{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:35:26Z","timestamp":1761597326936},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s11655-012-0995-0","type":"journal-article","created":{"date-parts":[[2012,2,4]],"date-time":"2012-02-04T03:47:54Z","timestamp":1328327274000},"page":"137-145","source":"Crossref","is-referenced-by-count":10,"title":["Xiaoyin Recipe (\u6d88\u94f6\u65b9) for psoriasis induces a Th1\/Th2 balance drift toward Th2 in peripheral blood mononuclear cells of experimental autoimmune thyroiditis rats"],"prefix":"10.1007","volume":"18","author":[{"given":"Xiao-guang","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-ling","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-ling","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,27]]},"reference":[{"key":"995_CR1","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.4049\/jimmunol.136.7.2348","volume":"136","author":"T.R. Mosmann","year":"1986","unstructured":"Mosmann TR, Cherwinski H, Bond MW, Gieldlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348\u20132357.","journal-title":"J Immunol"},{"key":"995_CR2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3109\/08830189809043004","volume":"16","author":"G. Prete Del","year":"1998","unstructured":"Del Prete G. The concept of type-1 and type-2 helper T cells and their cytokines in humans. Int Rev Immunol 1998;16:427\u2013455.","journal-title":"Int Rev Immunol"},{"key":"995_CR3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1196\/annals.1321.010","volume":"1024","author":"I.J. Elenkov","year":"2004","unstructured":"Elenkov IJ. Glucocorticoids and the Th1\/Th2 balance. Ann N Y Acad Sci 2004;1024:138\u2013146.","journal-title":"Ann N Y Acad Sci"},{"key":"995_CR4","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1126\/science.7520605","volume":"265","author":"Y. Chen","year":"1994","unstructured":"Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994;265:1237\u20131240.","journal-title":"Science"},{"key":"995_CR5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/1074-7613(95)90169-8","volume":"3","author":"L.B. Nicholson","year":"1995","unstructured":"Nicholson LB, Greer JM, Sobel RA, Lees MB, Kuchroo VK. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 1995;3:397\u2013405.","journal-title":"Immunity"},{"key":"995_CR6","first-page":"223","volume":"8","author":"P. Kidd","year":"2003","unstructured":"Kidd P. Thl\/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev 2003;8:223\u2013246.","journal-title":"Altern Med Rev"},{"key":"995_CR7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0165-2478(99)00156-X","volume":"71","author":"D. Drugarin","year":"2000","unstructured":"Drugarin D, Negru S, Koreck A, Zosin I, Cristea C. The pattern of a T(H)1 cytokine in autoimmune thyroiditis. Immunol Lett 2000;71:73\u201377.","journal-title":"Immunol Lett"},{"key":"995_CR8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0168-8227(99)00127-8","volume":"47","author":"M.G. Karlsson","year":"2000","unstructured":"Karlsson MG, Ludvigsson J. The ABBOS-peptide from bovine serum albumin causes an IFN-gamma and IL-4 mRNA response in lymphocytes from children with recent onset of type 1 diabetes. Diabetes Res Clin Pract 2000;47:199\u2013207.","journal-title":"Diabetes Res Clin Pract"},{"key":"995_CR9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000078438","volume":"11","author":"C. Phenekos","year":"2004","unstructured":"Phenekos C, Vryonidou A, Gritzapis AD, Baxevanis CN, Goula M, Papamichail M. Th1 and Th2 serum cytokine profiles characterize patients with Hashimoto\u2019s thyroiditis (Th1) and Graves\u2019 disease (Th2). Neuroimmunomodulation 2004;11:209\u2013213.","journal-title":"Neuroimmunomodulation"},{"key":"995_CR10","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1002\/eji.1830271117","volume":"27","author":"D. Damotte","year":"1997","unstructured":"Damotte D, Colomb E, Cailleau C, Brousse N, Charreire J, Carnaud C. Analysis of susceptibility of NOD mice to spontaneous and experimentally induced thyroiditis. Eur J Immunol 1997;27:2854\u20132862.","journal-title":"Eur J Immunol"},{"key":"995_CR11","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1046\/j.1523-1747.1999.00749.x","volume":"113","author":"L.M. Austin","year":"1999","unstructured":"Austin LM, Ozawa M, Kikuchi T, Walters IB, Krueger JG. The majority of epidermal T cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J Invest Dermatol 1999;113:752\u2013759.","journal-title":"J Invest Dermatol"},{"issue":"suppl2","key":"995_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1468-3083.17.s2.1.x","volume":"17","author":"C.E. Griffiths","year":"2003","unstructured":"Griffiths CE. The immunological basis of psoriasis. J Eur Acad Dermatol Venereol 2003;17(suppl 2):1\u20135.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"995_CR13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/nm804","volume":"9","author":"K. Ghoreschi","year":"2003","unstructured":"Ghoreschi K, Thomas P, Breit S, Dugas M, Mailhammer R, van Eden W, et al. Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease. Nat Med 2003;9:40\u201346.","journal-title":"Nat Med"},{"key":"995_CR14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00109-003-0460-9","volume":"81","author":"K. Ghoreschi","year":"2003","unstructured":"Ghoreschi K, Mrowietz U, R\u00f6cken M. A molecule solves psoriasis? Systemic therapies for psoriasis inducing interleukin 4 and Th2 responses. J Mol Med 2003;81:471\u2013480.","journal-title":"J Mol Med"},{"key":"995_CR15","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.clindermatol.2007.08.012","volume":"25","author":"K. Ghoreschi","year":"2007","unstructured":"Ghoreschi K, Weigert C, R\u00f6cken M. Immunopathogenesis and role of T cells in psoriasis. Clin Dermatol 2007;25:574\u2013580.","journal-title":"Clin Dermatol"},{"key":"995_CR16","first-page":"683","volume":"28","author":"H. Zhang","year":"2008","unstructured":"Zhang H, Xu XG, Gu J. Effect of Xiaoyin Recipe in treatment of psoriasis patients of blood-heat syndrome type and its impact on peripheral Th1\/Th2 equilibrium. Chin J Integr Tradit West Med (Chin) 2008;28:683\u2013685.","journal-title":"Chin J Integr Tradit West Med (Chin)"},{"key":"995_CR17","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/clin.1996.0191","volume":"81","author":"L. Rasooly","year":"1996","unstructured":"Rasooly L, Burek CL, Rose NR. Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice. Clin Immunol Immunopathol 1996;81:287\u2013292.","journal-title":"Clin Immunol Immunopathol"},{"key":"995_CR18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1007-4376(07)60013-6","volume":"21","author":"W. Tang","year":"2007","unstructured":"Tang W, Liu CP, Qin YW, Jia Y, Mao XD, Liu C. Effect of IL-10 gene transmission on the PTg-stimulated splenocytes proliferation and Thl cytokines production from experimental autoimminue thyroiditis rats. J Nanjing Med Univ (Chin) 2007;21:55\u201358.","journal-title":"J Nanjing Med Univ (Chin)"},{"key":"995_CR19","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1210\/en.2003-0656","volume":"145","author":"H.P. Ng","year":"2004","unstructured":"Ng HP, Banga JP, Kung AW. Development of a murine model of experimental autoimmune thyroiditis induced with homologous mouse thyroid peroxidase. Endocrinology 2004;145:809\u2013816.","journal-title":"Endocrinology"},{"key":"995_CR20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"K.J. Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001;25:402\u2013408.","journal-title":"Methods"},{"key":"995_CR21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0165-2478(03)00025-7","volume":"86","author":"A. Szegedi","year":"2003","unstructured":"Szegedi A, Aleksza M, Gonda A, Irinyi B, Sipka S, Hunyadi J, et al. Elevated rate of Thelper1 (T(H)1) lymphocytes and serum IFN-gamma levels in psoriatic patients. Immunol Lett 2003;86:277\u2013280.","journal-title":"Immunol Lett"},{"key":"995_CR22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/09629350310001619753","volume":"12","author":"S.E. Jacob","year":"2003","unstructured":"Jacob SE, Nassiri M, Kerdel FA, Vincek V. Simultaneous measurement of multiple Th1 and Th2 serum cytokines in psoriasis and correlation with disease severity. Mediators Inflamm 2003;12:309\u2013313.","journal-title":"Mediators Inflamm"},{"key":"995_CR23","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s004030050473","volume":"292","author":"M. Seifert","year":"2000","unstructured":"Seifert M, Sterry W, Effenberger E, Rexin A, Friedrich M, Haeussler-Quade A, et al. The antipsoriatic activity of IL-10 is rather caused by effects on peripheral blood cells than by a direct effect on human keratinocytes. Arch Dermatol Res 2000;292:164\u2013172.","journal-title":"Arch Dermatol Res"},{"key":"995_CR24","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1046\/j.0022-202x.2001.01317.x","volume":"116","author":"K. Asadullah","year":"2001","unstructured":"Asadullah K, Friedrich M, Hanneken S, Rohrbach C, Audring H, Vergopoulos A, et al. Effects of systemic interleukin-10 therapy on psoriatic skin lesions: histologic, immunohistologic, and molecular biology findings. J Invest Dermatol 2001;116:721\u2013727.","journal-title":"J Invest Dermatol"},{"key":"995_CR25","first-page":"735","volume":"4","author":"J.R. Gonz\u00e1lez-Chavez","year":"2005","unstructured":"Gonz\u00e1lez-Chavez JR, Berlingeri-Ramos AC, S\u00e1nchez Casiano MA. Puerto Rico psoriasis study group: efficacy and safety of etanercept. J Drugs Dermatol 2005;4:735\u2013739.","journal-title":"J Drugs Dermatol"},{"key":"995_CR26","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(05)67566-6","volume":"366","author":"K. Reich","year":"2005","unstructured":"Reich K, Nestle FO, Papp K, Ortonne JP, Evans R, Guzzo C, et al. Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, double-blind trial. Lancet 2005;366:1367\u20131374.","journal-title":"Lancet"},{"key":"995_CR27","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.mehy.2003.12.003","volume":"62","author":"A.N. Elias","year":"2004","unstructured":"Elias AN. Anti-thyroid thioureylenes in the treatment of psoriasis. Med Hypotheses 2004;62:431\u2013437.","journal-title":"Med Hypotheses"},{"key":"995_CR28","first-page":"353","volume":"17","author":"A.N. Elias","year":"2007","unstructured":"Elias AN, Barr RJ. Enhanced apoptosis in psoriatic plaques after treatment with propylthiouracil. Eur J Dermatol 2007;17:353\u2013354.","journal-title":"Eur J Dermatol"},{"key":"995_CR29","first-page":"1442","volume":"33","author":"B.E. Strober","year":"2006","unstructured":"Strober BE, Siu K, Menon K. Conventional systemic agents for psoriasis. A systematic review. J Rheumatol 2006;33:1442\u20131446.","journal-title":"A systematic review. J Rheumatol"},{"key":"995_CR30","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1248\/cpb.41.1948","volume":"41","author":"M. Yoshikawa","year":"1993","unstructured":"Yoshikawa M, Hatakeyama S, Tanaka N, Fukuda Y, Yamahara J, Murakami N. Crude drugs from aquatic plants. I. On the constituents of Alismatis rhizoma. (1). Absolute stereostructures of alisols E 23-acetate, F, and G, three new protostane-type triterpenes from Chinese Alismatis rhizoma. Chem Pharm Bull 1993;41:1948\u20131954.","journal-title":"Chem Pharm Bull"},{"key":"995_CR31","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0031-9422(03)00222-X","volume":"63","author":"G.P. Peng","year":"2003","unstructured":"Peng GP, Tian G, Huang XF, Lou FC. Guaiane-type sesquiterpenoids from Alisma orientalis. Phytochemistry 2003;63:877\u2013881.","journal-title":"Phytochemistry"},{"key":"995_CR32","first-page":"738","volume":"50","author":"K. Yamaguchi","year":"1994","unstructured":"Yamaguchi K, Ida Y, Satoh Y, Nakajima Y, Shoji J. A kaurane derivative isolated from Alisma orientale. Acta Cryst 1994;50:738\u2013740.","journal-title":"Acta Cryst"},{"key":"995_CR33","first-page":"127","volume-title":"Flora Reipublicae Popularis Sinicae. Vol. 8","author":"Y.D. Chen","year":"1992","unstructured":"Chen YD. Alismataceae. In: Sun XZ, ed. Flora Reipublicae Popularis Sinicae. Vol. 8. Beijing: Science Press; 1992:127\u2013145."},{"key":"995_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2003.12.031","volume":"92","author":"W.L. Li","year":"2004","unstructured":"Li WL, Zheng HC, Bukuru J, De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol 2004;92:1\u201321.","journal-title":"J Ethnopharmacol"},{"key":"995_CR35","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/S0960-894X(02)00401-8","volume":"12","author":"H.J. Shin","year":"2002","unstructured":"Shin HJ, Kim HJ, Kwak JH, Chun HO, Kim JH, Park H, et al. A prenylated flavonol, sophoflavescenol: A potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett 2002;12:2313\u20132316.","journal-title":"Bioorg Med Chem Lett"},{"key":"995_CR36","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.intimp.2008.08.008","volume":"8","author":"Y. Zhang","year":"2008","unstructured":"Zhang Y, Wang S, Li Y, Xiao Z, Hu Z, Zhang J. Sophocarpine and matrine inhibit the production of TNFalpha and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice. Int Immunopharmacol 2008;8:1767\u20131772.","journal-title":"Int Immunopharmacol"},{"key":"995_CR37","first-page":"2234","volume":"33","author":"Y.M. Zheng","year":"2008","unstructured":"Zheng YM, Li X, Zhao HY, Zhao JY. Effect of matrine and oxymatrine on proliferation and expression of Stat3 and Stat5 in SMMC-7721 cell line. China J Chin Mater Med (Chin) 2008;33:2234\u20132237.","journal-title":"China J Chin Mater Med (Chin)"},{"key":"995_CR38","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1089\/105072501300176381","volume":"11","author":"C. Ruwhof","year":"2001","unstructured":"Ruwhof C, Drexhage HA. Iodine and thyroid autoimmune disease in animal models. Thyroid 2001;11:427\u2013436.","journal-title":"Thyroid"},{"key":"995_CR39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00007890-199907150-00006","volume":"68","author":"E.M. Allen","year":"1999","unstructured":"Allen EM, Bartlett ST. The effect of methimazole, iodine and splenocytes on thyroid transplants in BB\/Wor rats. Transplantation 1999;68:25\u201330.","journal-title":"Transplantation"},{"key":"995_CR40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2174\/1568010043343868","volume":"3","author":"M. Ozawa","year":"2004","unstructured":"Ozawa M, Aiba S. Immunopathogenesis of psoriasis. Curr Drug Targets Inflamm Allergy 2004;3:137\u2013144.","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"995_CR41","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0960-9822(02)00830-8","volume":"12","author":"D.S. Robinson","year":"2002","unstructured":"Robinson DS, Lloyd CM. Asthma: T-bet-a master controller? Curr Biol 2002;12:322\u2013324.","journal-title":"Curr Biol"},{"key":"995_CR42","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00281-003-0143-1","volume":"25","author":"S. Finotto","year":"2004","unstructured":"Finotto S, Glimcher L. T cells directives for transcription regulation in asthma. Springer Semin Immunopathol 2004;25:281\u2013294.","journal-title":"Springer Semin Immunopathol"},{"key":"995_CR43","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.4049\/jimmunol.172.10.6158","volume":"172","author":"N. Seki","year":"2004","unstructured":"Seki N, Miyazaki M, Suzuki W, Hayashi K, Arima K, Myburgh E, et al. IL-4 induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiation. J Immunol 2004;172:6158\u20136166.","journal-title":"J Immunol"},{"key":"995_CR44","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","volume":"100","author":"S.J. Szabo","year":"2000","unstructured":"Szabo SJ, Kim ST, Costa GL, Zhang XK, Fathman CG, Glimcher LH, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000;100:655\u2013669.","journal-title":"Cell"},{"key":"995_CR45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0022-1759(03)00200-X","volume":"278","author":"H. Chakir","year":"2003","unstructured":"Chakir H, Wang HP, Lefebvre DE, Webb J, Scott FW. T-bet\/GATA-3 ratio as a measure of the Th1\/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3. J Immunol Methods 2003;278:157\u2013169.","journal-title":"J Immunol Methods"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-012-0995-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11655-012-0995-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-012-0995-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T08:53:57Z","timestamp":1686732837000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11655-012-0995-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["995"],"URL":"https:\/\/doi.org\/10.1007\/s11655-012-0995-0","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}