{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T02:47:20Z","timestamp":1774061240829,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s11626-022-00738-y","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T17:18:01Z","timestamp":1669655881000},"page":"912-921","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The immunotoxicity of ten insecticides against insect hemocyte cells in vitro"],"prefix":"10.1007","volume":"58","author":[{"given":"Dongmei","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingchun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"738_CR1","doi-asserted-by":"publisher","first-page":"46558","DOI":"10.1038\/srep46558","volume":"7","author":"S Ali","year":"2017","unstructured":"Ali S, Zhang C, Wang Z et al (2017) Toxicological and biochemical basis of synergism between the entomopathogenic fungus Lecanicillium muscarium and the insecticide matrine against Bemisia tabaci (Gennadius). Sci Rep 7:46558","journal-title":"Sci Rep"},{"key":"738_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.reprotox.2020.04.002","volume":"94","author":"JW Bae","year":"2020","unstructured":"Bae JW, Kwon WS (2020) Investigating the effects of fipronil on male fertility: insight into the mechanism of capacitation. Reprod Toxicol 94:1\u20137","journal-title":"Reprod Toxicol"},{"key":"738_CR3","doi-asserted-by":"publisher","first-page":"104100","DOI":"10.1016\/j.jinsphys.2020.104100","volume":"126","author":"KKDS Batista","year":"2020","unstructured":"Batista KKDS, Vieira CS, Florentino EB et al (2020) Nitric oxide effects on Rhodnius prolixus\u2019s immune responses, gut microbiota and Trypanosoma cruzi development. J Insect Physiol 126:104100","journal-title":"J Insect Physiol"},{"key":"738_CR4","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"issue":"1","key":"738_CR5","doi-asserted-by":"publisher","first-page":"4670","DOI":"10.1038\/s41598-020-61445-w","volume":"10","author":"A Brandt","year":"2020","unstructured":"Brandt A, Hohnheiser B, Sgolastra F et al (2020) Immunosuppression response to the neonicotinoid insecticide thiacloprid in females and males of the red mason bee Osmia bicornis L. Sci Rep 10(1):4670","journal-title":"Sci Rep"},{"issue":"1","key":"738_CR6","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.1038\/s41467-020-18950-3","volume":"11","author":"HR Bridges","year":"2020","unstructured":"Bridges HR, Fedor JG, Blaza JN et al (2020) Structure of inhibitor-bound mammalian complex I. Nat Commun 11(1):5261","journal-title":"Nat Commun"},{"key":"738_CR7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/bs.adgen.2016.01.006","volume":"94","author":"TM Butt","year":"2016","unstructured":"Butt TM, Coates CJ, Dubovskiy IM et al (2016) Entomopathogenic fungi: new insights into host-pathogen interactions. Adv Genet 94:307\u2013364","journal-title":"Adv Genet"},{"key":"738_CR8","first-page":"123","volume":"94","author":"KD Clark","year":"2020","unstructured":"Clark KD (2020) Insect hemolymph immune complexes. Sub-cellular. Biochem 94:123\u2013161","journal-title":"Biochem"},{"key":"738_CR9","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.cropro.2007.03.022","volume":"26","author":"J Cooper","year":"2007","unstructured":"Cooper J, Dobson H (2007) The benefits of pesticides to mankind and the environment. Crop Prot 26:1337\u20131348","journal-title":"Crop Prot"},{"issue":"10","key":"738_CR10","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.jinsphys.2007.04.001","volume":"53","author":"P de Winter","year":"2007","unstructured":"de Winter P, Rayne RC, Coast GM (2007) The effects of intracellular signalling pathway inhibitors on phagocytosis by haemocytes of Manduca sexta. J Insect Physiol 53(10):975\u2013982","journal-title":"J Insect Physiol"},{"issue":"4","key":"738_CR11","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/j.1365-2583.2009.00899.x","volume":"18","author":"I Eleftherianos","year":"2009","unstructured":"Eleftherianos I, Felf\u00f6ldi G, French-Constant RH et al (2009) Induced nitric oxide synthesis in the gut of Manduca sexta protects against oral infection by the bacterial pathogen Photorhabdus luminescens. Insect Mol Biol 18(4):507\u2013516","journal-title":"Insect Mol Biol"},{"issue":"3","key":"738_CR12","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/imm.13390","volume":"164","author":"I Eleftherianos","year":"2021","unstructured":"Eleftherianos I, Heryanto C, Bassal T et al (2021) Haemocyte-mediated immunity in insects: cells, processes and associated components in the fight against pathogens and parasites. Immunol 164(3):401\u2013432","journal-title":"Immunol"},{"issue":"8","key":"738_CR13","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3390\/ph13080196","volume":"13","author":"G El-Saber Batiha","year":"2020","unstructured":"El-Saber Batiha G, Alqahtani A, Ilesanmi OB et al (2020) Avermectin derivatives, pharmacokinetics, therapeutic and toxic dosages, mechanism of action, and their biological effects. Pharmaceuticals (Basel) 13(8):196","journal-title":"Pharmaceuticals (Basel)"},{"key":"738_CR14","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1378\/chest.123.4.1014","volume":"123","author":"RW England","year":"2003","unstructured":"England RW, Nugent JS, Grathwohl KW et al (2003) High dose inhaled fluticasone and delayed hypersensitivity skin testing. Chest 123:1014\u20131017","journal-title":"Chest"},{"issue":"3","key":"738_CR15","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10646-014-1189-7","volume":"23","author":"H Feltham","year":"2014","unstructured":"Feltham H, Park K, Goulson D (2014) Field realistic doses of pesticide imidacloprid reduce bumblebee pollen foraging efficiency. Ecotoxicol 23(3):317\u2013323","journal-title":"Ecotoxicol"},{"key":"738_CR16","doi-asserted-by":"publisher","first-page":"e96170","DOI":"10.1371\/journal.pone.0096170","volume":"9","author":"L Gong","year":"2014","unstructured":"Gong L, Chen X, Liu C et al (2014) Gene expression profile of Bombyx mori hemocyte under the stress of destruxin A. PLoS One 9:e96170","journal-title":"PLoS One"},{"issue":"2","key":"738_CR17","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.dci.2009.08.014","volume":"34","author":"JF Hillyer","year":"2010","unstructured":"Hillyer JF, Est\u00e9vez-Lao TY (2010) Nitric oxide is an essential component of the hemocyte-mediated mosquito immune response against bacteria. Dev Comp Immunol 34(2):141\u2013149","journal-title":"Dev Comp Immunol"},{"key":"738_CR18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.cois.2014.07.002","volume":"3","author":"JF Hillyer","year":"2014","unstructured":"Hillyer JF, Strand MR (2014) Mosquito hemocyte-mediated immune responses. Curr Opin Insect Sci 3:14\u201321","journal-title":"Curr Opin Insect Sci"},{"key":"738_CR19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.pestbp.2015.12.003","volume":"130","author":"QC Huang","year":"2016","unstructured":"Huang QC, Zhang L, Yang C et al (2016) The competence of hemocyte immunity in the armyworm Mythimna separata larvae to sublethal hexaflumuron exposure. Pestic Biochem Physiol 130:31\u201338","journal-title":"Pestic Biochem Physiol"},{"issue":"3","key":"738_CR20","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.dci.2012.10.014","volume":"39","author":"K Ishii","year":"2013","unstructured":"Ishii K, Adachi T, Hamamoto H et al (2013) Insect cytokine paralytic peptide activates innate immunity via nitric oxide production in the silkworm Bombyx mori. Dev Comp Immunol 39(3):147\u2013153","journal-title":"Dev Comp Immunol"},{"key":"738_CR21","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jip.2011.12.005","volume":"109","author":"RR James","year":"2012","unstructured":"James RR, Xu J (2012) Mechanisms by which pesticides affect insect immunity. J Invertebr Pathol 109:175\u2013182","journal-title":"J Invertebr Pathol"},{"key":"738_CR22","doi-asserted-by":"publisher","first-page":"28424","DOI":"10.1038\/srep28424","volume":"6","author":"M Jia","year":"2016","unstructured":"Jia M, Cao G, Li Y et al (2016) Biochemical basis of synergism between pathogenic fungus Metarhizium anisopliae and insecticide chlorantraniliprole in Locusta migratoria (Meyen). Sci Rep 6:28424","journal-title":"Sci Rep"},{"key":"738_CR23","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/978-1-4419-8059-5_10","volume-title":"Invertebrate Immunity. Advances in Experimental Medicine and Biology","author":"HB Jiang","year":"2010","unstructured":"Jiang HB, Vilcinskas A, Kanost MR (2010) Immunity in lepidopteran insects. In: S\u00f6derh\u00e4ll K (ed) Invertebrate Immunity. Advances in Experimental Medicine and Biology, vol 708. Springer, Boston, pp 181\u2013204"},{"issue":"4","key":"738_CR24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/arch.21173","volume":"86","author":"Y Kato","year":"2014","unstructured":"Kato Y, Yoshida T, Miura K et al (2014) A novel type of hemocytes localizing melanization with high-spreading behavior in Mythimna separata. Arch Insect Biochem Physiol 86(4):220\u2013239","journal-title":"Arch Insect Biochem Physiol"},{"key":"738_CR25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.aspen.2013.12.007","volume":"17","author":"A Koodalingam","year":"2014","unstructured":"Koodalingam A, Deepalakshmi R, Ammu M et al (2014) Effects of NeemAzal on marker enzymes and hemocyte phagocytic activity of larvae and pupae of the vector mosquito Aedes aegypti. J Asia-Pac Entomol 17:175\u2013181","journal-title":"J Asia-Pac Entomol"},{"key":"738_CR26","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1046\/j.1570-7458.2000.00630.x","volume":"94","author":"AM Koppenh\u00f6fer","year":"2000","unstructured":"Koppenh\u00f6fer AM, Grewal PS, Kaya HK (2000) Synergism of imidacloprid and entomopathogenic nematodes against white grubs: the mechanism. Entomol Exp Appl 94:283\u2013293","journal-title":"Entomol Exp Appl"},{"issue":"10","key":"738_CR27","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/S0965-1748(02)00092-9","volume":"32","author":"MD Lavine","year":"2002","unstructured":"Lavine MD, Strand MR (2002) Insect hemocytes and their role in immunity. Insect Biochem Mol Biol 32(10):1295\u20131309","journal-title":"Insect Biochem Mol Biol"},{"issue":"2","key":"738_CR28","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.aller.2011.11.001","volume":"40","author":"C Lee","year":"2012","unstructured":"Lee C, Klaustermeyer WB (2012) Effect of high dose inhaled corticosteroids on cell mediated immunity in patients with asthma. Allergol Immunopathol 40(2):100\u2013103","journal-title":"Allergol Immunopathol"},{"issue":"11","key":"738_CR29","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.jinsphys.2009.06.008","volume":"55","author":"LE Lenkic","year":"2009","unstructured":"Lenkic LE, Tiu SH, Tobe SS (2009) Suppression of JH biosynthesis by JH analog treatment: mechanism of suppression and roles of allatostatins and nervous connections in the cockroach Diploptera punctata. J Insect Physiol 55(11):967\u2013975","journal-title":"J Insect Physiol"},{"key":"738_CR30","doi-asserted-by":"publisher","first-page":"121419","DOI":"10.1016\/j.jhazmat.2019.121419","volume":"384","author":"X Li","year":"2020","unstructured":"Li X, Liu J, Wang X (2020) Exploring the multilevel hazards of thiamethoxam using Drosophila melanogaster. J Hazard Mater 384:121419","journal-title":"J Hazard Mater"},{"key":"738_CR31","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jphotobiol.2018.06.012","volume":"185","author":"S Luan","year":"2018","unstructured":"Luan S, Muhayimana S, Xu J et al (2018) Photosensitization of Chinese hamster V79 cells to photoactivated alpha-terthienyl involving membrane damage and oxidative stress. J Photochem Photobiol B 185:192\u2013198","journal-title":"J Photochem Photobiol B"},{"key":"738_CR32","doi-asserted-by":"publisher","first-page":"130120","DOI":"10.1016\/j.chemosphere.2021.130120","volume":"276","author":"SA Maggio","year":"2021","unstructured":"Maggio SA, Janney PK, Jenkins JJ (2021) Neurotoxicity of chlorpyrifos and chlorpyrifos-oxon to Daphnia magna. Chemosphere 276:130120","journal-title":"Chemosphere"},{"key":"738_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00360-005-0005-3","volume":"176","author":"H Merzendorfer","year":"2006","unstructured":"Merzendorfer H (2006) Insect chitin synthases: a review. J Comp Physiol [b] 176:1\u201315","journal-title":"J Comp Physiol [b]"},{"key":"738_CR34","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s13592-013-0207-8","volume":"44","author":"P Negri","year":"2013","unstructured":"Negri P, Maggi M, Correa-Aragunde N et al (2013) Nitric oxide participates at the first steps of Apis mellifera cellular immune activation in response to non-self recognition. Apidologie 44:575\u2013585","journal-title":"Apidologie"},{"issue":"21","key":"738_CR35","doi-asserted-by":"publisher","first-page":"6196","DOI":"10.1158\/0008-5472.CAN-18-1377","volume":"78","author":"BA Nichols","year":"2018","unstructured":"Nichols BA, Oswald NW, McMillan EA et al (2018) HORMAD1 is a negative prognostic indicator in lung adenocarcinoma and specifies resistance to oxidative and genotoxic stress. Can Res 78(21):6196\u20136208","journal-title":"Can Res"},{"issue":"3","key":"738_CR36","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s00253-014-6270-x","volume":"99","author":"A Ortiz-Urquiza","year":"2015","unstructured":"Ortiz-Urquiza A, Luo Z, Keyhani NO (2015) Improving mycoinsecticides for insect biological control. Appl Microbiol Biotechnol 99(3):1057\u20131068","journal-title":"Appl Microbiol Biotechnol"},{"key":"738_CR37","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1475-2875-10-16","volume":"10","author":"K Raghavendra","year":"2011","unstructured":"Raghavendra K, Barik TK, Sharma P et al (2011) Chlorfenapyr: a new insecticide with novel mode of action can control pyrethroid resistant malaria vectors. Malar J 10:16","journal-title":"Malar J"},{"issue":"10","key":"738_CR38","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1002\/ps.377","volume":"57","author":"A Retnakaran","year":"2001","unstructured":"Retnakaran A, Gelbic I, Sundaram M et al (2001) Mode of action of the ecdysone agonist tebufenozide (RH-5992), and an exclusion mechanism to explain resistance to it. Pest Manag Sci 57(10):951\u2013957","journal-title":"Pest Manag Sci"},{"issue":"5","key":"738_CR39","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.jinsphys.2006.01.005","volume":"52","author":"C Ribeiro","year":"2006","unstructured":"Ribeiro C, Breh\u00e9lin M (2006) Insect haemocytes: what type of cell is that? J Insect Physiol 52(5):417\u2013429","journal-title":"J Insect Physiol"},{"issue":"1","key":"738_CR40","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000481524","volume":"10","author":"M Sadekuzzaman","year":"2018","unstructured":"Sadekuzzaman M, Stanley D, Kim Y (2018) Nitric oxide mediates insect cellular immunity via phospholipase A2 activation. J Innate Immun 10(1):70\u201381","journal-title":"J Innate Immun"},{"key":"738_CR41","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.12688\/f1000research.27504.1","volume":"9","author":"NJ Senior","year":"2020","unstructured":"Senior NJ, Titball RW (2020) Isolation and primary culture of Galleria mellonella hemocytes for infection studies. F1000Res 9:1392","journal-title":"F1000Res"},{"key":"738_CR42","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.micron.2007.07.005","volume":"39","author":"PR Sharma","year":"2008","unstructured":"Sharma PR, Sharma OP, Saxena BP (2008) Effect of sweet flag rhizome oil (Acorus calamus) on hemogram and ultrastructure of hemocytes of the tobacco armyworm, Spodoptera litura (Lepidoptera: Noctuidae). Micron 39:544\u2013551","journal-title":"Micron"},{"key":"738_CR43","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.pestbp.2018.04.007","volume":"151","author":"E Taillebois","year":"2018","unstructured":"Taillebois E, Cartereau A, Jones AK et al (2018) Neonicotinoid insecticides mode of action on insect nicotinic acetylcholine receptors using binding studies. Pestic Biochem Physiol 151:59\u201366","journal-title":"Pestic Biochem Physiol"},{"key":"738_CR44","doi-asserted-by":"publisher","first-page":"104236","DOI":"10.1016\/j.jinsphys.2021.104236","volume":"131","author":"ML Vommaro","year":"2021","unstructured":"Vommaro ML, Giulianini PG, Giglio A (2021) Pendimethalin-based herbicide impairs cellular immune response and haemocyte morphology in a beneficial ground beetle. J Insect Physiol 131:104236","journal-title":"J Insect Physiol"},{"key":"738_CR45","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.pestbp.2019.07.007","volume":"160","author":"L Walderdorff","year":"2019","unstructured":"Walderdorff L, Laval-Gilly P, Wechtler L et al (2019) Phagocytic activity of human macrophages and Drosophila hemocytes after exposure to the neonicotinoid imidacloprid. Pestic Biochem Physiol 160:95\u2013101","journal-title":"Pestic Biochem Physiol"},{"key":"738_CR46","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.freeradbiomed.2019.09.006","volume":"143","author":"HS Wong","year":"2019","unstructured":"Wong HS, Monternier PA, Brand MD (2019) S1QELs suppress mitochondrial superoxide\/hydrogen peroxide production from site IQ without inhibiting reverse electron flow through Complex I. Free Radical Biol Med 143:545\u2013559","journal-title":"Free Radical Biol Med"},{"key":"738_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.dci.2013.04.006","volume":"41","author":"S Wu","year":"2013","unstructured":"Wu S, Wang F, Huang J et al (2013) Molecular and cellular analyses of a ryanodine receptor from hemocytes of Pieris rapae. Dev Comp Immunol 41:1\u201310","journal-title":"Dev Comp Immunol"},{"key":"738_CR48","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jip.2016.06.009","volume":"139","author":"Y Yu","year":"2016","unstructured":"Yu Y, Cao Y, Xia Y et al (2016) Wright-Giemsa staining to observe phagocytes in Locusta migratoria infected with Metarhizium acridum. J Invertebr Pathol 139:19\u201324","journal-title":"J Invertebr Pathol"},{"issue":"8","key":"738_CR49","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/ja.2016.71","volume":"69","author":"X Zhou","year":"2016","unstructured":"Zhou X, Fenical W (2016) The unique chemistry and biology of the piericidins. J Antibiot (Tokyo) 69(8):582\u2013593","journal-title":"J Antibiot (Tokyo)"},{"key":"738_CR50","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1673\/031.012.2701","volume":"12","author":"Q Zhu","year":"2012","unstructured":"Zhu Q, He Y, Yao J et al (2012) Effects of sublethal concentrations of the chitin synthesis inhibitor, hexaflumuron, on the development and hemolymph physiology of the cutworm, Spodoptera litura. J Insect Sci 12:27","journal-title":"J Insect Sci"}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-022-00738-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-022-00738-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-022-00738-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T16:18:34Z","timestamp":1671725914000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-022-00738-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,28]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["738"],"URL":"https:\/\/doi.org\/10.1007\/s11626-022-00738-y","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,28]]},"assertion":[{"value":"25 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}