{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:17:02Z","timestamp":1782814622095,"version":"3.54.5"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Wuxi Taihu Lake Talent Plan, Supports for Leading Talents in Medical and Health Profession","award":["2020-THRCTD-1"],"award-info":[{"award-number":["2020-THRCTD-1"]}]},{"name":"Wuxi Taihu Lake Talent Plan, Supports for Leading Talents in Medical and Health Profession","award":["HRC-DJ-1"],"award-info":[{"award-number":["HRC-DJ-1"]}]},{"name":"Top Talent Support Program for young and middle-aged people of Wuxi Health Committee","award":["BJ2023001"],"award-info":[{"award-number":["BJ2023001"]}]},{"name":"Top Talent Support Program for young and middle-aged people of Wuxi Health Committee","award":["HB2023014"],"award-info":[{"award-number":["HB2023014"]}]},{"name":"General Program of Wuxi Medical Center, Nanjing Medical University","award":["WMCG202347"],"award-info":[{"award-number":["WMCG202347"]}]},{"name":"General Program of Wuxi Medical Center, Nanjing Medical University","award":["WMCG202345"],"award-info":[{"award-number":["WMCG202345"]}]},{"name":"Medial Key Discipline Program of Wuxi Health Commission","award":["ZDXK2021001"],"award-info":[{"award-number":["ZDXK2021001"]}]},{"name":"The Science and Technology Development Fund Project of Nanjing Medical University","award":["NMUB20230240"],"award-info":[{"award-number":["NMUB20230240"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s11626-025-01064-9","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T13:08:05Z","timestamp":1751288885000},"page":"801-815","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["MiR-21-5p promotes RPE cell necroptosis by targeting Peli1 in a rat model of AMD"],"prefix":"10.1007","volume":"61","author":[{"given":"Yishun","family":"Shu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengye","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8089-6473","authenticated-orcid":false,"given":"Xiaolu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5506-7101","authenticated-orcid":false,"given":"Yong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"1064_CR1","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1111\/ceo.13121","volume":"46","author":"J Ao","year":"2018","unstructured":"Ao J, Wood JP, Chidlow G, Gillies MC, Casson RJ (2018) Retinal pigment epithelium in the pathogenesis of age-related macular degeneration and photobiomodulation as a potential therapy? Clin Exp Ophthalmol 46:670\u2013686","journal-title":"Clin Exp Ophthalmol"},{"key":"1064_CR2","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s10020-024-00920-w","volume":"30","author":"J Bai","year":"2024","unstructured":"Bai J, Wang Y, Li Y, Liu Y, Wang S (2024) Protective effect of ghrelin in oxidative stress-induced age-related macular degeneration in vitro and in vivo. Mol Med 30:142","journal-title":"Mol Med"},{"key":"1064_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1471-2415-10-31","volume":"10","author":"U Chakravarthy","year":"2010","unstructured":"Chakravarthy U, Wong TY, Fletcher A, Piault E, Evans C, Zlateva G, Buggage R, Pleil A, Mitchell P (2010) Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis. BMC Ophthalmol 10:31","journal-title":"BMC Ophthalmol"},{"key":"1064_CR4","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12929-019-0531-z","volume":"26","author":"CM Chan","year":"2019","unstructured":"Chan CM, Huang DY, Sekar P, Hsu SH, Lin WW (2019) Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death. J Biomed Sci 26:40","journal-title":"J Biomed Sci"},{"key":"1064_CR5","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/ni.1777","volume":"10","author":"M Chang","year":"2009","unstructured":"Chang M, Jin W, Sun SC (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol 10:1089\u20131095","journal-title":"Nat Immunol"},{"key":"1064_CR6","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1089\/ars.2012.4803","volume":"19","author":"Z Chen","year":"2013","unstructured":"Chen Z, Shentu TP, Wen L, Johnson DA, Shyy JY (2013) Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium. Antioxid Redox Signal 19:1522\u20131538","journal-title":"Antioxid Redox Signal"},{"key":"1064_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154560","volume":"11","author":"PS Coburn","year":"2016","unstructured":"Coburn PS, Wiskur BJ, Miller FC, LaGrow AL, Astley RA, Elliott MH, Callegan MC (2016) Bloodstream-To-Eye Infections Are Facilitated by Outer Blood-Retinal Barrier Dysfunction. PLoS ONE 11:e0154560","journal-title":"PLoS ONE"},{"key":"1064_CR8","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.preteyeres.2017.03.002","volume":"60","author":"S Datta","year":"2017","unstructured":"Datta S, Cano M, Ebrahimi K, Wang L, Handa JT (2017) The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD. Prog Retin Eye Res 60:201\u2013218","journal-title":"Prog Retin Eye Res"},{"key":"1064_CR9","first-page":"CD000254","volume":"7","author":"JR Evans","year":"2017","unstructured":"Evans JR, Lawrenson JG (2017) Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev 7:CD000254","journal-title":"Cochrane Database Syst Rev"},{"key":"1064_CR10","doi-asserted-by":"publisher","first-page":"7956","DOI":"10.7150\/thno.45192","volume":"10","author":"J Fan","year":"2020","unstructured":"Fan J, Shen W, Lee SR, Mathai AE, Zhang R, Xu G, Gillies MC (2020) Targeting the Notch and TGF-\u03b2 signaling pathways to prevent retinal fibrosis in vitro and in vivo. Theranostics 10:7956\u20137973","journal-title":"Theranostics"},{"key":"1064_CR11","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12943-019-1029-8","volume":"18","author":"Y Gong","year":"2019","unstructured":"Gong Y, Fan Z, Luo G, Yang C, Huang Q, Fan K, Cheng H, Jin K, Ni Q, Yu X, Liu C (2019) The role of necroptosis in cancer biology and therapy. Mol Cancer 18:100","journal-title":"Mol Cancer"},{"key":"1064_CR12","doi-asserted-by":"publisher","first-page":"4568","DOI":"10.3390\/ijms22094568","volume":"22","author":"MH Guerra","year":"2021","unstructured":"Guerra MH, Yumnamcha T, Ebrahim AS, Berger EA, Singh LP, Ibrahim AS (2021) Real-Time Monitoring the Effect of Cytopathic Hypoxia on Retinal Pigment Epithelial Barrier Functionality Using Electric Cell-Substrate Impedance Sensing (ECIS) Biosensor Technology. Int J Mol Sci 22:4568","journal-title":"Int J Mol Sci"},{"key":"1064_CR13","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.arr.2015.09.002","volume":"24","author":"J Hanus","year":"2015","unstructured":"Hanus J, Anderson C, Wang S (2015) RPE necroptosis in response to oxidative stress and in AMD. Ageing Res Rev 24:286\u2013298","journal-title":"Ageing Res Rev"},{"key":"1064_CR14","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/opo.12675","volume":"40","author":"TJ Heesterbeek","year":"2020","unstructured":"Heesterbeek TJ, Lor\u00e9s-Motta L, Hoyng CB, Lechanteur YTE, den Hollander AL (2020) Risk factors for progression of age-related macular degeneration. Ophthalmic Physiol Opt 40:140\u2013170","journal-title":"Ophthalmic Physiol Opt"},{"key":"1064_CR15","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12828","volume":"53","author":"C Hu","year":"2020","unstructured":"Hu C, Meiners S, Lukas C, Stathopoulos GT, Chen J (2020) Role of exosomal microRNAs in lung cancer biology and clinical applications. Cell Prolif 53:e12828","journal-title":"Cell Prolif"},{"key":"1064_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101336","volume":"28","author":"RN Jadeja","year":"2020","unstructured":"Jadeja RN, Jones MA, Abdelrahman AA, Powell FL, Thounaojam MC, Gutsaeva D, Bartoli M, Martin PM (2020) Inhibiting microRNA-144 potentiates Nrf2-dependent antioxidant signaling in RPE and protects against oxidative stress-induced outer retinal degeneration. Redox Biol 28:101336","journal-title":"Redox Biol"},{"key":"1064_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.437","volume":"8","author":"KH Jang","year":"2017","unstructured":"Jang KH, Do YJ, Son D, Son E, Choi JS, Kim E (2017) AIF-independent parthanatos in the pathogenesis of dry age-related macular degeneration. Cell Death Dis 8:e2526","journal-title":"Cell Death Dis"},{"key":"1064_CR18","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.mam.2012.03.009","volume":"33","author":"SG Jarrett","year":"2012","unstructured":"Jarrett SG, Boulton ME (2012) Consequences of oxidative stress in age-related macular degeneration. Mol Aspects Med 33:399\u2013417","journal-title":"Mol Aspects Med"},{"key":"1064_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/cmi.2011.60","volume":"9","author":"W Jin","year":"2012","unstructured":"Jin W, Chang M, Sun SC (2012) Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance. Cell Mol Immunol 9:113\u2013122","journal-title":"Cell Mol Immunol"},{"key":"1064_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100858","volume":"79","author":"K Kaarniranta","year":"2020","unstructured":"Kaarniranta K, Uusitalo H, Blasiak J, Felszeghy S, Kannan R, Kauppinen A, Salminen A, Sinha D, Ferrington D (2020) Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. Prog Retin Eye Res 79:100858","journal-title":"Prog Retin Eye Res"},{"key":"1064_CR21","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.7150\/thno.92943","volume":"14","author":"Y Liang","year":"2024","unstructured":"Liang Y, Kong L, Zhang Y, Zhang Y, Shi M, Huang J, Kong H, Qi S, Yang Y, Hong J, Zhu M, Zhu X, Sun X, Zhang S, Wu L, Zhao C (2024) Transfer RNA derived fragment, tRF-Glu-CTC, aggravates the development of neovascular age-related macular degeneration. Theranostics 14:1500\u20131516","journal-title":"Theranostics"},{"key":"1064_CR22","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3390\/ijms21020649","volume":"21","author":"CH Liu","year":"2020","unstructured":"Liu CH, Huang S, Britton WR, Chen J (2020) MicroRNAs in Vascular Eye Diseases. J Mol Sci 21:649","journal-title":"J Mol Sci"},{"key":"1064_CR23","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/s12974-022-02626-4","volume":"19","author":"M Liu","year":"2022","unstructured":"Liu M, Li H, Yang R, Ji D, Xia X (2022) GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1\/RIP3\/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma. J Neuroinflammation 19:262","journal-title":"J Neuroinflammation"},{"key":"1064_CR24","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1039\/c5pp00188a","volume":"14","author":"MD Marquioni-Ramella","year":"2015","unstructured":"Marquioni-Ramella MD, Suburo AM (2015) Photo-damage, photo-protection and age-related macular degeneration. Photochem Photobiol Sci 14:1560\u20131577","journal-title":"Photochem Photobiol Sci"},{"key":"1064_CR25","doi-asserted-by":"publisher","first-page":"19218","DOI":"10.1074\/jbc.M115.640128","volume":"29","author":"M Murphy","year":"2015","unstructured":"Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE (2015) Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance. J Biol Chem 29:19218\u201319232","journal-title":"J Biol Chem"},{"key":"1064_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.004","volume":"48","author":"H Nazari","year":"2015","unstructured":"Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, Rowland T, Clegg DO, Kashani AH, Hinton DR, Humayun MS (2015) Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Prog Retin Eye Res 48:1\u201339","journal-title":"Prog Retin Eye Res"},{"key":"1064_CR27","doi-asserted-by":"publisher","first-page":"2638130","DOI":"10.1155\/2020\/2638130","volume":"2020","author":"A Nunomura","year":"2020","unstructured":"Nunomura A, Perry G (2020) RNA and Oxidative Stress in Alzheimer\u2019s Disease: Focus on microRNAs. Oxid Med Cell Longev 2020:2638130","journal-title":"Oxid Med Cell Longev"},{"key":"1064_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.685344","volume":"12","author":"H Oshiumi","year":"2021","unstructured":"Oshiumi H (2021) Circulating Extracellular Vesicles Carry Immune Regulatory miRNAs and Regulate Vaccine Efficacy and Local Inflammatory Response After Vaccination. Front Immunol 12:685344","journal-title":"Front Immunol"},{"key":"1064_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202300893","volume":"68","author":"M Perus","year":"2024","unstructured":"Perus M, Courtaut F, Pais de Barros JP, Aires V, Hermetet F, Delmas D (2024) VEGF-R2\/CAV-1 Interaction Induced by Resveratrol\/Eicosapentaenoic Acid\/Docosahexaenoic Acid-Enriched Formulation through Functional Detergent-Resistant Membranes Is Associated with Decreased VEGF-A Release in ARPE-19 Cells. Mol Nutr Food Res 68:e2300893","journal-title":"Mol Nutr Food Res"},{"key":"1064_CR30","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1038\/nm.3739","volume":"20","author":"D Popovic","year":"2014","unstructured":"Popovic D, Vucic D, Dikic I (2014) Ubiquitination in disease pathogenesis and treatment. Nat Med 20:1242\u20131253","journal-title":"Nat Med"},{"key":"1064_CR31","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.4049\/jimmunol.2000060","volume":"204","author":"R Qiu","year":"2020","unstructured":"Qiu R, Yu X, Wang L, Han Z, Yao C, Cui Y, Hou G, Dai D, Jin W, Shen N (2020) Inhibition of Glycolysis in Pathogenic TH17 Cells through Targeting a miR -21-Peli1-c-Rel Pathway Prevents Autoimmunity. J Immunol 204:3160\u20133170","journal-title":"J Immunol"},{"key":"1064_CR32","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3389\/fphar.2017.00168","volume":"8","author":"GL Romano","year":"2017","unstructured":"Romano GL, Platania CBM, Drago F, Salomone S, Ragusa M, Barbagallo C, Di Pietro C, Purrello M, Reibaldi M, Avitabile T, Longo A, Bucolo C (2017) Retinal and Circulating miRNAs in Age-Related Macular Degeneration: An In vivo Animal and Human Study. Front Pharmacol 8:168","journal-title":"Front Pharmacol"},{"key":"1064_CR33","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200597R","volume":"37","author":"C Tang","year":"2023","unstructured":"Tang C, Hou YX, Shi PX, Zhu CH, Lu X, Wang XL, Que LL, Zhu GQ, Liu L, Chen Q, Li CF, Xu Y, Li JT, Li YH (2023) Cardiomyocyte-specific Peli1 contributes to the pressure overload-induced cardiac fibrosis through miR-494-3p-dependent exosomal communication. FASEB J 37:e22699","journal-title":"FASEB J"},{"key":"1064_CR34","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/path.4266","volume":"232","author":"MJ van Lookeren CampagneLeCouter","year":"2014","unstructured":"van Lookeren CampagneLeCouter MJ, Yaspan BL, Ye M (2014) Mechanisms of age-related macular degeneration and therapeutic opportunities. J Pathol 232:151\u2013164","journal-title":"J Pathol"},{"key":"1064_CR35","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s13578-022-00879-3","volume":"12","author":"K Wang","year":"2022","unstructured":"Wang K, Chen YS, Chien HW, Chiou HL, Yang SF, Hsieh YH (2022) Melatonin inhibits NaIO3-induced ARPE-19 cell apoptosis via suppression of HIF-1\u03b1\/BNIP3-LC3B\/mitophagy signaling. Cell Biosci 12:133","journal-title":"Cell Biosci"},{"key":"1064_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e32887","volume":"10","author":"L Wang","year":"2014","unstructured":"Wang L, Tian Y, Li L, Cai M, Zhou X, Su W, Hua X, Yuan X (2014) Temporary alleviation of MAPK by arbutin alleviates oxidative damage in the retina and ARPE-19 cells. Heliyon 10:e32887","journal-title":"Heliyon"},{"key":"1064_CR37","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1186\/s13046-019-1423-5","volume":"38","author":"Y Wang","year":"2019","unstructured":"Wang Y, Zhao M, He S, Luo Y, Zhao Y, Cheng J, Gong Y, Xie J, Wang Y, Hu B, Tian L, Liu X, Li C, Huang Q (2019) Necroptosis regulates tumor repopulation after radiotherapy via RIP1\/RIP3\/MLKL\/JNK\/IL8 pathway. J Exp Clin Cancer Res 38:461","journal-title":"J Exp Clin Cancer Res"},{"key":"1064_CR38","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/nm.3111","volume":"19","author":"Y Xiao","year":"2013","unstructured":"Xiao Y, Jin J, Chang M, Chang JH, Hu H, Zhou X, Brittain GC, Stansberg C, Torkildsen \u00d8, Wang X, Brink R, Cheng X, Sun SC (2013) Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nat Med 19:595\u2013602","journal-title":"Nat Med"},{"key":"1064_CR39","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1167\/iovs.66.1.63","volume":"66","author":"W Xu","year":"2025","unstructured":"Xu W, Cao L, Liu H (2025) CAMK2D and Complement Factor I-Involved Calcium\/Calmodulin Signaling Modulates Sodium Iodate-Induced Mouse Retinal Degeneration. Invest Ophthalmol vis Sci 66:63","journal-title":"Invest Ophthalmol vis Sci"},{"key":"1064_CR40","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202201448","volume":"6","author":"X Yang","year":"2023","unstructured":"Yang X, Chung JY, Rai U, Esumi N (2023) SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress. Life Sci Alliance 6:e202201448","journal-title":"Life Sci Alliance"},{"key":"1064_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109904","volume":"37","author":"L Zhang","year":"2021","unstructured":"Zhang L, Ko CJ, Li Y, Jie Z, Zhu L, Zhou X, Xie X, Gao T, Liu T, Cheng X, Sun SC (2021) Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination. Cell Rep 37:109904","journal-title":"Cell Rep"}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-025-01064-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-025-01064-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-025-01064-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T15:03:53Z","timestamp":1756998233000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-025-01064-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1064"],"URL":"https:\/\/doi.org\/10.1007\/s11626-025-01064-9","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]},"assertion":[{"value":"3 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants provided informed consent for this genetic study. This study was approved by the ethical principles outlined in the Declaration of Helsinki and was approved by the Human Research Ethics Committee of the Affiliated Wuxi People\u2019s Hospital, Nanjing Medical University (approval identifier: KY22076). All animal care and experimental protocols adhered to the NIH\u2019s Principles of Laboratory Animal Care and the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research, ensuring compliance with the highest ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors have nothing to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}