{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:19:30Z","timestamp":1784067570227,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s11655-016-2741-5","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T23:35:50Z","timestamp":1487115350000},"page":"663-670","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Anti-inflammatory Effect of Total Saponin Fraction from Dioscorea nipponica Makino on Gouty Arthritis and Its Influence on NALP3 Inflammasome"],"prefix":"10.1007","volume":"25","author":[{"given":"Qi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-hua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"2741_CR1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/BOR.0b013e3283438e13","volume":"23","author":"JA Singh","year":"2011","unstructured":"Singh JA, Reddy SG, Kundukulam J. Risk factors for gout and prevention: a systematic review of the literature. Curr Opin Rheumatol 2011;23:192\u2013202.","journal-title":"Curr Opin Rheumatol"},{"key":"2741_CR2","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/S0140-6736(04)16000-5","volume":"263","author":"HK Choi","year":"2004","unstructured":"Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G. Alcohol intake and risk of incident gout in men: a prospective study. Lancet 2004;263:1277\u20131281.","journal-title":"Lancet"},{"key":"2741_CR3","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1056\/NEJMoa035700","volume":"350","author":"HK Choi","year":"2004","unstructured":"Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G. Purin-rich food, dairy and protein intake, and the risk of gout in men. N Engl J Med 2004;350:1093\u20131103.","journal-title":"N Engl J Med"},{"key":"2741_CR4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S0140-6736(09)60883-7","volume":"375","author":"P Richette","year":"2010","unstructured":"Richette P, Bardin T. Gout. Lancet 2010;375:318\u2013328.","journal-title":"Lancet"},{"key":"2741_CR5","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.jpain.2011.06.009","volume":"12","author":"HS Smith","year":"2011","unstructured":"Smith HS, Bracken D, Smith JM. Gout: current insights and future perspectives. J Pain 2011;12:1113\u20131129.","journal-title":"J Pain"},{"key":"2741_CR6","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1369\/jhc.6A7101.2006","volume":"55","author":"JA Kummer","year":"2006","unstructured":"Kummer JA, Broekhuizen R, Everett H, Agostini L, Kuijk L, Martinon F, et al. Inflammasome components NALP1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem 2006;55:443\u2013452.","journal-title":"J Histochem Cytochem"},{"key":"2741_CR7","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00281-007-0082-3","volume":"29","author":"S Taniguchi","year":"2007","unstructured":"Taniguchi S, Sagar J. Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC. Semin Immunopathol 2007;29:231\u2013238.","journal-title":"Semin Immunopathol"},{"key":"2741_CR8","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/ar3110","volume":"12","author":"JA Singh","year":"2010","unstructured":"Singh JA. Advances in gout: some answers, more questions. Arthritis Res Ther 2010;12:136.","journal-title":"Arthritis Res Ther"},{"key":"2741_CR9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s11882-010-0109-z","volume":"10","author":"HM Hoffman","year":"2010","unstructured":"Hoffman HM, Wanderer AA. Inflamma some and IL-1beta-mediated disorders. Curr Allergy Asthma Rep 2010;10:229\u2013235.","journal-title":"Curr Allergy Asthma Rep"},{"key":"2741_CR10","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1056\/NEJMcp030733","volume":"349","author":"RA Terkeltaub","year":"2003","unstructured":"Terkeltaub RA. Clinical practice. Gout. N Engl J Med 2003;349:1647\u20131655.","journal-title":"Gout. N Engl J Med"},{"key":"2741_CR11","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1002\/art.23069","volume":"58","author":"DJ Mccarty","year":"2008","unstructured":"Mccarty DJ. Urate crystals, inflammation, and colchicine. Arthritis Rheum 2008;58:S20\u2013S40.","journal-title":"Arthritis Rheum"},{"key":"2741_CR12","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.fct.2009.10.005","volume":"48","author":"EP Sabina","year":"2010","unstructured":"Sabina EP, Rasool MK, Mathew L, Ezilrani P, Indu H. 6-Shogaol inhibits monosodium urate crystal-induced inflammation-an in vivo and in vitro study. Food Chem Toxicol 2010; 48:229\u2013235.","journal-title":"Food Chem Toxicol"},{"key":"2741_CR13","first-page":"250","volume-title":"The Pharmacopoeia of the Peple\u2019s Republic of China","author":"Chinese Pharmacopoeia Commission.","year":"2010","unstructured":"Chinese Pharmacopoeia Commission. The Pharmacopoeia of the Peple\u2019s Republic of China. Beijing: The Chemical Industry Publishing House; 2010:250\u2013251."},{"key":"2741_CR14","first-page":"55","volume":"2","author":"XL Ding","year":"2003","unstructured":"Ding XL, Li Q. Research progress of Chinese medicine of Rhizoma Dioscoreae Nipponicae. Chongqing J Res Chin Drugs Herbs (Chin) 2003;2:55\u201357.","journal-title":"Chongqing J Res Chin Drugs Herbs (Chin)"},{"key":"2741_CR15","first-page":"81","volume":"18","author":"SY Yu","year":"2010","unstructured":"Yu SY, Ji FR, Yu DH, Liu SM. Studies on chromatography fingerprint of Dioscorea nipponica serum. Chin J Exp Tradit Med Form (Chin) 2010;18:81.","journal-title":"Chin J Exp Tradit Med Form (Chin)"},{"key":"2741_CR16","first-page":"96","volume":"18","author":"SY Yu","year":"2012","unstructured":"Yu SY, Liu Y, Liu SM. Simultaneous determination of the contents of protodioscin, methy protodioscin and pseudo protodioscin in Rhizoma Dioscoreae Nipponicae with RP-HPLC. Chin J Exp Tradit Med Form (Chin) 2012;18:96\u201398.","journal-title":"Chin J Exp Tradit Med Form (Chin)"},{"key":"2741_CR17","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1002\/ptr.4997","volume":"28","author":"F Lu","year":"2014","unstructured":"Lu F, Liu L, Yu DH, Li XZ, Zhou Q, Liu SM. Therapeutic effect of Rhizoma Dioscoreae Nipponicae on gouty arthritis based on the SDF-1\/CXCR4 and p38 mark pathway: an in vivo and in vitro study. Phytother Res 2014;28:280\u2013288.","journal-title":"Phytother Res"},{"key":"2741_CR18","first-page":"1444","volume":"28","author":"Q Zhou","year":"2013","unstructured":"Zhou Q, Zhang C, Yu DH, Liu SM. Study on uric acid reducing effect of total saponins from Rhizoma Dioscoreae Nipponicae in treating hyperuricemia and in vitro study of its anti-inflammatory effect. Chin J Tradit Chin Med Pharm (Chin) 2013;28:1444\u20131448.","journal-title":"Chin J Tradit Chin Med Pharm (Chin)"},{"key":"2741_CR19","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1055\/s-0034-1382464","volume":"80","author":"Q Zhou","year":"2014","unstructured":"Zhou Q, Yu DH. Total saponins from Discorea nipponica ameliorate urate excretion in hyperuricemic mice. Planta Med 2014;80:1259\u20131268.","journal-title":"Planta Med"},{"key":"2741_CR20","first-page":"47","volume":"42","author":"J Xue","year":"2014","unstructured":"Xue J, Zhu RQ, Lu F, Liu SM, Zhou Q. Effects of total saponins from Discorea nipponica on the activities of \u03b2-galactosidase and \u03b2-N acetyl glucosamine enzyme in the liver of rats of gouty arthritis. Acta Chin Med Pharmacol (Chin) 2014;42:47\u201349.","journal-title":"Acta Chin Med Pharmacol (Chin)"},{"key":"2741_CR21","first-page":"444","volume":"29","author":"Q Zhou","year":"2013","unstructured":"Zhou Q, Lu F, Liu SM. The mechanism of cryopyrin inflammasome during the attack of gouty arthritis. Chin J Cell Mol Immunol (Chin) 2013;29:444\u2013447.","journal-title":"Chin J Cell Mol Immunol (Chin)"},{"key":"2741_CR22","doi-asserted-by":"publisher","first-page":"756","DOI":"10.7326\/0003-4819-131-10-199911160-00007","volume":"131","author":"E Pascual","year":"1999","unstructured":"Pascual E, Batle-Gualda E, Martinez A, Rosas J, Vela P. Synovial fluid analysis for diagnosis of intercritical gout. Ann Intern Med 1999;131:756\u2013759.","journal-title":"Ann Intern Med"},{"key":"2741_CR23","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s11926-001-0049-7","volume":"3","author":"RC Landis","year":"2001","unstructured":"Landis RC, Haskard DO. Pathogenesis of crystal-induced inflammation. Curr Rheumatol Rep 2001;3:36\u201341.","journal-title":"Curr Rheumatol Rep"},{"key":"2741_CR24","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/1056-8719(92)90060-E","volume":"28","author":"OP Gupta","year":"1992","unstructured":"Gupta OP, Sharma N, Chand DA. Sensitive and selective model for evaluating anti-inflammatory activity-papaya latex-induced rat paw inflammation. J Pharmacol Toxicol Meth 1992;28:15\u201319.","journal-title":"J Pharmacol Toxicol Meth"},{"key":"2741_CR25","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1248\/bpb.29.2483","volume":"29","author":"M Rassol","year":"2006","unstructured":"Rassol M, Sabina EP, Lavanya B. Anti-inflammatory effect of Spirulina fusiformis on adjuvant-induced arthritis in mice. Biol Pharm Bull 2006;29:2483\u20132487.","journal-title":"Biol Pharm Bull"},{"key":"2741_CR26","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.vph.2005.02.001","volume":"42","author":"VR Ramprasad","year":"2005","unstructured":"Ramprasad VR, Shanthi P, Sachdanandam P. Evaluation of antioxidant effect of Semecarpus anacardium Linn. nut extract on the components of immune system in adjuvant arthritis. Vasc Pharmacol 2005;42:179\u2013186.","journal-title":"Vasc Pharmacol"},{"key":"2741_CR27","doi-asserted-by":"publisher","first-page":"613","DOI":"10.4103\/0970-9290.147105","volume":"25","author":"T Biju","year":"2014","unstructured":"Biju T, Shabeer MM, Amitha R, Rajendra BP, Suchetha K. Comparative evaluation of serum superoxide dismutase and glutathione levels in periodontally diseased patients: an interventional study. Indian J Dent Res 2014;25:613\u2013616.","journal-title":"Indian J Dent Res"},{"key":"2741_CR28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1089\/jmf.2005.8.125","volume":"8","author":"R Grzanna","year":"2005","unstructured":"Grzanna R, Phan P, Polotsky A. Ginger-an herbal medicinal product with broad anti-inflammatory actions. J Med Food 2005;8:125\u2013132.","journal-title":"J Med Food"},{"key":"2741_CR29","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/S0891-5849(01)00773-0","volume":"32","author":"E Albano","year":"2002","unstructured":"Albano E. Free radical mechanisms in immune reactions associated with alcoholic liver disease. Free Radic Biol Med 2002;32:110\u2013114.","journal-title":"Free Radic Biol Med"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-016-2741-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11655-016-2741-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-016-2741-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T04:20:06Z","timestamp":1658636406000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11655-016-2741-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,15]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["2741"],"URL":"https:\/\/doi.org\/10.1007\/s11655-016-2741-5","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,15]]},"assertion":[{"value":"6 February 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2017","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no financial conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}