{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T19:21:56Z","timestamp":1781119316768,"version":"3.54.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100018917","name":"Hebei North University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s11626-025-01059-6","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T13:05:46Z","timestamp":1751893546000},"page":"753-762","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dexmedetomidine preserves neuronal function by promoting mitochondrial biogenesis through the AMPK\/PGC-1\u03b1 pathway"],"prefix":"10.1007","volume":"61","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8149-0454","authenticated-orcid":false,"given":"Zhen","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"1059_CR1","doi-asserted-by":"publisher","first-page":"122257","DOI":"10.1016\/j.lfs.2023.122257","volume":"334","author":"EE Alshial","year":"2023","unstructured":"Alshial EE, Abdulghaney MI, Wadan AS, Abdellatif MA, Ramadan NE, Suleiman AM, Mohammed HS (2023) Mitochondrial dysfunction and neurological disorders: a narrative review and treatment overview. Life Sci 334:122257. https:\/\/doi.org\/10.1016\/j.lfs.2023.122257","journal-title":"Life Sci"},{"issue":"1","key":"1059_CR2","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/alz.12683","volume":"19","author":"T Ashleigh","year":"2023","unstructured":"Ashleigh T, Swerdlow RH, Beal MF (2023) The role of mitochondrial dysfunction in Alzheimer\u2019s disease pathogenesis. Alzheimers Dement 19(1):333\u2013342. https:\/\/doi.org\/10.1002\/alz.12683","journal-title":"Alzheimers Dement"},{"issue":"4","key":"1059_CR3","doi-asserted-by":"publisher","first-page":"C817","DOI":"10.1152\/ajpcell.00139.2004","volume":"287","author":"PS Brookes","year":"2004","unstructured":"Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS (2004) Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol 287(4):C817-833. https:\/\/doi.org\/10.1152\/ajpcell.00139.2004","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"1059_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mito.2013.12.003","volume":"14","author":"MC Chiang","year":"2014","unstructured":"Chiang MC, Cheng YC, Chen HM, Liang YJ, Yen CH (2014) Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway. Mitochondrion 14(1):7\u201317. https:\/\/doi.org\/10.1016\/j.mito.2013.12.003","journal-title":"Mitochondrion"},{"issue":"5","key":"1059_CR5","doi-asserted-by":"publisher","first-page":"101406","DOI":"10.1016\/j.accpm.2024.101406","volume":"43","author":"R Cinotti","year":"2024","unstructured":"Cinotti R, Studd H, Forget P (2024) Dexmedetomidine, more than just an anaesthetic aid? An overview of latest evidence. Anaesth Crit Care Pain Med 43(5):101406. https:\/\/doi.org\/10.1016\/j.accpm.2024.101406","journal-title":"Anaesth Crit Care Pain Med"},{"issue":"8","key":"1059_CR6","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.3390\/antiox12081624","volume":"12","author":"A Espinosa","year":"2023","unstructured":"Espinosa A, Casas M, Jaimovich E (2023) Energy (and Reactive Oxygen Species Generation) saving distribution of mitochondria for the activation of ATP production in skeletal muscle. Antioxidants (Basel) 12(8):1624. https:\/\/doi.org\/10.3390\/antiox12081624","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"1059_CR7","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.bja.2019.08.026","volume":"123","author":"J Gao","year":"2019","unstructured":"Gao J, Sun Z, Xiao Z, Du Q, Niu X, Wang G, Chang YW, Sun Y, Sun W, Lin A, Bresnahan JC, Maze M, Beattie MS, Pan JZ (2019) Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury. Br J Anaesth 123(6):827\u2013838. https:\/\/doi.org\/10.1016\/j.bja.2019.08.026","journal-title":"Br J Anaesth"},{"issue":"1","key":"1059_CR8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/cns.12655","volume":"23","author":"M Golpich","year":"2017","unstructured":"Golpich M, Amini E, Mohamed Z, Ali RA, Ibrahim NM, Ahmadiani A (2017) Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment. CNS Neurosci Ther 23(1):5\u201322. https:\/\/doi.org\/10.1111\/cns.12655","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"1059_CR9","doi-asserted-by":"publisher","first-page":"14784","DOI":"10.1038\/s41598-024-65595-z","volume":"14","author":"B Gottschalk","year":"2024","unstructured":"Gottschalk B, Koshenov Z, Malli R, Graier WF (2024) Implications of mitochondrial membrane potential gradients on signaling and ATP production analyzed by correlative multi-parameter microscopy. Sci Rep 14(1):14784. https:\/\/doi.org\/10.1038\/s41598-024-65595-z","journal-title":"Sci Rep"},{"key":"1059_CR10","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.exger.2018.04.005","volume":"108","author":"YH Jing","year":"2018","unstructured":"Jing YH, Yan JL, Wang QJ, Chen HC, Ma XZ, Yin J, Gao LP (2018) Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro. Exp Gerontol 108:77\u201386. https:\/\/doi.org\/10.1016\/j.exger.2018.04.005","journal-title":"Exp Gerontol"},{"issue":"3","key":"1059_CR11","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.spen.2013.10.001","volume":"20","author":"DS Khurana","year":"2013","unstructured":"Khurana DS, Valencia I, Goldenthal MJ, Legido A (2013) Mitochondrial dysfunction in epilepsy. Semin Pediatr Neurol 20(3):176\u2013187. https:\/\/doi.org\/10.1016\/j.spen.2013.10.001","journal-title":"Semin Pediatr Neurol"},{"issue":"3","key":"1059_CR12","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.3390\/ijms23031851","volume":"23","author":"RN Lamptey","year":"2022","unstructured":"Lamptey RN, Chaulagain B, Trivedi R, Gothwal A, Layek B, Singh J (2022) A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics. Int J Mol Sci 23(3):1851. https:\/\/doi.org\/10.3390\/ijms23031851","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1059_CR13","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.spen.2013.10.009","volume":"20","author":"A Legido","year":"2013","unstructured":"Legido A (2013) Mitochondrial dysfunction in neurological diseases. Introduction Semin Pediatr Neurol 20(3):161\u2013162. https:\/\/doi.org\/10.1016\/j.spen.2013.10.009","journal-title":"Introduction Semin Pediatr Neurol"},{"issue":"6728","key":"1059_CR14","doi-asserted-by":"publisher","first-page":"eadp6547","DOI":"10.1126\/science.adp6547","volume":"386","author":"W Li","year":"2024","unstructured":"Li W, Li J, Li J, Wei C, Laviv T, Dong M et al (2024) Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice. Science 386(6728):eadp6547. https:\/\/doi.org\/10.1126\/science.adp6547","journal-title":"Science"},{"key":"1059_CR15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/978-1-61779-504-6_5","volume":"837","author":"Z Li","year":"2012","unstructured":"Li Z, Graham BH (2012) Measurement of mitochondrial oxygen consumption using a Clark electrode. Methods Mol Biol 837:63\u201372. https:\/\/doi.org\/10.1007\/978-1-61779-504-6_5","journal-title":"Methods Mol Biol"},{"key":"1059_CR16","doi-asserted-by":"publisher","first-page":"109910","DOI":"10.1016\/j.intimp.2023.109910","volume":"117","author":"Y Lin","year":"2023","unstructured":"Lin Y, Wei Y, Wei Y, Yu H, Zhang W, Li C et al (2023) Dexmedetomidine alleviates oxidative stress and mitochondrial dysfunction in diabetic peripheral neuropathy via the microRNA-34a\/SIRT2\/S1PR1 axis. Int Immunopharmacol 117:109910. https:\/\/doi.org\/10.1016\/j.intimp.2023.109910","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"1059_CR17","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12929-023-00975-7","volume":"30","author":"L Liu","year":"2023","unstructured":"Liu L, Li Y, Chen G, Chen Q (2023) Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis. J Biomed Sci 30(1):86. https:\/\/doi.org\/10.1186\/s12929-023-00975-7","journal-title":"J Biomed Sci"},{"issue":"1","key":"1059_CR18","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1080\/0886022X.2022.2097923","volume":"44","author":"X Liu","year":"2022","unstructured":"Liu X, Hu Q, Chen Q, Jia J, Liao YH, Feng J (2022) Effect of dexmedetomidine for prevention of acute kidney injury after cardiac surgery: an updated systematic review and meta-analysis. Ren Fail 44(1):1150\u20131159. https:\/\/doi.org\/10.1080\/0886022X.2022.2097923","journal-title":"Ren Fail"},{"key":"1059_CR19","doi-asserted-by":"publisher","unstructured":"Massaro M, Baudo G, Lee H, Liu H, Blanco E (2024) Nuclear respiratory factor-1 (NRF1) induction drives mitochondrial biogenesis and attenuates amyloid beta-induced mitochondrial dysfunction and neurotoxicity. Neurotherapeutics: e00513. https:\/\/doi.org\/10.1016\/j.neurot.2024.e00513","DOI":"10.1016\/j.neurot.2024.e00513"},{"issue":"1","key":"1059_CR20","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13019-025-03360-7","volume":"20","author":"C Meng","year":"2025","unstructured":"Meng C, Wang D, Zhao Y, Sun J, Miao G, Chen L et al (2025) Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trials. J Cardiothorac Surg 20(1):110. https:\/\/doi.org\/10.1186\/s13019-025-03360-7","journal-title":"J Cardiothorac Surg"},{"issue":"8","key":"1059_CR21","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1007\/s11064-023-03904-0","volume":"48","author":"S Moradi Vastegani","year":"2023","unstructured":"Moradi Vastegani S, Nasrolahi A, Ghaderi S, Belali R, Rashno M, Farzaneh M, Khoshnam SE (2023) Mitochondrial dysfunction and Parkinson\u2019s disease: pathogenesis and therapeutic strategies. Neurochem Res 48(8):2285\u20132308. https:\/\/doi.org\/10.1007\/s11064-023-03904-0","journal-title":"Neurochem Res"},{"issue":"1","key":"1059_CR22","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12871-025-02918-1","volume":"25","author":"AK Oguz","year":"2025","unstructured":"Oguz AK, Soyalp C, Tuncdemir YE, Tekeli AE, Yuzkat N (2025) Sedoanalgesia with dexmedetomidine in daily anesthesia practices: a prospective randomized controlled trial. BMC Anesthesiol 25(1):45. https:\/\/doi.org\/10.1186\/s12871-025-02918-1","journal-title":"BMC Anesthesiol"},{"issue":"5","key":"1059_CR23","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s41388-023-02907-z","volume":"43","author":"FR Palma","year":"2024","unstructured":"Palma FR, Gantner BN, Sakiyama MJ, Kayzuka C, Shukla S, Lacchini R et al (2024) ROS production by mitochondria: function or dysfunction? Oncogene 43(5):295\u2013303. https:\/\/doi.org\/10.1038\/s41388-023-02907-z","journal-title":"Oncogene"},{"issue":"9","key":"1059_CR24","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1002\/iub.235","volume":"61","author":"N Petrakis","year":"2009","unstructured":"Petrakis N, Alcock F, Tokatlidis K (2009) Mitochondrial ATP-independent chaperones. IUBMB Life 61(9):909\u2013914. https:\/\/doi.org\/10.1002\/iub.235","journal-title":"IUBMB Life"},{"issue":"9","key":"1059_CR25","doi-asserted-by":"publisher","first-page":"4892","DOI":"10.1111\/jcmm.15194","volume":"24","author":"LD Popov","year":"2020","unstructured":"Popov LD (2020) Mitochondrial biogenesis: an update. J Cell Mol Med 24(9):4892\u20134899. https:\/\/doi.org\/10.1111\/jcmm.15194","journal-title":"J Cell Mol Med"},{"key":"1059_CR26","doi-asserted-by":"publisher","first-page":"102255","DOI":"10.1016\/j.arr.2024.102255","volume":"96","author":"PS Rakshe","year":"2024","unstructured":"Rakshe PS, Dutta BJ, Chib S, Maurya N, Singh S (2024) Unveiling the interplay of AMPK\/SIRT1\/PGC-1alpha axis in brain health: promising targets against aging and NDDs. Ageing Res Rev 96:102255. https:\/\/doi.org\/10.1016\/j.arr.2024.102255","journal-title":"Ageing Res Rev"},{"issue":"Pt B","key":"1059_CR27","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.nbd.2017.04.004","volume":"109","author":"EM Rocha","year":"2018","unstructured":"Rocha EM, De Miranda B, Sanders LH (2018) Alpha-synuclein: pathology, mitochondrial dysfunction and neuroinflammation in Parkinson\u2019s disease. Neurobiol Dis 109(Pt B):249\u2013257. https:\/\/doi.org\/10.1016\/j.nbd.2017.04.004","journal-title":"Neurobiol Dis"},{"key":"1059_CR28","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bcp.2018.10.032","volume":"162","author":"C Rubio-Patino","year":"2019","unstructured":"Rubio-Patino C, Trotta AP, Chipuk JE (2019) MDM2 and mitochondrial function: one complex intersection. Biochem Pharmacol 162:14\u201320. https:\/\/doi.org\/10.1016\/j.bcp.2018.10.032","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"1059_CR29","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s13023-024-03212-y","volume":"19","author":"D Sala","year":"2024","unstructured":"Sala D, Marchet S, Nanetti L, Legati A, Mariotti C, Lamantea E et al (2024) A novel MT-ATP6 variant associated with complicated ataxia in two unrelated Italian patients: case report and functional studies. Orphanet J Rare Dis 19(1):200. https:\/\/doi.org\/10.1186\/s13023-024-03212-y","journal-title":"Orphanet J Rare Dis"},{"issue":"48","key":"1059_CR30","doi-asserted-by":"publisher","first-page":"e2409499","DOI":"10.1002\/advs.202409499","volume":"11","author":"H She","year":"2024","unstructured":"She H, Hu Y, Zhao G, Du Y, Wu Y, Chen W et al (2024) Dexmedetomidine ameliorates myocardial ischemia-reperfusion injury by inhibiting MDH2 lactylation via regulating metabolic reprogramming. Adv Sci (Weinh) 11(48):e2409499. https:\/\/doi.org\/10.1002\/advs.202409499","journal-title":"Adv Sci (Weinh)"},{"issue":"7","key":"1059_CR31","doi-asserted-by":"publisher","first-page":"4381","DOI":"10.1007\/s12035-023-03841-7","volume":"61","author":"Y Song","year":"2024","unstructured":"Song Y, Wang W, Wang B, Shi Q (2024) The protective mechanism of TFAM on mitochondrial DNA and its role in neurodegenerative diseases. Mol Neurobiol 61(7):4381\u20134390. https:\/\/doi.org\/10.1007\/s12035-023-03841-7","journal-title":"Mol Neurobiol"},{"key":"1059_CR32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbi.2022.02.015","volume":"102","author":"J Sun","year":"2022","unstructured":"Sun J, Song FH, Wu JY, Zhang LQ, Li DY, Gao SJ et al (2022) Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK\/PGC-1alpha-mediated mitochondrial biogenesis and suppression of neuroinflammation. Brain Behav Immun 102:53\u201370. https:\/\/doi.org\/10.1016\/j.bbi.2022.02.015","journal-title":"Brain Behav Immun"},{"issue":"3","key":"1059_CR33","doi-asserted-by":"publisher","first-page":"e70071","DOI":"10.1002\/fsn3.70071","volume":"13","author":"L Tang","year":"2025","unstructured":"Tang L, Fan X, Xu Y, Zhang Y, Li G (2025) Luteolin inhibits dexamethasone-induced osteoporosis by autophagy activation through miR-125b-5p\/SIRT3\/AMPK\/mTOR axis, an in vitro and in vivo study. Food Sci Nutr 13(3):e70071. https:\/\/doi.org\/10.1002\/fsn3.70071","journal-title":"Food Sci Nutr"},{"issue":"19","key":"1059_CR34","doi-asserted-by":"publisher","first-page":"14824","DOI":"10.3390\/ijms241914824","volume":"24","author":"B Tessema","year":"2023","unstructured":"Tessema B, Haag J, Sack U, K\u00f6nig B (2023) The determination of mitochondrial mass is a prerequisite for accurate assessment of peripheral blood mononuclear cells\u2019 oxidative metabolism. Int J Mol Sci 24(19):14824. https:\/\/doi.org\/10.3390\/ijms241914824","journal-title":"Int J Mol Sci"},{"issue":"35","key":"1059_CR35","doi-asserted-by":"publisher","first-page":"5507","DOI":"10.2174\/138161282035140911142118","volume":"20","author":"T Valero","year":"2014","unstructured":"Valero T (2014) Mitochondrial biogenesis: pharmacological approaches. Curr Pharm des 20(35):5507\u20135509. https:\/\/doi.org\/10.2174\/138161282035140911142118","journal-title":"Curr Pharm des"},{"key":"1059_CR36","doi-asserted-by":"publisher","unstructured":"Wan L, Qian Y, Ni W, Lu Y, Li W, Pan Y, Chen W (2023) Linagliptin improves diabetic kidney disease in rats by promoting mitochondrial biogenesis through the AMPK\/PGC-1alpha\/TFAM pathway. Nan Fang Yi Ke Da Xue Xue Bao 43(12):2053\u20132060. https:\/\/doi.org\/10.12122\/j.issn.1673-4254.2023.12.09","DOI":"10.12122\/j.issn.1673-4254.2023.12.09"},{"issue":"1","key":"1059_CR37","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12974-024-03016-8","volume":"21","author":"PF Wang","year":"2024","unstructured":"Wang PF, Jiang F, ZengQM YWF, Hu YZ, Li Q, Hu ZL (2024) Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis. J Neuroinflammation 21(1):28. https:\/\/doi.org\/10.1186\/s12974-024-03016-8","journal-title":"J Neuroinflammation"},{"issue":"14","key":"1059_CR38","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.2174\/1389450121999201230204050","volume":"22","author":"R Waseem","year":"2021","unstructured":"Waseem R, Shamsi A, Kazim SN, Islam A (2021) An insight into mitochondrial dysfunction and its implications in neurological diseases. Curr Drug Targets 22(14):1585\u20131595. https:\/\/doi.org\/10.2174\/1389450121999201230204050","journal-title":"Curr Drug Targets"},{"issue":"1","key":"1059_CR39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41392-024-02044-3","volume":"10","author":"H Wen","year":"2025","unstructured":"Wen H, Deng H, Li B, Chen J, Zhu J, Zhang X et al (2025) Mitochondrial diseases: from molecular mechanisms to therapeutic advances. Signal Transduct Target Ther 10(1):9. https:\/\/doi.org\/10.1038\/s41392-024-02044-3","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"1059_CR40","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/s41467-024-55768-9","volume":"16","author":"Y Yi","year":"2025","unstructured":"Yi Y, Wang G, Zhang W, Yu S, Fei J, An T et al (2025) Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation. Nat Commun 16(1):212. https:\/\/doi.org\/10.1038\/s41467-024-55768-9","journal-title":"Nat Commun"},{"key":"1059_CR41","doi-asserted-by":"publisher","first-page":"111137","DOI":"10.1016\/j.brainresbull.2024.111137","volume":"220","author":"H Zhao","year":"2025","unstructured":"Zhao H, Fan M, Zhang J, Gao Y, Chen L, Huang L (2025) Amyloid beta-induced mitochondrial dysfunction and endothelial permeability in cerebral microvascular endothelial cells: the protective role of dexmedetomidine. Brain Res Bull 220:111137","journal-title":"Brain Res Bull"},{"issue":"13","key":"1059_CR42","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.3390\/cells11132049","volume":"11","author":"J Zhao","year":"2022","unstructured":"Zhao J, Wang X, Huo Z, Chen Y, Liu J, Zhao Z et al (2022) The impact of mitochondrial dysfunction in amyotrophic lateral sclerosis. Cells 11(13):2049. https:\/\/doi.org\/10.3390\/cells11132049","journal-title":"Cells"},{"issue":"1","key":"1059_CR43","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","volume":"9","author":"Y Zong","year":"2024","unstructured":"Zong Y, Li H, Liao P, Chen L, Pan Y, Zheng Y et al (2024) Mitochondrial dysfunction: mechanisms and advances in therapy. Signal Transduct Target Ther 9(1):124. https:\/\/doi.org\/10.1038\/s41392-024-01839-8","journal-title":"Signal Transduct Target Ther"}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-025-01059-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-025-01059-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-025-01059-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:38:27Z","timestamp":1756993107000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-025-01059-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1059"],"URL":"https:\/\/doi.org\/10.1007\/s11626-025-01059-6","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]},"assertion":[{"value":"13 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}