{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T19:47:10Z","timestamp":1793994430237,"version":"4.8.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s11626-025-01134-y","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T19:19:08Z","timestamp":1763666348000},"page":"104-117","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["M2 macrophages alleviate podocyte apoptosis induced by supernatant of glomerular mesangial cells with aIgA1 via targeting UCHL1"],"prefix":"10.1007","volume":"62","author":[{"given":"Yuanjie","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lantao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"1134_CR1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.5414\/CN110897","volume":"99","author":"N Chebotareva","year":"2023","unstructured":"Chebotareva N, Cao V, Vinogradov A, Alentov I, Sergeeva N, Kononikhin A, Moiseev S (2023) A cross-sectional study of antibodies to ubiquitin proteasome system in different glomerulopathies. Clin Nephrol 99:78\u201384. https:\/\/doi.org\/10.5414\/CN110897","journal-title":"Clin Nephrol"},{"key":"1134_CR2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.173651","author":"X Chen","year":"2024","unstructured":"Chen X, Wang T, Chen L, Zhao Y, Deng Y, Shen W et al (2024) Cross-species single-cell analysis uncovers the immunopathological mechanisms associated with IgA nephropathy progression. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.173651","journal-title":"JCI Insight"},{"key":"1134_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-024-00885-3","author":"CK Cheung","year":"2025","unstructured":"Cheung CK, Alexander S, Reich HN, Selvaskandan H, Zhang H, Barratt J (2025) The pathogenesis of IgA nephropathy and implications for treatment. Nat Rev Nephrol. https:\/\/doi.org\/10.1038\/s41581-024-00885-3","journal-title":"Nat Rev Nephrol"},{"key":"1134_CR4","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s10753-017-0512-x","volume":"40","author":"J-H Cui","year":"2017","unstructured":"Cui J-H, Xie X (2017) UCH-L1 expressed by podocytes: a potentially therapeutic target for Lupus nephritis? Inflammation 40:657\u2013665. https:\/\/doi.org\/10.1007\/s10753-017-0512-x","journal-title":"Inflammation"},{"key":"1134_CR5","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1681\/ASN.0000000000000242","volume":"35","author":"K El Karoui","year":"2024","unstructured":"El Karoui K, Fervenza FC, De Vriese AS (2024) Treatment of IgA nephropathy: a rapidly evolving field. J Am Soc Nephrol 35:103\u2013116. https:\/\/doi.org\/10.1681\/ASN.0000000000000242","journal-title":"J Am Soc Nephrol"},{"key":"1134_CR6","doi-asserted-by":"publisher","first-page":"F1409","DOI":"10.1152\/ajprenal.00380.2019","volume":"317","author":"JE Engel","year":"2019","unstructured":"Engel JE, Chade AR (2019) Macrophage polarization in chronic kidney disease: a balancing act between renal recovery and decline? Am J Physiol Renal Physiol 317:F1409\u2013F1413. https:\/\/doi.org\/10.1152\/ajprenal.00380.2019","journal-title":"Am J Physiol Renal Physiol"},{"key":"1134_CR7","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1089\/ars.2012.4834","volume":"18","author":"A Etzerodt","year":"2013","unstructured":"Etzerodt A, Moestrup SK (2013) CD163 and inflammation: biological, diagnostic, and therapeutic aspects. Antioxid Redox Signal 18:2352\u20132363. https:\/\/doi.org\/10.1089\/ars.2012.4834","journal-title":"Antioxid Redox Signal"},{"key":"1134_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111891","volume":"141","author":"N Farzamikia","year":"2021","unstructured":"Farzamikia N, Baradaran B, Mostafavi S, Ahmadian E, Hosseiniyan Khatibi SM, Zununi Vahed S, Ardalan M (2021) Podocyte-derived microparticles in IgA nephropathy. Biomed Pharmacother 141:111891. https:\/\/doi.org\/10.1016\/j.biopha.2021.111891","journal-title":"Biomed Pharmacother"},{"key":"1134_CR9","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s00281-021-00888-3","volume":"43","author":"J Floege","year":"2021","unstructured":"Floege J, Rauen T, Tang SCW (2021) Current treatment of IgA nephropathy. Semin Immunopathol 43:717\u2013728. https:\/\/doi.org\/10.1007\/s00281-021-00888-3","journal-title":"Semin Immunopathol"},{"key":"1134_CR10","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s10157-012-0643-1","volume":"16","author":"H Fukasawa","year":"2012","unstructured":"Fukasawa H (2012) The role of the ubiquitin-proteasome system in kidney diseases. Clin Exp Nephrol 16:507\u2013517. https:\/\/doi.org\/10.1007\/s10157-012-0643-1","journal-title":"Clin Exp Nephrol"},{"key":"1134_CR11","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1093\/ndt\/gfad146","volume":"38","author":"PJ Gleeson","year":"2023","unstructured":"Gleeson PJ, O\u2019Shaughnessy MM, Barratt J (2023) IgA nephropathy in adults-treatment standard. Nephrol Dial Transplant 38:2464\u20132473. https:\/\/doi.org\/10.1093\/ndt\/gfad146","journal-title":"Nephrol Dial Transplant"},{"key":"1134_CR12","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1146\/annurev-physiol-022516-034219","volume":"79","author":"SC Huen","year":"2017","unstructured":"Huen SC, Cantley LG (2017) Macrophages in renal injury and repair. Annu Rev Physiol 79:449\u2013469. https:\/\/doi.org\/10.1146\/annurev-physiol-022516-034219","journal-title":"Annu Rev Physiol"},{"key":"1134_CR13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jaut.2017.12.014","volume":"89","author":"A Jamin","year":"2018","unstructured":"Jamin A, Berthelot L, Couderc A, Chemouny JM, Boedec E, Dehoux L et al (2018) Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice. J Autoimmun 89:149\u2013161. https:\/\/doi.org\/10.1016\/j.jaut.2017.12.014","journal-title":"J Autoimmun"},{"key":"1134_CR14","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1159\/000475484","volume":"42","author":"S Liang","year":"2017","unstructured":"Liang S, Jin J, Lin B, Gong J, Li Y, He Q (2017) Rapamycin induces autophagy and reduces the apoptosis of podocytes under a stimulated condition of immunoglobulin A nephropathy. Kidney Blood Press Res 42:177\u2013187. https:\/\/doi.org\/10.1159\/000475484","journal-title":"Kidney Blood Press Res"},{"key":"1134_CR15","doi-asserted-by":"publisher","first-page":"1192941","DOI":"10.3389\/fimmu.2023.1192941","volume":"14","author":"Y Liu","year":"2023","unstructured":"Liu Y, Gong Y, Xu G (2023) The role of mononuclear phagocyte system in IgA nephropathy: pathogenesis and prognosis. Front Immunol 14:1192941. https:\/\/doi.org\/10.3389\/fimmu.2023.1192941","journal-title":"Front Immunol"},{"key":"1134_CR16","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1002\/path.2511","volume":"217","author":"Y Liu","year":"2009","unstructured":"Liu Y, Wu J, Wu H, Wang T, Gan H, Zhang X et al (2009) Uch-l1 expression of podocytes in diseased glomeruli and in vitro. J Pathol 217:642\u2013653. https:\/\/doi.org\/10.1002\/path.2511","journal-title":"J Pathol"},{"key":"1134_CR17","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.bbadis.2014.02.011","volume":"1842","author":"F Lohmann","year":"2014","unstructured":"Lohmann F, Sachs M, Meyer TN, Sievert H, Lindenmeyer MT, Wiech T et al (2014) UCH-l1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation. Biochim Biophys Acta 1842:945\u2013958. https:\/\/doi.org\/10.1016\/j.bbadis.2014.02.011","journal-title":"Biochim Biophys Acta"},{"key":"1134_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217585","volume":"14","author":"TG Lopes","year":"2019","unstructured":"Lopes TG, de Souza ML, da Silva VD, Dos Santos M, da Silva WIC, Itaquy TP, Garbin HI, Veronese FV (2019) Markers of renal fibrosis: how do they correlate with podocyte damage in glomerular diseases? PLoS ONE 14:e0217585. https:\/\/doi.org\/10.1371\/journal.pone.0217585","journal-title":"PLoS ONE"},{"key":"1134_CR19","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.bcp.2018.05.007","volume":"154","author":"H Lu","year":"2018","unstructured":"Lu H, Wu L, Liu L, Ruan Q, Zhang X, Hong W, Wu S, Jin G, Bai Y (2018) Quercetin ameliorates kidney injury and fibrosis by modulating M1\/M2 macrophage polarization. Biochem Pharmacol 154:203\u2013212. https:\/\/doi.org\/10.1016\/j.bcp.2018.05.007","journal-title":"Biochem Pharmacol"},{"key":"1134_CR20","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1002\/ar.23567","volume":"300","author":"KM Mak","year":"2017","unstructured":"Mak KM, Mei R (2017) Basement membrane type IV collagen and laminin: an overview of their biology and value as fibrosis biomarkers of liver disease. Anat Rec (Hoboken) 300:1371\u20131390. https:\/\/doi.org\/10.1002\/ar.23567","journal-title":"Anat Rec (Hoboken)"},{"key":"1134_CR21","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/s41419-021-03688-7","volume":"12","author":"JA Manning","year":"2021","unstructured":"Manning JA, Shah SS, Nikolic A, Henshall TL, Khew-Goodall Y, Kumar S (2021) The ubiquitin ligase NEDD4-2\/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease. Cell Death Dis 12:398. https:\/\/doi.org\/10.1038\/s41419-021-03688-7","journal-title":"Cell Death Dis"},{"key":"1134_CR22","doi-asserted-by":"publisher","DOI":"10.12703\/p6-13","volume":"6","author":"FO Martinez","year":"2014","unstructured":"Martinez FO, Gordon S (2014) The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep 6:13. https:\/\/doi.org\/10.12703\/p6-13","journal-title":"F1000Prime Rep"},{"key":"1134_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1159\/000348461","volume":"181","author":"MC Menon","year":"2013","unstructured":"Menon MC, Chuang PY, He JC (2013) Role of podocyte injury in IgA nephropathy. Contrib Nephrol 181:41\u201351. https:\/\/doi.org\/10.1159\/000348461","journal-title":"Contrib Nephrol"},{"key":"1134_CR24","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41581-019-0148-1","volume":"15","author":"C Meyer-Schwesinger","year":"2019","unstructured":"Meyer-Schwesinger C (2019) The ubiquitin-proteasome system in kidney physiology and disease. Nat Rev Nephrol 15:393\u2013411. https:\/\/doi.org\/10.1038\/s41581-019-0148-1","journal-title":"Nat Rev Nephrol"},{"key":"1134_CR25","doi-asserted-by":"publisher","first-page":"1868152","DOI":"10.1080\/20002297.2020.1868152","volume":"13","author":"M Mohamed Elashiry","year":"2021","unstructured":"Mohamed Elashiry M, Tian F, Elashiry M, Zeitoun R, Elsayed R, Andrews ML, Bergeon BE, Cutler C, Tay F (2021) Enterococcus faecalis shifts macrophage polarization toward M1-like phenotype with an altered cytokine profile. J Oral Microbiol 13:1868152. https:\/\/doi.org\/10.1080\/20002297.2020.1868152","journal-title":"J Oral Microbiol"},{"key":"1134_CR26","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add6734","volume":"9","author":"Y Nihei","year":"2023","unstructured":"Nihei Y, Haniuda K, Higashiyama M, Asami S, Iwasaki H, Fukao Y et al (2023) Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy. Sci Adv 9:eadd6734. https:\/\/doi.org\/10.1126\/sciadv.add6734","journal-title":"Sci Adv"},{"key":"1134_CR27","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.amjms.2020.10.003","volume":"361","author":"A Rajasekaran","year":"2021","unstructured":"Rajasekaran A, Julian BA, Rizk DV (2021) IgA nephropathy: an interesting autoimmune kidney disease. Am J Med Sci 361:176\u2013194. https:\/\/doi.org\/10.1016\/j.amjms.2020.10.003","journal-title":"Am J Med Sci"},{"key":"1134_CR28","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1681\/ASN.2011050464","volume":"22","author":"H Suzuki","year":"2011","unstructured":"Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr AB, Renfrow MB et al (2011) The pathophysiology of IgA nephropathy. J Am Soc Nephrol 22:1795\u20131803. https:\/\/doi.org\/10.1681\/ASN.2011050464","journal-title":"J Am Soc Nephrol"},{"key":"1134_CR29","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2011.13304","volume":"141","author":"C Wang","year":"2011","unstructured":"Wang C, Liu X, Tang Y, Peng H, Ye Z, Zhang J, Tang H, Lou T (2011) Medium from mesangial cells incubated with aggregated IgA1 from IgA nephropathy patients reduces podocyte adhesion through activation of the renin angiotensin system. Swiss Med Wkly 141:w13304. https:\/\/doi.org\/10.4414\/smw.2011.13304","journal-title":"Swiss Med Wkly"},{"key":"1134_CR30","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1056\/NEJMra1206793","volume":"368","author":"RJ Wyatt","year":"2013","unstructured":"Wyatt RJ, Julian BA (2013) IgA nephropathy. N Engl J Med 368:2402\u20132414. https:\/\/doi.org\/10.1056\/NEJMra1206793","journal-title":"N Engl J Med"},{"key":"1134_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.06.008","volume":"382","author":"Y Xu","year":"2019","unstructured":"Xu Y, Gao H, Hu Y, Fang Y, Qi C, Huang J et al (2019) High glucose-induced apoptosis and necroptosis in podocytes is regulated by UCHL1 via RIPK1\/RIPK3 pathway. Exp Cell Res 382:111463. https:\/\/doi.org\/10.1016\/j.yexcr.2019.06.008","journal-title":"Exp Cell Res"},{"key":"1134_CR32","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.3892\/mmr.2015.3780","volume":"12","author":"H Zhang","year":"2015","unstructured":"Zhang H, Mao X, Sun Y, Hu R, Luo W, Zhao Z, Chen Q, Zhang Z (2015) NF-\u03bab upregulates ubiquitin C-terminal hydrolase 1 in diseased podocytes in glomerulonephritis. Mol Med Rep 12:2893\u20132901. https:\/\/doi.org\/10.3892\/mmr.2015.3780","journal-title":"Mol Med Rep"},{"key":"1134_CR33","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1016\/j.cellsig.2013.03.018","volume":"25","author":"H Zhang","year":"2013","unstructured":"Zhang H, Sun Y, Hu R, Luo W, Mao X, Zhao Z, Chen Q, Zhang Z (2013) The regulation of the UCH-L1 gene by transcription factor NF-\u03baB in podocytes. Cell Signal 25:1574\u20131585. https:\/\/doi.org\/10.1016\/j.cellsig.2013.03.018","journal-title":"Cell Signal"},{"issue":"Suppl 4","key":"1134_CR34","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/nep.13453","volume":"23","author":"Y-M Zhang","year":"2018","unstructured":"Zhang Y-M, Zhang H (2018) Update on treatment of immunoglobulin A nephropathy. Nephrology (Carlton) 23 (Suppl 4):62\u201367. https:\/\/doi.org\/10.1111\/nep.13453","journal-title":"Nephrology (Carlton)"},{"key":"1134_CR35","doi-asserted-by":"publisher","first-page":"5731","DOI":"10.7150\/ijbs.99738","volume":"20","author":"J Zhao","year":"2024","unstructured":"Zhao J, Liu H, Chen Q, Xia M, Wan L, Yu W et al (2024) Mechanistic study of celastrol-mediated inhibition of proinflammatory activation of macrophages in IgA nephropathy via down-regulating ECM1. Int J Biol Sci 20:5731\u20135746. https:\/\/doi.org\/10.7150\/ijbs.99738","journal-title":"Int J Biol Sci"},{"key":"1134_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.889008","volume":"13","author":"X Zhu","year":"2022","unstructured":"Zhu X, Shen X, Lin B, Fang J, Jin J, He Q (2022) Liuwei dihuang pills inhibit podocyte injury and alleviate IgA nephropathy by directly altering mesangial cell-derived exosome function and secretion. Front Pharmacol 13:889008. https:\/\/doi.org\/10.3389\/fphar.2022.889008","journal-title":"Front Pharmacol"}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-025-01134-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-025-01134-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-025-01134-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T18:43:10Z","timestamp":1772908990000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-025-01134-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["1134"],"URL":"https:\/\/doi.org\/10.1007\/s11626-025-01134-y","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"30 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Medical Ethics Committee of the Affiliated Hospital of Putian University (PUTIEN HOSPITAL AFFILIATED ETHICS [No. 202411]). The research was conducted according to the World Medical Association Declaration of Helsinki. All the information about the study will be fully explained to the subjects by the researchers. All the participants provided informed consent before sampling.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"N\/A.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"N\/A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Registry and the Registration No. of the study\/trial"}},{"value":"The study was approved by the Medical Ethics Committee of the Affiliated Hospital of Putian University (PUTIEN HOSPITAL AFFILIATED ETHICS [No. 202411]).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal Studies"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}]}}