{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:10:39Z","timestamp":1790964639671,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2022JM-612"],"award-info":[{"award-number":["2022JM-612"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s11626-025-01088-1","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T17:58:28Z","timestamp":1753984708000},"page":"977-990","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nuclear protein 1 protects against neonatal hypoxic-ischemic encephalopathy by inhibiting neuronal ferroptosis by improving iron storage"],"prefix":"10.1007","volume":"61","author":[{"given":"Xining","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsheng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6198-199X","authenticated-orcid":false,"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"1088_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103211","volume":"75","author":"C Berndt","year":"2024","unstructured":"Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Bottcher JP, Brabletz S, Brabletz T, Brown AR, Brune B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distefano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, Garcia-Saez AJ, Garbowicz K, Gotz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Muller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wolk M, Wu K, Yang X, Yu F, Zou Y, Conrad M (2024) Ferroptosis in health and disease. Redox Biol 75:103211","journal-title":"Redox Biol"},{"key":"1088_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1615\/CritRevEukaryotGeneExpr.2024054011","volume":"34","author":"Y Chen","year":"2024","unstructured":"Chen Y, Huang J (2024) FTO-mediated m6A modification of FTH1 inhibits ferroptosis of neurons in neonatal cerebral hypoxic ischemia. Crit Rev Eukaryot Gene Expr 34:47\u201357","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"1088_CR3","doi-asserted-by":"crossref","unstructured":"Finder M, Boylan GB, Twomey D, Ahearne C, Murray DM, Hallberg B (2020) Two-year neurodevelopmental outcomes after mild hypoxic ischemic encephalopathy in the era of therapeutic hypothermia. JAMA Pediatr 174:48\u201355","DOI":"10.1001\/jamapediatrics.2019.4011"},{"key":"1088_CR4","doi-asserted-by":"crossref","unstructured":"Galichon P, Bataille A, Vandermeersch S, Wetzstein M, Xu-Dubois YC, Legouis D, Hertig A, Buob D, Placier S, Bige N, Lefevre G, Jouanneau C, Martin C, Iovanna JL, Rondeau E (2017) Stress response gene Nupr1 alleviates cyclosporin A nephrotoxicity in vivo. J Am Soc Nephrol 28:545\u2013556","DOI":"10.1681\/ASN.2015080936"},{"key":"1088_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13153670","volume":"13","author":"C Huang","year":"2021","unstructured":"Huang C, Santofimia-Castano P, Iovanna J (2021) NUPR1: a critical regulator of the antioxidant system. Cancers (Basel) 13:3670","journal-title":"Cancers (Basel)"},{"key":"1088_CR6","doi-asserted-by":"crossref","unstructured":"Huang C, Santofimia-Castano P, Liu X, Xia Y, Peng L, Gotorbe C, Neira JL, Tang D, Pouyssegur J, Iovanna J (2021) Nupr1 inhibitor zzw-115 induces ferroptosis in a mitochondria-dependent manner. Cell Death Discov 7:269","DOI":"10.1038\/s41420-021-00662-2"},{"key":"1088_CR7","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.clp.2024.04.008","volume":"51","author":"SL Huntingford","year":"2024","unstructured":"Huntingford SL, Boyd SM, McIntyre SJ, Goldsmith SC, Hunt RW, Badawi N (2024) Long-term outcomes following hypoxic ischemic encephalopathy. Clin Perinatol 51:683\u2013709","journal-title":"Clin Perinatol"},{"key":"1088_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116453","volume":"271","author":"L Huo","year":"2024","unstructured":"Huo L, Fu J, Wang S, Wang H, Liu X (2024) Emerging ferroptosis inhibitors as a novel therapeutic strategy for the treatment of neonatal hypoxic-ischemic encephalopathy. Eur J Med Chem 271:116453","journal-title":"Eur J Med Chem"},{"key":"1088_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12070609","volume":"12","author":"NK Kotla","year":"2022","unstructured":"Kotla NK, Dutta P, Parimi S, Das NK (2022) The role of ferritin in health and disease: recent advances and understandings. Metabolites 12:609","journal-title":"Metabolites"},{"key":"1088_CR10","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18505","volume":"28","author":"H Li","year":"2024","unstructured":"Li H, Sun H, Li S, Huang L, Zhang M, Wang S, Liu Q, Ying J, Zhao F, Su X, Mu D, Qu Y (2024) Hydrogen alleviates hypoxic-ischaemic brain damage in neonatal rats by inhibiting injury of brain pericytes. J Cell Mol Med 28:e18505","journal-title":"J Cell Mol Med"},{"key":"1088_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13621","volume":"57","author":"JY Li","year":"2024","unstructured":"Li JY, Feng YH, Li YX, He PY, Zhou QY, Tian YP, Yao RQ, Yao YM (2024) Ferritinophagy: a novel insight into the double-edged sword in ferritinophagy-ferroptosis axis and human diseases. Cell Prolif 57:e13621","journal-title":"Cell Prolif"},{"key":"1088_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176406","volume":"968","author":"J Lin","year":"2024","unstructured":"Lin J, Deng L, Qi A, Jiang H, Xu D, Zheng Y, Zhang Z, Guo X, Hu B, Li P (2024) Catalpol alleviates hypoxia ischemia-induced brain damage by inhibiting ferroptosis through the PI3K\/NRF2\/system Xc-\/GPX4 axis in neonatal rats. Eur J Pharmacol 968:176406","journal-title":"Eur J Pharmacol"},{"key":"1088_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-20904-2","volume":"12","author":"J Liu","year":"2021","unstructured":"Liu J, Song X, Kuang F, Zhang Q, Xie Y, Kang R, Kroemer G, Tang D (2021) NUPR1 is a critical repressor of ferroptosis. Nat Commun 12:647","journal-title":"Nat Commun"},{"key":"1088_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2022.116244","volume":"454","author":"S Liu","year":"2022","unstructured":"Liu S, Costa M (2022) The role of NUPR1 in response to stress and cancer development. Toxicol Appl Pharmacol 454:116244","journal-title":"Toxicol Appl Pharmacol"},{"key":"1088_CR15","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1007\/s11064-024-04161-5","volume":"49","author":"X Liu","year":"2024","unstructured":"Liu X, Xie C, Wang Y, Xiang J, Chen L, Yuan J, Chen C, Tian H (2024) Ferritinophagy and ferroptosis in cerebral ischemia reperfusion injury. Neurochem Res 49:1965\u20131979","journal-title":"Neurochem Res"},{"key":"1088_CR16","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3892\/ijo.2021.5201","volume":"58","author":"TA Martin","year":"2021","unstructured":"Martin TA, Li AX, Sanders AJ, Ye L, Frewer K, Hargest R, Jiang WG (2021) NUPR1 and its potential role in cancer and pathological conditions (review). Int J Oncol 58:21","journal-title":"Int J Oncol"},{"key":"1088_CR17","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3164\/jcbn.18-112","volume":"64","author":"K Matsunaga","year":"2019","unstructured":"Matsunaga K, Fujisawa K, Takami T, Burganova G, Sasai N, Matsumoto T, Yamamoto N, Sakaida I (2019) NUPR1 acts as a pro-survival factor in human bone marrow-derived mesenchymal stem cells and is induced by the hypoxia mimetic reagent deferoxamine. J Clin Biochem Nutr 64:209\u2013216","journal-title":"J Clin Biochem Nutr"},{"key":"1088_CR18","doi-asserted-by":"publisher","first-page":"E338","DOI":"10.1152\/ajpendo.00088.2020","volume":"319","author":"G Path","year":"2020","unstructured":"Path G, Mehana AE, Pilz IH, Alt M, Baumann J, Sommerer I, Hoffmeister A, Seufert J (2020) Nupr1 preserves insulin secretion of pancreatic beta-cells during inflammatory stress by multiple low-dose streptozotocin and high-fat diet. Am J Physiol Endocrinol Metab 319:E338\u2013E344","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1088_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137420","volume":"23","author":"ES Peeples","year":"2022","unstructured":"Peeples ES, Genaro-Mattos TC (2022) Ferroptosis: a promising therapeutic target for neonatal hypoxic-ischemic brain injury. Int J Mol Sci 23:7420","journal-title":"Int J Mol Sci"},{"key":"1088_CR20","first-page":"79","volume":"37","author":"K Placha","year":"2016","unstructured":"Placha K, Luptakova D, Baciak L, Ujhazy E, Juranek I (2016) Neonatal brain injury as a consequence of insufficient cerebral oxygenation. Neuro Endocrinol Lett 37:79\u201396","journal-title":"Neuro Endocrinol Lett"},{"key":"1088_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03705-1","volume":"5","author":"P Santofimia-Castano","year":"2022","unstructured":"Santofimia-Castano P, Huang C, Liu X, Xia Y, Audebert S, Camoin L, Peng L, Lomberk G, Urrutia R, Soubeyran P, Neira JL, Iovanna J (2022) NUPR1 protects against hyperPARylation-dependent cell death. Commun Biol 5:732","journal-title":"Commun Biol"},{"key":"1088_CR22","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","volume":"185","author":"BR Stockwell","year":"2022","unstructured":"Stockwell BR (2022) Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell 185:2401\u20132421","journal-title":"Cell"},{"key":"1088_CR23","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201700RR","volume":"37","author":"L Tan","year":"2023","unstructured":"Tan L, Armstrong AR, Rosas S, Patel CM, Vander Wiele SS, Willey JS, Carlson CS, Yammani RR (2023) Nuclear protein-1 is the common link for pathways activated by aging and obesity in chondrocytes: a potential therapeutic target for osteoarthritis. FASEB J 37:e23133","journal-title":"FASEB J"},{"key":"1088_CR24","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1007\/s10528-023-10423-8","volume":"62","author":"M Tan","year":"2024","unstructured":"Tan M, He Y, Yi J, Chen J, Guo Q, Liao N, Peng L (2024) WTAP mediates NUPR1 regulation of LCN2 through m(6)a modification to influence ferroptosis, thereby promoting breast cancer proliferation, migration and invasion. Biochem Genet 62:876\u2013891","journal-title":"Biochem Genet"},{"key":"1088_CR25","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1749-6632.1997.tb48634.x","volume":"835","author":"RC Vannucci","year":"1997","unstructured":"Vannucci RC, Vannucci SJ (1997) A model of perinatal hypoxic-ischemic brain damage. Ann N Y Acad Sci 835:234\u2013249","journal-title":"Ann N Y Acad Sci"},{"key":"1088_CR26","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/s00431-021-04320-8","volume":"181","author":"S Victor","year":"2022","unstructured":"Victor S, Rocha-Ferreira E, Rahim A, Hagberg H, Edwards D (2022) New possibilities for neuroprotection in neonatal hypoxic-ischemic encephalopathy. Eur J Pediatr 181:875\u2013887","journal-title":"Eur J Pediatr"},{"key":"1088_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41401-024-01365-x","volume":"46","author":"XX Wang","year":"2024","unstructured":"Wang XX, Li M, Xu XW, Zhao WB, Jin YM, Li LL, Qin ZH, Sheng R, Ni H (2024) BNIP3-mediated mitophagy attenuates hypoxic-ischemic brain damage in neonatal rats by inhibiting ferroptosis through P62-KEAP1-NRF2 pathway activation to maintain iron and redox homeostasis. Acta Pharmacol Sin 46:33\u201351","journal-title":"Acta Pharmacol Sin"},{"key":"1088_CR28","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1007\/s12035-024-04398-9","volume":"62","author":"M Yang","year":"2024","unstructured":"Yang M, Wang K, Liu B, Shen Y, Liu G (2024) Hypoxic-ischemic encephalopathy: pathogenesis and promising therapies. Mol Neurobiol 62:2105\u20132122","journal-title":"Mol Neurobiol"},{"key":"1088_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114868","volume":"379","author":"X Yu","year":"2024","unstructured":"Yu X, Wang S, Wang X, Li Y, Dai Z (2024) Melatonin improves stroke by inhibiting autophagy-dependent ferroptosis mediated by NCOA4 binding to FTH1. Exp Neurol 379:114868","journal-title":"Exp Neurol"},{"key":"1088_CR30","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12943-024-02030-x","volume":"23","author":"XY Zhang","year":"2024","unstructured":"Zhang XY, Li SS, Gu YR, Xiao LX, Ma XY, Chen XR, Wang JL, Liao CH, Lin BL, Huang YH, Lian YF (2024) CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p\/NUPR1\/FTH1 axis. Mol Cancer 23:113","journal-title":"Mol Cancer"},{"key":"1088_CR31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s10565-024-09849-6","volume":"40","author":"J Zhou","year":"2024","unstructured":"Zhou J, Guo D, Xu ZZ, Liao JS, Li XT, Duan K, Chen SY, Xie WB (2024) Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension. Cell Biol Toxicol 40:13","journal-title":"Cell Biol Toxicol"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-025-01088-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-025-01088-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-025-01088-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T15:08:53Z","timestamp":1762355333000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-025-01088-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["1088"],"URL":"https:\/\/doi.org\/10.1007\/s11626-025-01088-1","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]},"assertion":[{"value":"29 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental protocols were approved by the Institutional Animal Care and Use Committee of the First Affiliated Hospital of Xi\u2019an Jiaotong University and adhered to the guidelines set forth by the National Institutes of Health for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval\u00a0"}},{"value":"The authors declare that they have no conflicts of interest related to this work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}