{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:12:38Z","timestamp":1777450358654,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s11655-021-3298-5","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T16:03:17Z","timestamp":1623168197000},"page":"60-68","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ethyl Acetate Fraction of Dicliptera chinensis (L.) Juss. Ameliorates Liver Fibrosis by Inducing Autophagy via PI3K\/AKT\/mTOR\/p70S6K Signaling Pathway"],"prefix":"10.1007","volume":"28","author":[{"given":"Yuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-meng","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-ping","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"3298_CR1","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1002\/hep.26885","volume":"59","author":"J Sun","year":"2014","unstructured":"Sun J, Xie Q, Tan D, Ning Q, Niu J, Bai X, et al. The 104-week efficacy and safety of telbivudine-based optimization strategy in chronic hepatitis B patients: a randomized, controlled study. Hepatology 2014;59:1283\u20131292.","journal-title":"Hepatology"},{"key":"3298_CR2","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/nrgastro.2010.97","volume":"7","author":"SL Friedman","year":"2010","unstructured":"Friedman SL. Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol 2010;7:425\u2013436.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"3298_CR3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.cgh.2013.01.005","volume":"11","author":"DC Rockey","year":"2013","unstructured":"Rockey DC. Translating an understanding of the pathogenesis of hepatic fibrosis to novel therapies. Clin Gastroenterol Hepatol 2013;11:224\u2013231.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3298_CR4","first-page":"235","volume":"6","author":"B Ye","year":"2011","unstructured":"Ye B, Zhang Y, He W. Advances in research on Dicliptera chinensis (L.) Juss. China Pract Med (Chin) 2011;6:235\u2013237.","journal-title":"China Pract Med (Chin)"},{"key":"3298_CR5","first-page":"675","volume":"19","author":"D Xu","year":"2016","unstructured":"Xu D, He Y, Yang S, Li K, Yang X, Shen Z. Protective effect of Dicliptera chinensis (L.) Juss. Polysaccharide P2B on carbon tetrachloride-induced injury of liver cell line L-02. China Pharm (Chin) 2016;19:675\u2013677.","journal-title":"China Pharm (Chin)"},{"key":"3298_CR6","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.ijbiomac.2017.03.112","volume":"101","author":"Y Xu","year":"2017","unstructured":"Xu Y, Gao Y, Zhong M, Li J, Cao H, Huang S, et al. Isolation, characterization and bioactivities of the polysaccharides from Dicliptera chinensis (L.) Juss. Int J Biol Macromol 2017;101:603\u2013611.","journal-title":"Int J Biol Macromol"},{"key":"3298_CR7","first-page":"4862","volume":"34","author":"Y Xu","year":"2015","unstructured":"Xu Y, Zhang K, Zhong M, Gao Y, Duan X. Advances in research on chemical constituents and pharmacology of Dicliptera chinensis (L.) Juss. Chin Pharm (Chin) 2015;34:4862\u20134864.","journal-title":"Chin Pharm (Chin)"},{"key":"3298_CR8","first-page":"497","volume":"35","author":"K Zhang","year":"2010","unstructured":"Zhang K, Zhu H, Gao Y. Research on active extracts of Dicliptera chinensis (L.) Juss. on liver protection. China J Chin Mater Med (Chin) 2010;35:497\u2013498.","journal-title":"China J Chin Mater Med (Chin)"},{"key":"3298_CR9","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jep.2015.12.053","volume":"179","author":"K Zhang","year":"2016","unstructured":"Zhang K, Gao Y, Zhong M, Xu Y, Li J, Chen Y, et al. Hepatoprotective effects of Dicliptera chinensis polysaccharides on dimethylnitrosamine-induced hepatic fibrosis rats and its underlying mechanism. J Ethnopharmacol 2016;179:38\u201344.","journal-title":"J Ethnopharmacol"},{"key":"3298_CR10","first-page":"99","volume":"62","author":"X Zhang","year":"2016","unstructured":"Zhang X, Zhang J, Jia L, Xiao S. Dicliptera Chinensis polysaccharides target TGF-beta\/Smad pathway and inhibit stellate cells activation in rats with dimethylnitrosamine-induced hepatic fibrosis. Cell Mol Biol (Noisy-le-grand) 2016;62:99\u2013103.","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"3298_CR11","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/cdd.2011.146","volume":"19","author":"D Denton","year":"2012","unstructured":"Denton D, Nicolson S, Kumar S. Cell death by autophagy: facts and apparent artefacts. Cell Death Differ 2012;19:87\u201395.","journal-title":"Cell Death Differ"},{"key":"3298_CR12","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nature06639","volume":"451","author":"N Mizushima","year":"2008","unstructured":"Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008;451:1069\u20131075.","journal-title":"Nature"},{"key":"3298_CR13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/cr.2013.161","volume":"24","author":"P Jiang","year":"2014","unstructured":"Jiang P, Mizushima N. Autophagy and human diseases. Cell Res 2014;24:69\u201379.","journal-title":"Cell Res"},{"key":"3298_CR14","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/jpi.12247","volume":"59","author":"B San-Miguel","year":"2015","unstructured":"San-Miguel B, Crespo I, S\u00e1nchez DI, Gonz\u00e1lez-Fern\u00e1ndez B, Ortiz de Urbina JJ, Tu\u00f1\u00f3n MJ, et al. Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis. J Pineal Res 2015;59:151\u2013162.","journal-title":"J Pineal Res"},{"key":"3298_CR15","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1136\/gutjnl-2014-306842","volume":"64","author":"YA Lee","year":"2015","unstructured":"Lee YA, Wallace MC, Friedman SL. Pathobiology of liver fibrosis: a translational success story. Gut 2015;64:830\u2013841.","journal-title":"Gut"},{"key":"3298_CR16","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s11418-018-1262-2","volume":"73","author":"Y Liu","year":"2019","unstructured":"Liu Y, Bi Y, Mo C, Zeng T, Huang S, Gao L, et al. Betulinic acid attenuates liver fibrosis by inducing autophagy via the mitogen-activated protein kinase\/extracellular signalregulated kinase pathway. J Nat Med 2019;73:179\u2013189.","journal-title":"J Nat Med"},{"key":"3298_CR17","doi-asserted-by":"publisher","first-page":"40486","DOI":"10.18632\/oncotarget.17119","volume":"8","author":"W Zhong","year":"2017","unstructured":"Zhong W, Gao L, Zhou Z, Lin H, Chen C, Huang P, et al. Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation. Oncotarget 2017;8:40486\u201340500.","journal-title":"Oncotarget"},{"key":"3298_CR18","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1002\/hep.27792","volume":"62","author":"PN Mimche","year":"2015","unstructured":"Mimche PN, Brady LM, Bray CF, Lee CM, Thapa M, King TP, et al. The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice. Hepatology 2015;62:900\u2013914.","journal-title":"Hepatology"},{"key":"3298_CR19","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.freeradbiomed.2020.07.038","volume":"160","author":"C Mo","year":"2020","unstructured":"Mo C, Xie S, Zhong W, Zeng T, Huang S, Lai Y, et al. Mutual antagonism between indoleamine 2,3-dioxygenase 1 and nuclear factor E2-related factor 2 regulates the maturation status of DCs in liver fibrosis. Free Radic Biol Med 2020;160:178\u2013190.","journal-title":"Free Radic Biol Med"},{"key":"3298_CR20","doi-asserted-by":"publisher","first-page":"561","DOI":"10.2131\/jts.41.561","volume":"41","author":"S Dong","year":"2016","unstructured":"Dong S, Chen Q, Song Y, Sun Y, Wei B, Li X, et al. Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis. J Toxicol Sci 2016;41:561\u2013572.","journal-title":"J Toxicol Sci"},{"key":"3298_CR21","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00535-008-2181-x","volume":"43","author":"NJ T\u00f6r\u00f6k","year":"2008","unstructured":"T\u00f6r\u00f6k NJ. Recent advances in the pathogenesis and diagnosis of liver fibrosis. J Gastroenterol 2008;43:315\u2013321.","journal-title":"J Gastroenterol"},{"key":"3298_CR22","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.lfs.2015.07.019","volume":"137","author":"C Zhao","year":"2015","unstructured":"Zhao C, She T, Wang L, Su Y, Qu L, Gao Y, et al. Daucosterol inhibits cancer cell proliferation by inducing autophagy through reactive oxygen species-dependent manner. Life Sci 2015;137:37\u201343.","journal-title":"Life Sci"},{"key":"3298_CR23","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ajg.2011.07.001","volume":"12","author":"AN Shafik","year":"2011","unstructured":"Shafik AN, Khodeir MM, Gouda NA, Mahmoud ME. Improved antifibrotic effect of a combination of verapamil and silymarin in rat-induced liver fibrosis. Arab J Gastroenterol 2011;12:143\u2013149.","journal-title":"Arab J Gastroenterol"},{"key":"3298_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13020-015-0036-y","volume":"10","author":"SR Chen","year":"2015","unstructured":"Chen SR, Chen XP, Lu JJ, Wang Y, Wang YT. Potent natural products and herbal medicines for treating liver fibrosis. Chin Med 2015;10:7.","journal-title":"Chin Med"},{"key":"3298_CR25","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s11655-016-2627-6","volume":"23","author":"Y Cheng","year":"2017","unstructured":"Cheng Y, Mai JY, Wang MF, Chen GF, Ping J. Antifibrotic effect of total flavonoids of Astmgali Radix on dimethylnitrosamine-induced liver cirrhosis in rats. Chin J Integr Med 2017;23:48\u201354.","journal-title":"Chin J Integr Med"},{"key":"3298_CR26","doi-asserted-by":"publisher","first-page":"6397","DOI":"10.1111\/jcmm.15286","volume":"24","author":"K Zhang","year":"2020","unstructured":"Zhang K, Xu Q, Gao Y, Cao H, Lian Y, Li Z, et al. Polysaccharides from Dicliptera chinensis ameliorate liver disturbance by regulating TLR-4\/NF- \u03ba B and AMPK\/Nrf2 signalling pathways. J Cell Mol Med 2020;24:6397\u20136409.","journal-title":"J Cell Mol Med"},{"key":"3298_CR27","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1159\/000366330","volume":"34","author":"JW Chen","year":"2014","unstructured":"Chen JW, Ni BB, Li B, Yang YH, Jiang SD, Jiang LS. The responses of autophagy and apoptosis to oxidative stress in nucleus pulposus cells: implications for disc degeneration. Cell Physiol Biochem 2014;34:1175\u20131189.","journal-title":"Cell Physiol Biochem"},{"key":"3298_CR28","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nrgastro.2013.211","volume":"11","author":"JL Schneider","year":"2014","unstructured":"Schneider JL, Cuervo AM. Liver autophagy: much more than just taking out the trash. Nat Rev Gastroenterol Hepatol 2014;11:187\u2013200.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"3298_CR29","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.mib.2013.03.010","volume":"16","author":"KB Boyle","year":"2013","unstructured":"Boyle KB, Randow F. The role of \u2018eat-me\u2019 signals and autophagy cargo receptors in innate immunity. Curr Opin Microbiol 2013;16:339\u2013348.","journal-title":"Curr Opin Microbiol"},{"key":"3298_CR30","doi-asserted-by":"publisher","first-page":"84","DOI":"10.4161\/auto.1.2.1697","volume":"1","author":"I Tanida","year":"2005","unstructured":"Tanida I, Minematsu-Ikeguchi N, Ueno T, Kominami E. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 2005;1:84\u201391.","journal-title":"Autophagy"},{"key":"3298_CR31","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.lfs.2017.08.019","volume":"187","author":"KA El-Mihi","year":"2017","unstructured":"El-Mihi KA, Kenawy HI, El-Karef A, Elsherbiny NM, Eissa LA. Naringin attenuates thioacetamide-induced liver fibrosis in rats through modulation of the PI3K\/Akt pathway. Life Sci 2017;187:50\u201357.","journal-title":"Life Sci"},{"key":"3298_CR32","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1111\/liv.12638","volume":"35","author":"J Li","year":"2015","unstructured":"Li J, Li X, Xu W, Wang S, Hu Z, Zhang Q, et al. Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT\/mTOR\/p70S6K and TGFbeta\/Smad signalling pathways. Liver Int 2015;35:1222\u20131233.","journal-title":"Liver Int"},{"key":"3298_CR33","doi-asserted-by":"publisher","unstructured":"Lin X, Li Y, Zhang X, Wei Y, Wen S, Lu Z, et al. Tormentic acid inhibits hepatic stellate cells activation via blocking PI3K\/Akt\/mTOR and NF- \u03ba B signalling pathways. Cell Biochem Funct 2020; doi: https:\/\/doi.org\/10.1002\/cbf.3564.","DOI":"10.1002\/cbf.3564"},{"key":"3298_CR34","first-page":"161020","volume":"2015","author":"S Fan","year":"2015","unstructured":"Fan S, Zhang B, Luan P, Gu B, Wan Q, Huang X, et al. PI3K\/AKT\/mTOR\/p70S6K pathway is involved in A \u03b225\u201335-induced autophagy. BioMed Res Int 2015;2015:161020.","journal-title":"BioMed Res Int"},{"key":"3298_CR35","doi-asserted-by":"publisher","first-page":"176","DOI":"10.4161\/auto.7.2.14074","volume":"7","author":"S Shinji","year":"2011","unstructured":"Shinji S, Yukiko S, Yoko I, Sumihiro K, Takahiro F, Isei T, et al. Caffeine induces apoptosis by enhancement of autophagy via PI3K\/Akt\/mTOR\/p70S6K inhibition. Autophagy 2011;7:176\u2013187.","journal-title":"Autophagy"},{"key":"3298_CR36","doi-asserted-by":"publisher","first-page":"a11189","DOI":"10.1101\/cshperspect.a011189","volume":"4","author":"BA Hemmings","year":"2012","unstructured":"Hemmings BA, Restuccia DF. PI3K-PKB\/Akt pathway. Cold Spring Harb Perspect Biol 2012;4:a11189.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3298_CR37","doi-asserted-by":"publisher","first-page":"59","DOI":"10.4161\/auto.1.1.1536","volume":"1","author":"DJ Klionsky","year":"2005","unstructured":"Klionsky DJ, Meijer AJ, Codogno P. Autophagy and p70S6 kinase. Autophagy 2005;1:59\u201360.","journal-title":"Autophagy"},{"key":"3298_CR38","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1042\/BST20130018","volume":"41","author":"MA Destefano","year":"2013","unstructured":"Destefano MA, Jacinto E. Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2). Biochem Soc Trans 2013;41:896\u2013901.","journal-title":"Biochem Soc Trans"},{"key":"3298_CR39","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1136\/annrheumdis-2012-201671","volume":"72","author":"NY Lin","year":"2013","unstructured":"Lin NY, Beyer C, Giessl A, Kireva T, Scholtysek C, Uderhardt S, et al. Autophagy regulates TNF alpha-mediated joint destruction in experimental arthritis. Ann Rheumat Dis 2013;72:761\u2013768.","journal-title":"Ann Rheumat Dis"},{"key":"3298_CR40","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jhep.2013.02.016","volume":"59","author":"V Hern\u00e1ndez-Gea","year":"2013","unstructured":"Hern\u00e1ndez-Gea V, Hilscher M, Rozenfeld R, Lim MP, Nieto N, Werner S, et al. Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy. J Hepatol 2013;59:98\u2013104.","journal-title":"J Hepatol"},{"key":"3298_CR41","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.jhep.2013.01.011","volume":"58","author":"CW Lin","year":"2013","unstructured":"Lin CW, Zhang H, Li M, Xiong X, Chen X, Chen X, et al. Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. J Hepatol 2013;58:993\u2013999.","journal-title":"J Hepatol"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-021-3298-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-021-3298-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-021-3298-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T16:10:25Z","timestamp":1640707825000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-021-3298-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,8]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["3298"],"URL":"https:\/\/doi.org\/10.1007\/s11655-021-3298-5","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,8]]},"assertion":[{"value":"17 November 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}