{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:02:15Z","timestamp":1787756535447,"version":"build-2784847793"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s11655-020-3267-4","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T09:03:41Z","timestamp":1593853421000},"page":"729-735","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial"],"prefix":"10.1007","volume":"26","author":[{"given":"Hamide Khorram","family":"Pazhouh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyd Musa al-Reza","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Taghipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shokouhsadat","family":"Hamedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Noras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,4]]},"reference":[{"key":"3267_CR1","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/apt.12938","volume":"40","author":"C Canavan","year":"2014","unstructured":"Canavan C, West J, Card T. The economic impact of the irritable bowel syndrome. Aliment Pharm Ther 2014;40:1023\u20131034.","journal-title":"Aliment Pharm Ther"},{"key":"3267_CR2","doi-asserted-by":"publisher","first-page":"149","DOI":"10.15171\/mejdd.2018.104","volume":"10","author":"P Arasteh","year":"2018","unstructured":"Arasteh P, Maharlouei N, Eghbali SS, Amini M, Lankarani KB, Malekzadeh R. A comprehensive look at irritable bowel syndrome and its associated factors considering the Rome W criteria: a penalized smoothly clipped absolute deviation regression approach in the Pars Cohort Study. Middle East J Digest Dis 2018;10:149\u2013159.","journal-title":"Middle East J Digest Dis"},{"issue":"Suppl 1","key":"3267_CR3","first-page":"S1","volume":"3","author":"P Jahangiri","year":"2012","unstructured":"Jahangiri P, Jazi MSH, Keshteli AH, Sadeghpour S, Amini E, Adibi P. Irritable bowel syndrome in Iran: SEPAHAN systematic review No. 1. Intern J Prevent Med 2012;3 (Suppl1):S1.","journal-title":"Intern J Prevent Med"},{"key":"3267_CR4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12876-017-0698-2","volume":"17","author":"R Chatila","year":"2017","unstructured":"Chatila R, Merhi M, Hariri E, Sabbah N, Deeb ME. Irritable bowel syndrome: prevalence, risk factors in an adult Lebanese population. BMC Gastroenterol 2017;17:137.","journal-title":"BMC Gastroenterol"},{"key":"3267_CR5","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S2468-1253(16)30023-1","volume":"1","author":"GJ Holtmann","year":"2016","unstructured":"Holtmann GJ, Ford AC, Talley NJ. Pathophysiology of irritable bowel syndrome. Lancet Gastroenterol Hepatol 2016;1: 133\u2013146.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"3267_CR6","first-page":"56","volume":"1","author":"DQ Shih","year":"2007","unstructured":"Shih DQ, Kwan LY. All roads lead to Rome: update on Rome M criteria and new treatment options. Gastroenterol Rep 2007;1:56\u201365.","journal-title":"Gastroenterol Rep"},{"key":"3267_CR7","doi-asserted-by":"publisher","first-page":"e0123861","DOI":"10.1371\/journal.pone.0123861","volume":"10","author":"B Kuo","year":"2015","unstructured":"Kuo B, Bhasin M, Jacquart J, Scult MA, Slipp L, Riklin EIK, et al. Genomic and clinical effects associated with a relaxation response mind-body intervention in patients with irritable bowel syndrome and inflammatory bowel disease. PLoS One 2015;10:e0123861.","journal-title":"PLoS One"},{"key":"3267_CR8","doi-asserted-by":"publisher","first-page":"589","DOI":"10.3748\/wjg.v18.i7.589","volume":"18","author":"R Rahimi","year":"2012","unstructured":"Rahimi R, Abdollahi M. Herbal medicines for the management of irritable bowel syndrome: a comprehensive review. World J Gastroenterol 2012;18:589\u2013600.","journal-title":"World J Gastroenterol"},{"key":"3267_CR9","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.gtc.2010.12.005","volume":"40","author":"S Magge","year":"2011","unstructured":"Magge S, Lembo A. Complementary and alternative medicine for the irritable bowel syndrome. Gastroenterol Clin 2011;40:245\u2013253.","journal-title":"Gastroenterol Clin"},{"key":"3267_CR10","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/01.mcg.0000155570.19340.61","volume":"39","author":"SC Kong","year":"2005","unstructured":"Kong SC, Hurlstone DP, Pocock CY, Walkington LA, Farquharson NR, Bramble MG, et al. The incidence of self-prescribed oral complementary and alternative medicine use by patients with gastrointestinal diseases. J Clin Gastroenterol 2005;39:138\u2013141.","journal-title":"J Clin Gastroenterol"},{"key":"3267_CR11","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1097\/01.mcg.0000177234.36640.68","volume":"39","author":"DS Sanders","year":"2005","unstructured":"Sanders DS, Kong SC, Hurlstone DP. The incidence of self-prescribed oral complementary and alternative medicine usage: do international variations exist? J Clin Gastroenterol 2005;39:837.","journal-title":"J Clin Gastroenterol"},{"key":"3267_CR12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.5056\/jnm16214","volume":"23","author":"MJ Schmulson","year":"2017","unstructured":"Schmulson MJ, Drossman DA. What is new in Rome IV. J Neurogastroenterol Motil 2017;23:151\u2013163.","journal-title":"J Neurogastroenterol Motil"},{"key":"3267_CR13","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1590\/S0104-11692012000300021","volume":"20","author":"AP Martinez","year":"2012","unstructured":"Martinez AP, Azevedo GRd. The Bristol Stool Form Scale: its translation to Portuguese, cultural adaptation and validation. Revista latino-americana de enfermagem. 2012;20:583\u2013589.","journal-title":"Revista latino-americana de enfermagem"},{"key":"3267_CR14","first-page":"11","volume":"11","author":"L Dehghanian","year":"2016","unstructured":"Dehghanian L. The effect of vitamin D3 supplement on clinical signs of disease, in patients with irritable bowel syndrome and vitamin deficiency, clinical trial. Iran J Nutrit Food Tech 2016;11:11\u201318.","journal-title":"Iran J Nutrit Food Tech"},{"key":"3267_CR15","first-page":"317","volume":"12","author":"A Fatemeh","year":"2014","unstructured":"Fatemeh A, Hamid Taher ND, Mehrdad K, Hossein Ali M, Hamid A, Hamed DZ. The effect of therapeutic spirituality on physical symptoms in patients with irritable bowel syndrome. J Behav Sci Res 2014;12:317\u2013327.","journal-title":"J Behav Sci Res"},{"key":"3267_CR16","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1038\/ajg.2009.156","volume":"104","author":"AJ Lembo","year":"2009","unstructured":"Lembo AJ, Conboy L, Kelley JM, Schnyer RS, McManus C, Quilty MT, et al. A treatment trial of acupuncture in IBS patients. Am J Gastroenterol 2009;104:1489.","journal-title":"Am J Gastroenterol"},{"key":"3267_CR17","first-page":"219","volume":"14","author":"G Ali","year":"2010","unstructured":"Ali Gh, Mohammad M, Kianoush N, Hamed DZ, Hamid T, Seyed Mohammad Hassan A. Non-intestinal symptoms and its association with psychological symptoms in patients with irritable bowel syndrome. J Digest 2010;14:219\u2013225.","journal-title":"J Digest"},{"key":"3267_CR18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1477-7525-1-14","volume":"1","author":"A Montazeri","year":"2003","unstructured":"Montazeri A, Vahdaninia M, Ebrahimi M, Jarvandi S. The Hospital Anxiety and Depression Scale (HADS): translation and validation study of the Iranian version. Health Quality Life Outcome 2003;1:14.","journal-title":"Health Quality Life Outcome"},{"key":"3267_CR19","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1053\/j.gastro.2016.02.014","volume":"150","author":"OS Palsson","year":"2016","unstructured":"Palsson OS, Whitehead WE, Chang L, Chey W, Crowell M, Keefer L, et al. Rome W diagnostic questionnaires and tables for investigators and clinicians. Gastroenterology 2016;150:1481\u20131491.","journal-title":"Gastroenterology"},{"key":"3267_CR20","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1053\/j.gastro.2016.03.035","volume":"150","author":"DA Drossman","year":"2016","unstructured":"Drossman DA, Hasler WL. Rome IV\u2014functional GI disorders: disorders of gut-brain interaction. Gastroenterology 2016;150:1257\u20131261.","journal-title":"Gastroenterology"},{"key":"3267_CR21","first-page":"222","volume":"20","author":"LD Tafti","year":"2017","unstructured":"Tafti LD, Shariatpanahi SM, Damghani MM, Javadi B. Traditional Persian topical medications for gastrointestinal diseases. Iran J Basic Med Sci 2017;20:222.","journal-title":"Iran J Basic Med Sci"},{"key":"3267_CR22","first-page":"77","volume":"4","author":"BJ Goud","year":"2015","unstructured":"Goud BJ, Swamy B. A review on history, controversy, traditional use, ethnobotany, phytochemistry and pharmacology of Artemisia absinthium Linn. Int J Adv Res Eng Appl Sci 2015;4:77\u2013107.","journal-title":"Int J Adv Res Eng Appl Sci"},{"key":"3267_CR23","first-page":"105","volume":"2","author":"S Nikhat","year":"2013","unstructured":"Nikhat S, Ahmad S, Akhtar J, Jamil S. Phytochemical and ethnopharmacological perspective of Afsantin (Artemisia absinthium Linn.). Ann Phytomed 2013;2:105\u2013109.","journal-title":"Ann Phytomed"},{"key":"3267_CR24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/(SICI)1099-1573(199603)10:2<117::AID-PTR782>3.0.CO;2-X","volume":"10","author":"AM Agha","year":"1996","unstructured":"Agha AM, Sattar EA, Galal A. Pharmacological study of Cuscuta campestris Yuncker. Phytother Res 1996;10:117\u2013120.","journal-title":"Phytother Res"},{"key":"3267_CR25","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0308-8146(02)00179-6","volume":"79","author":"P Siddhuraju","year":"2002","unstructured":"Siddhuraju P, Mohan P, Becker K. Studies on the antioxidant activity of Indian Laburnum (Cassia fistula L.): a preliminary assessment of crude extracts from stem bark, leaves, flowers and fruit pulp. Food Chem 2002;79:61\u201367.","journal-title":"Food Chem"},{"key":"3267_CR26","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3390\/molecules19010767","volume":"19","author":"S Vladimir-Knezevic","year":"2014","unstructured":"Vladimir-Knezevic S, Blazekovic B, Kindl M, Vladic J, Lower-Nedza A, Brantner A. Acetylcholinesterase inhibitory, antioxidant and phytochemical properties of selected medicinal plants of the Lamiaceae family. Molecules 2014;19:767\u2013782.","journal-title":"Molecules"},{"key":"3267_CR27","first-page":"1530","volume":"4","author":"T Bahorun","year":"2005","unstructured":"Bahorun T, Neergheen VS, Aruoma OI. Phytochemical constituents of Cassia fistula. Afr J Biotechnol 2005;4:1530\u20131540.","journal-title":"Afr J Biotechnol"},{"key":"3267_CR28","first-page":"932","volume":"5","author":"DA Latmahalleh","year":"2011","unstructured":"Latmahalleh DA, Niyaki SAN, Vishekaei MNS. Effects of plant density and planting pattern on yield and yield components of Iranian ox-tongue (Echium amoenum Fisch and Mey) in North of Iran. J Med Plants Res 2011;5:932\u2013937.","journal-title":"J Med Plants Res"},{"key":"3267_CR29","doi-asserted-by":"publisher","first-page":"285","DOI":"10.2174\/2210315506666160218232531","volume":"6","author":"M Zarshenas","year":"2016","unstructured":"Zarshenas M, Dabaghian F, Moein M. An overview on phytochemical and pharmacological aspects of Echium amoenum. Natural Products J 2016;6:285\u2013291.","journal-title":"Natural Products J"},{"key":"3267_CR30","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/j.1365-2982.2005.00650.x","volume":"17","author":"S Patel","year":"2005","unstructured":"Patel S, Stason W, Legedza A, Ock S, Kaptchuk T, Conboy L, et al. The placebo effect in irritable bowel syndrome trials: a meta-analysis. Neurogastroenterol Motility 2005;17:332\u2013340.","journal-title":"Neurogastroenterol Motility"},{"key":"3267_CR31","first-page":"377","volume":"20","author":"HBM Naderi","year":"2004","unstructured":"Naderi HBM, Rezaei M. Primory phytochemical investigation of Echium amoenium. Iran J Med Arom Plants Res 2004;20:377\u2013383.","journal-title":"Iran J Med Arom Plants Res"},{"key":"3267_CR32","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jep.2016.05.010","volume":"188","author":"A Shakeri","year":"2016","unstructured":"Shakeri A, Sahebkar A, Javadi B. Melissa officinalis L.-a review of its traditional uses, phytochemistry and pharmacology. J Ethnopharm 2016;188:204\u2013228.","journal-title":"J Ethnopharm"},{"key":"3267_CR33","doi-asserted-by":"publisher","first-page":"589","DOI":"10.3748\/wjg.v18.i7.589","volume":"18","author":"R Rahimi","year":"2012","unstructured":"Rahimi R, Abdollahi M. Herbal medicines for the management of irritable bowel syndrome: a comprehensive review. World J Gastroenterol 2012;18:589.","journal-title":"World J Gastroenterol"},{"key":"3267_CR34","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1002\/ptr.5826","volume":"31","author":"F Alt","year":"2017","unstructured":"Alt F, Chong PW, Teng E, Uebelhack R. Evaluation of benefit and tolerability of IQP-CL-101 (xanthofen) in the symptomatic improvement of irritable bowel syndrome: a double-blinded, randomised, placebo-controlled clinical trial. Phytother Res 2017;31:1056\u20131062.","journal-title":"Phytother Res"},{"key":"3267_CR35","doi-asserted-by":"publisher","first-page":"S15423565150084","DOI":"10.1016\/j.cgh.2015.06.022","volume":"13","author":"A Bensoussan","year":"2015","unstructured":"Bensoussan A, Kellow JE, Bourchier SJ, Fahey P, Shim L, Malcolm A, et al. Efficacy of a Chinese herbal medicine in providing adequate relief of constipation-predominant irritable bowel syndrome: a randomized controlled trial. Clin Gastroenterol Hepatol 2015;13:S1542356515008460.","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-020-3267-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-020-3267-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-020-3267-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T20:06:34Z","timestamp":1625342794000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-020-3267-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,4]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["3267"],"URL":"https:\/\/doi.org\/10.1007\/s11655-020-3267-4","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,4]]},"assertion":[{"value":"29 August 2019","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there are no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}