{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:57:17Z","timestamp":1791377837411,"version":"4.3.2"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s11655-021-3296-7","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T10:03:03Z","timestamp":1625824983000},"page":"1072-1080","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and Mechanism of Buxue Yimu Pills on Gynecological Anemia: A Combination of Clinical and Network Pharmacology Study"],"prefix":"10.1007","volume":"28","author":[{"given":"Yan-fang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-lin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-jun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"3296_CR1","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1017\/S1368980008002401","volume":"12","author":"E McLean","year":"2009","unstructured":"McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B. Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993\u20132005. Public Health Nutr 2009;12:444\u2013454.","journal-title":"Public Health Nutr"},{"key":"3296_CR2","doi-asserted-by":"publisher","first-page":"17048","DOI":"10.1038\/s41598-019-52798-y","volume":"9","author":"K Hisa","year":"2019","unstructured":"Hisa K, Haruna M, Hikita N, Sasagawa E, Yonezawa K, Suto M, et al. Prevalence of and factors related to anemia among Japanese adult women: secondary data analysis using health check-up database. Sci Rep 2019;9:17048.","journal-title":"Sci Rep"},{"key":"3296_CR3","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","volume":"123","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood 2014;123:615\u2013624.","journal-title":"Blood"},{"key":"3296_CR4","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3324\/haematol.2014.112813","volume":"100","author":"A Maccio","year":"2015","unstructured":"Maccio A, Madeddu C, Gramignano G, Mulas C, Tanca L, Cherchi MC, et al. The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study. Haematologica 2015;100:124\u2013132.","journal-title":"Haematologica"},{"key":"3296_CR5","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.ygyno.2018.01.010","volume":"148","author":"CC Gunderson","year":"2018","unstructured":"Gunderson CC, Matulonis U, Moore KN. Management of the toxicities of common targeted therapeutics for gynecologic cancers. Gynecol Oncol 2018;148:591\u2013600.","journal-title":"Gynecol Oncol"},{"key":"3296_CR6","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1056\/NEJMoa1910962","volume":"381","author":"A Gonzalez-Martin","year":"2019","unstructured":"Gonzalez-Martin A, Pothuri B, Vergote I, DePont Christensen R, Graybill W, Mirza MR, et al. Niraparib in patients with newly diagnosed advanced ovarian cancer. N Engl J Med 2019;381:2391\u20132402.","journal-title":"N Engl J Med"},{"key":"3296_CR7","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1139\/o06-040","volume":"84","author":"R Paesano","year":"2006","unstructured":"Paesano R, Torcia F, Berlutti F, Pacifici E, Ebano V, Moscarini M, et al. Oral administration of lactoferrin increases hemoglobin and total serum iron in pregnant women. Biochem Cell Biol 2006;84:377\u2013380.","journal-title":"Biochem Cell Biol"},{"key":"3296_CR8","doi-asserted-by":"publisher","first-page":"604","DOI":"10.12669\/pjms.323.9799","volume":"32","author":"C Gereklioglu","year":"2016","unstructured":"Gereklioglu C, Asma S, Korur A, Erdogan F, Kut A. Medication adherence to oral iron therapy in patients with iron deficiency anemia. Pak J Med Sci 2016;32:604\u2013607.","journal-title":"Pak J Med Sci"},{"key":"3296_CR9","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1093\/humupd\/dmv038","volume":"21","author":"JA Maybin","year":"2015","unstructured":"Maybin JA, Critchley HO. Menstrual physiology: implications for endometrial pathology and beyond. Hum Reprod Update 2015;21:748\u2013761.","journal-title":"Hum Reprod Update"},{"key":"3296_CR10","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1182\/blood-2005-01-0160","volume":"106","author":"A Maccio","year":"2005","unstructured":"Maccio A, Madeddu C, Massa D, Mudu MC, Lusso MR, Gramignano G, et al. Hemoglobin levels correlate with interleukin-6 levels in patients with advanced untreated epithelial ovarian cancer: role of inflammation in cancer-related anemia. Blood 2005;106:362\u2013367.","journal-title":"Blood"},{"key":"3296_CR11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1182\/blood-2013-10-512624","volume":"123","author":"C Hershko","year":"2014","unstructured":"Hershko C, Camaschella C. How I treat unexplained refractory iron deficiency anemia. Blood 2014;123:326\u2013333.","journal-title":"Blood"},{"key":"3296_CR12","doi-asserted-by":"publisher","first-page":"221","DOI":"10.2147\/DDDT.S181182","volume":"13","author":"Z Dang","year":"2019","unstructured":"Dang Z, Liu X, Wang X, Li M, Jiang Y, Wang X, et al. Comparative effectiveness and safety of traditional Chinese medicine supporting Qi and enriching blood for cancer related anemia in patients not receiving chemoradiotherapy: a meta-analysis and systematic review. Drug Des Devel Ther 2019;13:221\u2013230.","journal-title":"Drug Des Devel Ther"},{"key":"3296_CR13","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/ptr.2144","volume":"21","author":"XL Zhu","year":"2007","unstructured":"Zhu XL, Zhu BD. Mechanisms by which Astragalus membranaceus Injection regulates hematopoiesis in myelosuppressed mice. Phytother Res 2007;21:663\u2013667.","journal-title":"Phytother Res"},{"key":"3296_CR14","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.jep.2014.02.012","volume":"152","author":"M Liu","year":"2014","unstructured":"Liu M, Tan H, Zhang X, Liu Z, Cheng Y, Wang D, et al. Hematopoietic effects and mechanisms of Fufang e\u2019jiao jiang on radiotherapy and chemotherapy-induced myelosuppressed mice. J Ethnopharmacol 2014;152:575\u2013584.","journal-title":"J Ethnopharmacol"},{"key":"3296_CR15","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.2174\/0929867043365189","volume":"11","author":"SD Sarker","year":"2004","unstructured":"Sarker SD, Nahar L. Natural medicine: the genus Angelica. Curr Med Chem 2004;11:1479\u20131500.","journal-title":"Curr Med Chem"},{"key":"3296_CR16","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.jep.2016.09.044","volume":"194","author":"JY Liu","year":"2016","unstructured":"Liu JY, Morisseau C, Huang H, Hammock BD. Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use. J Ethnopharmacol 2016;194:475\u2013482.","journal-title":"J Ethnopharmacol"},{"key":"3296_CR17","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jep.2016.06.027","volume":"191","author":"LJ Zhong","year":"2016","unstructured":"Zhong LJ, Hua YL, Ji P, Yao WL, Zhang WQ, Li J, et al. Evaluation of the anti-inflammatory effects of volatile oils from processed products of Angelica sinensis Radix by GC-MS-based metabolomics. J Ethnopharmacol 2016;191:195\u2013205.","journal-title":"J Ethnopharmacol"},{"key":"3296_CR18","unstructured":"World Health Organization. Iron deficiency anaemia: assessment, prevention and control 2001. Available at: https:\/\/www.who.int\/nutrition\/publications\/micronutrients\/anaemia_iron_deficiency\/WHO_NHD_01.3\/en\/."},{"key":"3296_CR19","first-page":"2308","volume-title":"Practice of internal medicine","year":"2014","unstructured":"Chen HZ, ed. Practice of internal medicine. 14 ed. Beijing: People\u2019s Medical Publishing House; 2014:2308\u20132312.","edition":"14 ed."},{"key":"3296_CR20","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun 2019;10:1523.","journal-title":"Nat Commun"},{"issue":"Suppl2","key":"3296_CR21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3109\/13697137.2014.963964","volume":"17","author":"M Berbic","year":"2014","unstructured":"Berbic M, Ng CH, Fraser IS. Inflammation and endometrial bleeding. Climacteric 2014;17 Suppl 2:47\u201353.","journal-title":"Climacteric"},{"key":"3296_CR22","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1056\/NEJMra1401038","volume":"372","author":"C Camaschella","year":"2015","unstructured":"Camaschella C. Iron-deficiency anemia. N Engl J Med 2015;372:1832\u20131843.","journal-title":"N Engl J Med"},{"key":"3296_CR23","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1182\/blood-2017-06-780882","volume":"130","author":"EM Pietras","year":"2017","unstructured":"Pietras EM. Inflammation: a key regulator of hematopoietic stem cell fate in health and disease. Blood 2017;130:1693\u20131698.","journal-title":"Blood"},{"key":"3296_CR24","doi-asserted-by":"publisher","first-page":"502","DOI":"10.3389\/fimmu.2016.00502","volume":"7","author":"LV Kovtonyuk","year":"2016","unstructured":"Kovtonyuk LV, Fritsch K, Feng X, Manz MG, Takizawa H. Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment. Front Immunol 2016;7:502.","journal-title":"Front Immunol"},{"key":"3296_CR25","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nri3062","volume":"11","author":"KY King","year":"2011","unstructured":"King KY, Goodell MA. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol 2011;11:685\u2013692.","journal-title":"Nat Rev Immunol"},{"key":"3296_CR26","first-page":"175","volume":"20","author":"H SM","year":"2002","unstructured":"SM Hyder, LA Persson, AM Chowdhury, EC Ekstr\u00f6m. Do side-effects reduce compliance to iron supplementation? A study of daily- and weekly-dose regimens in pregnancy. J Health Populat Nutr 2002;20:175\u2013179.","journal-title":"J Health Populat Nutr"},{"key":"3296_CR27","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1741-7015-10-8","volume":"10","author":"S Waldvogel","year":"2012","unstructured":"Waldvogel S, Pedrazzini B, Vaucher P, Bize R, Cornuz J, Tissot JD, et al. Clinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trial. BMC Med 2012;10:8.","journal-title":"BMC Med"},{"key":"3296_CR28","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1182\/blood-2010-06-287292","volume":"117","author":"AS Zhang","year":"2011","unstructured":"Zhang AS, Anderson SA, Wang J, Yang F, DeMaster K, Ahmed R, et al. Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. Blood 2011;117:1687\u20131699.","journal-title":"Blood"},{"key":"3296_CR29","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nm.2073","volume":"16","author":"H Li","year":"2010","unstructured":"Li H, Rybicki AC, Suzuka SM, von Bonsdorff L, Breuer W, Hall CB, et al. Transferrin therapy ameliorates disease in beta-thalassemic mice. Nature Med 2010;16:177\u2013182.","journal-title":"Nature Med"},{"key":"3296_CR30","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.freeradbiomed.2005.01.014","volume":"38","author":"G Sen","year":"2005","unstructured":"Sen G, Mandal S, Saha Roy S, Mukhopadhyay S, Biswas T. Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis. Free Radic Biol Med 2005;38:1257\u20131264.","journal-title":"Free Radic Biol Med"},{"key":"3296_CR31","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1177\/1534735414523315","volume":"13","author":"SE Mahoney","year":"2014","unstructured":"Mahoney SE, Davis JM, Murphy EA, McClellan JL, Pena MM. Dietary quercetin reduces chemotherapy-induced fatigue in mice. Integr Cancer Ther 2014;13:417\u2013424.","journal-title":"Integr Cancer Ther"},{"key":"3296_CR32","doi-asserted-by":"publisher","first-page":"976","DOI":"10.3389\/fphys.2019.00976","volume":"10","author":"H Al Balushi","year":"2019","unstructured":"Al Balushi H, Hannemann A, Rees D, Brewin J, Gibson JS. The effect of antioxidants on the properties of red blood cells from patients with sickle cell anemia. Front Physiol 2019;10:976.","journal-title":"Front Physiol"},{"key":"3296_CR33","doi-asserted-by":"publisher","first-page":"40097","DOI":"10.1038\/srep40097","volume":"7","author":"S Angmo","year":"2017","unstructured":"Angmo S, Tripathi N, Abbat S, Sharma S, Singh SS, Halder A, et al. Identification of guanosine 5\u2032-diphosphate as potential iron mobilizer: preventing the hepcidin-ferroportin interaction and modulating the interleukin-6\/Stat-3 pathway. Sci Rep 2017;7:40097.","journal-title":"Sci Rep"},{"key":"3296_CR34","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.3390\/ijms18112265","volume":"18","author":"H Xiao","year":"2017","unstructured":"Xiao H, Xiong L, Song X, Jin P, Chen L, Chen X, et al. Angelica sinensis Polysaccharides ameliorate stress-induced premature senescence of hematopoietic cell via protecting bone marrow stromal cells from oxidative injuries caused by 5-fluorouracil. Int J Mol Sci 2017;18:2265\u20132286.","journal-title":"Int J Mol Sci"},{"key":"3296_CR35","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1093\/jn\/136.12.3010","volume":"136","author":"K Thompson","year":"2006","unstructured":"Thompson K, Molina RM, Brain JD, Wessling-Resnick M. Belgrade rats display liver iron loading. J Nutr 2006;136:3010\u20133014.","journal-title":"J Nutr"},{"key":"3296_CR36","doi-asserted-by":"publisher","first-page":"e66010","DOI":"10.1371\/journal.pone.0066010","volume":"8","author":"S Gulec","year":"2013","unstructured":"Gulec S, Collins JF. Investigation of iron metabolism in mice expressing a mutant Menke\u2019s copper transporting ATPase (Atp7a) protein with diminished activity (Brindled; Mo (Br) (\/y)). PLoS One 2013;8:e66010.","journal-title":"PLoS One"},{"key":"3296_CR37","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.mayocp.2018.12.012","volume":"94","author":"ML Marnach","year":"2019","unstructured":"Marnach ML, Laughlin-Tommaso SK. Evaluation and management of abnormal uterine bleeding. Mayo Clin Proc 2019;94:326\u2013335.","journal-title":"Mayo Clin Proc"},{"key":"3296_CR38","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1111\/j.1471-0528.2004.00176.x","volume":"111","author":"M Shankar","year":"2004","unstructured":"Shankar M, Lee CA, Sabin CA, Economides DL, Kadir RA. von Willebrand disease in women with menorrhagia: a systematic review. BJOG 2004;111:734\u2013740.","journal-title":"BJOG"},{"key":"3296_CR39","doi-asserted-by":"publisher","first-page":"e100314","DOI":"10.1371\/journal.pone.0100314","volume":"9","author":"N Li","year":"2014","unstructured":"Li N, Sun C, Zhou B, Xing H, Ma D, Chen G, et al. Low concentration of quercetin antagonizes the cytotoxic effects of anti-neoplastic drugs in ovarian cancer. PLoS One 2014;9:e100314.","journal-title":"PLoS One"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-021-3296-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-021-3296-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-021-3296-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T09:19:00Z","timestamp":1669195140000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-021-3296-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,9]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3296"],"URL":"https:\/\/doi.org\/10.1007\/s11655-021-3296-7","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,9]]},"assertion":[{"value":"17 September 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}