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Prior to enrollment, all subjects were required to provide written consent subsequent to receiving complete study details. This study was conducted in accordance with the NIH Guide for the Care and Use of Laboratory Animals (Pub No. 85-23, rev. 1985) and received approval from the Harbin Medical University Institutional Animal Care Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical consent and study participation"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}