional differences in the long non-coding RNA hotair in mouse and human. PLoS Genet 7:e1002071","journal-title":"PLoS Genet"},{"key":"657_CR29","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1101\/gad.1612708","volume":"22","author":"A Suzuki","year":"2008","unstructured":"Suzuki A, Saga Y (2008) Nanos2 suppresses meiosis and promotes male germ cell differentiation. Genes Dev 22:430\u2013435","journal-title":"Genes Dev"},{"key":"657_CR30","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.ydbio.2009.10.002","volume":"336","author":"H Suzuki","year":"2009","unstructured":"Suzuki H, Sada A, Yoshida S, Saga Y (2009) The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3. Dev Biol 336:222\u2013231","journal-title":"Dev Biol"},{"key":"657_CR31","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1242\/dev.02697","volume":"134","author":"A Suzuki","year":"2007","unstructured":"Suzuki A, Tsuda M, Saga Y (2007) Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development. Development 134:77\u201383","journal-title":"Development"},{"key":"657_CR32","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nature12986","volume":"505","author":"Y Tay","year":"2014","unstructured":"Tay Y, Rinn J, Pandolfi PP (2014) The multilayered complexity of ceRNA crosstalk and competition. Nature 505:344\u2013352","journal-title":"Nature"},{"key":"657_CR33","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1126\/science.1085222","volume":"301","author":"M Tsuda","year":"2003","unstructured":"Tsuda M, Sasaoka Y, Kiso M, Abe K, Haraguchi S, Kobayashi S, Saga Y (2003) Conserved role of Nanos proteins in germ cell development. Science 301:1239\u20131241","journal-title":"Science"},{"key":"657_CR34","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1186\/s12864-017-3662-1","volume":"18","author":"M Uesaka","year":"2017","unstructured":"Uesaka M, Agata K, Oishi T, Nakashima K, Imamura T (2017) Evolutionary acquisition of promoter-associated non-coding RNA (pancRNA) repertoires diversifies species-dependent gene activation mechanisms in mammals. BMC Genomics 18:285","journal-title":"BMC Genomics"},{"key":"657_CR35","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1530\/REP-07-0536","volume":"136","author":"MP Van Bragt","year":"2008","unstructured":"Van Bragt MP, Roepers-Gajadien HL, Korver CM, Bogerd J, Okuda A, Eggen BJ, de Rooij DG, van Pelt AM (2008) Expression of the pluripotency marker UTF1 is restricted to a subpopulation of early A spermatogonia in rat testis. Reproduction 136:33\u201340","journal-title":"Reproduction"},{"key":"657_CR36","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","volume":"43","author":"KC Wang","year":"2011","unstructured":"Wang KC, Chang HY (2011) Molecular mechanisms of long noncoding RNAs. Mol Cell 43:904\u2013914","journal-title":"Mol Cell"},{"key":"657_CR37","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1186\/s13059-014-0429-8","volume":"15","author":"NM White","year":"2014","unstructured":"White NM, Cabanski CR, Silva-Fisher JM, Dang HX, Govindan R, Maher CA (2014) Transcriptome sequencing reveals altered long intergenic noncoding RNAs in lung cancer. Genome Biol 15:429","journal-title":"Genome Biol"},{"key":"657_CR38","doi-asserted-by":"publisher","unstructured":"Xu ZY, Chen H, Yang B, Liu XF, Zhou XL, Kong HF (2019) The association of HOTAIR with the diagnosis and prognosis of gastric cancer and its effect on the proliferation of gastric cancer cells. Can J Gastroenterol Hepatol\u00a02019:3076345.\u00a0https:\/\/doi.org\/10.1155\/2019\/3076345","DOI":"10.1155\/2019\/3076345"},{"key":"657_CR39","doi-asserted-by":"publisher","first-page":"260","DOI":"10.4251\/wjgo.v10.i9.260","volume":"10","author":"H Yu","year":"2018","unstructured":"Yu H, Rong L (2018) Emerging role of long non-coding RNA in the development of gastric cancer. World J Gastrointest Oncol 10:260\u2013270","journal-title":"World J Gastrointest Oncol"},{"key":"657_CR40","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/jcb.24655","volume":"115","author":"M Yu","year":"2014","unstructured":"Yu M, Mu H, Niu Z, Chu Z, Zhu H, Hua J (2014) miR-34c enhances mouse spermatogonial stem cells differentiation by targeting Nanos2. J Cell Biochem 115:232\u2013242","journal-title":"J Cell Biochem"},{"key":"657_CR41","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature13992","volume":"515","author":"F Yue","year":"2014","unstructured":"Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, Sandstrom R, Ma Z, Davis C, Pope BD et al (2014) A comparative encyclopedia of DNA elements in the mouse genome. Nature 515:355\u2013364","journal-title":"Nature"},{"key":"657_CR42","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.3892\/mmr.2016.5572","volume":"14","author":"Z Zhang","year":"2016","unstructured":"Zhang Z, Cheng J, Wu Y, Qiu J, Sun Y, Tong X (2016) LncRNA HOTAIR controls the expression of Rab22a by sponging miR-373 in ovarian cancer. Mol Med Rep 14:2465\u20132472","journal-title":"Mol Med Rep"}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-022-00657-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-022-00657-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-022-00657-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T23:39:31Z","timestamp":1651880371000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-022-00657-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["657"],"URL":"https:\/\/doi.org\/10.1007\/s11626-022-00657-y","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"22 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}