{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:56:29Z","timestamp":1784404589263,"version":"3.55.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s11655-014-1817-3","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T15:43:42Z","timestamp":1402674222000},"page":"776-781","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of quercetin on hedgehog signaling in chronic myeloid leukemia KBM7 cells"],"prefix":"10.1007","volume":"20","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"1817_CR1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-9966-30-8","volume":"30","author":"B Long","year":"2011","unstructured":"Long B, Zhu H, Zhu C, Liu T, Meng W. Activation of the hedgehog pathway in chronic myelogeneous leukemia patients. J Exp Clin Cancer Res 2011;30:8.","journal-title":"J Exp Clin Cancer Res"},{"key":"1817_CR2","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.4161\/cc.9.17.12945","volume":"9","author":"Z Jagani","year":"2010","unstructured":"Jagani Z, Dorsch M, Warmuth M. Hedgehog pathway activation in chronic myeloid leukemia. Cell Cycle 2010;9:3449\u20133456.","journal-title":"Cell Cycle"},{"key":"1817_CR3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/287795a0","volume":"287","author":"C N\u00fcsslein-Volhard","year":"1980","unstructured":"N\u00fcsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980;287:795\u2013801.","journal-title":"Nature"},{"key":"1817_CR4","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1158\/1541-7786.MCR-08-0142","volume":"6","author":"GV Hegde","year":"2008","unstructured":"Hegde GV, Peterson KJ, Emanuel K, Mittal AK, Joshi AD, Dickinson JD, et al. Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target. Mol Cancer Res 2008;6:1928\u20131936.","journal-title":"Mol Cancer Res"},{"key":"1817_CR5","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1158\/1535-7163.MCT-11-0422","volume":"10","author":"A Uhmann","year":"2011","unstructured":"Uhmann A, Niemann H, Lammering B, Henkel C, Hess I, Nitzki F, et al. Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation. Mol Cancer Ther 2011;10:2179\u20132188.","journal-title":"Mol Cancer Ther"},{"key":"1817_CR6","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1158\/0008-5472.CAN-09-3012","volume":"70","author":"A Slusarz","year":"2010","unstructured":"Slusarz A, Shenouda NS, Sakla MS, Drenkhahn SK, Narula AS, MacDonald RS, et al. Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer. Cancer Res 2010;70:3382\u20133390.","journal-title":"Cancer Res"},{"key":"1817_CR7","doi-asserted-by":"crossref","first-page":"638","DOI":"10.18632\/oncotarget.310","volume":"2","author":"T Mazumdar","year":"2011","unstructured":"Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton JA. The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer. Oncotarget 2011;2:638\u2013645.","journal-title":"Oncotarget"},{"key":"1817_CR8","first-page":"w13208","volume":"141","author":"J Yao","year":"2011","unstructured":"Yao J, An Y, Wie JS, Ji ZL, Lu ZP, Wu JL, et al. Cyclopamine reverts acquired chemoresistance and downregulates cancer stem cell markers in pancreatic cancer cell lines. Swiss Med Wkly 2011;141:w13208.","journal-title":"Swiss Med Wkly"},{"key":"1817_CR9","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1349-7006.2010.01584.x","volume":"101","author":"K Naka","year":"2010","unstructured":"Naka K, Hoshii T, Hirao A. Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells. Cancer Sci 2010;101:1577\u20131581.","journal-title":"Cancer Sci"},{"key":"1817_CR10","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1158\/1078-0432.CCR-10-1565","volume":"16","author":"S Cheng","year":"2010","unstructured":"Cheng S, Gao N, Zhang Z, Chen G, Budhraja A, Ke Z, et al. Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax. Clin Cancer Res 2010;16:5679\u20135691.","journal-title":"Clin Cancer Res"},{"key":"1817_CR11","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1038\/sj.leu.2403135","volume":"17","author":"J Gabert","year":"2003","unstructured":"Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N, et al. Standardization and quality control studies of \u2018real-time\u2019 quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia-a Europe Against Cancer program. Leukemia 2003;17:2318\u20132357.","journal-title":"Leukemia"},{"key":"1817_CR12","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s11655-012-1206-8","volume":"18","author":"CH Yeh","year":"2012","unstructured":"Yeh CH, Yang YY, Huang YF, Chow KC, Chen MF. Induction of apoptosis in human Hep3B hepatoma cells by norcantharidin through a p53 independent pathway via TRAIL\/DR5 signal transduction. Chin J Integr Med 2012;18:676\u2013682.","journal-title":"Chin J Integr Med"},{"key":"1817_CR13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2174\/187152010790909326","volume":"10","author":"Y Chen","year":"2010","unstructured":"Chen Y, Peng C, Sullivan C, Li D, Li S. Novel therapeutic agents against cancer stem cells of chronic myeloid leukemia. Anticancer Agents Med Chem 2010;10:111\u2013115.","journal-title":"Anticancer Agents Med Chem"},{"key":"1817_CR14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ccr.2008.08.003","volume":"14","author":"C Dierks","year":"2008","unstructured":"Dierks C, Beigi R, Guo GR, Zirlik K, Stegert MR, Manley P, et al. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 2008;14:238\u2013249.","journal-title":"Cancer Cell"},{"key":"1817_CR15","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tips.2009.03.007","volume":"30","author":"SJ Scales","year":"2009","unstructured":"Scales SJ, de Sauvage FJ. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 2009;30:303\u2013312.","journal-title":"Trends Pharmacol Sci"},{"key":"1817_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2153(03)53002-2","volume":"53","author":"AP McMahon","year":"2003","unstructured":"McMahon AP, Ingham PW, Tabin CJ. Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol 2003;53:1\u2013114.","journal-title":"Curr Top Dev Biol"},{"key":"1817_CR17","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/sj.leu.2404657","volume":"21","author":"A Sengupta","year":"2007","unstructured":"Sengupta A, Banerjee D, Chandra S, Banerji SK, Ghosh R, Roy R, et al. Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progression. Leukemia 2007;21:949\u2013955.","journal-title":"Leukemia"},{"key":"1817_CR18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/417299a","volume":"417","author":"M Duman-Scheel","year":"2002","unstructured":"Duman-Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 2002;417:299\u2013304.","journal-title":"Nature"},{"key":"1817_CR19","doi-asserted-by":"crossref","first-page":"7724","DOI":"10.1158\/0008-5472.CAN-04-1085","volume":"64","author":"G Regl","year":"2004","unstructured":"Regl G, Kasper M, Schnidar H, Eichberger T, Neill GW, Philpott MP, et al. Activation of the Bcl-2 promoter in response to Hedgehog\/GLI signal transduction is predominantly mediated by GLI2. Cancer Res 2004;64:7724\u20137731.","journal-title":"Cancer Res"},{"key":"1817_CR20","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nature07737","volume":"458","author":"C Zhao","year":"2009","unstructured":"Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009;458:776\u2013779.","journal-title":"Nature"},{"key":"1817_CR21","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.biopha.2011.12.008","volume":"66","author":"HF Liao","year":"2012","unstructured":"Liao HF, Su YC, Zheng ZY, Jhih Cai C, Hou MH, Chao KS, et al. Sonic hedgehog signaling regulates Bcr-Abl expression in human chronic myeloid leukemia cells. Biomed Pharmacother 2012;66:378\u2013383.","journal-title":"Biomed Pharmacother"},{"key":"1817_CR22","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/leu.2011.143","volume":"25","author":"BG Mar","year":"2011","unstructured":"Mar BG, Amakye D, Aifantis I, Buonamici S. The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis. Leukemia 2011;25:1665\u20131673.","journal-title":"Leukemia"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-014-1817-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11655-014-1817-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-014-1817-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T14:25:34Z","timestamp":1565533534000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11655-014-1817-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,13]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["1817"],"URL":"https:\/\/doi.org\/10.1007\/s11655-014-1817-3","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,13]]}}}