{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:13:36Z","timestamp":1783098816640,"version":"3.54.6"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s11655-019-2939-4","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T02:02:32Z","timestamp":1559613752000},"page":"654-662","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Changes of Intestinal Microecology in Patients with Primary Sjogren\u2019s Syndrome after Therapy of Yangyin Yiqi Huoxue Recipe (\u517b\u9634\u76ca\u6c14\u6d3b\u8840\u65b9)"],"prefix":"10.1007","volume":"25","author":[{"given":"Guo-lin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-feng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-lian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"2939_CR1","doi-asserted-by":"publisher","first-page":"e000495","DOI":"10.1136\/rmdopen-2017-000495","volume":"3","author":"A Chou","year":"2017","unstructured":"Chou A, Gonzales JA, Daniels TE, Criswell LA, Shiboski SC, Shiboski CH. Health-related quality of life and depression among participants in the Sj\u00f6gren\u2019s International Collaborative Clinical Alliance registry. RMD Open 2017;3:e000495.","journal-title":"RMD Open"},{"key":"2939_CR2","doi-asserted-by":"crossref","unstructured":"Nezos A, Mavragani CP. Contribution of genetic factors to Sj\u00f6gren\u2019s syndrome and Sj\u00f6gren\u2019s syndrome related lymphoma genesis. Immunol Res 2015:754825.","DOI":"10.1155\/2015\/754825"},{"key":"2939_CR3","first-page":"131","volume":"36","author":"Y Wang","year":"2017","unstructured":"Wang Y, Guo F. The progress in the treatment of Sjogren\u2019s syndrome with traditional Chinese medicine. Nei Mongol J Tradit Chin Med (Chin) 2017;36:131\u2013133.","journal-title":"Nei Mongol J Tradit Chin Med (Chin)"},{"key":"2939_CR4","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1007\/s11655-015-2323-y","volume":"21","author":"GL Wu","year":"2015","unstructured":"Wu GL, Wu NY, Li TY, Fan YS, Yu GY, Lu WW. Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the reproductive endocrine and immune networks in patients with primary Sjogren\u2019s syndrome. Chin J Integr Med 2015;21:778\u2013783.","journal-title":"Chin J Integr Med"},{"key":"2939_CR5","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1007\/s11655-013-1565-9","volume":"19","author":"GL Wu","year":"2013","unstructured":"Wu GL, Li TY, Fan YS, Yu GY, Chen J. Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the Th1\/Th2 immune balance in peripheral blood in patients with primary Sjogren\u2019s syndrome. Chin J Integr Med 2013;19:696\u2013700.","journal-title":"Chin J Integr Med"},{"key":"2939_CR6","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/odi.12472","volume":"22","author":"TA Van der Meulen","year":"2016","unstructured":"Van der Meulen TA, Harmsen H, Bootsma H, Spijkervet F, Kroese F, Vissink A. The microbiome-systemic diseases connection. Oral Dis 2016;22:719\u2013734.","journal-title":"Oral Dis"},{"key":"2939_CR7","doi-asserted-by":"publisher","unstructured":"De Luca F, Shoenfeld Y. The microbiome in autoimmune diseases. Clin Exp Immunol 2018;19. doi: \n                    https:\/\/doi.org\/10.1111\/cei.13158\n                    \n                  .","DOI":"10.1111\/cei.13158"},{"key":"2939_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1136\/annrheumdis-2016-210571","volume":"76","author":"CH Shiboski","year":"2017","unstructured":"Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, et al. 2016 American College of Rheumatology\/European League Against Rheumatism Classification Criteria for primary Sjogren\u2019s syndrome: a consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis 2017;76:9\u201316.","journal-title":"Ann Rheum Dis"},{"key":"2939_CR9","unstructured":"Ministry of Health, P.R.C. The research guidelines for new drugs of traditional Chinese medicine;1995:188."},{"key":"2939_CR10","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1136\/ard.2009.110619","volume":"69","author":"R Seror","year":"2010","unstructured":"Seror R, Ravaud P, Bowman SJ, Baron G, Tzioufas A, Theander E, et al. EULAR Sjogren\u2019s syndrome disease activity index: development of a consenses systemic disease activity index for primary Sjogren\u2019s syndrome. Ann Rheum Dis 2010;69:1103\u20131109.","journal-title":"Ann Rheum Dis"},{"key":"2939_CR11","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nmeth.2604","volume":"10","author":"RC Edgar","year":"2013","unstructured":"Edgar RC. UPARSE: highly accurate OTU sequences from microbial amplicon reads. Nat Methods 2013;10:996\u2013998.","journal-title":"Nat Methods"},{"key":"2939_CR12","doi-asserted-by":"publisher","first-page":"7537","DOI":"10.1128\/AEM.01541-09","volume":"75","author":"PD Schloss","year":"2009","unstructured":"Schloss PD, Westcott SL, Ryabin T, Hall JR, Hartmann M, Hollister EB, et al. Introducing mothur: open-source, platform-independent, community supported software for describing and comparing microbial communities. Appl Environ Microbiol 2009;75:7537\u20137541.","journal-title":"Appl Environ Microbiol"},{"key":"2939_CR13","doi-asserted-by":"publisher","first-page":"e1000352","DOI":"10.1371\/journal.pcbi.1000352","volume":"5","author":"JR White","year":"2009","unstructured":"White JR, Nagarajan N, Pop M. Statistical methods for detecting differentially abundant features in clinical metagenomic samples. PLoS Comput Biol 2009;5: e1000352.","journal-title":"PLoS Comput Biol"},{"key":"2939_CR14","first-page":"138","volume":"20","author":"Y Li","year":"2016","unstructured":"Li Y, Zhang FC. Disease assessment system for primary Sjogren\u2019s syndrome. Chin J Rheumatol (Chin) 2016;20:138\u2013140.","journal-title":"Chin J Rheumatol (Chin)"},{"key":"2939_CR15","first-page":"22","volume":"12","author":"D Xu","year":"2016","unstructured":"Xu D, Zhao Y. Disease activity index and damage index in Sjogren\u2019s syndrome. Pract Hosp Clin J (Chin) 2016;12:22\u201326.","journal-title":"Pract Hosp Clin J (Chin)"},{"key":"2939_CR16","first-page":"132","volume":"1","author":"L Wang","year":"2010","unstructured":"Wang L, Zhang W, Li MT, Zhao Y. Correlation of memory B cell and B cell activation factor with clinical indicators in primary Sjogren\u2019s syndrome patients and their first-degree relatives. Med J Peking Union Med Coll Hosp (Chin) 2010;1:132\u2013136.","journal-title":"Med J Peking Union Med Coll Hosp (Chin)"},{"key":"2939_CR17","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1146\/annurev-med-043015-123313","volume":"14","author":"CP Mavragani","year":"2017","unstructured":"Mavragani CP. Mechanisms and new strategies for primary Sj\u00f6gren\u2019s syndrome. Annu Rev Med 2017;14:331\u2013343.","journal-title":"Annu Rev Med"},{"key":"2939_CR18","first-page":"497","volume":"10","author":"SJ Huang","year":"2017","unstructured":"Huang SJ, Wa Z, Zhong M. Research progress in the pathogeny and pathogenesis of Sjogren\u2019s syndrome. Chin J Pract Stomatol (Chin) 2017;10:497\u2013481.","journal-title":"Chin J Pract Stomatol (Chin)"},{"key":"2939_CR19","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.cell.2015.08.058","volume":"163","author":"K Atarashi","year":"2015","unstructured":"Atarashi K, Tanoue T, Ando M, Kamada N, Nagano Y, Narushima S, et al. Th17 cell induction by adhesion of microbes to intestinal epithelial cells. Cell 2015;163:367\u2013380.","journal-title":"Cell"},{"key":"2939_CR20","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/B978-0-12-394300-2.00003-X","volume":"116","author":"B Chassaing","year":"2012","unstructured":"Chassaing B, Aitken JD, Gewirtz AT, Vijay-Kumar M. Gut microbiota drives metabolic disease in immunologically altered mice. Adv Immunol 2012;116:93\u2013112.","journal-title":"Adv Immunol"},{"key":"2939_CR21","first-page":"122","volume":"68C","author":"I Koboziev","year":"2013","unstructured":"Koboziev I, Reinoso Webb C, Furr KL, Grisham MB. Role of the enteric microbiota in intestinal homeostasis and inflammation. Free Radic Biol Med 2013;68C:122\u2013133.","journal-title":"Free Radic Biol Med"},{"key":"2939_CR22","doi-asserted-by":"publisher","first-page":"542","DOI":"10.3724\/SP.J.1145.2013.00542","volume":"19","author":"DD Chen","year":"2013","unstructured":"Chen DD, Gu SH, Zhang JN, Bao FK, Tang YQ, Wu XL. Effect of intestinal microbes on the immune system and the latest research methods. Chin J Appl Environ Biol (Chin) 2013;19:542\u2013546.","journal-title":"Chin J Appl Environ Biol (Chin)"},{"key":"2939_CR23","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1007\/s10096-009-0749-x","volume":"28","author":"F Armougom","year":"2009","unstructured":"Armougom F, Bittar N, Stremler JM, Rolain C, Robert JC, Dubus J, et al. Microbial diversity in the sputum of a cystic fibrosis patient studied with 16SrDNA pyrosequencing. Eur J Clin Microbiol Infect Dis 2009;28:1151\u20131154.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2939_CR24","first-page":"98","volume":"38","author":"P Zeng","year":"2016","unstructured":"Zeng P, He XL, Ma WK, Hou L. Advances in TCM diagnosis and treatment of Sjogren\u2019s syndrome. J Guiyang Coll Tradit Chin Med (Chin) 2016;38:98\u2013101.","journal-title":"J Guiyang Coll Tradit Chin Med (Chin)"},{"key":"2939_CR25","first-page":"4148","volume":"38","author":"GL Wu","year":"2013","unstructured":"Wu GL, Li TY, Lu WW, Yu GY, Fan YS. Effect of Chinese herbal medicine for the Nourishing yin, Strengthening qi and Activating blood Decoction on Fas\/FasL and their mRNA in submandibular glands of NOD mice with Sjogren\u2019s syndrome. Chin J Chin Mater Med (Chin) 2013;38:4148\u20134151.","journal-title":"Chin J Chin Mater Med (Chin)"},{"key":"2939_CR26","first-page":"1653","volume":"33","author":"GL Wu","year":"2013","unstructured":"Wu GL, Pu XH, Li TY, Yu GY, Lu WW, Fan YS. Effect of Yangyin Yiqi Huoxue Decoction on immune balance of Th1\/Th2 in serum and submaxillary glands of NOD mice with Sjogren\u2019s syndrome. Chin J Integr Tradit West Med (Chin) 2013;33:1653\u20131657.","journal-title":"Chin J Integr Tradit West Med (Chin)"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-019-2939-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11655-019-2939-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-019-2939-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T23:09:56Z","timestamp":1591139396000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11655-019-2939-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,4]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["2939"],"URL":"https:\/\/doi.org\/10.1007\/s11655-019-2939-4","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,4]]},"assertion":[{"value":"2 December 2018","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors declare that they have no any conflict of interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}