{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:13:38Z","timestamp":1768623218210,"version":"3.49.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s11626-024-00901-7","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T14:01:48Z","timestamp":1712844108000},"page":"678-688","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["3,3\u2032-Diindolylmethane inhibits Th17 cell differentiation via impairing IRF-7-mediated plasmacytoid dendritic cell activation in imiquimod-induced psoriasis mice"],"prefix":"10.1007","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-5355","authenticated-orcid":false,"given":"Mahaboobkhan","family":"Rasool","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manupati","family":"Srikanth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arulkumaran","family":"Rithvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"issue":"6","key":"901_CR1","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1111\/j.1468-3083.2012.04582.x","volume":"27","author":"M Afshar","year":"2013","unstructured":"Afshar M, Martinez AD, Gallo RL, Hata TR (2013) Induction and exacerbation of psoriasis with Interferon-alpha therapy for hepatitis C: a review and analysis of 36 cases. J Eur Acad Dermatol Venereol 27(6):771\u2013778","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"5546","key":"901_CR2","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1126\/science.1064890","volume":"294","author":"P Blanco","year":"2001","unstructured":"Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J (2001) Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 294(5546):1540\u20131543. https:\/\/doi.org\/10.1126\/science.1064890","journal-title":"Science"},{"issue":"12","key":"901_CR3","doi-asserted-by":"publisher","first-page":"621956","DOI":"10.3389\/fimmu.2021.621956","volume":"25","author":"H Bugaut","year":"2021","unstructured":"Bugaut H, Aractingi S (2021) Major role of the IL17\/23 axis in psoriasis supports the development of new targeted therapies. Front Immunol 25(12):621956. https:\/\/doi.org\/10.3389\/fimmu.2021.621956","journal-title":"Front Immunol"},{"issue":"6","key":"901_CR4","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s11596-006-0634-0","volume":"26","author":"J Chen","year":"2006","unstructured":"Chen J, Tan Z, Liu H, Liu Z, Wu Y, Li J (2006) Expression of plasmacytoid dendritic cells, IRF-7, IFN-\u03b1 mRNA in the lesions of psoriasis vulgaris. J Huazhong Univ Sci Technol 26(6):747\u2013749. https:\/\/doi.org\/10.1007\/s11596-006-0634-0","journal-title":"J Huazhong Univ Sci Technol"},{"issue":"6","key":"901_CR5","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1038\/jid.2009.59","volume":"129","author":"A Di Cesare","year":"2009","unstructured":"Di Cesare A, Di Meglio P, Nestle FO (2009) The IL-23\/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol 129(6):1339\u20131350. https:\/\/doi.org\/10.1038\/jid.2009.59","journal-title":"J Invest Dermatol"},{"issue":"8","key":"901_CR6","doi-asserted-by":"publisher","first-page":"a015354","DOI":"10.1101\/cshperspect.a015354","volume":"4","author":"P Di Meglio","year":"2014","unstructured":"Di Meglio P, Villanova F, Nestle FO (2014) Psoriasis. Cold Spring Harb Perspect Med 4(8):a015354. https:\/\/doi.org\/10.1101\/cshperspect.a015354","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"10275","key":"901_CR7","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/s0140-6736(21)00184-7","volume":"397","author":"K Ghoreschi","year":"2021","unstructured":"Ghoreschi K, Balato A, Enerb\u00e4ck C, Sabat R (2021) Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. The Lancet 397(10275):754\u2013766. https:\/\/doi.org\/10.1016\/s0140-6736(21)00184-7","journal-title":"The Lancet"},{"issue":"1","key":"901_CR8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1365-2796.2008.02050.x","volume":"265","author":"C Guiducci","year":"2009","unstructured":"Guiducci C, Coffman RL, Barrat FJ (2009) Signalling pathways leading to IFN-\u03b1 production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications. J Intern Med 265(1):43\u201357. https:\/\/doi.org\/10.1111\/j.1365-2796.2008.02050.x","journal-title":"J Intern Med"},{"issue":"1","key":"901_CR9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jdermsci.2016.07.007","volume":"84","author":"SW Huang","year":"2016","unstructured":"Huang SW, Chenb YJ, Wang ST, Hod LW, Kaod JK, Naritaf M, Takahashi M, Wuc CY, Cheng HY, Shieh JJ (2016) Azithromycin impairs TLR7 signaling in dendritic cells and improves the severity of imiquimod-induced psoriasis-like skin inflammation in mice. J Dermatol Sci 84(1):59\u201370. https:\/\/doi.org\/10.1016\/j.jdermsci.2016.07.007","journal-title":"J Dermatol Sci"},{"key":"901_CR10","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3389\/fimmu.2019.00325","volume":"10","author":"CA Jefferies","year":"2019","unstructured":"Jefferies CA (2019) Regulating IRFs in IFN driven disease. Front Immunol 10:325. https:\/\/doi.org\/10.3389\/fimmu.2019.00325","journal-title":"Front Immunol"},{"key":"901_CR11","doi-asserted-by":"publisher","first-page":"941071","DOI":"10.3389\/fimmu.2022.941071","volume":"13","author":"M Kamata","year":"2022","unstructured":"Kamata M, Tada Y (2022) Dendritic cells and macrophages in the pathogenesis of psoriasis. Front Immunol 13:941071","journal-title":"Front Immunol"},{"issue":"1","key":"901_CR12","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1084\/jem.20030451","volume":"199","author":"E Lee","year":"2004","unstructured":"Lee E, Trepicchio WL, Oestreicher JL et al (2004) Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 199(1):125\u2013130. https:\/\/doi.org\/10.1084\/jem.20030451","journal-title":"J Exp Med"},{"key":"901_CR13","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1016\/j.biopha.2018.10.062","volume":"109","author":"Y Li","year":"2019","unstructured":"Li Y, Zhang G, Chen M, Tong M, Zhao M, Tang F, Xiao R, Wen H (2019) Rutaecarpine inhibited imiquimod-induced psoriasis-like dermatitis via inhibiting the NF-\u03baB and TLR7 pathways in mice. Biomed Pharmacother 109:1876\u20131883. https:\/\/doi.org\/10.1016\/j.biopha.2018.10.062","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"901_CR14","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1038\/sj.jid.5701213","volume":"128","author":"MA Lowes","year":"2008","unstructured":"Lowes MA, Kikuchi T, Fuentes-Duculan J, Cardinale I, Zaba LC, Haider AS, Bowman EP, Krueger JG (2008) Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 128(5):1207\u20131211. https:\/\/doi.org\/10.1038\/sj.jid.5701213","journal-title":"J Invest Dermatol"},{"issue":"1","key":"901_CR15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1084\/jem.20050500","volume":"202","author":"FO Nestle","year":"2005","unstructured":"Nestle FO, Conrad C, Tun-Kyi A, Homey B, Gombert M, Boyman O, Burg G, Liu YJ, Gilliet M (2005) Plasmacytoid predendritic cells initiate psoriasis through interferon-\u03b1 production. J Exp Med 202(1):135\u2013143. https:\/\/doi.org\/10.1084\/jem.20050500","journal-title":"J Exp Med"},{"issue":"6","key":"901_CR16","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.3390\/ijms20061475","volume":"20","author":"A Rendon","year":"2019","unstructured":"Rendon A, Sch\u00e4kel K (2019) Psoriasis pathogenesis and treatment. Int J Mol Sci. 20(6):1475. https:\/\/doi.org\/10.3390\/ijms20061475","journal-title":"Int J Mol Sci."},{"key":"901_CR17","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.3389\/fimmu.2019.01764","volume":"10","author":"MP Sch\u00f6n","year":"2019","unstructured":"Sch\u00f6n MP (2019) Adaptive and innate immunity in psoriasis and other inflammatory disorders. Front Immunol 10:1764. https:\/\/doi.org\/10.3389\/fimmu.2019.01764","journal-title":"Front Immunol"},{"issue":"1","key":"901_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-020-02356-z","volume":"22","author":"M Shigesaka","year":"2020","unstructured":"Shigesaka M, Ito T, Inaba M, Imai K, Yamanaka H, Azuma Y, Tanaka A, Amuro H, Nishizawa T, Son Y, Satake A (2020) Mycophenolic acid, the active form of mycophenolate mofetil, interferes with IRF7 nuclear translocation and type I IFN production by plasmacytoid dendritic cells. Arthritis Res Ther 22(1):1\u201311. https:\/\/doi.org\/10.1186\/s13075-020-02356-z","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"901_CR19","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.4049\/jimmunol.1501727","volume":"196","author":"NP Singh","year":"2016","unstructured":"Singh NP, Singh UP, Rouse M, Zhang J, Chatterjee S, Nagarkatti PS, Nagarkatti M (2016) Dietary indoles suppress delayed-type hypersensitivity by inducing a switch from proinflammatory Th17 cells to anti-inflammatory regulatory T cells through regulation of microRNA. J Immunol 196(3):1108\u20131122. https:\/\/doi.org\/10.4049\/jimmunol.1501727","journal-title":"J Immunol"},{"key":"901_CR20","doi-asserted-by":"publisher","first-page":"108795","DOI":"10.1016\/j.intimp.2022.108795","volume":"109","author":"M Srikanth","year":"2022","unstructured":"Srikanth M, Rasool M (2022) 3, 3\u02b9- Diindolylmethane hinders IL-17A\/IL-17RA interaction and mitigates imiquimod-induced psoriasiform in mice. Int Immunopharmacol 109:108795. https:\/\/doi.org\/10.1016\/j.intimp.2022.108795","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"901_CR21","doi-asserted-by":"publisher","first-page":"4953","DOI":"10.4049\/jimmunol.1500551","volume":"195","author":"D Terhorst","year":"2015","unstructured":"Terhorst D, Chelbi R, Wohn C, Malosse C, Tamoutounour S, Jorquera A, Bajenoff M, Dalod M, Malissen B, Henri S (2015) Dynamics and transcriptomics of skin dendritic cells and macrophages in an imiquimod-induced, biphasic mouse model of psoriasis. J Immunol (Baltimore, Md: 1950) 195(10):4953\u20134961. https:\/\/doi.org\/10.4049\/jimmunol.1500551","journal-title":"J Immunol (Baltimore, Md: 1950)"},{"issue":"1","key":"901_CR22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1046\/j.0022-202X.2003.22113.x","volume":"122","author":"L Van der Fits","year":"2004","unstructured":"Van der Fits L, van der Wel LI, Laman JD, Prens EP, Verschuren MC (2004) In psoriasis lesional skin the type I interferon signaling pathway is activated, whereas interferon-alpha sensitivity is unaltered. J Invest Dermatol. 122(1):51\u201360. https:\/\/doi.org\/10.1046\/j.0022-202X.2003.22113.x","journal-title":"J Invest Dermatol."},{"key":"901_CR23","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.lfs.2018.05.044","volume":"207","author":"MX Wang","year":"2018","unstructured":"Wang MX, Zhao JX, Meng YJ, Di TT, Xu XI, Xie XJ, Lin Y, Zhang L, Wang N, Li P, Wang Y (2018) Acetyl-11-keto-\u03b2-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7\/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro. Life Sci 207:90\u2013104","journal-title":"Life Sci"},{"issue":"16","key":"901_CR24","doi-asserted-by":"publisher","first-page":"3794","DOI":"10.7150\/ijms.61973","volume":"18","author":"WM Wang","year":"2021","unstructured":"Wang WM, Li F, Jin HZ (2021) Role of interferon regulatory factor-mediated signaling in psoriasis. Int J Med Sci 18(16):3794\u20133799. https:\/\/doi.org\/10.7150\/ijms.61973","journal-title":"Int J Med Sci"},{"key":"901_CR25","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.molimm.2020.11.013","volume":"130","author":"X Wu","year":"2021","unstructured":"Wu X, Liu J, Chen C, Huang Z, Chen J, Dong L, Zhang J, Ding Z (2021) 3,3\u02b9-Diindolylmethane alleviates acute atopic dermatitis by regulating T cell differentiation in a mouse model. Mol Immunol 130:104\u2013112. https:\/\/doi.org\/10.1016\/j.molimm.2020.11.013","journal-title":"Mol Immunol"},{"issue":"5","key":"901_CR26","doi-asserted-by":"publisher","first-page":"R96","DOI":"10.1186\/ar2297","volume":"9","author":"T Yago","year":"2007","unstructured":"Yago T, Nanke Y, Kawamoto M et al (2007) IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res Ther 9(5):R96. https:\/\/doi.org\/10.1186\/ar2297","journal-title":"Arthritis Res Ther"},{"issue":"13","key":"901_CR27","doi-asserted-by":"publisher","first-page":"778755","DOI":"10.3389\/fphar.2022.778755","volume":"1","author":"HF Zhou","year":"2022","unstructured":"Zhou HF, Wang FX, Sun F, Liu X, Rong SJ, Luo JH, Yue TT, Xiao J, Yang CL, Lu WY, Luo X, Zhou Q, Zhu H, Yang P, Xiong F, Yu QL, Zhang S, Wang CY (2022) Aloperine ameliorates IMQ-induced psoriasis by attenuating Th17 differentiation and facilitating their conversion to Treg. Front Pharmacol 1(13):778755. https:\/\/doi.org\/10.3389\/fphar.2022.778755","journal-title":"Front Pharmacol"}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-024-00901-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-024-00901-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-024-00901-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T16:40:06Z","timestamp":1722271206000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-024-00901-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,11]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["901"],"URL":"https:\/\/doi.org\/10.1007\/s11626-024-00901-7","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,11]]},"assertion":[{"value":"4 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the experiments performed were certified and reviewed by Institutional Animal Ethical Committee (IAEC) members. All the experimental procedures were performed according to the guidelines proposed by the Committee for Control and Supervision of Experiments on Animals (CPCSEA), New Delhi, India.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}