{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:02:58Z","timestamp":1792011778018,"version":"4.4.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,2,27]],"date-time":"2011-02-27T00:00:00Z","timestamp":1298764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1007\/s11655-011-0668-4","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T11:20:08Z","timestamp":1298719208000},"page":"205-211","source":"Crossref","is-referenced-by-count":38,"title":["Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats"],"prefix":"10.1007","volume":"17","author":[{"given":"Qin-he","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-ping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-pei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-ning","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-yuan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-li","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-feng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,2,27]]},"reference":[{"key":"668_CR1","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1053\/gast.2002.33573","volume":"122","author":"J.M. Clark","year":"2002","unstructured":"Clark JM, Brancati FL, Diehl AM. Non-alcoholic fatty liver disease. Gastroenterology 2002;122:1649\u20131657.","journal-title":"Gastroenterology"},{"key":"668_CR2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1136\/gut.50.5.585","volume":"50","author":"C.P. Day","year":"2002","unstructured":"Day CP. Non-alcoholic steatohepatitis (NASH): where are we now and where are we going? Gut 2002;50: 585\u2013588.","journal-title":"Gut"},{"key":"668_CR3","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1440-1746.2007.05002.x","volume":"22","author":"G.C. Farrell","year":"2007","unstructured":"Farrell GC, Chitturi S, Lau GKK, Sollano JD. Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary. J Gastroen Hepatol 2007;22:775\u2013777.","journal-title":"J Gastroen Hepatol"},{"key":"668_CR4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ng0397-269","volume":"15","author":"C. Fleury","year":"1997","unstructured":"Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, LeviMeyrueis C, et al. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia. Nat Genet 1997;15:269\u2013272.","journal-title":"Nat Genet"},{"key":"668_CR5","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1006\/bbrc.1997.6852","volume":"235","author":"D. Larrouy","year":"1997","unstructured":"Larrouy D, Laharrague P, Carrera G, Viguerie-Bascands N, Levi-Meyrueis C, Fleury C, et al. Kupffer cells are a dominant site of uncoupling protein 2 expression in rat liver. Biochem Biophys Res Commun 1997;235:760\u2013764.","journal-title":"Biochem Biophys Res Commun"},{"key":"668_CR6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0014-5793(97)01381-1","volume":"418","author":"J. Matsuda","year":"1997","unstructured":"Matsuda J, Hosoda K, Itoh H, Son C, Doi K, Tanaka T, et al. Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet. FEBS Lett 1997;418:200\u2013204.","journal-title":"FEBS Lett"},{"key":"668_CR7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/bbrc.1998.8219","volume":"244","author":"R. Faggioni","year":"1998","unstructured":"Faggioni R, Shigenaga J, Moser A, Smith B, Grunfeld C. Induction of UCP2 gene expression by infection. Biochem Biophys Res Commun 1998;244:75\u201378.","journal-title":"Biochem Biophys Res Commun"},{"key":"668_CR8","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0016-5085(99)70022-3","volume":"116","author":"H. Cortez-Pinto","year":"1999","unstructured":"Cortez-Pinto H, Lin HZ, Yang SQ, Odwin Da Costa S, Diehl AM. Lipids up-regulate uncoupling protein-2 expression in rat hepatocytes. Gastroenterology 1999;116:1184\u20131193.","journal-title":"Gastroenterology"},{"key":"668_CR9","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.2741\/1683","volume":"10","author":"G. Baffy","year":"2005","unstructured":"Baffy G. Uncoupling protein-2 and non-alcoholic fatty liver disease. Front Biosci 2005;10:2082\u20132096.","journal-title":"Front Biosci"},{"key":"668_CR10","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.2337\/db06-0006","volume":"55","author":"Y.S. Lee","year":"2006","unstructured":"Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006;55:2256\u20132264.","journal-title":"Diabetes"},{"key":"668_CR11","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1053\/meta.2002.34715","volume":"51","author":"J. Yin","year":"2002","unstructured":"Yin J, Hu R, Chen M, Tang JF, Li FY, Yang Y, et al. Effects of berberine on glucose metabolism in vitro. Metabolism 2002;51:1439\u20131443.","journal-title":"Metabolism"},{"key":"668_CR12","first-page":"496","volume":"25","author":"S.H. Leng","year":"2004","unstructured":"Leng SH, Lu FE, Xu LJ. Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacol Sin 2004;25:496\u2013502.","journal-title":"Acta Pharmacol Sin"},{"key":"668_CR13","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1248\/bpb.28.1431","volume":"28","author":"B.S. Ko","year":"2005","unstructured":"Ko BS, Choi SB, Park SK, Jang JS, Kim YE, Park S. Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma. Biol Pharm Bull 2005;28:1431\u20131437.","journal-title":"Biol Pharm Bull"},{"key":"668_CR14","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1194\/jlr.M600020-JLR200","volume":"47","author":"J.M. Brusq","year":"2006","unstructured":"Brusq JM, Ancellin N, Grondin P, Guillard R, Martin S, Saintillan Y, et al. Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine. J Lipid Res 2006;47:1281\u20131288.","journal-title":"J Lipid Res"},{"key":"668_CR15","first-page":"49","volume":"13","author":"J. Wei","year":"2005","unstructured":"Wei J, Jiang JD, Wu JD, Wang SK, Wang ZZ, Pan HN, et al. Research on the effective improvement of hyperlipidemia by berberine. Chin J Diabetes (Chin) 2005;13:49\u201351.","journal-title":"Chin J Diabetes (Chin)"},{"key":"668_CR16","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.bbrc.2006.07.095","volume":"348","author":"C. Huang","year":"2006","unstructured":"Huang C, Zhang Y, Gong Z, Sheng XY, Li ZM, Zhang W, et al. Berberine inhibits 3T3-L1 adi-pocyte differentiation through the PPAR\u03b3 pathway. Biochem Biophys Res Commun 2006;348:571\u2013578.","journal-title":"Biochem Biophys Res Commun"},{"key":"668_CR17","first-page":"334","volume-title":"Experimental zoology of modern medicine","author":"X.Y. Shi","year":"2000","unstructured":"Shi XY. Experimental zoology of modern medicine. 1st ed. Beijing: People\u2019s Military Medical Press; 2000:334.","edition":"1st ed."},{"key":"668_CR18","doi-asserted-by":"crossref","first-page":"900","DOI":"10.2337\/diabetes.46.5.900","volume":"46","author":"R.E. Gimeno","year":"1997","unstructured":"Gimeno RE, Dembski M, Weng X, Deng N, Shyjan AW, Gimeno CJ, et al. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 1997;46:900\u2013906.","journal-title":"Diabetes"},{"key":"668_CR19","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1074\/jbc.274.9.5692","volume":"274","author":"K.D. Chavin","year":"1999","unstructured":"Chavin KD, Yang SQ, Lin HZ, Chatham J, Chacko VP, Hoek JB, et al. Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J Biol Chem 1999;274:5692\u20135700.","journal-title":"J Biol Chem"},{"key":"668_CR20","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/hep.510290428","volume":"29","author":"A. Rashid","year":"1999","unstructured":"Rashid A, Wu TC, Huang CC, Chen CH, Lin HZ, Yang SQ, et al. Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology 1999;29:1131\u20131138.","journal-title":"Hepatology"},{"key":"668_CR21","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1053\/jhep.2002.32028","volume":"35","author":"G. Baffy","year":"2002","unstructured":"Baffy G, Zhang CY, Glickman JN, Lowell BB. Obesityrelated fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2. Hepatology 2002;35:753\u2013761.","journal-title":"Hepatology"},{"key":"668_CR22","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0168-8278(03)00360-X","volume":"39","author":"P. Starkel","year":"2003","unstructured":"Starkel P, Sempoux C, Leclercq I, Herin M, Deby C, Desager JP, et al. Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats. J Hepatol 2003;39:538\u2013546.","journal-title":"J Hepatol"},{"key":"668_CR23","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S1357-2725(02)00061-4","volume":"34","author":"P. Jezek","year":"2002","unstructured":"Jezek P. Possible physiological roles of mitochondrial uncoupling proteins-UCPn. Int J Biochem Cell Biol 2002;34:1190\u20131206.","journal-title":"Int J Biochem Cell Biol"},{"key":"668_CR24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/abbi.2000.1829","volume":"15","author":"S.Q. Yang","year":"2000","unstructured":"Yang SQ, Zhu H, Li Y, Lin H, Gabrielson K, Trush MA, et al. Mitochondrial adaptations to obesity-related oxidant stress. Arch Biochem Biophys 2000;15:259\u2013268.","journal-title":"Arch Biochem Biophys"},{"key":"668_CR25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1998.9473","volume":"251","author":"H. Cortez-Pinto","year":"1998","unstructured":"Cortez-Pinto H, Yang SQ, Lin HZ, Costa S, Hwang CS, Lane MD, et al. Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism. Biochem Biophys Res Commun 1998;251:313\u2013319.","journal-title":"Biochem Biophys Res Commun"},{"key":"668_CR26","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1001\/jama.282.17.1659","volume":"282","author":"H. Cortez-Pinto","year":"1999","unstructured":"Cortez-Pinto H, Chatham J, Chacko VP, Arnold C, Rashid A, Diehl AM. Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. JAMA 1999;282:1659\u20131664.","journal-title":"JAMA"},{"key":"668_CR27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/82489","volume":"26","author":"A.J. Vidal-Puig","year":"2000","unstructured":"Vidal-Puig AJ. Uncoupling expectations. Nat Genet 2000;26:387\u2013388.","journal-title":"Nat Genet"},{"key":"668_CR28","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1074\/jbc.M706784200","volume":"283","author":"Z.P. Evans","year":"2008","unstructured":"Evans ZP, Ellett JD, Schmidt MG, Schnellmann RG, Chavin KD. Mitochondrial uncoupling protein-2 mediates steatotic liver injury following ischemia\/reperfusion. J Biol Chem 2008;283:8573\u20138579.","journal-title":"J Biol Chem"},{"key":"668_CR29","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/hep.21310","volume":"44","author":"P. Fulop","year":"2006","unstructured":"Fulop P, Derdak Z, Sheets A, Sabo E, Berthiaume EP, Resnick MB, et al. Lack of UCP2 reduces Fas-mediated liver injury in ob\/ob mice and reveals importance of cellspecific UCP2 expression. Hepatology 2006;44:592\u2013601.","journal-title":"Hepatology"},{"key":"668_CR30","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/79697","volume":"6","author":"H.Z. Lin","year":"2000","unstructured":"Lin HZ, Yang SQ, Chuckaree C, Kuhajda F, Ronnet G, Diehl AM. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med 2000;6:998\u20131003.","journal-title":"Nat Med"},{"key":"668_CR31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1053\/jhep.2003.50048","volume":"37","author":"Z.P. Li","year":"2003","unstructured":"Li ZP, Yang SQ, Lin HZ, Huang J, Watkins PA, Moser AB, et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003;37:343\u2013350.","journal-title":"Hepatology"},{"key":"668_CR32","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","volume":"114","author":"C.P. Day","year":"1998","unstructured":"Day CP, James OFW. Steatohepatitis: a tale of two \u201chits\u201d? Gastroenterology 1998;114:842\u2013845.","journal-title":"Gastroenterology"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-011-0668-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11655-011-0668-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-011-0668-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T18:54:48Z","timestamp":1559415288000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11655-011-0668-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,27]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["668"],"URL":"https:\/\/doi.org\/10.1007\/s11655-011-0668-4","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,27]]}}}