{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:54:11Z","timestamp":1786982051840,"version":"build-2736575974"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s11655-021-2867-y","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T11:03:27Z","timestamp":1622199807000},"page":"470-480","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Kuanxiong Aerosol (\u5bbd\u80f8\u6c14\u96fe\u5242) in Treatment of Angina Pectoris: A Literature Review and Network Pharmacology"],"prefix":"10.1007","volume":"27","author":[{"given":"Yu-zhuo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-xiang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-shen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-zhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"2867_CR1","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1161\/CIRCULATIONAHA.114.012636","volume":"131","author":"BK Lee","year":"2015","unstructured":"Lee BK, Lim HS, Fearon WF, et al. Invasive evaluation of patients with angina in the absence of obstructive coronary artery disease. Circulation 2015;131:1054\u20131060.","journal-title":"Circulation"},{"key":"2867_CR2","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1093\/eurheartj\/ehy335","volume":"39","author":"TF Luescher","year":"2018","unstructured":"Luescher TF. Revisiting angina pectoris with and without obstructive coronary artery disease. Eur Heart J 2018;39:2119\u20132122.","journal-title":"Eur Heart J"},{"key":"2867_CR3","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.gheart.2016.10.024","volume":"11","author":"CP Benziger","year":"2016","unstructured":"Benziger CP, Roth GA, Moran AE. The global burden of disease study and the preventable burden of NCD. Glob Heart 2016;11:393\u2013397.","journal-title":"Glob Heart"},{"key":"2867_CR4","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1377\/hlthaff.26.1.38","volume":"26","author":"GA Mensah","year":"2007","unstructured":"Mensah GA, Brown DW. An overview of cardiovascular disease burden in the United States. Health Aff (Millwood) 2007;26:38\u201348.","journal-title":"Health Aff (Millwood)"},{"key":"2867_CR5","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/nrcardio.2017.131","volume":"15","author":"R Ferrari","year":"2018","unstructured":"Ferrari R, Camici PG, Crea F, et al. A \u2018diamond\u2019 approach to personalized treatment of angina. Nat Rev Cardiol 2018;15:120\u2013132.","journal-title":"Nat Rev Cardiol"},{"key":"2867_CR6","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1093\/eurheartj\/ehx421","volume":"38","author":"J Waltenberger","year":"2017","unstructured":"Waltenberger J. Chronic refractory angina pectoris: recent progress and remaining challenges. Eur Heart J 2017;38:2556\u20132558.","journal-title":"Eur Heart J"},{"key":"2867_CR7","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s11655-018-2833-5","volume":"24","author":"QN Yang","year":"2018","unstructured":"Yang QN, Bai RN, Dong GJ, et al. Effect of Kuanxiong Aerosol on patients with angina pectoris: a non-inferiority multi-center randomized controlled trial. Chin J Integr Med 2018;24:336\u2013342.","journal-title":"Chin J Integr Med"},{"key":"2867_CR8","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1055\/s-2007-969967","volume":"47","author":"SK Guo","year":"1983","unstructured":"Guo SK, Chen KJ, Weng WL, et al. Immediate effect of Kuan-xiong Aerosol in the treatment of anginal attacks. Planta Med 1983;47:116\u2013116.","journal-title":"Planta Med"},{"key":"2867_CR9","first-page":"712","volume":"21","author":"S Cai","year":"1996","unstructured":"Cai S, Wang X, Zhu S, et al. Botanical origin of commercial samples of traditional Chinese drug Xixin (Herba Aasari). China J Chin Mater Med (Chin) 1996;21:712\u2013760.","journal-title":"China J Chin Mater Med (Chin)"},{"key":"2867_CR10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jpba.2013.07.034","volume":"85","author":"C Li","year":"2013","unstructured":"Li C, Xu F, Cao C, et al. Comparative analysis of two species of Asari Radix et Rhizoma by electronic nose, headspace GC-MS and chemometrics. J Pharm Biomed Anal 2013;85:231\u2013238.","journal-title":"J Pharm Biomed Anal"},{"key":"2867_CR11","first-page":"5","volume":"88","author":"SJ Kim","year":"2003","unstructured":"Kim SJ, Zhang CG, Lim JT. Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. Radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways. J Ethnopharmacol 2003;88:5\u20139.","journal-title":"Radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways. J Ethnopharmacol"},{"key":"2867_CR12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ejphar.2006.09.020","volume":"553","author":"S Yano","year":"2006","unstructured":"Yano S, Suzuki Y, Yuzurihara M, et al. Antinociceptive effect of methyleugenol on formalin-induced hyperalgesia in mice. Eur J Pharmacol 2006;553:99\u2013103.","journal-title":"Eur J Pharmacol"},{"key":"2867_CR13","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3109\/08923973.2011.572261","volume":"34","author":"JA Lee","year":"2012","unstructured":"Lee JA, Lee MY, Seo CS, et al. Asiasari sieboldii suppresses inflammatory mediators through the induction of hemeoxygenase-1 expression in RAW264.7 cells. Immunopharmacol Immunotoxicol 2012;34:15\u201320.","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"2867_CR14","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1159\/000213895","volume":"16","author":"C Chen","year":"2009","unstructured":"Chen C, Spriano D, Lehmann T, et al. Reduction of safrole and methyleugenol in Asari radix et rhizoma by decoction. Forsch Komplementarmed 2009;16:162\u2013166.","journal-title":"Forsch Komplementarmed"},{"key":"2867_CR15","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1111\/1750-3841.13326","volume":"81","author":"LY Lin","year":"2016","unstructured":"Lin LY, Shen KH, Yeh XY, et al. Integrated process for production of galangal acetate, the \"Wasabi-like\" spicy compound, and analysis of essential oils of Rhizoma Alpinia officinarum (Hance) Farw. J Food Sci 2016;81:1565\u20131575.","journal-title":"J Food Sci"},{"key":"2867_CR16","doi-asserted-by":"publisher","first-page":"726","DOI":"10.5740\/jaoacint.18-0307","volume":"102","author":"WX Zhang","year":"2019","unstructured":"Zhang WX, Chao IC, Hu DJ, et al. Comparison of antioxidant activity and main active compounds among different parts of Alpinia officinarum Hance using highperformance thin layer chromatography-bioautography. J AOAC Int 2019;102:726\u2013733.","journal-title":"J AOAC Int"},{"key":"2867_CR17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.phrs.2018.03.009","volume":"131","author":"A Saeidinia","year":"2018","unstructured":"Saeidinia A, Keihanian F, Butler AE, et al. Curcumin in heart failure: a choice for complementary therapy? Pharmacol Res 2018;131:112\u2013119.","journal-title":"Pharmacol Res"},{"key":"2867_CR18","doi-asserted-by":"publisher","first-page":"H1847","DOI":"10.1152\/ajpheart.00434.2006","volume":"292","author":"MR Bergman","year":"2007","unstructured":"Bergman MR, Teerlink JR, Mahimkar R, et al. Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction. Am J Physiol Heart Circ Physiol 2007;292:H1847\u2013H1860.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2867_CR19","first-page":"262","volume":"37","author":"YH Tang","year":"2009","unstructured":"Tang YH, Bao MW, Yang B, et al. Curcumin attenuates left ventricular dysfunction and remodeling in rabbits with chronic heart failure. Chin J Cardiol (Chin) 2009;37:262\u2013267.","journal-title":"Chin J Cardiol (Chin)"},{"key":"2867_CR20","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1080\/21691401.2016.1261033","volume":"45","author":"M Namdari","year":"2017","unstructured":"Namdari M, Eatemadi A. Cardioprotective effects of curcuminloaded magnetic hydrogel nanocomposite (nanocurcumin) against doxorubicin-induced cardiac toxicity in rat cardiomyocyte cell lines. Artif Cells Nanomed Biotechnol 2017;45:731\u2013739.","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"2867_CR21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4103\/0253-7613.201015","volume":"49","author":"M Chakraborty","year":"2017","unstructured":"Chakraborty M, Bhattacharjee A, Kamath JV. Cardioprotective effect of curcumin and piperine combination against cyclophosphamide-induced cardiotoxicity. Indian J Pharmacol 2017;49:65\u201370.","journal-title":"Indian J Pharmacol"},{"key":"2867_CR22","doi-asserted-by":"publisher","first-page":"2790","DOI":"10.1080\/10408398.2017.1341865","volume":"58","author":"MS Campbell","year":"2018","unstructured":"Campbell MS, Fleenor BS. The emerging role of curcumin for improving vascular dysfunction: a review. Crit Rev Food Sci Nutr 2018;58:2790\u20132799.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2867_CR23","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1039\/C4FO00901K","volume":"6","author":"LY Lin","year":"2015","unstructured":"Lin LY, Peng CC, Yeh XY, et al. Antihyperlipidemic bioactivity of Alpinia officinarum (Hance) Farw Zingiberaceae can be attributed to the coexistance of curcumin, polyphenolics, dietary fibers and phytosterols. Food Funct 2015;6:1600\u20131610.","journal-title":"Food Funct"},{"key":"2867_CR24","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.phrs.2017.02.008","volume":"119","author":"S Ganjali","year":"2017","unstructured":"Ganjali S, Bless CN, Banach M, et al. Effects of curcumin on HDL functionality. Pharmacol Res 2017;119:208\u2013218.","journal-title":"Pharmacol Res"},{"key":"2867_CR25","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.jep.2018.10.019","volume":"229","author":"VS Honmore","year":"2019","unstructured":"Honmore VS, Kandhare AD, Kadam PP, et al. Diarylheptanoid, a constituent isolated from methanol extract of Alpinia officinarum attenuates TNF-alpha level in Freund's complete adjuvant-induced arthritis in rats. J Ethnopharmacol 2019;229:233\u2013245.","journal-title":"J Ethnopharmacol"},{"key":"2867_CR26","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.intimp.2016.01.024","volume":"33","author":"VS Honmore","year":"2016","unstructured":"Honmore VS, Kandhare AD, Kadam PP, et al. Isolates of Alpinia officinarum Hance as COX-2 inhibitors: evidence from anti-inflammatory, antioxidant and molecular docking studies. Int Immunopharmacol 2016;33:8\u201317.","journal-title":"Int Immunopharmacol"},{"key":"2867_CR27","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1080\/13880209.2018.1474931","volume":"56","author":"AA Aloud","year":"2018","unstructured":"Aloud AA, Chinnadurai V, Govindasamy C, et al. Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia. Pharm Biol 2018;56:302\u2013308.","journal-title":"Pharm Biol"},{"key":"2867_CR28","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1159\/000504372","volume":"105","author":"NS Younis","year":"2020","unstructured":"Younis NS. Doxorubicin-induced cardiac abnormalities in rats: attenuation via sandalwood oil. Pharmacology 2020;105:522\u2013530.","journal-title":"Pharmacology"},{"key":"2867_CR29","first-page":"962","volume":"29","author":"M Qin","year":"2010","unstructured":"Qin M, Xie J, Zhou H, et al. Experimental study of the effect of ethanol sediments from sandalwood tea on cardiovascular function and anti-fatigue. Genomics Appl Biol 2010;29:962\u2013968.","journal-title":"Genomics Appl Biol"},{"key":"2867_CR30","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.ejphar.2016.07.046","volume":"789","author":"R Kosuru","year":"2016","unstructured":"Kosuru R, Rai U, Prakash S, et al. Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence. Eur J Pharmacol 2016;789:229\u2013243.","journal-title":"Eur J Pharmacol"},{"key":"2867_CR31","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1111\/lam.12005","volume":"55","author":"BB Misra","year":"2012","unstructured":"Misra BB, Dey S. Comparative phytochemical analysis and antibacterial efficacy of in vitro and in vivo extracts from East Indian sandalwood tree (Santalum album L.). Lett Appl Microbiol 2012;55:476\u2013486.","journal-title":"Lett Appl Microbiol"},{"key":"2867_CR32","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3892\/mmr.2014.2719","volume":"11","author":"M Lv","year":"2015","unstructured":"Lv M, Liu KX, Fu SP, et al. Pterostilbene attenuates the inflammatory reaction induced by ischemia\/reperfusion in rat heart. Mol Med Rep 2015;11:724\u2013728.","journal-title":"Mol Med Rep"},{"key":"2867_CR33","doi-asserted-by":"publisher","first-page":"e0143964","DOI":"10.1371\/journal.pone.0143964","volume":"10","author":"H Yuan","year":"2015","unstructured":"Yuan H, Houck KL, Tian Y, et al. Piperlongumine blocks JAK2-STAT3 to inhibit collagen-induced platelet reactivity independent of reactive oxygen species. PLoS One 2015;10:e0143964.","journal-title":"PLoS One"},{"key":"2867_CR34","doi-asserted-by":"publisher","first-page":"3384","DOI":"10.1038\/s41388-017-0110-2","volume":"37","author":"W Hang","year":"2018","unstructured":"Hang W, Yin ZX, Liu G, et al. Piperlongumine and p53-reactivator APR-246 selectively induce cell death in HNSCC by targeting GSTP1. Oncogene 2018;37:3384\u20133398.","journal-title":"Oncogene"},{"key":"2867_CR35","first-page":"3561","volume":"52","author":"MS Krishna","year":"2015","unstructured":"Krishna MS, Joy B, Sundaresan A. Effect on oxidative stress, glucose uptake level and lipid droplet content by apigenin 7, 4 '-dimethyl ether isolated from Piper longum L. J Food Sci Technol 2015;52:3561\u20133570.","journal-title":"J Food Sci Technol"},{"key":"2867_CR36","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.bbrc.2012.09.061","volume":"427","author":"DJ Son","year":"2012","unstructured":"Son DJ, Kim SY, Han SS, et al. Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling. Biochem Biophys Res Commun 2012;427:349\u2013354.","journal-title":"Biochem Biophys Res Commun"},{"key":"2867_CR37","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.3390\/molecules22091446","volume":"22","author":"L Zou","year":"2017","unstructured":"Zou L, Zhang Y, Li W, et al. Comparison of chemical profiles, anti-inflammatory activity, and UPLC-Q-TOF\/MS-based metabolomics in endotoxic fever rats between synthetic borneol and natural borneol. Molecules 2017;22:1446.","journal-title":"Molecules"},{"key":"2867_CR38","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.neuroscience.2010.11.029","volume":"176","author":"R Liu","year":"2011","unstructured":"Liu R, Zhang L, Lan X, et al. Protection by borneol on cortical neurons against oxygen-glucose deprivation\/reperfusion: involvement of anti-oxidation and anti-inflammation through nuclear transcription factor kappa B signaling pathway. Neuroscience 2011;176:408\u2013419.","journal-title":"Neuroscience"},{"key":"2867_CR39","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1007\/s11655-016-2584-0","volume":"24","author":"LN Liang","year":"2018","unstructured":"Liang LN, Bai YY, Tang YZ, et al. Contribution of borneolum syntheticum to the intervention effect of Liuwei Dihuang Pill on experimental retinal degeneration. Chin J Integr Med 2018;24:442\u2013447.","journal-title":"Chin J Integr Med"},{"key":"2867_CR40","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/bmc.3037","volume":"28","author":"P Jiang","year":"2014","unstructured":"Jiang P, Fu P, Xiang L, et al. The effectiveness of borneol on pharmacokinetics changes of four ginsenosides in Shexiang Baoxin Pill in vivo. Biomed Chromatogr 2014;28:419\u2013427.","journal-title":"Biomed Chromatogr"},{"key":"2867_CR41","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1080\/10717544.2016.1259372","volume":"24","author":"T Yi","year":"2017","unstructured":"Yi T, Tang DD, Wang F, et al. Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies. Drug Delivery 2017;24:422\u2013429.","journal-title":"Drug Delivery"},{"key":"2867_CR42","first-page":"2936737","volume":"2019","author":"ZX Chen","year":"2019","unstructured":"Chen ZX, Xu QQ, Shan CS, et al. Borneol for regulating the permeability of the blood-brain barrier in experimental ischemic stroke: preclinical evidence and possible mechanism. Oxid Med Cell Longev 2019;2019:2936737.","journal-title":"Oxid Med Cell Longev"},{"key":"2867_CR43","first-page":"1041","volume":"44","author":"PL Wei","year":"2019","unstructured":"Wei PL, Gu H, Guan S, et al. Core prescription excavation of launched Chinese patent medicines for treating different syndromes of angina pectoris. China J Chin Mater Med (Chin) 2019;44:1041\u20131047.","journal-title":"China J Chin Mater Med (Chin)"},{"key":"2867_CR44","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1142\/S0192415X08006181","volume":"36","author":"YH Li","year":"2008","unstructured":"Li YH, Sun XP, Zhang YQ, et al. The antithrombotic effect of borneol related to its anticoagulant property. Am J Chin Med 2008;36:719\u2013727.","journal-title":"Am J Chin Med"},{"key":"2867_CR45","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/j.1742-7843.2011.00784.x","volume":"110","author":"JC Silva-Filho","year":"2012","unstructured":"Silva-Filho JC, Oliveira NNPM, Arcanjo DDR, et al. Investigation of mechanisms involved in (-)-borneol-induced vasorelaxant response on rat thoracic aorta. Basic Clin Pharmacol Toxicol 2012;110:171\u2013177.","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2867_CR46","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1007\/s12272-011-0714-y","volume":"34","author":"HJ He","year":"2011","unstructured":"He HJ, Shen Q, Li J. Effects of borneol on the intestinal transport and absorption of two P-glycoprotein substrates in rats. Arch Pharmacal Res 2011;34:1161\u20131170.","journal-title":"Arch Pharmacal Res"},{"key":"2867_CR47","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0006-2952(02)01444-2","volume":"65","author":"TJ Park","year":"2003","unstructured":"Park TJ, Park YS, Lee TG, et al. Inhibition of acetylcholinemediated effects by borneol. Biochem Pharmacol 2003;65:83\u201390.","journal-title":"Biochem Pharmacol"},{"key":"2867_CR48","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jacc.2010.07.037","volume":"57","author":"A Liuni","year":"2011","unstructured":"Liuni A, Luca MC, Di Stolfo G, et al. Coadministration of atorvastatin prevents nitroglycerin-induced endothelial dysfunction and nitrate tolerance in healthy humans. J Am Coll Cardiol 2011;57:93\u201398.","journal-title":"J Am Coll Cardiol"},{"key":"2867_CR49","first-page":"2519","volume":"37","author":"DF Song","year":"2019","unstructured":"Song DF, Cao JL, Ke QJ. Clinical observation of Kuanxiong Aerosol in relieving angina Iectoris of coronary heart disease and effect on patients ECG. Chin Arch Tradit Chin Med (Chin) 2019;37:2519\u20132522.","journal-title":"Chin Arch Tradit Chin Med (Chin)"},{"key":"2867_CR50","first-page":"396","volume":"34","author":"LZ Li","year":"2014","unstructured":"Li LZ, Dong GJ, Ge CJ, et al. Effect of Kuanxiong Aerosol on coronary heart disease angina patients: a multicenter randomized controlled clinical study. Chin J Integr Med 2014;34:396\u2013401.","journal-title":"Chin J Integr Med"},{"key":"2867_CR51","first-page":"19","volume":"2","author":"QF Ma","year":"2017","unstructured":"Ma QF, Zhang T, Li N. Comparison of curative effect of Kuanxiong Aerosol and isosorbide dinitrate in treatment of angina pectoris of coronary heart disease. Clin Res Pract (Chin) 2017;2:19\u201320.","journal-title":"Clin Res Pract (Chin)"},{"key":"2867_CR52","first-page":"14","volume":"10","author":"Cardiovascular Research Group of Xiyuan Hospital.","year":"1973","unstructured":"Cardiovascular Research Group of Xiyuan Hospital. Observation on analgesic effect of Kuanxiong Aerosol on acute attack of angina pectoris. J Tradit Chin Med (Chin) 1973;10:14\u201316.","journal-title":"J Tradit Chin Med (Chin)"},{"key":"2867_CR53","first-page":"124","volume":"2","author":"H Deng","year":"2017","unstructured":"Deng H, Zhang XG. Clinical effect observation of Kuanxiong Aerosol in the treatment of unstable angina pectoris with cold accumulation and qi stagnation. Clin Res Pract (Chin) 2017;2:124\u2013125.","journal-title":"Clin Res Pract (Chin)"},{"key":"2867_CR54","first-page":"108","volume":"4","author":"KJ Chen","year":"1982","unstructured":"Chen KJ. Observation on the analgesic effect of Huan-Xiong Aerosol on anginal attack. J NIMA 1982;4:108\u2013110.","journal-title":"J NIMA"},{"key":"2867_CR55","first-page":"287","volume":"40","author":"DP Xu","year":"2020","unstructured":"Xu DP, Wu BX, Li Q, et al. Clinical study of Kuanxiong Aerosol's efficacy on exercise tolerance of patients with coronary heart disease complicated with chest tightness\/pain after activities. Chin J Integr Tradit West Med (Chin) 2020;40:287\u2013289.","journal-title":"Chin J Integr Tradit West Med (Chin)"},{"key":"2867_CR56","first-page":"193","volume":"18","author":"SH Wang","year":"2020","unstructured":"Wang SH. Enlightenment of Kuanxiong Aerosol on chest obstruction. Chin J Integr Med Cardiocerebrovasc Dis (Chin) 2020;18:193\u2013194.","journal-title":"Chin J Integr Med Cardiocerebrovasc Dis (Chin)"},{"key":"2867_CR57","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1093\/eurheartj\/ehi242","volume":"26","author":"JF Beltrame","year":"2005","unstructured":"Beltrame JF. Advances in understanding the mechanisms of angina pectoris in cardiac syndrome X. Eur Heart J 2005;26:946\u2013948.","journal-title":"Eur Heart J"},{"key":"2867_CR58","first-page":"3561","volume":"16","author":"GP Zhang","year":"2018","unstructured":"Zhang GP, Xie HN. Clinical observation on 65 cases of cardiac syndrome X treated with Kuanxiong Aerosol. Chin J Integr Med Cardiocerebrovasc Dis (Chin) 2018;16:3561\u20133563.","journal-title":"Chin J Integr Med Cardiocerebrovasc Dis (Chin)"},{"key":"2867_CR59","first-page":"43","volume":"5","author":"JG Liu","year":"1995","unstructured":"Liu JG, Cui J, Liu ZQ. Effect of Kangxin Zhitong Ointment on experimental microcirculation disturbance. Chin J Microcirc (Chin) 1995;5:43.","journal-title":"Chin J Microcirc (Chin)"},{"key":"2867_CR60","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nchembio.118","volume":"4","author":"AL Hopkins","year":"2008","unstructured":"Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 2008;4:682\u2013690.","journal-title":"Nat Chem Biol"},{"key":"2867_CR61","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1758-2946-6-13","volume":"6","author":"JL Ru","year":"2014","unstructured":"Ru JL, Li P, Wang JN, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform 2014;6:13.","journal-title":"J Cheminform"},{"key":"2867_CR62","doi-asserted-by":"publisher","first-page":"D1102","DOI":"10.1093\/nar\/gky1033","volume":"47","author":"S Kim","year":"2019","unstructured":"Kim S, Chen J, Cheng T, et al. PubChem 2019 update: improved access to chemical data. Nucleic Acids Res 2019;47:D1102\u2013D1109.","journal-title":"Nucleic Acids Res"},{"key":"2867_CR63","doi-asserted-by":"publisher","first-page":"W357","DOI":"10.1093\/nar\/gkz382","volume":"47","author":"A Daina","year":"2019","unstructured":"Daina A, Michielin O, Zoete V. SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res 2019;47:W357\u2013W364.","journal-title":"Nucleic Acids Res"},{"key":"2867_CR64","doi-asserted-by":"publisher","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","volume":"46","author":"DS Wishart","year":"2018","unstructured":"Wishart DS, Feunang YD, Guo AC, et al. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res 2018;46:D1074\u2013D1082.","journal-title":"Nucleic Acids Res"},{"key":"2867_CR65","first-page":"D1031","volume":"48","author":"YX Wang","year":"2020","unstructured":"Wang YX, Zhang S, Li FC, et al. Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics. Nucleic Acids Res 2020;48:D1031\u2013D1041.","journal-title":"Nucleic Acids Res"},{"key":"2867_CR66","doi-asserted-by":"publisher","first-page":"D833","DOI":"10.1093\/nar\/gkw943","volume":"45","author":"J Pinero","year":"2017","unstructured":"Pinero J, Bravo A, Queralt-Rosinach N, et al. DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants. Nucleic Acids Res 2017;45:D833\u2013D839.","journal-title":"Nucleic Acids Res"},{"key":"2867_CR67","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/cpbi.5","volume":"54","author":"G Stelzer","year":"2016","unstructured":"Stelzer G, Rosen N, Plaschkes I, et al. The GeneCards Suite: from gene data mining to disease genome sequence analyses. Current protocols in bioinformatics 2016;54:31\u201333.","journal-title":"Current protocols in bioinformatics"},{"key":"2867_CR68","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/nar\/gkg034","volume":"31","author":"C von Mering","year":"2003","unstructured":"von Mering C, Huynen M, Jaeggi D, et al. STRING: a database of predicted functional associations between proteins. Nucleic Acids Res 2003;31:258\u2013261.","journal-title":"Nucleic Acids Res"},{"key":"2867_CR69","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009;4:44\u201357.","journal-title":"Nat Protoc"},{"key":"2867_CR70","first-page":"2175","volume":"24","author":"BJ Wang","year":"2015","unstructured":"Wang BJ, Dong GJ, Liu JG, et al. The relieving effects of Kuanxiong Aerosol on angina pectoris and its influences on endothelial function index in patients with coronary heart disease. J Emerg Tradit Chin Med (Chin) 2015;24:2175\u20132178.","journal-title":"J Emerg Tradit Chin Med (Chin)"},{"key":"2867_CR71","first-page":"503","volume":"53","author":"LJ Ignarro","year":"2002","unstructured":"Ignarro LJ. Nitric oxide as a unique signaling molecule in the vascular system: a historical overview. J Physiol Pharmacol 2002;53:503\u2013514.","journal-title":"J Physiol Pharmacol"},{"key":"2867_CR72","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrd4623","volume":"14","author":"JO Lundberg","year":"2015","unstructured":"Lundberg JO, Gladwin MT, Weitzberg E. Strategies to increase nitric oxide signalling in cardiovascular disease. Nat Rev Drug Discovery 2015;14:623\u2013641.","journal-title":"Nat Rev Drug Discovery"},{"key":"2867_CR73","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1515\/hsz-2019-0386","volume":"401","author":"F Hofmann","year":"2020","unstructured":"Hofmann F. The cGMP system: components and function. Biol Chem 2020;401:447\u2013469.","journal-title":"Biol Chem"},{"key":"2867_CR74","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jphs.2015.09.002","volume":"129","author":"YZ Zhao","year":"2015","unstructured":"Zhao YZ, Vanhoutte PM, Leung SWS. Vascular nitric oxide: beyond eNOS. J Pharmacol Sci 2015;129:83\u201394.","journal-title":"J Pharmacol Sci"},{"key":"2867_CR75","first-page":"1483","volume":"39","author":"BH Wu","year":"2019","unstructured":"Wu BH, Wang GW, Lu X, et al. Network pharmacologybased analysis on pharmacological mechanism of Kuanxiong Aerosol for angina pectoris therapy. Chin J Integr Tradit West Med (Chin) 2019;39:1483\u20131493.","journal-title":"Chin J Integr Tradit West Med (Chin)"},{"key":"2867_CR76","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/S0140-6736(87)91481-4","volume":"2","author":"MW Radomski","year":"1987","unstructured":"Radomski MW, Palmer RMJ, Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet 1987;2:1057\u20131058.","journal-title":"Lancet"},{"key":"2867_CR77","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1016\/S0006-291X(87)80299-1","volume":"148","author":"MW Radomski","year":"1987","unstructured":"Radomski MW, Palmer RMJ, Moncada S. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun 1987;148:1482\u20131489.","journal-title":"Biochem Biophys Res Commun"},{"key":"2867_CR78","doi-asserted-by":"publisher","first-page":"867","DOI":"10.3390\/ijms20040867","volume":"20","author":"R Esse","year":"2019","unstructured":"Esse R, Barroso M, de Almeida IT, et al. The contribution of homocysteine metabolism disruption to endothelialdysfunction: state-of-the-art. Int J Mol Sci 2019;20:867.","journal-title":"Int J Mol Sci"},{"key":"2867_CR79","doi-asserted-by":"publisher","first-page":"34","DOI":"10.18821\/0869-2084-2019-64-1-34-41","volume":"64","author":"TV Stepanova","year":"2019","unstructured":"Stepanova TV, Ivanov AN, Tereshkina NE, et al. Markers of endothelial dysfunction: pathogenetic role and diagnostic significance. Klin Lab Diagn 2019;64:34\u201341.","journal-title":"Klin Lab Diagn"},{"key":"2867_CR80","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.2174\/1381612824666180625125450","volume":"24","author":"A Koller","year":"2018","unstructured":"Koller A, Szenasi A, Dornyei G, et al. Coronary microvascular and cardiac dysfunction due to homocysteine pathometabolism; a complex therapeutic design. Curr Pharm Des 2018;24:2911\u20132920.","journal-title":"Curr Pharm Des"},{"key":"2867_CR81","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1159\/000343329","volume":"30","author":"LH Liu","year":"2012","unstructured":"Liu LH, Guo Z, Feng M, et al. Protection of DDAH2 overexpression against homocysteine-induced impairments of DDAH\/ADMA\/NOS\/NO pathway in endothelial cells. Cell Physiol Biochem 2012;30:1413\u20131422.","journal-title":"Cell Physiol Biochem"},{"key":"2867_CR82","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mvr.2018.03.012","volume":"119","author":"MF Yuyun","year":"2018","unstructured":"Yuyun MF, Ng LL, Ng GA. Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy?. Microvasc Res 2018;119:7\u201312.","journal-title":"Microvasc Res"},{"key":"2867_CR83","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/bs.apha.2016.05.002","volume-title":"Endothelin-1: biosynthesis, signaling and vasoreactivity","author":"M Houde","year":"2016","unstructured":"Houde M, Desbiens L, D'Orleans-Juste P. Endothelin-1: biosynthesis, signaling and vasoreactivity. London: Academic Press Ltd-Elsvier Science Ltd; 2016:143\u2013175."},{"key":"2867_CR84","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1124\/pr.115.011833","volume":"68","author":"AP Davenport","year":"2016","unstructured":"Davenport AP, Hyndman KA, Dhaun N, et al. Endothelin. Pharmacol Rev 2016;68:357\u2013418.","journal-title":"Pharmacol Rev"},{"key":"2867_CR85","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0140-6736(17)32814-3","volume":"391","author":"PM Ridker","year":"2018","unstructured":"Ridker PM, MacFadyen JG, Everett BM, et al. Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial. Lancet 2018;391:319\u2013328.","journal-title":"Lancet"},{"key":"2867_CR86","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1177\/1060028018765939","volume":"52","author":"BK Martinez","year":"2018","unstructured":"Martinez BK, White CM. The emerging role of inflammation in cardiovascular disease. Ann Pharmacother 2018;52:801\u2013809.","journal-title":"Ann Pharmacother"},{"key":"2867_CR87","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.bbadis.2015.10.019","volume":"1862","author":"M Barroso","year":"2016","unstructured":"Barroso M, Kao D, Blom HJ, et al. S-adenosylhomocysteine induces inflammation through NF\u03baB: a possible role for EZH2 in endothelial cell activation. Biochim Biophys Acta Mol Basis Dis 2016;1862:82\u201392.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2867_CR88","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.jacc.2013.05.016","volume":"62","author":"O Yousuf","year":"2013","unstructured":"Yousuf O, Mohanty BD, Martin SS, et al. High-sensitivity C-reactive protein and cardiovascular disease a resolute belief or an elusive link? J Am Coll Cardiol 2013;62:397\u2013408.","journal-title":"J Am Coll Cardiol"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-021-2867-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-021-2867-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-021-2867-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T15:23:30Z","timestamp":1725117810000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-021-2867-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,28]]},"references-count":88,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2867"],"URL":"https:\/\/doi.org\/10.1007\/s11655-021-2867-y","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,28]]},"assertion":[{"value":"9 August 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}