{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:45:33Z","timestamp":1784547933651,"version":"3.55.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s11655-019-3203-7","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T12:17:33Z","timestamp":1572005853000},"page":"671-676","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antioxidant Mechanism of Xiaojin Pill (\u5c0f\u91d1\u4e38) for Treatment of Peyronie\u2019s Disease in Rats Based on Matrix Metalloproteinases"],"prefix":"10.1007","volume":"25","author":[{"given":"Qiang","family":"Geng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-he","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-jin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"3203_CR1","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.ucl.2007.08.017","volume":"34","author":"FL Taylor","year":"2007","unstructured":"Taylor FL, Levine LA. Peyronie\u2019s disease. Urol Clin North Am 2007;34:517\u2013534.","journal-title":"Urol Clin North Am"},{"key":"3203_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.urology.2017.05.029","volume":"107","author":"EC Serefoglu","year":"2017","unstructured":"Serefoglu EC, Smith TM, Kaufman GJ, Liu GZ, Yafi FA, Hellstrom WJG. Factors associated with erectile dysfunction and the Peyronie\u2019s disease questionnaire in patients with Peyronie disease. Urol Sci 2017;107:155\u2013160.","journal-title":"Urol Sci"},{"key":"3203_CR3","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1590\/s1677-5538.ibju.2016.06.02","volume":"42","author":"R P Terlecki","year":"2016","unstructured":"Terlecki RP, Rasper AM. Data vs Dogma in Peyronie\u2019s disease. Int Braz J Urol Sci 2016;42:1058\u20131061.","journal-title":"Int Braz J Urol Sci"},{"key":"3203_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.urology.2016.02.009","volume":"95","author":"BA Sherer","year":"2016","unstructured":"Sherer BA, Levine LA. Contemporary review of treatment options for Peyronie\u2019s disease. Urol Sci 2016;95:16\u201324.","journal-title":"Urol Sci"},{"key":"3203_CR5","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.juro.2015.05.098","volume":"194","author":"A Nehra","year":"2015","unstructured":"Nehra A, Alterowitz R, Culkin DJ, Faraday MM, Hakim LS, Heidelbaugh JJ, et al. Peyronie\u2019s disease: AUA Guideline. J Urol Sci 2015;194:745\u2013753.","journal-title":"J Urol Sci"},{"key":"3203_CR6","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.bjoms.2016.11.323","volume":"55","author":"V Patel","year":"2017","unstructured":"Patel V, McGurk M. Use of pentoxifylline and tocopherol in radiation-induced fibrosis and fibroatrophy. Br J Oral Maxillofac Surg Sci 2017;55:235\u2013241.","journal-title":"Br J Oral Maxillofac Surg Sci"},{"key":"3203_CR7","first-page":"129","volume":"9","author":"G Paulis","year":"2017","unstructured":"Paulis G, Paulis A, Romano G, Barletta D, Fabiani A. Rationale of combination therapy with antioxidants in medical management of Peyronie\u2019s disease: results of clinical application. Res Rep Urol Sci 2017;9:129\u2013139.","journal-title":"Res Rep Urol Sci"},{"key":"3203_CR8","first-page":"61","volume":"8","author":"AO Kevin","year":"2016","unstructured":"Kevin AO, John RG, Thomas JW. A review of the epidemiology and treatment of Peyronie\u2019s disease. Res Rep Urol 2016;8:61\u201370.","journal-title":"Res Rep Urol"},{"key":"3203_CR9","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/jsm.12760","volume":"12","author":"RA Gelfand","year":"2015","unstructured":"Gelfand RA, Vernet D, Kovanecz I, Rajfer J, Gonzalez-Cadavid NF. The transcriptional signatures of cells from the human Peyronie\u2019s disease plaque and the ability of these cells to generate a plaque in a rat model suggest potential therapeutic targets. J Sex Med 2015;12:313\u2013327.","journal-title":"J Sex Med"},{"key":"3203_CR10","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ncpuro0201","volume":"2","author":"NF Gonzalez-Cadavid","year":"2005","unstructured":"Gonzalez-Cadavid NF, Rajfer J. Mechanisms of Disease: new insights into the cellular and molecular pathology of Peyronie\u2019s disease. Nat Clin Pract Urol 2005;2:291\u2013297.","journal-title":"Nat Clin Pract Urol"},{"key":"3203_CR11","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.eururo.2007.06.036","volume":"53","author":"SM Haag","year":"2008","unstructured":"Haag SM, Hauck EW, Eickelberg O, Szardening-Kirchner C, Diemer T, Weidner W. Investigation of the antifibrotic effect of IFN-gamma on fibroblasts in a cell culture model of Peyronie\u2019s disease. Eur Urol 2008;53:425\u2013430.","journal-title":"Eur Urol"},{"key":"3203_CR12","doi-asserted-by":"publisher","first-page":"H647","DOI":"10.1152\/ajpheart.00090.2018","volume":"316","author":"MM Ali","year":"2019","unstructured":"Ali MM, Mahmoud AM, Master EL, Levitan I, Phillips SA. Role of matrix metalloproteinases and histone deacetylase in oxidative stress-induced degradation of the endothelial glycocalyx. Am J Physiol Heart Circ Physiol 2019;316:H647\u2013H663.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3203_CR13","first-page":"568","volume-title":"Pharmacopoeia of the People\u2019s Republic of China. Part I","author":"Committee of Pharmacopoeia of the People\u2019s Republic of China.","year":"2015","unstructured":"Committee of Pharmacopoeia of the People\u2019s Republic of China. Pharmacopoeia of the People\u2019s Republic of China. Part I. Bejing: China Med Pharm Sci Tech Press;2015:568."},{"key":"3203_CR14","first-page":"83","volume":"25","author":"Y Feng","year":"2009","unstructured":"Feng Y, Qing J. Xiao Jin Pill joint with 6 flavour glutinous rehmannia treatment of Peyronie\u2019s disease in 2 cases. Hunan J Tradit Chin Med (Chin) 2009;25:83.","journal-title":"Hunan J Tradit Chin Med (Chin)"},{"key":"3203_CR15","first-page":"73","volume":"20","author":"YW Zhao","year":"2011","unstructured":"Zhao YW, Li YP, Yi T. The effect of treatment of chronic hepatitis B liver fibrosis by Xiao Jin Pill. Chin Pharm (Chin) 2011;20:73.","journal-title":"Chin Pharm (Chin)"},{"key":"3203_CR16","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.eururo.2012.09.034","volume":"63","author":"F Castiglione","year":"2013","unstructured":"Castiglione F, Hedlund P, Van der Aa F, Bivalacqua TJ, Rigatti P, Van Poppel H, et al. Intratunical injection of human adipose tissue-derived stem cells prevents fibrosis and is associated with improved erectile function in a rat model of Peyronie\u2019s disease. Eur Urol 2013;63:551\u2013560.","journal-title":"Eur Urol"},{"key":"3203_CR17","first-page":"607","volume":"21","author":"OU Zorba","year":"2012","unstructured":"Zorba OU, Sirma S, Ozgon G, Salabas E, Ozbek U, Van Poppel H, et al. Comparison of apoptotic gene expression profiles between Peyronie\u2019s disease plaque and tunica albuginea. Adv Clin Exp Med 2012;21:607\u2013614.","journal-title":"Adv Clin Exp Med"},{"key":"3203_CR18","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/S0006-291X(02)00765-9","volume":"295","author":"CS Lin","year":"2002","unstructured":"Lin CS, Lin G, Wang Z, Maddah SA, Lue TF. Upregulation of monocyte chemoattractant protein 1 and effects of transforming growth factor-beta 1 in Peyronie\u2019s disease. Biochem Biophys Res Commun 2002;295:1014\u20131019.","journal-title":"Biochem Biophys Res Commun"},{"key":"3203_CR19","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0022-5347(17)35997-9","volume":"149","author":"JA Lopez","year":"1993","unstructured":"Lopez JA, Jarow JP. Penile vascular evaluation of men with Peyronie\u2019s disease. J Urol 1993;149:53\u201355.","journal-title":"J Urol"},{"key":"3203_CR20","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/j.jsxm.2016.09.008","volume":"13","author":"LW Trost","year":"2016","unstructured":"Trost LW, Munarriz R, Wang R, Morey A, Levine L. External mechanical devices and vascular surgery for erectile dysfunction. J Sex Med 2016;13:1579\u20131617.","journal-title":"J Sex Med"},{"key":"3203_CR21","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/bju.13371","volume":"117","author":"L Rolle","year":"2016","unstructured":"Rolle L, Falcone M, Ceruti C, Timpano M, Sedigh O, Ralph DJ, et al. A prospective multicentric international study on the surgical outcomes and patients\u2019 satisfaction rates of the\u2019 sliding \u2018technique for end-stage Peyronie\u2019s disease with severe shortening of the penis and erectile dysfunction. BJU Int 2016;117:814\u2013820.","journal-title":"BJU Int"},{"key":"3203_CR22","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/path.2277","volume":"214","author":"TA Wynn","year":"2008","unstructured":"Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008;214:199\u2013210.","journal-title":"J Pathol"},{"key":"3203_CR23","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3109\/14756366.2016.1161620","volume":"31","author":"A Jablonska Trypuc","year":"2016","unstructured":"Jablonska Trypuc A, Matejczyk M, Rosochacki S. Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs. J Enzyme Inhib Med Chem Sci 2016;31:177\u2013183.","journal-title":"J Enzyme Inhib Med Chem Sci"},{"key":"3203_CR24","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1046\/j.1464-410X.2003.04224.x","volume":"91","author":"HH Davila","year":"2003","unstructured":"Davila HH, Ferrini MG, Rajfer J, Gonzalez-Cadavid NF. Fibrin as an inducer of fibrosis in the tunica albuginea of the rat: a new animal model of Peyronie\u2019s disease. BJU Int 2003;91:830\u2013838.","journal-title":"BJU Int"},{"key":"3203_CR25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1242\/dmm.012062","volume":"7","author":"M Giannandrea","year":"2014","unstructured":"Giannandrea M, Parks WC. Diverse functions of matrix metalloproteinases during fibrosis. Dis Model Mech 2014;7:193\u2013203.","journal-title":"Dis Model Mech"},{"key":"3203_CR26","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.bbadis.2012.12.007","volume":"1832","author":"J Rosenbloom","year":"2013","unstructured":"Rosenbloom J, Mendoza FA, Jimenez SA. Strategies for antifibrotic therapies. Biochim Biophys Acta 2013;1832:1088\u20131103.","journal-title":"Biochim Biophys Acta"},{"key":"3203_CR27","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm.2807","volume":"18","author":"TA Wynn","year":"2012","unstructured":"Wynn TA, Ramalingam TR. Mechanisms of fibrosis:therapeutic translation for fibrotic disease. Nat Med 2012;18:1028\u20131040.","journal-title":"Nat Med"},{"key":"3203_CR28","first-page":"2563","volume":"44","author":"Y Chen","year":"2013","unstructured":"Chen Y, Jiang QH, Luo ZH. Effect of Shexiang Baoxin Pill on immunological liver fibrosis in rats and its mechanism. Chin Tradit Herb Drugs (Chin) 2013;44:2563\u20132568.","journal-title":"Chin Tradit Herb Drugs (Chin)"},{"key":"3203_CR29","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2174\/187152812798889321","volume":"11","author":"G Paulis","year":"2012","unstructured":"Paulis G, Brancato T. Inflammatory mechanisms and oxidative stress in Peyronie\u2019s disease: therapeutic \"rationale\" and related emerging treatment strategies. Inflamm Allergy Drug Targets Sci 2012;11:48\u201357.","journal-title":"Inflamm Allergy Drug Targets Sci"},{"key":"3203_CR30","doi-asserted-by":"publisher","first-page":"e0146592","DOI":"10.1371\/journal.pone.0146592","volume":"11","author":"T Moro","year":"2016","unstructured":"Moro T, Nakao S, Sumiyoshi H, Ishii T, Miyazawa M, Ishii N, et al. A combination of mitochondrial oxidative stress and excess fat\/calorie intake accelerates steatohepatitis by enhancing hepatic CC chemokine production in mice. PloS One 2016;11:e0146592.","journal-title":"PloS One"},{"key":"3203_CR31","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/j.1939-4640.2001.tb02207.x","volume":"22","author":"TJ Bivalacqua","year":"2001","unstructured":"Bivalacqua TJ, Champion HC, Leungwattanakij S, Yang DY, Hyun JS, Abdel-Mageed AB, et al. Evaluation of nitric oxide synthase and arginase in the induction of a Peyronie\u2019s-like condition in the rat. J Androl 2001;22:497\u2013506.","journal-title":"J Androl"},{"key":"3203_CR32","volume-title":"Program and abstracts from the American Urological Association 95th Annual Meeting. April 29\u2013May 4, 2000; Atlanta, Georgia, USA","author":"G Matkov","year":"2000","unstructured":"Matkov G, Levine LA, Storm DW. Peyronie\u2019s disease affecting the younger male. Program and abstracts from the American Urological Association 95th Annual Meeting. April 29\u2013May 4, 2000; Atlanta, Georgia, USA, 2000:abstr 743."},{"key":"3203_CR33","first-page":"1190","volume":"43","author":"HB Xu","year":"2008","unstructured":"Xu HB, Li L, Liu GQ. Protection against hydrogen peroxideinduced cytotoxicity in PC12 cells by guggulsterone. Acta Pharm Sin (Chin) 2008;43:1190\u20131197.","journal-title":"Acta Pharm Sin (Chin)"},{"key":"3203_CR34","first-page":"193","volume":"17","author":"Y Tan","year":"2010","unstructured":"Tan Y, Xu X, Zhou K, He J, Qu CQ, Gao XM. The study on hepatotoxicity of Mastic and Myrrha in rats. Chin Pharm Affairs (Chin) 2010;17:193\u2013195.","journal-title":"Chin Pharm Affairs (Chin)"},{"key":"3203_CR35","first-page":"334","volume":"19","author":"YQ Zhang","year":"2013","unstructured":"Zhang YQ. Influence of Shexiang Baoxin Pills on oxidative stress in patients with unstable angina pectoris of coronary heart disease. Chin J Exp Med Formul (Chin) 2013;19:334\u2013336.","journal-title":"Chin J Exp Med Formul (Chin)"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-019-3203-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11655-019-3203-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-019-3203-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T18:50:22Z","timestamp":1721933422000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11655-019-3203-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["3203"],"URL":"https:\/\/doi.org\/10.1007\/s11655-019-3203-7","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"25 January 2018","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"There is no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}