{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T18:30:26Z","timestamp":1794421826128,"version":"4.9.1"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100006378","name":"Universitas Indonesia","doi-asserted-by":"publisher","award":["PUTI Q2 Batch 2 2022-2023"],"award-info":[{"award-number":["PUTI Q2 Batch 2 2022-2023"]}],"id":[{"id":"10.13039\/501100006378","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NUS","award":["Fellowship"],"award-info":[{"award-number":["Fellowship"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s11626-023-00817-8","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T19:03:00Z","timestamp":1702926180000},"page":"747-763","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Liver organoids cocultured on decellularized native liver scaffolds as a bridging therapy improves survival from liver failure in rabbits"],"prefix":"10.1007","volume":"59","author":[{"given":"Wahyunia Likhayati","family":"Septiana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wulan","family":"Ayudyasari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardian","family":"Gunardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne Adiwinata","family":"Pawitan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gowri Manohari","family":"Balachander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanry","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8578-7505","authenticated-orcid":false,"given":"Radiana Dhewayani","family":"Antarianto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,18]]},"reference":[{"key":"817_CR1","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3389\/fcell.2019.00345","volume":"7","author":"S Akbari","year":"2019","unstructured":"Akbari S, Arslan N, Senturk S, Erdal E (2019) Next-generation liver medicine using organoid models. Front Cell Dev Biol 7:345. https:\/\/doi.org\/10.3389\/fcell.2019.00345","journal-title":"Front Cell Dev Biol"},{"key":"817_CR2","doi-asserted-by":"publisher","unstructured":"Antarianto RD, Dewi AAAP, Pragiwaksana A, Pawitan JA (2019) Decellularization of liver cubes using multiple site syringe injection for generating native liver scaffold: preliminary report. AIP Conference Proceedings. AIP Publishing LLC, pp 040005. https:\/\/doi.org\/10.1063\/1.5139367","DOI":"10.1063\/1.5139367"},{"key":"817_CR3","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s10735-022-10085-7","volume":"53","author":"RD Antarianto","year":"2022","unstructured":"Antarianto RD, Mahmood A, Giselvania A, Asri Dewi AAP, Gustinanda J, Pawitan JA (2022a) Inventing engineered organoids for end-stage liver failure patients. J Mol Histol 53:611\u2013621. https:\/\/doi.org\/10.1007\/s10735-022-10085-7","journal-title":"J Mol Histol"},{"key":"817_CR4","doi-asserted-by":"publisher","first-page":"2061263","DOI":"10.1080\/15476278.2022.2061263","volume":"18","author":"RD Antarianto","year":"2022","unstructured":"Antarianto RD, Pragiwaksana A, Septiana WL, Mazfufah NF, Mahmood A (2022b) Hepatocyte differentiation from iPSCs or MSCs in decellularized liver scaffold: cell\u2013ECM adhesion, spatial distribution, and hepatocyte maturation profile. Organogenesis 18:2061263","journal-title":"Organogenesis"},{"key":"817_CR5","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1056\/NEJMra1914900","volume":"382","author":"V Arroyo","year":"2020","unstructured":"Arroyo V, Moreau R, Jalan R (2020) Acute-on-chronic liver failure. N Engl J Med 382:2137\u20132145. https:\/\/doi.org\/10.1056\/NEJMra1914900","journal-title":"N Engl J Med"},{"key":"817_CR6","doi-asserted-by":"publisher","first-page":"666138","DOI":"10.3389\/fphys.2021.666138","volume":"12","author":"Y-l Bao","year":"2021","unstructured":"Bao Y-l, Wang L, Pan H-t, Zhang T-r, Chen Y-h, Xu S-j, Mao X-l, Li S-w (2021) Animal and organoid models of liver fibrosis. Front Physiol 12:666138. https:\/\/doi.org\/10.3389\/fphys.2021.666138","journal-title":"Front Physiol"},{"key":"817_CR7","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/sctm.18-0084","volume":"8","author":"SJ Blackford","year":"2019","unstructured":"Blackford SJ, Ng SS, Segal JM, King AJ, Austin AL, Kent D, Moore J, Sheldon M, Ilic D, Dhawan A (2019) Validation of current good manufacturing practice compliant human pluripotent stem cell-derived hepatocytes for cell-based therapy. Stem Cells Transl Med 8:124\u2013137. https:\/\/doi.org\/10.1002\/sctm.18-0084","journal-title":"Stem Cells Transl Med"},{"key":"817_CR8","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1038\/s41467-020-15058-6","volume":"11","author":"R Boon","year":"2020","unstructured":"Boon R, Kumar M, Tricot T, Elia I, Ordovas L, Jacobs F, One J, De Smedt J, Eelen G, Bird M (2020) Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines. Nat Commun 11:1393. https:\/\/doi.org\/10.1038\/s41467-020-15058-6","journal-title":"Nat Commun"},{"key":"817_CR9","doi-asserted-by":"publisher","unstructured":"Bouffi C, Wikenheiser-Brokamp KA, Chaturvedi P, Sundaram N, Goddard GR, Wunderlich M, Brown NE, Staab JF, Latanich R, Zachos NC (2023) In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice.\u00a0Nat Biotechnol 1\u20138. https:\/\/doi.org\/10.1038\/s41587-022-01558-x","DOI":"10.1038\/s41587-022-01558-x"},{"key":"817_CR10","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.jhep.2019.05.022","volume":"71","author":"O Braissant","year":"2019","unstructured":"Braissant O, Rackayov\u00e1 V, Pierzchala K, Grosse J, McLin VA, Cudalbu C (2019) Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy. J Hepatol 71:505\u2013515","journal-title":"J Hepatol"},{"key":"817_CR11","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1046\/j.1440-1681.2000.03381.x","volume":"27","author":"C Brandao","year":"2000","unstructured":"Brandao C, Ferreira H, Piovesana H, Polimeno N, Ferraz J, De Nucci G, Pedrazzoli J Jr (2000) Development of an experimental model of liver cirrhosis in rabbits. Clin Exp Pharmacol Physiol 27:987\u2013990. https:\/\/doi.org\/10.1046\/j.1440-1681.2000.03381.x","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"817_CR12","doi-asserted-by":"publisher","first-page":"151795","DOI":"10.1016\/j.acthis.2021.151795","volume":"123","author":"GM B\u00fcrgisser","year":"2021","unstructured":"B\u00fcrgisser GM, Evrova O, Heuberger DM, Rieber J, Giovanoli P, Calcagni M, Buschmann J (2021) Delineation of the healthy rabbit liver by immunohistochemistry\u2013a technical note. Acta Histochem 123:151795","journal-title":"Acta Histochem"},{"key":"817_CR13","doi-asserted-by":"publisher","first-page":"748576","DOI":"10.3389\/fcell.2021.748576","volume":"9","author":"M Chang","year":"2021","unstructured":"Chang M, Bogacheva MS, Lou Y-R (2021) Challenges for the applications of human pluripotent stem cell-derived liver organoids. Frontiers Cell Develop Biol 9:748576. https:\/\/doi.org\/10.3389\/fcell.2021.748576","journal-title":"Frontiers Cell Develop Biol"},{"key":"817_CR14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.17085\/apm.2020.15.1.19","volume":"15","author":"I Cho","year":"2020","unstructured":"Cho I, Koo BN, Kam EH, Lee SK, Oh H, Kim SY (2020) Bile duct ligation of C57BL\/6 mice as a model of hepatic encephalopathy. Anesth Pain Med Seoul 15:19\u201327. https:\/\/doi.org\/10.17085\/apm.2020.15.1.19","journal-title":"Anesth Pain Med Seoul"},{"key":"817_CR15","doi-asserted-by":"publisher","unstructured":"Coletta M, Nicolini D, Cacciaguerra AB, Mazzocato S, Rossi R, Vivarelli M (2017) Bridging patients with hepatocellular cancer waiting for liver transplant: all the patients are the same?\u00a0Transl Gastroenterol Hepatol 2. https:\/\/doi.org\/10.21037\/tgh.2017.09.01","DOI":"10.21037\/tgh.2017.09.01"},{"key":"817_CR16","doi-asserted-by":"publisher","first-page":"813","DOI":"10.3390\/biom9120813","volume":"9","author":"S Croce","year":"2019","unstructured":"Croce S, Peloso A, Zoro T, Avanzini MA, Cobianchi L (2019) A hepatic scaffold from decellularized liver tissue: food for thought. Biomolecules 9:813. https:\/\/doi.org\/10.3390\/biom9120813","journal-title":"Biomolecules"},{"key":"817_CR17","doi-asserted-by":"publisher","first-page":"831477","DOI":"10.3389\/fbioe.2022.831477","volume":"10","author":"Q Dai","year":"2022","unstructured":"Dai Q, Jiang W, Huang F, Song F, Zhang J, Zhao H (2022) Recent advances in liver engineering with decellularized scaffold. Frontiers in Bioengineering Biotechnol 10:831477. https:\/\/doi.org\/10.3389\/fbioe.2022.831477","journal-title":"Frontiers in Bioengineering Biotechnol"},{"key":"817_CR18","doi-asserted-by":"publisher","first-page":"204173142211053","DOI":"10.1177\/20417314221105305","volume":"13","author":"ML Dias","year":"2022","unstructured":"Dias ML, Paranhos BA, Goldenberg RCdS (2022) Liver scaffolds obtained by decellularization: a transplant perspective in liver bioengineering. J Tissue Eng 13:20417314221105304","journal-title":"J Tissue Eng"},{"key":"817_CR19","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/S0736-0266(01)00037-7","volume":"19","author":"MA DiMicco","year":"2001","unstructured":"DiMicco MA, Sah RL (2001) Integrative cartilage repair: adhesive strength is correlated with collagen deposition. J Orthop Res 19:1105\u20131112","journal-title":"J Orthop Res"},{"key":"817_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0094-1","volume":"50","author":"PJ Esteves","year":"2018","unstructured":"Esteves PJ, Abrantes J, Baldauf H-M, BenMohamed L, Chen Y, Christensen N, Gonz\u00e1lez-Gallego J, Giacani L, Hu J, Kaplan G (2018) The wide utility of rabbits as models of human diseases. Exp Mol Med 50:1\u201310","journal-title":"Exp Mol Med"},{"key":"817_CR21","doi-asserted-by":"publisher","unstructured":"Fathi I, Eltawila A (2017) Whole-liver decellularization: advances and insights into current understanding. Xenotransplant New Insights 139. https:\/\/doi.org\/10.5772\/intechopen.69487","DOI":"10.5772\/intechopen.69487"},{"key":"817_CR22","first-page":"35","volume":"68","author":"R Garg","year":"2020","unstructured":"Garg R, Kaur K, Kaur A, Kaur R, Bansal P, Kaur S, Khutan H, Aggarwal S (2020) Association of CD4\/CD8 ratio with viral load, genotype and cirrhosis in chronic hepatitis C. J Assoc Physicians India 68:35\u201338","journal-title":"J Assoc Physicians India"},{"key":"817_CR23","doi-asserted-by":"publisher","unstructured":"Garrido M, Escobar C, Zamora C, Rejas C, Varas J, P\u00e1rraga M, San Mart\u00edn S, Montedonico S (2017) Bile duct ligature in young rats: a revisited animal model for biliary atresia. EuropeaN Journal of Histochemistry: EJH 61. https:\/\/doi.org\/10.4081\/ejh.2017.2803","DOI":"10.4081\/ejh.2017.2803"},{"key":"817_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-019-1367-x","volume":"10","author":"E Goulart","year":"2019","unstructured":"Goulart E, de Caires-Junior LC, Telles-Silva KA, Araujo BHS, Kobayashi GS, Musso CM, Assoni AF, Oliveira D, Caldini E, Gerstenhaber JA (2019) Adult and iPS-derived non-parenchymal cells regulate liver organoid development through differential modulation of Wnt and TGF-\u03b2. Stem Cell Res Ther 10:1\u201311","journal-title":"Stem Cell Res Ther"},{"key":"817_CR25","doi-asserted-by":"publisher","first-page":"574047","DOI":"10.3389\/fmed.2021.574047","volume":"8","author":"SP Harrison","year":"2021","unstructured":"Harrison SP, Baumgarten SF, Verma R, Lunov O, Dejneka A, Sullivan GJ (2021) Liver organoids: recent developments, limitations and potential. Front Med 8:574047. https:\/\/doi.org\/10.3389\/fmed.2021.574047","journal-title":"Front Med"},{"key":"817_CR26","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3390\/biomedicines11020384","volume":"11","author":"M Hayashi","year":"2023","unstructured":"Hayashi M, Kuwabara Y, Ito K, Hojo Y, Arai F, Kamijima K, Takeiri M, Wang X, Diao P, Nakayama J (2023) Development of the rabbit NASH model resembling human NASH and atherosclerosis. Biomedicines 11:384. https:\/\/doi.org\/10.3390\/biomedicines11020384","journal-title":"Biomedicines"},{"key":"817_CR27","doi-asserted-by":"publisher","first-page":"3634","DOI":"10.3748\/wjg.v25.i27.3634","volume":"25","author":"Y-T He","year":"2019","unstructured":"He Y-T, Qi Y-N, Zhang B-Q, Li J-B, Bao J (2019) Bioartificial liver support systems for acute liver failure: a systematic review and meta-analysis of the clinical and preclinical literature. World J Gastroenterol 25:3634","journal-title":"World J Gastroenterol"},{"key":"817_CR28","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1136\/gutjnl-2016-312670","volume":"66","author":"R Hernaez","year":"2017","unstructured":"Hernaez R, Sol\u00e0 E, Moreau R, Gin\u00e8s P (2017) Acute-on-Chronic Liver Failure: an Update Gut 66:541\u2013553. https:\/\/doi.org\/10.1136\/gutjnl-2016-312670","journal-title":"Acute-on-Chronic Liver Failure: an Update Gut"},{"key":"817_CR29","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1002\/hep.32030","volume":"74","author":"H Hirao","year":"2021","unstructured":"Hirao H, Ito T, Kadono K, Kojima H, Naini BV, Nakamura K, Kageyama S, Busuttil RW, Kupiec-Weglinski JW, Kaldas FM (2021) Donor hepatic occult collagen deposition predisposes to peritransplant stress and impacts human liver transplantation. Hepatology 74:2759\u20132773. https:\/\/doi.org\/10.1002\/hep.32030","journal-title":"Hepatology"},{"key":"817_CR30","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1158\/0008-5472.CAN-15-2402","volume":"76","author":"CG Hubert","year":"2016","unstructured":"Hubert CG, Rivera M, Spangler LC, Wu Q, Mack SC, Prager BC, Couce M, McLendon RE, Sloan AE, Rich JN (2016) A three-dimensional organoid culture system derived from human glioblastomas recapitulates the hypoxic gradients and cancer stem cell heterogeneity of tumors found in vivo brain cancer stem cell organoids. Can Res 76:2465\u20132477","journal-title":"Can Res"},{"key":"817_CR31","doi-asserted-by":"publisher","unstructured":"Janel N, Noll C (2014) Protection and reversal of hepatic fibrosis by polyphenols. Polyphenols in human health and disease. Elsevier, pp 665\u2013679. https:\/\/doi.org\/10.1016\/B978-0-12-398456-2.00051-7","DOI":"10.1016\/B978-0-12-398456-2.00051-7"},{"key":"817_CR32","doi-asserted-by":"publisher","first-page":"bpac034","DOI":"10.1093\/biomethods\/bpac034","volume":"8","author":"Y Kamishibahara","year":"2022","unstructured":"Kamishibahara Y, Okamoto S, Ohkuma T, Taniguchi H (2022) Stabilized generation of human iPSC-derived liver organoids using a modified coating approach. Biol Methods Protocols 8:bpac034. https:\/\/doi.org\/10.1093\/biomethods\/bpac034","journal-title":"Biol Methods Protocols"},{"key":"817_CR33","doi-asserted-by":"publisher","unstructured":"Kanter M, Yener Z (2001) A rabbit model for liver fibrosis.\u00a0Scand J Lab Anim Sci 28. https:\/\/doi.org\/10.23675\/sjlas.v28i4.861","DOI":"10.23675\/sjlas.v28i4.861"},{"key":"817_CR34","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13287-023-03235-5","volume":"14","author":"HJ Kim","year":"2023","unstructured":"Kim HJ, Kim G, Chi KY, Kim H, Jang YJ, Jo S, Lee J, Lee Y, Woo D-H, Han C (2023) Generation of multilineage liver organoids with luminal vasculature and bile ducts from human pluripotent stem cells via modulation of Notch signaling. Stem Cell Res Ther 14:19","journal-title":"Stem Cell Res Ther"},{"key":"817_CR35","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.3390\/cells11081258","volume":"11","author":"H Kojima","year":"2022","unstructured":"Kojima H, Yagi H, Kushige H, Toda Y, Takayama K, Masuda S, Morisaku T, Tsuchida T, Kuroda K, Hirukawa K (2022) Decellularized organ-derived scaffold is a promising carrier for human induced pluripotent stem cells-derived hepatocytes. Cells 11:1258","journal-title":"Cells"},{"key":"817_CR36","doi-asserted-by":"publisher","first-page":"410","DOI":"10.3390\/cells9020410","volume":"9","author":"HS Kruitwagen","year":"2020","unstructured":"Kruitwagen HS, Oosterhoff LA, van Wolferen ME, Chen C, Nantasanti Assawarachan S, Schneeberger K, Kummeling A, van Straten G, Akkerdaas IC, Vinke CR (2020) Long-term survival of transplanted autologous canine liver organoids in a COMMD1-deficient dog model of metabolic liver disease. Cells 9:410. https:\/\/doi.org\/10.3390\/cells9020410","journal-title":"Cells"},{"key":"817_CR37","doi-asserted-by":"publisher","first-page":"e9968","DOI":"10.7717\/peerj.9968","volume":"8","author":"K Kulkeaw","year":"2020","unstructured":"Kulkeaw K, Tubsuwan A, Tongkrajang N, Whangviboonkij N (2020) Generation of human liver organoids from pluripotent stem cell-derived hepatic endoderms. PeerJ 8:e9968. https:\/\/doi.org\/10.7717\/peerj.9968","journal-title":"PeerJ"},{"key":"817_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13619-021-00089-1","volume":"10","author":"DTUH Lam","year":"2021","unstructured":"Lam DTUH, Dan YY, Chan Y-S, Ng H-H (2021) Emerging liver organoid platforms and technologies. Cell Regeneration 10:1\u201319. https:\/\/doi.org\/10.1186\/s13619-021-00089-1","journal-title":"Cell Regeneration"},{"key":"817_CR39","doi-asserted-by":"publisher","first-page":"796","DOI":"10.3390\/bioengineering9120796","volume":"9","author":"J Li","year":"2022","unstructured":"Li J, Chu J, Lui VCH, Chen S, Chen Y, Tam PKH (2022) Bioengineering liver organoids for diseases modelling and transplantation. Bioengineering 9:796. https:\/\/doi.org\/10.3390\/bioengineering9120796","journal-title":"Bioengineering"},{"key":"817_CR40","doi-asserted-by":"publisher","first-page":"110049","DOI":"10.1016\/j.matdes.2021.110049","volume":"210","author":"Y Li","year":"2021","unstructured":"Li Y, Liu Y, Li R, Bai H, Zhu Z, Zhu L, Zhu C, Che Z, Liu H, Wang J (2021) Collagen-based biomaterials for bone tissue engineering. Mater Des 210:110049","journal-title":"Mater Des"},{"key":"817_CR41","doi-asserted-by":"publisher","first-page":"2202505","DOI":"10.1002\/advs.202202505","volume":"9","author":"G Liu","year":"2022","unstructured":"Liu G, Wei J, Li X, Tian M, Wang Z, Shen C, Sun W, Li C, Li X, Lv E (2022b) Near-infrared-responded high sensitivity nanoprobe for steady and visualized detection of albumin in hepatic organoids and mouse liver. Advanced Science 9:2202505. https:\/\/doi.org\/10.1002\/advs.202202505","journal-title":"Advanced Science"},{"key":"817_CR42","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.3389\/fphys.2022.956244","volume":"13","author":"Q Liu","year":"2022","unstructured":"Liu Q, Zeng A, Liu Z, Wu C, Song L (2022a) Liver organoids: from fabrication to application in liver diseases. Front Physiol 13:1489. https:\/\/doi.org\/10.3389\/fphys.2022.956244","journal-title":"Front Physiol"},{"key":"817_CR43","doi-asserted-by":"publisher","first-page":"925135","DOI":"10.1155\/2012\/925135","volume":"2012","author":"RV Luckheeram","year":"2012","unstructured":"Luckheeram RV, Zhou R, Verma AD, Xia B (2012) CD4+ T cells: differentiation and functions. Clin Dev Immunol 2012:925135. https:\/\/doi.org\/10.1155\/2012\/925135","journal-title":"Clin Dev Immunol"},{"key":"817_CR44","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3390\/cells9020420","volume":"9","author":"A Messina","year":"2020","unstructured":"Messina A, Luce E, Hussein M, Dubart-Kupperschmitt A (2020) Pluripotent-stem-cell-derived hepatic cells: hepatocytes and organoids for liver therapy and regeneration. Cells 9:420. https:\/\/doi.org\/10.3390\/cells9020420","journal-title":"Cells"},{"key":"817_CR45","doi-asserted-by":"publisher","unstructured":"Muscate F, Woestemeier A, Gagliani N (2021) Functional heterogeneity of CD4+ T cells in liver inflammation.\u00a0Semin Immunol. Springer, pp 549\u2013561. https:\/\/doi.org\/10.1007\/s00281-021-00881-w","DOI":"10.1007\/s00281-021-00881-w"},{"key":"817_CR46","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/0022-4804(88)90144-8","volume":"45","author":"SI Myers","year":"1988","unstructured":"Myers SI, Haley-Russell D, Parks L, Husband K (1988) Common bile duct ligation in rabbit: a new model of acute cholecystitis description of histology and bile analysis. J Surg Res 45:556\u2013564","journal-title":"J Surg Res"},{"key":"817_CR47","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1021\/acs.biomac.0c00045","volume":"21","author":"J Nicolas","year":"2020","unstructured":"Nicolas J, Magli S, Rabbachin L, Sampaolesi S, Nicotra F, Russo L (2020) 3D extracellular matrix mimics: fundamental concepts and role of materials chemistry to influence stem cell fate. Biomacromol 21:1968\u20131994. https:\/\/doi.org\/10.1021\/acs.biomac.0c00045","journal-title":"Biomacromol"},{"key":"817_CR48","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ebiom.2018.08.014","volume":"35","author":"Y-Z Nie","year":"2018","unstructured":"Nie Y-Z, Zheng Y-W, Miyakawa K, Murata S, Zhang R-R, Sekine K, Ueno Y, Takebe T, Wakita T, Ryo A (2018b) Recapitulation of hepatitis B virus\u2013host interactions in liver organoids from human induced pluripotent stem cells. EBioMedicine 35:114\u2013123. https:\/\/doi.org\/10.1016\/j.ebiom.2018.08.014","journal-title":"EBioMedicine"},{"key":"817_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-017-0749-1","volume":"9","author":"Y-Z Nie","year":"2018","unstructured":"Nie Y-Z, Zheng Y-W, Ogawa M, Miyagi E, Taniguchi H (2018a) Human liver organoids generated with single donor-derived multiple cells rescue mice from acute liver failure. Stem Cell Res Ther 9:1\u201312. https:\/\/doi.org\/10.1186\/s13287-017-0749-1","journal-title":"Stem Cell Res Ther"},{"key":"817_CR50","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.3390\/cells11091410","volume":"11","author":"C Nikokiraki","year":"2022","unstructured":"Nikokiraki C, Psaraki A, Roubelakis MG (2022) The potential clinical use of stem\/progenitor cells and organoids in liver diseases. Cells 11:1410. https:\/\/doi.org\/10.3390\/cells11091410","journal-title":"Cells"},{"key":"817_CR51","doi-asserted-by":"publisher","first-page":"100198","DOI":"10.1016\/j.jhepr.2020.100198","volume":"3","author":"S Nuciforo","year":"2021","unstructured":"Nuciforo S, Heim MH (2021) Organoids to model liver disease. JHEP Reports 3:100198. https:\/\/doi.org\/10.1016\/j.jhepr.2020.100198","journal-title":"JHEP Reports"},{"key":"817_CR52","doi-asserted-by":"publisher","first-page":"8920","DOI":"10.1038\/s41598-019-45514-3","volume":"9","author":"G Pettinato","year":"2019","unstructured":"Pettinato G, Lehoux S, Ramanathan R, Salem MM, He LX, Muse O, Flaumenhaft R, Thompson MT, Rouse EA, Cummings RD, Wen X, Fisher RA (2019a) Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with endothelial cells. Sci Rep 9:8920. https:\/\/doi.org\/10.1038\/s41598-019-45514-3","journal-title":"Sci Rep"},{"key":"817_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-45514-3","volume":"9","author":"G Pettinato","year":"2019","unstructured":"Pettinato G, Lehoux S, Ramanathan R, Salem MM, He L-X, Muse O, Flaumenhaft R, Thompson MT, Rouse EA, Cummings RD (2019b) Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with endothelial cells. Sci Rep 9:1\u201321. https:\/\/doi.org\/10.1038\/s41598-019-45514-3","journal-title":"Sci Rep"},{"key":"817_CR54","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1136\/gutjnl-2019-319256","volume":"68","author":"N Prior","year":"2019","unstructured":"Prior N, Inacio P, Huch M (2019) Liver organoids: from basic research to therapeutic applications. Gut 68:2228\u20132237. https:\/\/doi.org\/10.1136\/gutjnl-2019-319256","journal-title":"Gut"},{"issue":"1471\u20131486","key":"817_CR55","first-page":"e1412","volume":"159","author":"MNB Ramli","year":"2020","unstructured":"Ramli MNB, Lim YS, Koe CT, Demircioglu D, Tng W, Gonzales KAU, Tan CP, Szczerbinska I, Liang H, Soe EL (2020) Human pluripotent stem cell-derived organoids as models of liver disease. Gastroenterology 159(1471\u20131486):e1412","journal-title":"Gastroenterology"},{"key":"817_CR56","doi-asserted-by":"publisher","first-page":"35","DOI":"10.5114\/ceh.2019.83155","volume":"5","author":"MS Salim","year":"2019","unstructured":"Salim MS, Issa AM, Farrag ARH, Gabr H (2019) Decellularized liver bioscaffold: a histological and immunohistochemical comparison between normal, fibrotic and hepatocellular carcinoma. Clin Experimental Hepatol 5:35\u201347","journal-title":"Clin Experimental Hepatol"},{"key":"817_CR57","doi-asserted-by":"publisher","first-page":"12543","DOI":"10.1038\/s41598-019-48948-x","volume":"9","author":"H Shimoda","year":"2019","unstructured":"Shimoda H, Yagi H, Higashi H, Tajima K, Kuroda K, Abe Y, Kitago M, Shinoda M, Kitagawa Y (2019) Decellularized liver scaffolds promote liver regeneration after partial hepatectomy. Sci Rep 9:12543. https:\/\/doi.org\/10.1038\/s41598-019-48948-x","journal-title":"Sci Rep"},{"key":"817_CR58","doi-asserted-by":"publisher","first-page":"951","DOI":"10.14716\/ijtech.v11i5.4317","volume":"11","author":"CV Sibuea","year":"2020","unstructured":"Sibuea CV, Pawitan J, Antarianto R, Jasirwan CO, Sianipar IR, Luviah E, Nurhayati RW, Mubarok W, Mazfufah NF (2020) 3D co-culture of hepatocyte, a hepatic stellate cell line, and stem cells for developing a bioartificial liver prototype. Int J Technol 11:951\u2013962","journal-title":"Int J Technol"},{"key":"817_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-17161-0","volume":"11","author":"G Sorrentino","year":"2020","unstructured":"Sorrentino G, Rezakhani S, Yildiz E, Nuciforo S, Heim MH, Lutolf MP, Schoonjans K (2020) Mechano-modulatory synthetic niches for liver organoid derivation. Nat Commun 11:1\u201310. https:\/\/doi.org\/10.1038\/s41467-020-17161-0","journal-title":"Nat Commun"},{"key":"817_CR60","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fbioe.2022.845360","volume":"10","author":"KA Telles-Silva","year":"2022","unstructured":"Telles-Silva KA, Pacheco L, Komatsu S, Chianca F, Caires-J\u00fanior LC, Araujo BHS, Goulart E, Zatz M (2022) Applied hepatic bioengineering: modeling the human liver using organoid and liver-on-a-chip technologies. Frontiers in Bioengineering Biotech 10:109. https:\/\/doi.org\/10.3389\/fbioe.2022.845360","journal-title":"Frontiers in Bioengineering Biotech"},{"key":"817_CR61","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3390\/cells12020301","volume":"12","author":"B Toprakhisar","year":"2023","unstructured":"Toprakhisar B, Verfaillie CM, Kumar M (2023) Advances in recellularization of decellularized liver grafts with different liver (stem) cells: towards clinical applications. Cells 12:301. https:\/\/doi.org\/10.3390\/cells12020301","journal-title":"Cells"},{"key":"817_CR62","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3390\/ijms21010178","volume":"21","author":"T Tsuchida","year":"2019","unstructured":"Tsuchida T, Murata S, Matsuki K, Mori A, Matsuo M, Mikami S, Okamoto S, Ueno Y, Tadokoro T, Zheng Y-W (2019) The regenerative effect of portal vein injection of liver organoids by retrorsine\/partial hepatectomy in rats. Int J Mol Sci 21:178","journal-title":"Int J Mol Sci"},{"key":"817_CR63","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/nm.2170","volume":"16","author":"BE Uygun","year":"2010","unstructured":"Uygun BE, Soto-Gutierrez A, Yagi H, Izamis M-L, Guzzardi MA, Shulman C, Milwid J, Kobayashi N, Tilles A, Berthiaume F (2010) Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med 16:814\u2013820","journal-title":"Nat Med"},{"key":"817_CR64","doi-asserted-by":"publisher","unstructured":"Vis AM, Ito K, Hofmann S (2020) Imapact of culture meduim on cellular interactions in vitro co-culture systems.\u00a0Front Bioeng Biotechnol 8:911. https:\/\/doi.org\/10.3389\/fbioe.2020.00911","DOI":"10.3389\/fbioe.2020.00911"},{"key":"817_CR65","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.engreg.2022.02.003","volume":"3","author":"J Wang","year":"2022","unstructured":"Wang J, Huang D, Yu H, Cheng Y, Ren H, Zhao Y (2022) Developing tissue engineering strategies for liver regeneration. Engineered Regen 3:80\u201391. https:\/\/doi.org\/10.1016\/j.engreg.2022.02.003","journal-title":"Engineered Regen"},{"key":"817_CR66","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1136\/gutjnl-2020-323771","volume":"71","author":"BG Wiggins","year":"2022","unstructured":"Wiggins BG, Pallett LJ, Li X, Davies SP, Amin OE, Gill US, Kucykowicz S, Patel AM, Aliazis K, Liu YS (2022) The human liver microenvironment shapes the homing and function of CD4+ T-cell populations. Gut 71:1399\u20131411. https:\/\/doi.org\/10.1136\/gutjnl-2020-323771","journal-title":"Gut"},{"key":"817_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-14542-2","volume":"7","author":"Y Yanagi","year":"2017","unstructured":"Yanagi Y, Nakayama K, Taguchi T, Enosawa S, Tamura T, Yoshimaru K, Matsuura T, Hayashida M, Kohashi K, Oda Y (2017) In vivo and ex vivo methods of growing a liver bud through tissue connection. Sci Rep 7:1\u201315","journal-title":"Sci Rep"},{"key":"817_CR68","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1136\/gutjnl-2019-319960","volume":"70","author":"H Yang","year":"2021","unstructured":"Yang H, Sun L, Pang Y, Hu D, Xu H, Mao S, Peng W, Wang Y, Xu Y, Zheng Y-C (2021) Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure. Gut 70:567\u2013574. https:\/\/doi.org\/10.1136\/gutjnl-2019-319960","journal-title":"Gut"},{"key":"817_CR69","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.3389\/fped.2021.786017","volume":"9","author":"A Yanir","year":"2022","unstructured":"Yanir A, Schulz A, Lawitschka A, Nierkens S, Eyrich M (2022) Immune reconstitution after allogeneic haematopoietic cell transplantation: from observational studies to targeted interventions. Front Pediatr 9:1598. https:\/\/doi.org\/10.3389\/fped.2021.786017","journal-title":"Front Pediatr"},{"key":"817_CR70","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.stemcr.2018.01.006","volume":"10","author":"R-R Zhang","year":"2018","unstructured":"Zhang R-R, Koido M, Tadokoro T, Ouchi R, Matsuno T, Ueno Y, Sekine K, Takebe T, Taniguchi H (2018) Human iPSC-derived posterior gut progenitors are expandable and capable of forming gut and liver organoids. Stem Cell Reports 10:780\u2013793. https:\/\/doi.org\/10.1016\/j.stemcr.2018.01.006","journal-title":"Stem Cell Reports"},{"key":"817_CR71","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.bioactmat.2021.09.014","volume":"10","author":"X Zhang","year":"2022","unstructured":"Zhang X, Chen X, Hong H, Hu R, Liu J, Liu C (2022) Decellularized extracellular matrix scaffolds: recent trends and emerging strategies in tissue engineering. Bioactive Materials 10:15\u201331. https:\/\/doi.org\/10.1016\/j.bioactmat.2021.09.014","journal-title":"Bioactive Materials"},{"key":"817_CR72","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jss.2016.12.028","volume":"211","author":"VX Zhou","year":"2017","unstructured":"Zhou VX, Lolas M, Chang TT (2017) Direct orthotopic implantation of hepatic organoids. J Surg Res 211:251\u2013260. https:\/\/doi.org\/10.1016\/j.jss.2016.12.028","journal-title":"J Surg Res"},{"key":"817_CR73","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s13770-021-00357-w","volume":"18","author":"X Zhu","year":"2021","unstructured":"Zhu X, Zhang B, He Y, Bao J (2021) Liver organoids: formation strategies and biomedical applications. Tissue Engineering and Regenerative Medicine 18:573\u2013585. https:\/\/doi.org\/10.1007\/s13770-021-00357-w","journal-title":"Tissue Engineering and Regenerative Medicine"},{"key":"817_CR74","doi-asserted-by":"publisher","first-page":"5069","DOI":"10.7150\/jca.44697","volume":"11","author":"J-Y Zhuo","year":"2020","unstructured":"Zhuo J-Y, Lu D, Tan W-Y, Zheng S-S, Shen Y-Q, Xu X (2020) CK19-positive hepatocellular carcinoma is a characteristic subtype. J Cancer 11:5069\u20135077","journal-title":"J Cancer"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-023-00817-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-023-00817-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-023-00817-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T16:24:18Z","timestamp":1703175858000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-023-00817-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":74,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["817"],"URL":"https:\/\/doi.org\/10.1007\/s11626-023-00817-8","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"18 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}