{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T15:58:03Z","timestamp":1780934283541,"version":"3.54.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-MSX0052"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX0052"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2023NSCQ-BHX0096"],"award-info":[{"award-number":["CSTB2023NSCQ-BHX0096"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s11626-026-01170-2","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:33:36Z","timestamp":1773779616000},"page":"713-726","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["VEGFA is essential for the potentiation of ATRA on BMP9-induced osteogenesis of preadipocytes and osteoporotic fracture healing"],"prefix":"10.1007","volume":"62","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyu","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"issue":"5","key":"1170_CR1","first-page":"1367","volume":"43","author":"H Akiyama","year":"2002","unstructured":"Akiyama H, Tanaka T, Maeno T, Kanai H, Kimura Y, Kishi S, Kurabayashi M (2002) Induction of VEGF gene expression by retinoic acid through Sp1-binding sites in retinoblastoma Y79 cells. Invest Ophth Vis Sci 43(5):1367\u201374","journal-title":"Invest Ophth Vis Sci"},{"issue":"4","key":"1170_CR2","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1177\/1933719113503411","volume":"21","author":"I Akiyama","year":"2014","unstructured":"Akiyama I, Yoshino O, Osuga Y, Shi J, Harada M, Koga K, Hirota Y, Hirata T, Fujii T, Saito S, Kozuma S (2014) Bone morphogenetic protein 7 increased vascular endothelial growth factor (VEGF)-a expression in human granulosa cells and VEGF receptor expression in endothelial cells. Reprod Sci 21(4):477\u2013482","journal-title":"Reprod Sci"},{"issue":"3","key":"1170_CR3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/os.12112","volume":"6","author":"R Aryal","year":"2014","unstructured":"Aryal R, Chen X, Fang C, Hu Y (2014) Bone morphogenetic protein-2 and vascular endothelial growth factor in bone tissue regeneration: new insight and perspectives. Orthop Surg 6(3):171\u2013178","journal-title":"Orthop Surg"},{"issue":"6","key":"1170_CR4","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1111\/joim.12364","volume":"277","author":"AD Berendsen","year":"2015","unstructured":"Berendsen AD, Olsen BR (2015) Regulation of adipogenesis and osteogenesis in mesenchymal stem cells by vascular endothelial growth factor A. J Intern Med 277(6):674\u2013680","journal-title":"J Intern Med"},{"issue":"Suppl 2","key":"1170_CR5","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1016\/S0020-1383(16)47004-X","volume":"47","author":"WH Cheung","year":"2016","unstructured":"Cheung WH, Miclau T, Chow SK, Yang FF, Alt V (2016) Fracture healing in osteoporotic bone. Injury 47(Suppl 2):S21\u2013S26","journal-title":"Injury"},{"issue":"4","key":"1170_CR6","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.bbrc.2016.06.151","volume":"477","author":"CY Chien","year":"2016","unstructured":"Chien CY, Yuan TA, Cho CH, Chang FP, Mao WY, Wu RR, Lee HS, Shen CN (2016) All-trans retinoic acid ameliorates glycemic control in diabetic mice via modulating pancreatic islet production of vascular endothelial growth factor-A. Biochem Biophys Res Commun 477(4):874\u2013880","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"1170_CR7","doi-asserted-by":"publisher","first-page":"306","DOI":"10.3109\/08977194.2010.484423","volume":"28","author":"F Cui","year":"2010","unstructured":"Cui F, Wang X, Liu X, Dighe AS, Balian G, Cui Q (2010) VEGF and BMP-6 enhance bone formation mediated by cloned mouse osteoprogenitor cells. Growth Factors 28(5):306\u2013317","journal-title":"Growth Factors"},{"issue":"4","key":"1170_CR8","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1210\/endo.143.4.8719","volume":"143","author":"MM Deckers","year":"2002","unstructured":"Deckers MM, van Bezooijen RL, van der Horst G, Hoogendam J, van Der Bent C, Papapoulos SE, L\u00f6wik CW (2002) Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology 143(4):1545\u20131553","journal-title":"Endocrinology"},{"key":"1170_CR9","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.ijbiomac.2018.11.099","volume":"123","author":"DD Dou","year":"2019","unstructured":"Dou DD, Zhou G, Liu HW, Zhang J, Liu ML, Xiao XF, Fei JJ, Guan XL, Fan YB (2019) Sequential releasing of VEGF and BMP-2 in hydroxyapatite collagen scaffolds for bone tissue engineering: design and characterization. Int J Biol Macromol 123:622\u2013628","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"1170_CR10","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.cell.2007.10.004","volume":"131","author":"S Gesta","year":"2007","unstructured":"Gesta S, Tseng Y, Kahn CR (2007) Developmental origin of fat: tracking obesity to its source. Cell 131(2):242\u2013256","journal-title":"Cell"},{"key":"1170_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2015.09.008","volume":"94","author":"KD Hankenson","year":"2015","unstructured":"Hankenson KD, Gagne K, Shaughnessy M (2015) Extracellular signaling molecules to promote fracture healing and bone regeneration. Adv Drug Deliv Rev 94:3\u201312","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"1170_CR12","first-page":"238","volume":"107","author":"K Harris","year":"2023","unstructured":"Harris K, Zagar CA, Lawrence KV (2023) Osteoporosis: common questions and answers. Am Fam Physician 107(3):238\u2013246","journal-title":"Am Fam Physician"},{"issue":"3","key":"1170_CR13","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s007740050103","volume":"18","author":"X Ji","year":"2000","unstructured":"Ji X, Chen D, Xu C, Harris SE, Mundy GR, Yoneda T (2000) Patterns of gene expression associated with BMP-2-induced osteoblast and adipocyte differentiation of mesenchymal progenitor cell 3T3-F442A. J Bone Miner Metab 18(3):132\u2013139","journal-title":"J Bone Miner Metab"},{"issue":"3\u20134","key":"1170_CR14","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1089\/107632704323061744","volume":"10","author":"J Justesen","year":"2004","unstructured":"Justesen J, Pedersen SB, Stenderup K, Kassem M (2004) Subcutaneous adipocytes can differentiate into bone-forming cells in vitro and in vivo. Tissue Eng 10(3\u20134):381\u2013391","journal-title":"Tissue Eng"},{"issue":"6","key":"1170_CR15","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.biomaterials.2009.10.059","volume":"31","author":"JM Kanczler","year":"2010","unstructured":"Kanczler JM, Ginty PJ, White L, Clarke NM, Howdle SM, Shakesheff KM, Oreffo RO (2010) The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation. Biomaterials 31(6):1242\u20131250","journal-title":"Biomaterials"},{"issue":"17","key":"1170_CR16","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1038\/sj.gt.3302298","volume":"11","author":"Q Kang","year":"2004","unstructured":"Kang Q, Sun MH, Cheng H, Peng Y, Montag AG, Deyrup AT, Jiang W, Luu HH, Luo J, Szatkowski JP, Vanichakarn P, Park JY, Li Y, Haydon RC, He TC (2004) Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther 11(17):1312\u20131320","journal-title":"Gene Ther"},{"issue":"12","key":"1170_CR17","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.1182\/blood.V97.12.3919","volume":"97","author":"AR Kini","year":"2001","unstructured":"Kini AR, Peterson LA, Tallman MS, Lingen MW (2001) Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid. Blood 97(12):3919\u20133924","journal-title":"Blood"},{"issue":"12","key":"1170_CR18","doi-asserted-by":"publisher","first-page":"3582","DOI":"10.1002\/jcb.23289","volume":"112","author":"TG Kwon","year":"2011","unstructured":"Kwon TG, Zhao X, Yang Q, Li Y, Ge C, Zhao G, Franceschi RT (2011) Physical and functional interactions between Runx2 and HIF-1\u03b1 induce vascular endothelial growth factor gene expression. J Cell Biochem 112(12):3582\u20133593","journal-title":"J Cell Biochem"},{"key":"1170_CR19","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2869572","volume":"2016","author":"B Li","year":"2016","unstructured":"Li B, Wang H, Qiu G, Su X, Wu Z (2016) Synergistic effects of vascular endothelial growth factor on bone morphogenetic proteins induced bone formation in vivo: influencing factors and future research directions. Biomed Res Int 2016:2869572","journal-title":"Biomed Res Int"},{"issue":"1","key":"1170_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01717-2","volume":"9","author":"J Li","year":"2023","unstructured":"Li J, Chen K, Li X, Zhang X, Zhang L, Yang Q, Xia Y, Xie C, Wang X, Tong J, Shen Y (2023) Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy. Cell Death Discov 9(1):418","journal-title":"Cell Death Discov"},{"issue":"5","key":"1170_CR21","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.3892\/mmr.2014.2543","volume":"10","author":"C Liang","year":"2014","unstructured":"Liang C, Guo S, Yang L (2014) Effects of all-trans retinoic acid on VEGF and HIF-1\u03b1 expression in glioma cells under normoxia and hypoxia and its anti-angiogenic effect in an intracerebral glioma model. Mol Med Rep 10(5):2713\u20132719","journal-title":"Mol Med Rep"},{"issue":"2","key":"1170_CR22","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s11596-022-2517-4","volume":"42","author":"C Liang","year":"2022","unstructured":"Liang C, Yang L, Guo S, Li R (2022) Downregulation of astrocyte elevated gene-1 expression combined with all-trans retinoic acid inhibits development of vasculogenic mimicry and angiogenesis in glioma. Curr Med Sci 42(2):397\u2013406","journal-title":"Curr Med Sci"},{"issue":"3","key":"1170_CR23","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s12013-020-00935-0","volume":"78","author":"K Liang","year":"2020","unstructured":"Liang K, Du Y, Chen L, Wang L, Li R, Yan Z, Liu Y (2020) Contrary roles of Wnt\/\u03b2-Catenin signaling in BMP9-induced osteogenic and adipogenic differentiation of 3T3-L1 preadipocytes. Cell Biochem Biophys 78(3):347\u2013356","journal-title":"Cell Biochem Biophys"},{"key":"1170_CR24","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.biocel.2013.11.018","volume":"47","author":"Y Liu","year":"2014","unstructured":"Liu Y, Liu Y, Zhang R, Wang X, Huang F, Yan Z, Nie M, Huang J, Wang Y, Wang Y, Chen L, Yin L, He B, Deng Z (2014) All-trans retinoic acid modulates bone morphogenic protein 9-induced osteogenesis and adipogenesis of preadipocytes through BMP\/Smad and Wnt\/\u03b2-catenin signaling pathways. Int J Biochem Cell Biol 47:47\u201356","journal-title":"Int J Biochem Cell Biol"},{"issue":"22","key":"1170_CR25","doi-asserted-by":"publisher","first-page":"24829","DOI":"10.18632\/aging.203718","volume":"13","author":"Z Liu","year":"2021","unstructured":"Liu Z, Li Y, Yang J, Huang J, Luo C, Zhang J, Yan W, Ao Y (2021) Bone morphogenetic protein 9 enhances osteogenic and angiogenic responses of human amniotic mesenchymal stem cells cocultured with umbilical vein endothelial cells through the PI3K\/AKT\/m-TOR signaling pathway. Aging Albany NY 13(22):24829\u201324849","journal-title":"Aging Albany NY"},{"issue":"5","key":"1170_CR26","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/nprot.2007.135","volume":"2","author":"J Luo","year":"2007","unstructured":"Luo J, Deng ZL, Luo X, Tang N, Song WX, Chen J, Sharff KA, Luu HH, Haydon RC, Kinzler KW, Vogelstein B, He TC (2007) A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat Protoc 2(5):1236\u20131247","journal-title":"Nat Protoc"},{"issue":"2","key":"1170_CR27","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1165\/ajrcmb.26.2.4509","volume":"26","author":"T Maeno","year":"2002","unstructured":"Maeno T, Tanaka T, Sando Y, Suga T, Maeno Y, Nakagawa J, Hosono T, Sato M, Akiyama H, Kishi S, Nagai R, Kurabayashi M (2002) Stimulation of vascular endothelial growth factor gene transcription by all trans retinoic acid through Sp1 and Sp3 sites in human bronchioloalveolar carcinoma cells. Am J Respir Cell Mol Biol 26(2):246\u2013253","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"1170_CR28","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","volume":"169","author":"BD Manning","year":"2017","unstructured":"Manning BD, Toker A (2017) AKT\/PKB signaling: navigating the network. Cell 169(3):381\u2013405","journal-title":"Cell"},{"issue":"3","key":"1170_CR29","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.bbrc.2017.02.001","volume":"484","author":"J Murakami","year":"2017","unstructured":"Murakami J, Ishii M, Suehiro F, Ishihata K, Nakamura N, Nishimura M (2017) Vascular endothelial growth factor-C induces osteogenic differentiation of human mesenchymal stem cells through the ERK and RUNX2 pathway. Biochem Biophys Res Commun 484(3):710\u2013718","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"1170_CR30","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S8756-3282(99)00084-8","volume":"24","author":"SR Park","year":"1999","unstructured":"Park SR, Oreffo RO, Triffitt JT (1999) Interconversion potential of cloned human marrow adipocytes in vitro. Bone 24(6):549\u2013554","journal-title":"Bone"},{"issue":"11","key":"1170_CR31","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1359\/JBMR.050708","volume":"20","author":"H Peng","year":"2005","unstructured":"Peng H, Usas A, Olshanski A, Ho AM, Gearhart B, Cooper GM, Huard J (2005) VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis. J Bone Miner Res 20(11):2017\u20132027","journal-title":"J Bone Miner Res"},{"issue":"8","key":"1170_CR32","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1515\/hsz-2015-0296","volume":"397","author":"CJ Pi","year":"2016","unstructured":"Pi CJ, Liang KL, Ke ZY, Chen F, Cheng Y, Yin LJ, Deng ZL, He BC, Chen L (2016) Adenovirus-mediated expression of vascular endothelial growth factor-A potentiates bone morphogenetic protein9-induced osteogenic differentiation and bone formation. Biol Chem 397(8):765\u2013775","journal-title":"Biol Chem"},{"issue":"3","key":"1170_CR33","doi-asserted-by":"publisher","first-page":"279","DOI":"10.4067\/S0716-97602012000300009","volume":"45","author":"AM Pino","year":"2012","unstructured":"Pino AM, Rosen CJ, Rodr\u00edguez JP (2012) In osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis. Biol Res 45(3):279\u2013287","journal-title":"Biol Res"},{"issue":"9773","key":"1170_CR34","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","volume":"377","author":"TD Rachner","year":"2011","unstructured":"Rachner TD, Khosla S, Hofbauer LC (2011) Osteoporosis: now and the future. Lancet 377(9773):1276\u20131287","journal-title":"Lancet"},{"issue":"3","key":"1170_CR35","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1210\/en.2006-0900","volume":"148","author":"A Saito","year":"2007","unstructured":"Saito A, Sugawara A, Uruno A, Kudo M, Kagechika H, Sato Y, Owada Y, Kondo H, Sato M, Kurabayashi M, Imaizumi M, Tsuchiya S, Ito S (2007) All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: possible involvement of paracrine effects of endogenous vascular endothelial growth factor signaling. Endocrinology 148(3):1412\u20131423","journal-title":"Endocrinology"},{"issue":"9","key":"1170_CR36","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1111\/j.1740-0929.2012.01032.x","volume":"83","author":"T Shimizu","year":"2012","unstructured":"Shimizu T, Magata F, Abe Y, Miyamoto A (2012) Bone morphogenetic protein 4 (BMP-4) and BMP-7 induce vascular endothelial growth factor expression in bovine granulosa cells. Anim Sci J 83(9):663\u2013667","journal-title":"Anim Sci J"},{"issue":"1","key":"1170_CR37","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1083\/jcb.200204060","volume":"159","author":"J Skillington","year":"2002","unstructured":"Skillington J, Choy L, Derynck R (2002) Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. J Cell Biol 159(1):135\u2013146","journal-title":"J Cell Biol"},{"issue":"12","key":"1170_CR38","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1111\/iej.13179","volume":"52","author":"X Sun","year":"2019","unstructured":"Sun X, Meng L, Qiao W, Yang R, Gao Q, Peng Y, Bian Z (2019) Vascular endothelial growth factor A\/vascular endothelial growth factor receptor 2 axis promotes human dental pulp stem cell migration via the FAK\/PI3K\/Akt and p38 MAPK signalling pathways. Int Endod J 52(12):1691\u20131703","journal-title":"Int Endod J"},{"issue":"33","key":"1170_CR39","doi-asserted-by":"publisher","first-page":"21881","DOI":"10.1074\/jbc.M109.019091","volume":"284","author":"X Sun","year":"2009","unstructured":"Sun X, Wei L, Chen Q, Terek RM (2009) HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity. J Biol Chem 284(33):21881\u201321890","journal-title":"J Biol Chem"},{"issue":"4","key":"1170_CR40","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s00223-011-9461-9","volume":"88","author":"T Takahashi","year":"2011","unstructured":"Takahashi T (2011) Overexpression of Runx2 and MKP-1 stimulates transdifferentiation of 3T3-L1 preadipocytes into bone-forming osteoblasts in vitro. Calcif Tissue Int 88(4):336\u2013347","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"1170_CR41","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1210\/en.2005-0854","volume":"147","author":"MK Tee","year":"2006","unstructured":"Tee MK, Vigne J, Taylor RN (2006) All-trans retinoic acid inhibits vascular endothelial growth factor expression in a cell model of neutrophil activation. Endocrinology 147(3):1264\u20131270","journal-title":"Endocrinology"},{"issue":"5","key":"1170_CR42","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1002\/jcb.20831","volume":"98","author":"RR Vogt","year":"2006","unstructured":"Vogt RR, Unda R, Yeh LC, Vidro EK, Lee JC, Tsin AT (2006) Bone morphogenetic protein-4 enhances vascular endothelial growth factor secretion by human retinal pigment epithelial cells. J Cell Biochem 98(5):1196\u20131202","journal-title":"J Cell Biochem"},{"issue":"7","key":"1170_CR43","doi-asserted-by":"publisher","first-page":"4276","DOI":"10.1167\/iovs.14-14170","volume":"55","author":"L Wang","year":"2014","unstructured":"Wang L, Shi P, Xu Z, Li J, Xie Y, Mitton K, Drenser K, Yan Q (2014) Up-regulation of VEGF by retinoic acid during hyperoxia prevents retinal neovascularization and retinopathy. Invest Ophthalmol Vis Sci 55(7):4276\u20134287","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1170_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.599281","volume":"8","author":"X Wang","year":"2020","unstructured":"Wang X, Bove AM, Simone G, Ma B (2020) Molecular bases of VEGFR-2-mediated physiological function and pathological role. Front Cell Dev Biol 8:599281","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"1170_CR45","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.3892\/mmr.2017.6302","volume":"15","author":"X Wang","year":"2017","unstructured":"Wang X, Huang J, Huang F, Zong JC, Tang X, Liu Y, Zhang QF, Wang Y, Chen L, Yin LJ, He BC, Deng ZL (2017) Bone morphogenetic protein 9 stimulates callus formation in osteoporotic rats during fracture healing. Mol Med Rep 15(5):2537\u20132545","journal-title":"Mol Med Rep"},{"issue":"1","key":"1170_CR46","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2024.5385","volume":"54","author":"X Wang","year":"2024","unstructured":"Wang X, Zhang C, Zhao G, Yang K, Tao L (2024) Obesity and lipid metabolism in the development of osteoporosis (review). Int J Mol Med 54(1):61","journal-title":"Int J Mol Med"},{"issue":"1","key":"1170_CR47","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1177\/11206721211000674","volume":"32","author":"J Wu","year":"2022","unstructured":"Wu J, Cui D, Li H, Zeng J (2022) Protective effects of NAC and salubrinal on apoptosis of retinal pigment epithelial cells induced by all-trans retinoic acid. Eur J Ophthalmol 32(1):395\u2013401","journal-title":"Eur J Ophthalmol"},{"issue":"9","key":"1170_CR48","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.18240\/ijo.2020.09.01","volume":"13","author":"J Wu","year":"2020","unstructured":"Wu J, Gao Z, Cui D, Li H, Zeng J (2020) All-trans retinoic acid increases ARPE-19 cell apoptosis via activation of reactive oxygen species and endoplasmic reticulum stress pathways. Int J Ophthalmol-Chi 13(9):1345\u20131350","journal-title":"Int J Ophthalmol-Chi"},{"issue":"1","key":"1170_CR49","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/6\/1\/015013","volume":"6","author":"C Xiao","year":"2011","unstructured":"Xiao C, Zhou H, Liu G, Zhang P, Fu Y, Gu P, Hou H, Tang T, Fan X (2011) Bone marrow stromal cells with a combined expression of BMP-2 and VEGF-165 enhanced bone regeneration. Biomed Mater 6(1):015013","journal-title":"Biomed Mater"},{"issue":"5","key":"1170_CR50","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1210\/me.2011-1287","volume":"26","author":"YY Zhang","year":"2012","unstructured":"Zhang YY, Li X, Qian SW, Guo L, Huang HY, He Q, Liu Y, Ma CG, Tang QQ (2012) Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis. Mol Endocrinol 26(5):798\u2013808","journal-title":"Mol Endocrinol"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-026-01170-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-026-01170-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-026-01170-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T15:02:58Z","timestamp":1780930978000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-026-01170-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["1170"],"URL":"https:\/\/doi.org\/10.1007\/s11626-026-01170-2","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"30 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animals were handled according to the Experimental Animal Research Guide. The animal experiments were approved by Ethics Committee of the second affiliated hospital of Chongqing Medical University (No. 2021\u2013623).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare no competing interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}