{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:01:06Z","timestamp":1784908866841,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Vitro Cell.Dev.Biol.-Animal"],"DOI":"10.1007\/s11626-026-01207-6","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:06:47Z","timestamp":1784905607000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Daphnetin alleviates cisplatin-induced acute kidney injury by inhibiting the HIF-1\u03b1 signaling pathway"],"prefix":"10.1007","author":[{"given":"Li","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congxian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunju","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"1207_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154952","volume":"127","author":"H Deng","year":"2020","unstructured":"Deng H, Zheng M, Hu Z, Zeng X, Kuang N, Fu Y (2020) Effects of daphnetin on the autophagy signaling pathway of fibroblast-like synoviocytes in rats with collagen-induced arthritis (CIA) induced by TNF-\u03b1. Cytokine 127:154952","journal-title":"Cytokine"},{"key":"1207_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1134\/S1607672921040128","volume":"499","author":"Q Deng","year":"2021","unstructured":"Deng Q, Wu L, Li Y, Zou L (2021) Chemoprotective effect of daphnetin in doxorubicin treated esophageal cancer stem cell xenograft tumor mouse. Dokl Biochem Biophys 499:273\u2013281","journal-title":"Dokl Biochem Biophys"},{"key":"1207_CR3","doi-asserted-by":"publisher","first-page":"899","DOI":"10.2147\/DDDT.S361972","volume":"16","author":"H Fan","year":"2022","unstructured":"Fan H, Su BJ, Le JW, Zhu JH (2022) Salidroside protects acute kidney injury in septic rats by inhibiting inflammation and apoptosis. Drug Des Devel Ther 16:899\u2013907","journal-title":"Drug Des Devel Ther"},{"key":"1207_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122450","volume":"339","author":"J Gao","year":"2024","unstructured":"Gao J, Deng Q, Yu J, Wang C, Wei W (2024) Role of renal tubular epithelial cells and macrophages in cisplatin-induced acute renal injury. Life Sci 339:122450","journal-title":"Life Sci"},{"key":"1207_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202200261","volume":"19","author":"S Hang","year":"2022","unstructured":"Hang S, Wu W, Wang Y, Sheng R, Fang Y, Guo R (2022) Daphnetin, a coumarin in genus Stellera Chamaejasme Linn: chemistry, bioactivity and therapeutic potential. Chem Biodivers 19:e202200261","journal-title":"Chem Biodivers"},{"key":"1207_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2024.111103","volume":"218","author":"M Havasi Mehr","year":"2024","unstructured":"Havasi Mehr M, Momenabadi S, Vakili A, Pakdel A, Vafaei AA, Vakili A (2024) Neuroprotective effects of daphnetin on hippocampal neurons and blood-brain barrier integrity in a mouse model of cerebral ischemia. Brain Res Bull 218:111103","journal-title":"Brain Res Bull"},{"key":"1207_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.993562","volume":"13","author":"M Javed","year":"2022","unstructured":"Javed M, Saleem A, Xaveria A, Akhtar MF (2022) Daphnetin: a bioactive natural coumarin with diverse therapeutic potentials. Front Pharmacol 13:993562","journal-title":"Front Pharmacol"},{"key":"1207_CR8","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/2211-5463.12760","volume":"10","author":"Q Li","year":"2020","unstructured":"Li Q, Liang X, Yang Y, Zeng X, Zhong X, Huang C (2020) Panax notoginseng saponins ameliorate cisplatin-induced mitochondrial injury via the HIF-1\u03b1\/mitochondria\/ROS pathway. FEBS Open Bio 10:118\u2013126","journal-title":"FEBS Open Bio"},{"key":"1207_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111965","volume":"142","author":"Q Li","year":"2021","unstructured":"Li Q, Zhang Y, Yang Y, Huang S, Zou X, Wei C, Liang T, Zhong X (2021) Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1\u03b1\/BNIP3 to inhibit mitochondrial apoptosis pathway. Biomed Pharmacother 142:111965","journal-title":"Biomed Pharmacother"},{"key":"1207_CR10","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2561218","volume":"47","author":"X Li","year":"2025","unstructured":"Li X, Hu Y, Li J, Shi Y, Zhong Q, Ma X, Jiang D, Zhang S, Zhuang S, Liu N (2025) Roxadustat alleviates cisplatin-induced acute kidney injury by regulating fatty acid oxidation and mitochondrial function. Ren Fail 47:2561218","journal-title":"Ren Fail"},{"key":"1207_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05854-5","volume":"14","author":"ZL Li","year":"2023","unstructured":"Li ZL, Ding L, Ma RX, Zhang Y, Zhang YL, Ni WJ, Tang TT, Wang GH, Wang B, Lv LL, Wu QL, Wen Y, Liu BC (2023) Activation of HIF-1\u03b1 C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy. Cell Death Dis 14:339","journal-title":"Cell Death Dis"},{"key":"1207_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105294","volume":"107","author":"ZL Li","year":"2024","unstructured":"Li ZL, Li XY, Zhou Y, Wang B, Lv LL, Liu BC (2024) Renal tubular epithelial cells response to injury in acute kidney injury. EBioMedicine 107:105294","journal-title":"EBioMedicine"},{"key":"1207_CR13","doi-asserted-by":"publisher","DOI":"10.3892\/br.2021.1414","volume":"14","author":"T Liang","year":"2021","unstructured":"Liang T, Wei C, Lu S, Qin M, Qin G, Zhang Y, Zhong X, Zou X, Yang Y (2021) Ginaton injection alleviates cisplatin-induced renal interstitial fibrosis in rats via inhibition of apoptosis through regulation of the p38MAPK\/TGF-\u03b21 and p38MAPK\/HIF-1\u03b1 pathways. Biomed Rep 14:38","journal-title":"Biomed Rep"},{"key":"1207_CR14","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.7150\/ijbs.80775","volume":"19","author":"Q Lin","year":"2023","unstructured":"Lin Q, Li S, Jin H, Cai H, Zhu X, Yang Y, Wu J, Qi C, Shao X, Li J, Zhang K, Zhou W, Zhang M, Cheng J, Gu L, Mou S, Ni Z (2023) Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS\/HO-1\/GPX4 axis. Int J Biol Sci 19:1192\u20131210","journal-title":"Int J Biol Sci"},{"key":"1207_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/19336918.2024.2418049","volume":"18","author":"Z Lv","year":"2024","unstructured":"Lv Z, Du Y, Zhang H, Fang H, Guo Y, Zeng L, Chen Y, Li D, Li R (2024) Inhibition of JNK\/STAT3\/NF-KB pathway-mediated migration and clonal formation of lung adenocarcinoma A549 cells by daphnetin. Cell Adh Migr 18:27\u201337","journal-title":"Cell Adh Migr"},{"key":"1207_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13071572","author":"KR McSweeney","year":"2021","unstructured":"McSweeney KR, Gadanec LK, Qaradakhi T, Ali BA, Zulli A, Apostolopoulos V (2021) Mechanisms of cisplatin-induced acute kidney injury: pathological mechanisms, pharmacological interventions, and genetic mitigations. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers13071572","journal-title":"Cancers (Basel)"},{"key":"1207_CR17","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/sj.ki.5002786","volume":"73","author":"N Pabla","year":"2008","unstructured":"Pabla N, Dong Z (2008) Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 73:994\u20131007","journal-title":"Kidney Int"},{"key":"1207_CR18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.bulcan.2016.11.011","volume":"104","author":"C Rancoule","year":"2017","unstructured":"Rancoule C, Guy JB, Vallard A, Ben Mrad M, Rehailia A, Magn\u00e9 N (2017) Les 50\u00a0ans du cisplatine. Bull Cancer 104:167\u2013176","journal-title":"Bull Cancer"},{"key":"1207_CR19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/ki.1994.6","volume":"45","author":"MJ Ryan","year":"1994","unstructured":"Ryan MJ, Johnson G, Kirk J, Fuerstenberg SM, Zager RA, Torok-Storb B (1994) HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int 45:48\u201357","journal-title":"Kidney Int"},{"key":"1207_CR20","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","volume":"148","author":"GL Semenza","year":"2012","unstructured":"Semenza GL (2012) Hypoxia-inducible factors in physiology and medicine. Cell 148:399\u2013408","journal-title":"Cell"},{"key":"1207_CR21","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1007\/s43440-021-00261-z","volume":"73","author":"L Singh","year":"2021","unstructured":"Singh L, Singh AP, Bhatti R (2021) Mechanistic interplay of various mediators involved in mediating the neuroprotective effect of daphnetin. Pharmacol Rep 73:1220\u20131229","journal-title":"Pharmacol Rep"},{"key":"1207_CR22","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41581-022-00631-7","volume":"19","author":"C Tang","year":"2023","unstructured":"Tang C, Livingston MJ, Safirstein R, Dong Z (2023) Cisplatin nephrotoxicity: new insights and therapeutic implications. Nat Rev Nephrol 19:53\u201372","journal-title":"Nat Rev Nephrol"},{"key":"1207_CR23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1177\/19458924221124363","volume":"37","author":"B Tian","year":"2023","unstructured":"Tian B, Ma X, Jiang R (2023) Daphnetin mitigates ovalbumin-induced allergic rhinitis in mice by regulating Nrf2\/HO-1 and TLR4\/NF-kB signaling. Am J Rhinol Allergy 37:19\u201325","journal-title":"Am J Rhinol Allergy"},{"key":"1207_CR24","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s10529-013-1389-x","volume":"36","author":"W Wang","year":"2014","unstructured":"Wang W, Wang W, Jiang Y, Li Z, Cheng J, Liu N, Han G, Lu S, Zhang J (2014) Human adipose-derived stem cells modified by HIF-1\u03b1 accelerate the recovery of cisplatin-induced acute renal injury in vitro. Biotechnol Lett 36:667\u2013676","journal-title":"Biotechnol Lett"},{"key":"1207_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/srep10851","volume":"5","author":"WW Wang","year":"2015","unstructured":"Wang WW, Li ZZ, Wang W, Jiang Y, Cheng J, Lu S, Zhang JY (2015) Enhanced renoprotective effect of HIF-1\u03b1 modified human adipose-derived stem cells on cisplatin-induced acute kidney injury in vivo. Sci Rep 5:10851","journal-title":"Sci Rep"},{"key":"1207_CR26","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1681\/ASN.2007040419","volume":"19","author":"A Weidemann","year":"2008","unstructured":"Weidemann A, Bernhardt WM, Klanke B, Daniel C, Buchholz B, C\u00e2mpean V, Amann K, Warnecke C, Wiesener MS, Eckardt KU, Willam C (2008) HIF activation protects from acute kidney injury. J Am Soc Nephrol 19:486\u2013494","journal-title":"J Am Soc Nephrol"},{"key":"1207_CR27","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1042\/CS20171625","volume":"132","author":"Y Yang","year":"2018","unstructured":"Yang Y, Yu X, Zhang Y, Ding G, Zhu C, Huang S, Jia Z, Zhang A (2018) Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury. Clin Sci (Lond) 132:825\u2013838","journal-title":"Clin Sci (Lond)"},{"key":"1207_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1477680","volume":"15","author":"Y Yuan","year":"2024","unstructured":"Yuan Y, Li R, Zhang Y, Zhao Y, Liu Q, Wang J, Yan X, Su J (2024) Attenuating mitochondrial dysfunction-derived reactive oxygen species and reducing inflammation: the potential of Daphnetin in the viral pneumonia crisis. Front Pharmacol 15:1477680","journal-title":"Front Pharmacol"},{"key":"1207_CR29","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1002\/tox.23523","volume":"37","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Bian ZX, Song Y, Wang X, Zhang H, Ren Q, Chen S (2022) Regulation of mitophagy through HIF-1\u03b1\/miR-140-5p\/PARKIN axis in acute kidney injury. Environ Toxicol 37:1759\u20131767","journal-title":"Environ Toxicol"},{"key":"1207_CR30","first-page":"651","volume":"41","author":"Z Zhang","year":"2026","unstructured":"Zhang Z, Hu P, Li Q, Wang Y, Yao R (2026) Daphnetin alleviates renal inflammation, oxidative stress, and apoptosis in septic rats via the JAK2\/STAT3 signaling pathway. Histol Histopathol 41:651\u2013660","journal-title":"Histol Histopathol"},{"key":"1207_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156550","volume":"139","author":"L Zhao","year":"2025","unstructured":"Zhao L, Yue Z, Wang G, Qin J, Ma H, Tang D, Yin G (2025) Smilax glabra roxb. alleviates cisplatin-induced acute kidney injury in mice by activating the Nrf2\/HO-1 signalling pathway. Phytomedicine 139:156550","journal-title":"Phytomedicine"},{"key":"1207_CR32","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14377","volume":"46","author":"R Zhou","year":"2022","unstructured":"Zhou R, Wen W, Gong X, Zhao Y, Zhang W (2022) Nephro-protective effect of Daphnetin in hyperoxaluria-induced rat renal injury via alterations of the gut microbiota. J Food Biochem 46:e14377","journal-title":"J Food Biochem"},{"key":"1207_CR33","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.7150\/ijbs.125930","volume":"22","author":"X Zhou","year":"2026","unstructured":"Zhou X, Fu X, Meng YW, Dai P, Jiang Q, Yin HH, Pan QJ, Lin AZ, Ni KD, Luo ZG, Liang RY, Chen YY, Yuan HX, Liu JY (2026) Targeting CDC42 protects mitochondrial function through KLF2\/HIF-1\u03b1\/PINK1 signaling in acute kidney injury. Int J Biol Sci 22:1247\u20131265","journal-title":"Int J Biol Sci"},{"key":"1207_CR34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jep.2018.08.024","volume":"227","author":"A Zhu","year":"2018","unstructured":"Zhu A, Zhang T, Wang Q (2018) The phytochemistry, pharmacokinetics, pharmacology and toxicity of Euphorbia semen. J Ethnopharmacol 227:41\u201355","journal-title":"J Ethnopharmacol"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-026-01207-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11626-026-01207-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11626-026-01207-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:06:48Z","timestamp":1784905608000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11626-026-01207-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":34,"alternative-id":["1207"],"URL":"https:\/\/doi.org\/10.1007\/s11626-026-01207-6","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"24 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were approved by the Animal Ethics Committee of The Second People\u2019s Hospital of Guiyang and were performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}