{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:17:45Z","timestamp":1778249865157,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s11626-025-01148-6","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:27:26Z","timestamp":1774286846000},"page":"489-499","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["miR-495-3p attenuates cerebral ischemia-reperfusion-induced neuronal inflammation and apoptosis by targeting CCL2 expression"],"prefix":"10.1007","volume":"62","author":[{"given":"XiaoDong","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LiZhi","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenQin","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YanQing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenXin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4674-1640","authenticated-orcid":false,"given":"GenShan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"issue":"6","key":"1148_CR1","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1007\/s12975-020-00806-z","volume":"11","author":"A Datta","year":"2020","unstructured":"Datta A, Sarmah D, Mounica L, Kaur H, Kesharwani R, Verma G et al (2020) Cell death pathways in ischemic stroke and targeted pharmacotherapy. Transl Stroke Res 11(6):1185\u20131202","journal-title":"Transl Stroke Res"},{"issue":"12","key":"1148_CR2","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1177\/0271678X231196982","volume":"43","author":"MA Edwardson","year":"2023","unstructured":"Edwardson MA, Shivapurkar N, Li J, Khan M, Smith J, Giannetti ML et al (2023) Expansion of plasma microRNAs over the first month following human stroke. J Cereb Blood Flow Metab 43(12):2130\u20132143","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"1148_CR3","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/nsmb.2296","volume":"19","author":"MR Fabian","year":"2012","unstructured":"Fabian MR, Sonenberg N (2012) The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat Struct Mol Biol 19(6):586\u2013593","journal-title":"Nat Struct Mol Biol"},{"issue":"12","key":"1148_CR4","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1016\/j.amjmed.2021.07.027","volume":"134","author":"SK Feske","year":"2021","unstructured":"Feske SK (2021) Ischemic stroke. Am J Med 134(12):1457\u20131464","journal-title":"Am J Med"},{"issue":"1, Cerebrovascu","key":"1148_CR5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1212\/CON.0000000000000416","volume":"23","author":"A Guzik","year":"2017","unstructured":"Guzik A, Bushnell C (2017) Stroke epidemiology and risk factor management. Continuum (Minneap Minn) 23(1, Cerebrovascular Disease):15\u201339","journal-title":"Continuum (Minneap Minn)"},{"key":"1148_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2023.105724","volume":"94","author":"J He","year":"2024","unstructured":"He J, Yu J, Han C, Yang W, Zhang C, Hao W et al (2024) The SNHG10-miR-495-3p-PTEN axis is involved in sevoflurane-mediated protective effects in cardiomyocytes against hypoxia\/reoxygenation injury. Toxicol in Vitro 94:105724","journal-title":"Toxicol in Vitro"},{"key":"1148_CR7","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3494262","volume":"2022","author":"Y Huang","year":"2022","unstructured":"Huang Y, Tang J, Li X, Long X, Huang Y, Zhang X (2022) MiR-92b-3p exerts neuroprotective effects on ischemia\/reperfusion-induced cerebral injury via targeting NOX4 in a rat model. Oxid Med Cell Longev 2022:3494262","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"1148_CR8","first-page":"311","volume":"72","author":"H Kimura","year":"2020","unstructured":"Kimura H (2020) [Stroke]. Brain Nerve 72(4):311\u2013321","journal-title":"Brain Nerve"},{"issue":"10","key":"1148_CR9","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1002\/alz.12341","volume":"17","author":"AB Lopez-Rodriguez","year":"2021","unstructured":"Lopez-Rodriguez AB, Hennessy E, Murray CL, Nazmi A, Delaney HJ, Healy D et al (2021) Acute systemic inflammation exacerbates neuroinflammation in Alzheimer\u2019s disease: IL-1beta drives amplified responses in primed astrocytes and neuronal network dysfunction. Alzheimers Dement 17(10):1735\u20131755","journal-title":"Alzheimers Dement"},{"issue":"1","key":"1148_CR10","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/jcp.28791","volume":"235","author":"M Luo","year":"2020","unstructured":"Luo M, Sun Q, Zhao H, Tao J, Yan D (2020) Long noncoding RNA NEAT1 sponges miR-495-3p to enhance myocardial ischemia-reperfusion injury via MAPK6 activation. J Cell Physiol 235(1):105\u2013113","journal-title":"J Cell Physiol"},{"issue":"2","key":"1148_CR11","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1212\/CON.0000000000000840","volume":"26","author":"AA Rabinstein","year":"2020","unstructured":"Rabinstein AA (2020) Update on treatment of acute ischemic stroke. Continuum (Minneap Minn) 26(2):268\u2013286","journal-title":"Continuum (Minneap Minn)"},{"issue":"1","key":"1148_CR12","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/s12974-019-1638-6","volume":"16","author":"Y Shan","year":"2019","unstructured":"Shan Y, Tan S, Lin Y, Liao S, Zhang B, Chen X et al (2019) The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke. J Neuroinflammation 16(1):242","journal-title":"J Neuroinflammation"},{"key":"1148_CR13","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.reth.2022.08.007","volume":"21","author":"W Song","year":"2022","unstructured":"Song W, Qiu N (2022) MiR-495-3p depletion contributes to myocardial ischemia\/reperfusion injury in cardiomyocytes by targeting TNC. Regen Ther 21:380\u2013388","journal-title":"Regen Ther"},{"issue":"10","key":"1148_CR14","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.7150\/thno.30879","volume":"9","author":"Y Song","year":"2019","unstructured":"Song Y, Li Z, He T, Qu M, Jiang L, Li W et al (2019) M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124. Theranostics 9(10):2910\u20132923","journal-title":"Theranostics"},{"issue":"4","key":"1148_CR15","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1159\/000489241","volume":"46","author":"MY Wu","year":"2018","unstructured":"Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW et al (2018) Current mechanistic concepts in ischemia and reperfusion injury. Cell Physiol Biochem 46(4):1650\u20131667","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"1148_CR16","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13287-021-02187-y","volume":"12","author":"B Yang","year":"2021","unstructured":"Yang B, Zang L, Cui J, Wei L (2021) Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p\/TLR4 axis in cerebral infarction. Stem Cell Res Ther 12(1):125","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"1148_CR17","first-page":"11","volume":"62","author":"X Yang","year":"2025","unstructured":"Yang X, Chen M, Shen Z, Rong T, Feng J, Wu M et al (2025) Linc00205\/Mir-495-3p\/Tnfsf15 axis is implicated in the treatment effect of hyperbaric oxygen therapy on patients with post-stroke cognitive impairment. Noro Psikiyatr Ars 62(1):11\u201319","journal-title":"Noro Psikiyatr Ars"},{"key":"1148_CR18","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1296816","volume":"2022","author":"ZB Yang","year":"2022","unstructured":"Yang ZB, Xiang Y, Zuo ML, Mao L, Hu GH, Song GL et al (2022) LncRNA PINK1-AS aggravates cerebral ischemia\/reperfusion oxidative stress injury through regulating ATF2 by sponging miR-203. Oxid Med Cell Longev 2022:1296816","journal-title":"Oxid Med Cell Longev"},{"key":"1148_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111303","volume":"137","author":"Q Yuan","year":"2021","unstructured":"Yuan Q, Yuan Y, Zheng Y, Sheng R, Liu L, Xie F et al (2021) Anti-cerebral ischemia reperfusion injury of polysaccharides: a review of the mechanisms. Biomed Pharmacother 137:111303","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"1148_CR20","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12974-021-02172-5","volume":"18","author":"F Zhou","year":"2021","unstructured":"Zhou F, Wang YK, Zhang CG, Wu BY (2021) MiR-19a\/b-3p promotes inflammation during cerebral ischemia\/reperfusion injury via SIRT1\/FoxO3\/SPHK1 pathway. J Neuroinflammation 18(1):122","journal-title":"J Neuroinflammation"}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-025-01148-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-025-01148-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-025-01148-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T13:59:12Z","timestamp":1778248752000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-025-01148-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["1148"],"URL":"https:\/\/doi.org\/10.1007\/s11626-025-01148-6","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"5 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were compliant with the ARRIVE guidelines and performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals. The experiments were approved by the Institutional Animal Care and Use Committee of Shiyan Renmin Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}