{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:58:00Z","timestamp":1780930680251,"version":"3.54.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shandong Provincial Medical and Health Science and Technology Development Plan Project","award":["202108011013"],"award-info":[{"award-number":["202108011013"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s11626-026-01168-w","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T17:17:21Z","timestamp":1774545441000},"page":"589-601","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanism of LPS-activated gingival fibroblasts promote the migration of gastric cancer cells via CXCL12\/CXCR4-Snail2-EMT axis"],"prefix":"10.1007","volume":"62","author":[{"given":"Tongbin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangping","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3284-4527","authenticated-orcid":false,"given":"Rubing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"issue":"1","key":"1168_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2478\/bjmg-2022-0007","volume":"25","author":"CT capital Ka","year":"2022","unstructured":"Capital Ka CT, Dong JH, Wang D, Li F, Zhang ZT (2022) MIR-147B regulated proliferation and apoptosis of gastric cancer cells by targeting CPEB2 via the PTEN pathway. Balkan J Med Genet 25(1):61\u201370. https:\/\/doi.org\/10.2478\/bjmg-2022-0007","journal-title":"Balkan J Med Genet"},{"issue":"1","key":"1168_CR2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1158\/0008-5472.CAN-10-2330","volume":"71","author":"E Casas","year":"2011","unstructured":"Casas E, Kim J, Bendesky A, Ohno-Machado L, Wolfe CJ, Yang J (2011) Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res 71(1):245\u2013254. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-2330","journal-title":"Cancer Res"},{"issue":"10","key":"1168_CR3","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1093\/annonc\/mdq739","volume":"22","author":"WL Cheng","year":"2011","unstructured":"Cheng WL, Wang CS, Huang YH, Tsai MM, Liang Y, Lin KH (2011) Overexpression of CXCL1 and its receptor CXCR2 promote tumor invasion in gastric cancer. Ann Oncol 22(10):2267\u20132276. https:\/\/doi.org\/10.1093\/annonc\/mdq739","journal-title":"Ann Oncol"},{"issue":"4","key":"1168_CR4","doi-asserted-by":"publisher","first-page":"E62","DOI":"10.1002\/ijc.29177","volume":"136","author":"A Diaz-Lopez","year":"2015","unstructured":"Diaz-Lopez A, Diaz-Martin J, Moreno-Bueno G, Cuevas EP, Santos V, Olmeda D, Portillo F, Palacios J, Cano A (2015) Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT. Int J Cancer 136(4):E62-73. https:\/\/doi.org\/10.1002\/ijc.29177","journal-title":"Int J Cancer"},{"issue":"2","key":"1168_CR5","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","volume":"20","author":"A Dongre","year":"2019","unstructured":"Dongre A, Weinberg RA (2019) New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol 20(2):69\u201384. https:\/\/doi.org\/10.1038\/s41580-018-0080-4","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"1168_CR6","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1902\/jop.2015.140520","volume":"86","author":"PI Eke","year":"2015","unstructured":"Eke PI, Dye BA, Wei L, Slade GD, Thornton-Evans GO, Borgnakke WS, Taylor GW, Page RC, Beck JD, Genco RJ (2015) Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012. J Periodontol 86(5):611\u2013622. https:\/\/doi.org\/10.1902\/jop.2015.140520","journal-title":"J Periodontol"},{"issue":"2","key":"1168_CR7","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s00784-017-2171-6","volume":"22","author":"TR Fitzsimmons","year":"2018","unstructured":"Fitzsimmons TR, Ge S, Bartold PM (2018) Compromised inflammatory cytokine response to P. gingivalis LPS by fibroblasts from inflamed human gingiva. Clin Oral Investig 22(2):919\u2013927. https:\/\/doi.org\/10.1007\/s00784-017-2171-6","journal-title":"Clin Oral Investig"},{"issue":"18","key":"1168_CR8","doi-asserted-by":"publisher","first-page":"S94","DOI":"10.1111\/jcpe.12677","volume":"44","author":"JE Frencken","year":"2017","unstructured":"Frencken JE, Sharma P, Stenhouse L, Green D, Laverty D, Dietrich T (2017) Global epidemiology of dental caries and severe periodontitis - a comprehensive review. J Clin Periodontol 44(18):S94\u2013S105. https:\/\/doi.org\/10.1111\/jcpe.12677","journal-title":"J Clin Periodontol"},{"issue":"10","key":"1168_CR9","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1093\/intimm\/dxh146","volume":"16","author":"M Hashimoto","year":"2004","unstructured":"Hashimoto M, Asai Y, Ogawa T (2004) Separation and structural analysis of lipoprotein in a lipopolysaccharide preparation from Porphyromonas gingivalis. Int Immunol 16(10):1431\u20131437. https:\/\/doi.org\/10.1093\/intimm\/dxh146","journal-title":"Int Immunol"},{"issue":"1","key":"1168_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-018-0592-y","volume":"10","author":"Y Hu","year":"2018","unstructured":"Hu Y, Dai M, Zheng Y, Wu J, Yu B, Zhang H, Kong W, Wu H, Yu X (2018) Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer. Clin Epigenetics 10(1):154. https:\/\/doi.org\/10.1186\/s13148-018-0592-y","journal-title":"Clin Epigenetics"},{"key":"1168_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00752","volume":"8","author":"Y Hu","year":"2020","unstructured":"Hu Y, Nie Q, Dai M, Chen F, Wu H (2020) Histone deacetylases inhibit the Snail2-mediated EMT during metastasis of hepatocellular carcinoma cells. Front Cell Dev Biol 8:752. https:\/\/doi.org\/10.3389\/fcell.2020.00752","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"1168_CR12","doi-asserted-by":"publisher","first-page":"3442","DOI":"10.1111\/cas.14173","volume":"110","author":"Y Hu","year":"2019","unstructured":"Hu Y, Zheng Y, Dai M, Wang X, Wu J, Yu B, Zhang H, Cui Y, Kong W, Wu H, Yu X (2019) G9a and histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma. Cancer Sci 110(11):3442\u20133452. https:\/\/doi.org\/10.1111\/cas.14173","journal-title":"Cancer Sci"},{"key":"1168_CR13","doi-asserted-by":"publisher","first-page":"4901","DOI":"10.2147\/DDDT.S269223","volume":"14","author":"C Huang","year":"2020","unstructured":"Huang C, Zhang C, Yang P, Chao R, Yue Z, Li C, Guo J, Li M (2020) Eldecalcitol inhibits LPS-induced NLRP3 inflammasome-dependent pyroptosis in human gingival fibroblasts by activating the Nrf2\/HO-1 signaling pathway. Drug Des Devel Ther 14:4901\u20134913. https:\/\/doi.org\/10.2147\/DDDT.S269223","journal-title":"Drug Des Devel Ther"},{"issue":"9","key":"1168_CR14","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1158\/1055-9965.EPI-22-0051","volume":"31","author":"J Jang","year":"2022","unstructured":"Jang J, Lee S, Ko KP, Abe SK, Rahman MS, Saito E, Islam MR, Sawada N, Shu X-O, Koh W-P, Sadakane A, Tsuji I, Kim J, Oze I, Nagata C, Tsugane S, Cai H, Yuan J-M, Gao Y-T, Ozasa K, Matsuyama S, Kanemura S, Shin A, Ito H, Wada K, Sugawara Y, Chen Yu, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao Y-L, Rothman N, Zheng W, Inoue M, Kang D, Park SK (2022) Association between body mass index and risk of gastric cancer by anatomic and histologic subtypes in over 500,000 East and Southeast Asian cohort participants. Cancer Epidemiol Biomarkers Prev 31(9):1727\u20131734. https:\/\/doi.org\/10.1158\/1055-9965.EPI-22-0051","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"1168_CR15","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1158\/1940-6207.CAPR-19-0372","volume":"13","author":"L Ji","year":"2020","unstructured":"Ji L, Liu Z, Zhou B, Cai Y, An F, Wang L, Lv Z, Xia M, Yang J, Yuan J, Wang H, Zhou Z, Yang S, Hu L, Zhan Q (2020) Community-based pilot study of a screening program for gastric cancer in a Chinese population. Cancer Prev Res (Phila) 13(1):73\u201382. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-19-0372","journal-title":"Cancer Prev Res (Phila)"},{"key":"1168_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-1-29","volume":"1","author":"Y Jing","year":"2011","unstructured":"Jing Y, Han Z, Zhang S, Liu Y, Wei L (2011) Epithelial-mesenchymal transition in tumor microenvironment. Cell Biosci 1:29. https:\/\/doi.org\/10.1186\/2045-3701-1-29","journal-title":"Cell Biosci"},{"issue":"10","key":"1168_CR17","doi-asserted-by":"publisher","first-page":"e169","DOI":"10.1902\/jop.2017.170168","volume":"88","author":"W Kang","year":"2017","unstructured":"Kang W, Wang T, Hu Z, Liu F, Sun Y, Ge S (2017) Metformin inhibits Porphyromonas gingivalis lipopolysaccharide-influenced inflammatory response in human gingival fibroblasts via regulating activating transcription factor-3 expression. J Periodontol 88(10):e169\u2013e178. https:\/\/doi.org\/10.1902\/jop.2017.170168","journal-title":"J Periodontol"},{"issue":"10","key":"1168_CR18","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.2174\/1381612821666141211120326","volume":"21","author":"MI Khan","year":"2015","unstructured":"Khan MI, Hamid A, Adhami VM, Lall RK, Mukhtar H (2015) Role of epithelial mesenchymal transition in prostate tumorigenesis. Curr Pharm Des 21(10):1240\u20131248. https:\/\/doi.org\/10.2174\/1381612821666141211120326","journal-title":"Curr Pharm Des"},{"issue":"3","key":"1168_CR19","doi-asserted-by":"publisher","first-page":"e259","DOI":"10.3747\/co.27.6017","volume":"27","author":"CY Kung","year":"2020","unstructured":"Kung CY, Fang WL, Wang RF, Liu CA, Li AFY, Wu CW, Shyr YM, Chou SC, Huang KH (2020) Prognosis and clinicopathologic features in patients with gastric stump cancer after curative surgery. Curr Oncol 27(3):e259\u2013e264. https:\/\/doi.org\/10.3747\/co.27.6017","journal-title":"Curr Oncol"},{"key":"1168_CR20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jbiotec.2024.07.009","volume":"393","author":"D Liccardo","year":"2024","unstructured":"Liccardo D, Valletta A, Spagnuolo G, Vinciguerra C, Lauria MR, Perrotta A, Del Giudice C, De Luca F, Rengo G, Rengo S, Rengo C, Cannavo A (2024) Porphyromonas gingivalis virulence factors induce toxic effects in SH-SY5Y neuroblastoma cells: GRK5 modulation as a protective strategy. J Biotechnol 393:7\u201316. https:\/\/doi.org\/10.1016\/j.jbiotec.2024.07.009","journal-title":"J Biotechnol"},{"issue":"5","key":"1168_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036132","volume":"7","author":"P Molina-Ortiz","year":"2012","unstructured":"Molina-Ortiz P, Villarejo A, MacPherson M, Santos V, Montes A, Souchelnytskyi S, Portillo F, Cano A (2012) Characterization of the SNAG and SLUG domains of Snail2 in the repression of E-cadherin and EMT induction: modulation by serine 4 phosphorylation. PLoS One 7(5):e36132. https:\/\/doi.org\/10.1371\/journal.pone.0036132","journal-title":"PLoS One"},{"issue":"3","key":"1168_CR22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.4143\/crt.2012.44.3.151","volume":"44","author":"F Nurwidya","year":"2012","unstructured":"Nurwidya F, Takahashi F, Murakami A, Takahashi K (2012) Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer. Cancer Res Treat 44(3):151\u2013156. https:\/\/doi.org\/10.4143\/crt.2012.44.3.151","journal-title":"Cancer Res Treat"},{"issue":"6","key":"1168_CR23","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nrc2131","volume":"7","author":"H Peinado","year":"2007","unstructured":"Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7(6):415\u2013428. https:\/\/doi.org\/10.1038\/nrc2131","journal-title":"Nat Rev Cancer"},{"issue":"10","key":"1168_CR24","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.7150\/jca.49707","volume":"12","author":"Y Qin","year":"2021","unstructured":"Qin Y, Wang F, Ni H, Liu Y, Yin Y, Zhou X, Li J (2021) Cancer-associated fibroblasts in gastric cancer affect malignant progression via the CXCL12-CXCR4 axis. J Cancer 12(10):3011\u20133023. https:\/\/doi.org\/10.7150\/jca.49707","journal-title":"J Cancer"},{"key":"1168_CR25","doi-asserted-by":"publisher","unstructured":"Repass J, Reproducibility Project: Cancer, B. (2018). Replication study: fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Elife 7. https:\/\/doi.org\/10.7554\/eLife.25801","DOI":"10.7554\/eLife.25801"},{"issue":"2","key":"1168_CR26","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.molonc.2014.08.016","volume":"9","author":"K Ronsch","year":"2015","unstructured":"Ronsch K, Jagle S, Rose K, Seidl M, Baumgartner F, Freihen V, Hecht A (2015) SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. Mol Oncol 9(2):335\u2013354. https:\/\/doi.org\/10.1016\/j.molonc.2014.08.016","journal-title":"Mol Oncol"},{"issue":"1","key":"1168_CR27","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/prd.12226","volume":"78","author":"A Sabharwal","year":"2018","unstructured":"Sabharwal A, Gomes-Filho IS, Stellrecht E, Scannapieco FA (2018) Role of periodontal therapy in management of common complex systemic diseases and conditions: an update. Periodontol 2000 78(1):212\u2013226. https:\/\/doi.org\/10.1111\/prd.12226","journal-title":"Periodontol 2000"},{"issue":"1-2","key":"1168_CR28","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1159\/000320360","volume":"193","author":"NA Said","year":"2011","unstructured":"Said NA, Williams ED (2011) Growth factors in induction of epithelial-mesenchymal transition and metastasis. Cells Tissues Organs 193(1\u20132):85\u201397. https:\/\/doi.org\/10.1159\/000320360","journal-title":"Cells Tissues Organs"},{"issue":"1","key":"1168_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12221","volume":"75","author":"J Slots","year":"2017","unstructured":"Slots J (2017) Periodontitis: facts, fallacies and the future. Periodontol 2000 75(1):7\u201323. https:\/\/doi.org\/10.1111\/prd.12221","journal-title":"Periodontol 2000"},{"issue":"5","key":"1168_CR30","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.ccr.2014.03.021","volume":"25","author":"S Su","year":"2014","unstructured":"Su S, Liu Q, Chen J, Chen J, Chen F, He C, Song E (2014) A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell 25(5):605\u2013620. https:\/\/doi.org\/10.1016\/j.ccr.2014.03.021","journal-title":"Cancer Cell"},{"issue":"11","key":"1168_CR31","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1158\/1078-0432.CCR-09-2329","volume":"16","author":"BA Teicher","year":"2010","unstructured":"Teicher BA, Fricker SP (2010) CXCL12 (SDF-1)\/CXCR4 pathway in cancer. Clin Cancer Res 16(11):2927\u20132931. https:\/\/doi.org\/10.1158\/1078-0432.CCR-09-2329","journal-title":"Clin Cancer Res"},{"key":"1168_CR32","doi-asserted-by":"publisher","unstructured":"Tkacz M, Tarnowski M, Poniewierska-Baran A, Serwin K, Madej-Michniewicz A, Deskur A, . . . Starzynska T (2022) Impact of Selected Serum Factors on Metastatic Potential of Gastric Cancer Cells. Diagnostics (Basel) 12(3). https:\/\/doi.org\/10.3390\/diagnostics12030700","DOI":"10.3390\/diagnostics12030700"},{"issue":"16","key":"1168_CR33","doi-asserted-by":"publisher","first-page":"4586","DOI":"10.1158\/0008-5472.CAN-17-3841","volume":"78","author":"X Wang","year":"2018","unstructured":"Wang X, Luo G, Zhang K, Cao J, Huang C, Jiang T, Qiu Z (2018) Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN\/PI3K\u03b3 to promote pancreatic cancer metastasis. Cancer Res 78(16):4586\u20134598. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-3841","journal-title":"Cancer Res"},{"issue":"6","key":"1168_CR34","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1177\/0022034520909312","volume":"99","author":"L Wen","year":"2020","unstructured":"Wen L, Mu W, Lu H, Wang X, Fang J, Jia Y, Li Q, Wang D, Wen S, Guo J, Dai W, Ren X, Cui J, Zeng G, Gao J, Wang Z, Cheng B (2020) Porphyromonas gingivalis promotes oral squamous cell carcinoma progression in an immune microenvironment. J Dent Res 99(6):666\u2013675. https:\/\/doi.org\/10.1177\/0022034520909312","journal-title":"J Dent Res"},{"key":"1168_CR35","doi-asserted-by":"publisher","unstructured":"Wroblewski LE, Peek RM Jr. (2016) Helicobacter pylori, cancer, and the gastric microbiota. Adv Exp Med Biol 908:393\u2013408. https:\/\/doi.org\/10.1007\/978-3-319-41388-4_19","DOI":"10.1007\/978-3-319-41388-4_19"},{"issue":"4","key":"1168_CR36","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1158\/0008-5472.CAN-05-3393","volume":"66","author":"K Yasumoto","year":"2006","unstructured":"Yasumoto K, Koizumi K, Kawashima A, Saitoh Y, Arita Y, Shinohara K, Minami T, Nakayama T, Sakurai H, Takahashi Y, Yoshie O, Saiki I (2006) Role of the CXCL12\/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res 66(4):2181\u20132187. https:\/\/doi.org\/10.1158\/0008-5472.CAN-05-3393","journal-title":"Cancer Res"},{"issue":"3","key":"1168_CR37","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1007\/s12032-011-9990-0","volume":"29","author":"J Ying","year":"2012","unstructured":"Ying J, Xu Q, Zhang G, Liu B, Zhu L (2012) The expression of CXCL12 and CXCR4 in gastric cancer and their correlation to lymph node metastasis. Med Oncol 29(3):1716\u20131722. https:\/\/doi.org\/10.1007\/s12032-011-9990-0","journal-title":"Med Oncol"},{"issue":"3","key":"1168_CR38","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1007\/s10620-011-1922-5","volume":"57","author":"Y Zhi","year":"2012","unstructured":"Zhi Y, Chen J, Zhang S, Chang X, Ma J, Dai D (2012) Down-regulation of CXCL12 by DNA hypermethylation and its involvement in gastric cancer metastatic progression. Dig Dis Sci 57(3):650\u2013659. https:\/\/doi.org\/10.1007\/s10620-011-1922-5","journal-title":"Dig Dis Sci"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-026-01168-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-026-01168-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-026-01168-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:00:25Z","timestamp":1780927225000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-026-01168-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["1168"],"URL":"https:\/\/doi.org\/10.1007\/s11626-026-01168-w","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]},"assertion":[{"value":"8 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Tongbin Liu: No conflict of interest. Qi Tang: No conflict of interest. Min Liu: No conflict of interest. Fangping Ren: No conflict of interest. Rubing Liu: No conflict of interest. All authors declare no financial or non-financial conflicts of interest related to the subject matter of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest\u00a0"}}]}}