{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:07:00Z","timestamp":1769162820110,"version":"3.49.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174120"],"award-info":[{"award-number":["82174120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["21ZR1463100"],"award-info":[{"award-number":["21ZR1463100"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"publisher","award":["22XD1423400"],"award-info":[{"award-number":["22XD1423400"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s11626-023-00773-3","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T14:06:06Z","timestamp":1686319566000},"page":"346-355","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Screening and identification of effective components from modified Taohong Siwu decoction for protecting H9c2 cells from damage"],"prefix":"10.1007","volume":"59","author":[{"given":"Ya-chao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-le","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-dong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"773_CR1","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1016\/j.cellsig.2006.02.001","volume":"18","author":"IK Aggeli","year":"2006","unstructured":"Aggeli IK, Gaitanaki C, Beis I (2006) Involvement of JNKs and p38-MAPK\/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells. Cell Signal 18:1801\u20131812","journal-title":"Cell Signal"},{"key":"773_CR2","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.jnutbio.2012.02.009","volume":"24","author":"I Anestopoulos","year":"2013","unstructured":"Anestopoulos I, Kavo A, Tentes I, Kortsaris A, Panayiotidis M, Lazou A, Pappa A (2013) Silibinin protects H9c2 cardiac cells from oxidative stress and inhibits phenylephrine-induced hypertrophy: potential mechanisms. J Nutr Biochem 24:586\u2013594","journal-title":"J Nutr Biochem"},{"key":"773_CR3","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1002\/jcp.26003","volume":"233","author":"A Badreddin","year":"2018","unstructured":"Badreddin A, Fady Y, Attia H, Hafez M, Khairallah A, Johar D, Bernstein L (2018) What role does the stress response have in congestive heart failure? J Cell Physiol 233:2863\u20132870","journal-title":"J Cell Physiol"},{"key":"773_CR4","first-page":"1952","volume":"14","author":"W Bu","year":"2022","unstructured":"Bu W, Zhang Z, Ocansey DKW, Yu Z, Yang X, Liu Z, Wang X, Ke Y (2022) Research on natural products from traditional Chinese medicine in the treatment of myocardial ischemia-reperfusion injury. Am J Transl Res 14:1952\u20131968","journal-title":"Am J Transl Res"},{"key":"773_CR5","doi-asserted-by":"crossref","unstructured":"Chen R, Chen W, Huang X, Rui Q (2021) Tanshinone IIA attenuates heart failure via inhibiting oxidative stress in myocardial infarction rats. Mol Med Rep 23:404","DOI":"10.3892\/mmr.2021.12043"},{"key":"773_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109487","volume":"120","author":"X Chen","year":"2019","unstructured":"Chen X, Wang Q, Shao M, Ma L, Guo D, Wu Y, Gao P, Wang X, Li W, Li C, Wang Y (2019) Ginsenoside Rb3 regulates energy metabolism and apoptosis in cardiomyocytes via activating PPARalpha pathway. Biomed Pharmacother 120:109487","journal-title":"Biomed Pharmacother"},{"key":"773_CR7","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1006\/jmcc.1999.0979","volume":"31","author":"SA Cook","year":"1999","unstructured":"Cook SA, Sugden PH, Clerk A (1999) Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease. J Mol Cell Cardiol 31:1429\u20131434","journal-title":"J Mol Cell Cardiol"},{"key":"773_CR8","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1111\/j.1476-5381.2010.01130.x","volume":"162","author":"F Di Lisa","year":"2011","unstructured":"Di Lisa F, Kaludercic N, Paolocci N (2011) beta(2)-Adrenoceptors, NADPH oxidase, ROS and p38 MAPK: another \u2018radical\u2019 road to heart failure? Br J Pharmacol 162:1009\u20131011","journal-title":"Br J Pharmacol"},{"key":"773_CR9","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1007\/BF01923990","volume":"52","author":"S Di Meo","year":"1996","unstructured":"Di Meo S, Venditti P, De Leo T (1996) Tissue protection against oxidative stress. Experientia 52:786\u2013794","journal-title":"Experientia"},{"key":"773_CR10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.cryobiol.2010.12.003","volume":"62","author":"A Diestel","year":"2011","unstructured":"Diestel A, Drescher C, Miera O, Berger F, Schmitt KR (2011) Hypothermia protects H9c2 cardiomyocytes from H2O2 induced apoptosis. Cryobiology 62:53\u201361","journal-title":"Cryobiology"},{"key":"773_CR11","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1111\/j.1742-4658.2008.06465.x","volume":"275","author":"M Eguchi","year":"2008","unstructured":"Eguchi M, Liu Y, Shin EJ, Sweeney G (2008) Leptin protects H9c2 rat cardiomyocytes from H2O2-induced apoptosis. FEBS J 275:3136\u20133144","journal-title":"FEBS J"},{"key":"773_CR12","doi-asserted-by":"crossref","unstructured":"Fang Y, Duan C, Chen S, Liu Z, Jiang B, Ai W, Wang L, Xie P, Fang H (2021) Tanshinone\u2011IIA inhibits myocardial infarct via decreasing of the mitochondrial apoptotic signaling pathway in myocardiocytes. Int J Mol Med 48:158","DOI":"10.3892\/ijmm.2021.4991"},{"key":"773_CR13","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1124\/pr.113.008300","volume":"66","author":"P Ferdinandy","year":"2014","unstructured":"Ferdinandy P, Hausenloy DJ, Heusch G, Baxter GF, Schulz R (2014) Interaction of risk factors, comorbidities, and comedications with ischemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning. Pharmacol Rev 66:1142\u20131174","journal-title":"Pharmacol Rev"},{"key":"773_CR14","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1002\/cphy.c150006","volume":"5","author":"NG Frangogiannis","year":"2015","unstructured":"Frangogiannis NG (2015) Pathophysiology of myocardial infarction. Compr Physiol 5:1841\u20131875","journal-title":"Compr Physiol"},{"key":"773_CR15","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3389\/fphys.2020.00366","volume":"11","author":"Z Fu","year":"2020","unstructured":"Fu Z, Jiao Y, Wang J, Zhang Y, Shen M, Reiter RJ, Xi Q, Chen Y (2020) Cardioprotective role of melatonin in acute myocardial infarction. Front Physiol 11:366","journal-title":"Front Physiol"},{"key":"773_CR16","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1006\/phrs.2000.0761","volume":"43","author":"Z Gao","year":"2001","unstructured":"Gao Z, Huang K, Xu H (2001) Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. Pharmacol Res 43:173\u2013178","journal-title":"Pharmacol Res"},{"key":"773_CR17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3892\/ijmm.2016.2584","volume":"38","author":"T Hu","year":"2016","unstructured":"Hu T, Wei G, Xi M, Yan J, Wu X, Wang Y, Zhu Y, Wang C, Wen A (2016) Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt\/Nrf2\/HO-1 pathway. Int J Mol Med 38:83\u201394","journal-title":"Int J Mol Med"},{"key":"773_CR18","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.3389\/fimmu.2017.01327","volume":"8","author":"F Huang","year":"2017","unstructured":"Huang F, Zhao JL, Wang L, Gao CC, Liang SQ, An DJ, Bai J, Chen Y, Han H, Qin HY (2017) miR-148a-3p Mediates notch signaling to promote the differentiation and M1 activation of macrophages. Front Immunol 8:1327","journal-title":"Front Immunol"},{"key":"773_CR19","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1089\/ars.2018.7624","volume":"31","author":"L Jiang","year":"2019","unstructured":"Jiang L, Zeng H, Ni L, Qi L, Xu Y, Xia L, Yu Y, Liu B, Yang H, Hao H, Li P (2019) HIF-1alpha preconditioning potentiates antioxidant activity in ischemic injury: the role of sequential administration of dihydrotanshinone I and protocatechuic aldehyde in cardioprotection. Antioxid Redox Signal 31:227\u2013242","journal-title":"Antioxid Redox Signal"},{"key":"773_CR20","first-page":"387","volume":"14","author":"X Jin","year":"2010","unstructured":"Jin X, Shi L, Wang SS, Liu RN, Chen C, Li Y, Li X (2010) Effects of different extracted parts of Tao-Hong-Si-Wu decoction on microcirculation of model rats with blood deficiency and blood stasis. Anhui Med Pharm: J 14:387\u2013389","journal-title":"Anhui Med Pharm: J"},{"key":"773_CR21","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/0014-4827(76)90447-X","volume":"98","author":"BW Kimes","year":"1976","unstructured":"Kimes BW, Brandt BL (1976) Properties of a clonal muscle cell line from rat heart. Exp Cell Res 98:367\u2013381","journal-title":"Exp Cell Res"},{"key":"773_CR22","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.tox.2012.11.006","volume":"303","author":"CH Law","year":"2013","unstructured":"Law CH, Li JM, Chou HC, Chen YH, Chan HL (2013) Hyaluronic acid-dependent protection in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment. Toxicology 303:54\u201371","journal-title":"Toxicology"},{"key":"773_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102384","volume":"54","author":"H Li","year":"2022","unstructured":"Li H, Zhu J, Xu YW, Mou FF, Shan XL, Wang QL, Liu BN, Ning K, Liu JJ, Wang YC et al (2022) Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial infarction. Redox Biol 54:102384","journal-title":"Redox Biol"},{"key":"773_CR24","first-page":"144","volume":"16","author":"P Li","year":"2010","unstructured":"Li P, Li X, Chen JW, Wu LL (2010) Spectrum-effect relationship of active components from Taohong Siwu tang in dysmenorrheal model mice. Chin J Exp Tradit Med Formulae 16:144\u2013149","journal-title":"Chin J Exp Tradit Med Formulae"},{"key":"773_CR25","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/925625","volume":"2013","author":"Q Liu","year":"2013","unstructured":"Liu Q, Li J, Wang J, Li J, Janicki JS, Fan D (2013) Effects and mechanisms of chinese herbal medicine in ameliorating myocardial ischemia-reperfusion injury. Evid Based Complement Alternat Med 2013:925625","journal-title":"Evid Based Complement Alternat Med"},{"key":"773_CR26","doi-asserted-by":"publisher","first-page":"5198278","DOI":"10.1155\/2019\/5198278","volume":"2019","author":"ZR Luo","year":"2019","unstructured":"Luo ZR, Li H, Xiao ZX, Shao SJ, Zhao TT, Zhao Y, Mou FF, Yu B, Guo HD (2019) Taohong Siwu decoction exerts a beneficial effect on cardiac function by possibly improving the microenvironment and decreasing mitochondrial fission after myocardial infarction. Cardiol Res Pract 2019:5198278","journal-title":"Cardiol Res Pract"},{"key":"773_CR27","first-page":"1","volume":"17","author":"LY Ma","year":"2020","unstructured":"Ma LY, Chen WW, Gao RL, Liu LS, Zhu ML, Wang YJ, Wu ZS, Li HJ, Gu DF, Yang YJ et al (2020) China cardiovascular diseases report 2018: an updated summary. J Geriatr Cardiol 17:1\u20138","journal-title":"J Geriatr Cardiol"},{"key":"773_CR28","doi-asserted-by":"publisher","first-page":"16235","DOI":"10.3390\/molecules200916235","volume":"20","author":"XH Ma","year":"2015","unstructured":"Ma XH, Ma Y, Tang JF, He YL, Liu YC, Ma XJ, Shen Y, Cui GH, Lin HX, Rong QX et al (2015) The biosynthetic pathways of tanshinones and phenolic acids in salvia miltiorrhiza. Molecules 20:16235\u201316254","journal-title":"Molecules"},{"key":"773_CR29","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.jep.2014.03.010","volume":"153","author":"M Maiwulanjiang","year":"2014","unstructured":"Maiwulanjiang M, Chen J, Xin G, Gong AG, Miernisha A, Du CY, Lau KM, Lee PS, Chen J, Dong TT et al (2014) The volatile oil of Nardostachyos Radix et Rhizoma inhibits the oxidative stress-induced cell injury via reactive oxygen species scavenging and Akt activation in H9c2 cardiomyocyte. J Ethnopharmacol 153:491\u2013498","journal-title":"J Ethnopharmacol"},{"key":"773_CR30","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1080\/13880209.2022.2116054","volume":"60","author":"WT Meng","year":"2022","unstructured":"Meng WT, Xiao ZX, Li H, Wang YC, Zhao Y, Zhu Y, Guo HD (2022) Modified Taohong Siwu decoction improves cardiac function after myocardial ischaemia and reperfusion in rats by promoting endogenous stem cell mobilization and regulating metabolites. Pharm Biol 60:1721\u20131731","journal-title":"Pharm Biol"},{"key":"773_CR31","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1161\/ATVBAHA.107.151175","volume":"28","author":"JB Morris","year":"2008","unstructured":"Morris JB, Olzinski AR, Bernard RE, Aravindhan K, Mirabile RC, Boyce R, Willette RN, Jucker BM (2008) p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of atherosclerosis: MRI assessment. Arterioscler Thromb Vasc Biol 28:265\u2013271","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"773_CR32","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/S0006-2952(03)00478-7","volume":"66","author":"C Park","year":"2003","unstructured":"Park C, So HS, Shin CH, Baek SH, Moon BS, Shin SH, Lee HS, Lee DW, Park R (2003) Quercetin protects the hydrogen peroxide-induced apoptosis via inhibition of mitochondrial dysfunction in H9c2 cardiomyoblast cells. Biochem Pharmacol 66:1287\u20131295","journal-title":"Biochem Pharmacol"},{"key":"773_CR33","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.jep.2014.02.019","volume":"153","author":"ES Park","year":"2014","unstructured":"Park ES, Kang JC, Jang YC, Park JS, Jang SY, Kim DE, Kim B, Shin HS (2014) Cardioprotective effects of rhamnetin in H9c2 cardiomyoblast cells under H(2)O(2)-induced apoptosis. J Ethnopharmacol 153:552\u2013560","journal-title":"J Ethnopharmacol"},{"key":"773_CR34","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.taap.2013.01.004","volume":"268","author":"ES Park","year":"2013","unstructured":"Park ES, Kang JC, Kang DH, Jang YC, Yi KY, Chung HJ, Park JS, Kim B, Feng ZP, Shin HS (2013) 5-AIQ inhibits H2O2-induced apoptosis through reactive oxygen species scavenging and Akt\/GSK-3beta signaling pathway in H9c2 cardiomyocytes. Toxicol Appl Pharmacol 268:90\u201398","journal-title":"Toxicol Appl Pharmacol"},{"key":"773_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0355-7","volume":"51","author":"JN Peoples","year":"2019","unstructured":"Peoples JN, Saraf A, Ghazal N, Pham TT, Kwong JQ (2019) Mitochondrial dysfunction and oxidative stress in heart disease. Exp Mol Med 51:1\u201313","journal-title":"Exp Mol Med"},{"key":"773_CR36","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.freeradbiomed.2010.05.004","volume":"49","author":"S Qu","year":"2010","unstructured":"Qu S, Zhu H, Wei X, Zhang C, Jiang L, Liu Y, Luo Q, Xiao X (2010) Oxidative stress-mediated up-regulation of myocardial ischemic preconditioning up-regulated protein 1 gene expression in H9c2 cardiomyocytes is regulated by cyclic AMP-response element binding protein. Free Radic Biol Med 49:580\u2013586","journal-title":"Free Radic Biol Med"},{"key":"773_CR37","doi-asserted-by":"publisher","first-page":"5839","DOI":"10.1073\/pnas.1804932115","volume":"115","author":"R Radi","year":"2018","unstructured":"Radi R (2018) Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine. Proc Natl Acad Sci U S A 115:5839\u20135848","journal-title":"Proc Natl Acad Sci U S A"},{"key":"773_CR38","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1098\/rstb.2007.2121","volume":"362","author":"M Radisic","year":"2007","unstructured":"Radisic M, Park H, Gerecht S, Cannizzaro C, Langer R, Vunjak-Novakovic G (2007) Biomimetic approach to cardiac tissue engineering. Philos Trans R Soc Lond B Biol Sci 362:1357\u20131368","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"773_CR39","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.33549\/physiolres.932396","volume":"61","author":"T Ravingerova","year":"2012","unstructured":"Ravingerova T, Carnicka S, Nemcekova M, Ledvenyiova V, Adameova A, Khandelwal VK, Zalesak M, Kolar F (2012) The impact of lifestyle-related risk factors on cardiac response to ischemia and possibilities to restore impaired ischemic tolerance. Physiol Res 61:S1-10","journal-title":"Physiol Res"},{"key":"773_CR40","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1161\/ATVBAHA.110.209205","volume":"30","author":"L Sarov-Blat","year":"2010","unstructured":"Sarov-Blat L, Morgan JM, Fernandez P, James R, Fang Z, Hurle MR, Baidoo C, Willette RN, Lepore JJ, Jensen SE, Sprecher DL (2010) Inhibition of p38 mitogen-activated protein kinase reduces inflammation after coronary vascular injury in humans. Arterioscler Thromb Vasc Biol 30:2256\u20132263","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"773_CR41","doi-asserted-by":"publisher","first-page":"5063","DOI":"10.1111\/jcmm.14367","volume":"23","author":"D Shen","year":"2019","unstructured":"Shen D, Chen R, Zhang L, Rao Z, Ruan Y, Li L, Chu M, Zhang Y (2019) Sulodexide attenuates endoplasmic reticulum stress induced by myocardial ischaemia\/reperfusion by activating the PI3K\/Akt pathway. J Cell Mol Med 23:5063\u20135075","journal-title":"J Cell Mol Med"},{"key":"773_CR42","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1006\/bbrc.1999.1649","volume":"265","author":"CY Su","year":"1999","unstructured":"Su CY, Chong KY, Edelstein K, Lille S, Khardori R, Lai CC (1999) Constitutive hsp70 attenuates hydrogen peroxide-induced membrane lipid peroxidation. Biochem Biophys Res Commun 265:279\u2013284","journal-title":"Biochem Biophys Res Commun"},{"key":"773_CR43","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.biopha.2018.09.002","volume":"109","author":"J Sun","year":"2019","unstructured":"Sun J, Yu X, Huangpu H, Yao F (2019) Ginsenoside Rb3 protects cardiomyocytes against hypoxia\/reoxygenation injury via activating the antioxidation signaling pathway of PERK\/Nrf2\/HMOX1. Biomed Pharmacother 109:254\u2013261","journal-title":"Biomed Pharmacother"},{"key":"773_CR44","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12967-017-1189-5","volume":"15","author":"A Szobi","year":"2017","unstructured":"Szobi A, Goncalvesova E, Varga ZV, Leszek P, Kusmierczyk M, Hulman M, Kyselovic J, Ferdinandy P, Adameova A (2017) Analysis of necroptotic proteins in failing human hearts. J Transl Med 15:86","journal-title":"J Transl Med"},{"key":"773_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113838","volume":"270","author":"Z Tan","year":"2021","unstructured":"Tan Z, Jiang X, Zhou W, Deng B, Cai M, Deng S, Xu Y, Ding W, Chen G, Chen R et al (2021) Taohong siwu decoction attenuates myocardial fibrosis by inhibiting fibrosis proliferation and collagen deposition via TGFBR1 signaling pathway. J Ethnopharmacol 270:113838","journal-title":"J Ethnopharmacol"},{"key":"773_CR46","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/jcb.10568","volume":"89","author":"H Tanaka","year":"2003","unstructured":"Tanaka H, Sakurai K, Takahashi K, Fujimoto Y (2003) Requirement of intracellular free thiols for hydrogen peroxide-induced hypertrophy in cardiomyocytes. J Cell Biochem 89:944\u2013955","journal-title":"J Cell Biochem"},{"key":"773_CR47","doi-asserted-by":"publisher","first-page":"651","DOI":"10.3389\/fphar.2020.00651","volume":"11","author":"T Tao","year":"2020","unstructured":"Tao T, He T, Mao H, Wu X, Liu X (2020) Non-targeted metabolomic profiling of coronary heart disease patients with Taohong Siwu decoction treatment. Front Pharmacol 11:651","journal-title":"Front Pharmacol"},{"key":"773_CR48","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.amjcard.2010.03.032","volume":"106","author":"AT Turer","year":"2010","unstructured":"Turer AT, Hill JA (2010) Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy. Am J Cardiol 106:360\u2013368","journal-title":"Am J Cardiol"},{"key":"773_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.590453","volume":"11","author":"M Wang","year":"2020","unstructured":"Wang M, Liu Z, Hu S, Duan X, Zhang Y, Peng C, Peng D, Han L (2020a) Taohong Siwu decoction ameliorates ischemic stroke injury via suppressing pyroptosis. Front Pharmacol 11:590453","journal-title":"Front Pharmacol"},{"key":"773_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.570867","volume":"11","author":"R Wang","year":"2020","unstructured":"Wang R, Wang M, Zhou J, Wu D, Ye J, Sun G, Sun X (2020b) Saponins in Chinese herbal medicine exerts protection in myocardial ischemia-reperfusion injury: possible mechanism and target analysis. Front Pharmacol 11:570867","journal-title":"Front Pharmacol"},{"key":"773_CR51","doi-asserted-by":"publisher","first-page":"10159","DOI":"10.1080\/21655979.2022.2060900","volume":"13","author":"T Wang","year":"2022","unstructured":"Wang T, Li Z, Xia S, Xu Z, Chen X, Sun H (2022) Dexmedetomidine promotes cell proliferation and inhibits cell apoptosis by regulating LINC00982 and activating the phosphoinositide-3-kinase (PI3K)\/protein kinase B (AKT) signaling in hypoxia\/reoxygenation-induced H9c2 cells. Bioengineered 13:10159\u201310167","journal-title":"Bioengineered"},{"key":"773_CR52","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ejphar.2010.03.035","volume":"636","author":"T Wang","year":"2010","unstructured":"Wang T, Yu X, Qu S, Xu H, Han B, Sui D (2010) Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats. Eur J Pharmacol 636:121\u2013125","journal-title":"Eur J Pharmacol"},{"key":"773_CR53","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s13046-020-01595-x","volume":"39","author":"X Wang","year":"2020","unstructured":"Wang X, Wang Q, Li W, Zhang Q, Jiang Y, Guo D, Sun X, Lu W, Li C, Wang Y (2020c) TFEB-NF-kappaB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity. J Exp Clin Cancer Res 39:93","journal-title":"J Exp Clin Cancer Res"},{"key":"773_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.644116","volume":"12","author":"YT Wu","year":"2021","unstructured":"Wu YT, Xie LP, Hua Y, Xu HL, Chen GH, Han X, Tan ZB, Fan HJ, Chen HM, Li J et al (2021) Tanshinone I inhibits oxidative stress-induced cardiomyocyte injury by modulating Nrf2 signaling. Front Pharmacol 12:644116","journal-title":"Front Pharmacol"},{"key":"773_CR55","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14078","volume":"46","author":"N Yan","year":"2022","unstructured":"Yan N, Xiao C, Wang X, Xu Z, Yang J (2022) Tanshinone IIA from Salvia miltiorrhiza exerts anti-fibrotic effects on cardiac fibroblasts and rat heart tissues by suppressing the levels of pro-fibrotic factors: the key role of miR-618. J Food Biochem 46:e14078","journal-title":"J Food Biochem"},{"key":"773_CR56","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1111\/j.1582-4934.2012.01600.x","volume":"16","author":"WJ Yang","year":"2012","unstructured":"Yang WJ, Li SH, Weisel RD, Liu SM, Li RK (2012) Cell fusion contributes to the rescue of apoptotic cardiomyocytes by bone marrow cells. J Cell Mol Med 16:3085\u20133095","journal-title":"J Cell Mol Med"},{"key":"773_CR57","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.ijbiomac.2019.11.063","volume":"155","author":"Y Yang","year":"2020","unstructured":"Yang Y, Ding Z, Zhong R, Xia T, Wang W, Zhao H, Wang Y, Shu Z (2020) Cardioprotective effects of a Fructus Aurantii polysaccharide in isoproterenol-induced myocardial ischemic rats. Int J Biol Macromol 155:995\u20131002","journal-title":"Int J Biol Macromol"},{"key":"773_CR58","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.ejphar.2012.11.005","volume":"699","author":"Y Yin","year":"2013","unstructured":"Yin Y, Guan Y, Duan J, Wei G, Zhu Y, Quan W, Guo C, Zhou D, Wang Y, Xi M, Wen A (2013) Cardioprotective effect of Danshensu against myocardial ischemia\/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1\/2 phosphorylation. Eur J Pharmacol 699:219\u2013226","journal-title":"Eur J Pharmacol"},{"key":"773_CR59","first-page":"14793","volume":"8","author":"J Yu","year":"2015","unstructured":"Yu J, Wang L, Akinyi M, Li Y, Duan Z, Zhu Y, Fan G (2015) Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt\/ERK1\/2\/Nrf2 signaling. Int J Clin Exp Med 8:14793\u201314804","journal-title":"Int J Clin Exp Med"},{"key":"773_CR60","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.intimp.2019.04.060","volume":"73","author":"BF Zhang","year":"2019","unstructured":"Zhang BF, Jiang H, Chen J, Guo X, Li Y, Hu Q, Yang S (2019) Nobiletin ameliorates myocardial ischemia and reperfusion injury by attenuating endoplasmic reticulum stress-associated apoptosis through regulation of the PI3K\/AKT signal pathway. Int Immunopharmacol 73:98\u2013107","journal-title":"Int Immunopharmacol"},{"key":"773_CR61","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3892\/mmr.2016.5243","volume":"14","author":"JM Zhou","year":"2016","unstructured":"Zhou JM, Xu ZL, Li N, Zhao YW, Wang ZZ, Xiao W (2016) Identification of cardioprotective agents from traditional Chinese medicine against oxidative damage. Mol Med Rep 14:77\u201388","journal-title":"Mol Med Rep"},{"key":"773_CR62","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s13020-021-00458-7","volume":"16","author":"Y Zhuo","year":"2021","unstructured":"Zhuo Y, Yuan R, Chen X, He J, Chen Y, Zhang C, Sun K, Yang S, Liu Z, Gao H (2021) Tanshinone I exerts cardiovascular protective effects in vivo and in vitro through inhibiting necroptosis via Akt\/Nrf2 signaling pathway. Chin Med 16:48","journal-title":"Chin Med"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-023-00773-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-023-00773-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-023-00773-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T15:35:02Z","timestamp":1688571302000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-023-00773-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["773"],"URL":"https:\/\/doi.org\/10.1007\/s11626-023-00773-3","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"17 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}