{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:46:07Z","timestamp":1788295567121,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s11655-021-3442-2","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T03:33:29Z","timestamp":1620444809000},"page":"832-837","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Landscape of Hepatobiliary Adverse Drug Reactions Related to Preparations Containing Psoraleae Fructus and Its Application in Pharmacovigilance"],"prefix":"10.1007","volume":"27","author":[{"given":"Fei-lin","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-xin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ling","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-fang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-bo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-he","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"3442_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jfda.2017.10.010","volume":"26","author":"JJ Yang","year":"2017","unstructured":"Yang JJ, Yang J, Du J, Feng YX, Chai X, Xiao MM, et al. General survey of Fructus Psoraleae from the different origins and chemical identification of the roasted from raw Fructus Psoraleae. J Food Drug Anal 2017;26:1\u20138.","journal-title":"J Food Drug Anal"},{"key":"3442_CR2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jep.2012.08.028","volume":"144","author":"JY Wang","year":"2012","unstructured":"Wang JY, Jiang ZZ, Ji JZ, Li YY, Chen M, Wang YR, et al. Evaluation of hepatotoxicity and cholestasis in rats treated with EtOH extract of Fructus Psoraleae. J Ethnopharmacology 2012;144:73\u201381.","journal-title":"J Ethnopharmacology"},{"key":"3442_CR3","first-page":"188","volume-title":"Pharmacopoeia of the People\u2019s Republic of China","author":"National Commission of Chinese Pharmacopoeia","year":"2015","unstructured":"National Commission of Chinese Pharmacopoeia. Pharmacopoeia of the People\u2019s Republic of China. Beijing: Chinese Medical Science and Technology Press 2015;1:188."},{"key":"3442_CR4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3109\/1061186X.2015.1070855","volume":"24","author":"BJ Garg","year":"2016","unstructured":"Garg BJ, Garg NK, Beg S, Singh B, Katare OP. Nanosized ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery against vitiligo: formulation optimization, in vitro evaluation and preclinical assessment. J Drug Target 2016;24:233\u2013246.","journal-title":"J Drug Target"},{"key":"3442_CR5","first-page":"36","volume":"27","author":"FF Huang","year":"2007","unstructured":"Huang FF, Liang SM, Wang LY, Yang DP. Study of the pharmacodynamics of psoralen gel on experimental vitiligo. Chin J Hosp Pharm (Chin) 2007;27:36\u201338.","journal-title":"Chin J Hosp Pharm (Chin)"},{"key":"3442_CR6","first-page":"77","volume":"11","author":"PL Zhou","year":"2005","unstructured":"Zhou PL, Ouyang H, Wang ZX. The advancement of drug therapy for vitiligo. Guid J Tradit Chin Med Pharm (Chin) 2005;11:77\u201379.","journal-title":"Guid J Tradit Chin Med Pharm (Chin)"},{"key":"3442_CR7","first-page":"89","volume":"24","author":"JY Cao","year":"2008","unstructured":"Cao JY, Liu JJ, Huang WH, Guo BL. Progress in the pharmacological action and clinical application of psoralen. Chin Med Pharm Clin (Chin) 2008;24:89\u201392.","journal-title":"Chin Med Pharm Clin (Chin)"},{"key":"3442_CR8","first-page":"193","volume":"38","author":"W Wang","year":"2015","unstructured":"Wang W, Liao SP, Wei L. Clinical efficacy of appendix treatment with Gukang capsules in elder patients with a distal radius fracture. J Chin Med Mater (Chin) 2015;38:193\u2013196.","journal-title":"J Chin Med Mater (Chin)"},{"key":"3442_CR9","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1002\/jssc.200600339","volume":"30","author":"CF Qiao","year":"2007","unstructured":"Qiao CF, Han QB, Song JZ, Mo SF, Kong LD, Kung SF, et al. Chemical fingerprint and quantitative analysis of Fructus Psoraleae by high-performance liquid chromatography. J Sep Sci 2007;30:813\u2013818.","journal-title":"J Sep Sci"},{"key":"3442_CR10","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.phymed.2013.09.015","volume":"21","author":"WD Li","year":"2014","unstructured":"Li WD, Yan CP, Wu Y, Weng ZB, Yin FZ, Yang GM, et al. Osteoblasts proliferation and differentiation stimulating activities of the main components of Fructus Psoraleae corylifoliae. Phytomedicine 2014;21:400\u2013405.","journal-title":"Phytomedicine"},{"key":"3442_CR11","volume-title":"Proceedings of the 7th National Toxicology Conference of the Chinese Society of Toxicology and the 8th Hubei Science and Technology Forum","author":"HB Song","year":"2015","unstructured":"Song HB. Risk signals and main risk characteristics of clinical psoralen drugs based on adverse reaction monitoring data. Chinese Society of Toxicology and Hubei Association for Science & Technology. Proceedings of the 7th National Toxicology Conference of the Chinese Society of Toxicology and the 8th Hubei Science and Technology Forum, Chinese Society of Toxicology and Hubei Association for Science & Technology. Wuhan; 2015."},{"key":"3442_CR12","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1081\/CLT-200068863","volume":"43","author":"SW Nam","year":"2005","unstructured":"Nam SW, Baek JT, Lee DS, Kang SB, Ahn BM, Chung KW. A case of acute cholestatic hepatitis associated with the seeds of Psoralea corylifolia (Boh-Gol-Zhee). Clin Tox 2005;43:589\u2013591.","journal-title":"Clin Tox"},{"key":"3442_CR13","first-page":"4059","volume":"42","author":"WY Tian","year":"2017","unstructured":"Tian WY, Lan S, Zhang L, Sun L, Huang JK, Yang XH, et al. Safety evaluation and risk control measures of Psoralea corylifolia. Chin a J Chin Mater Med (Chin) 2017;42:4059\u20134066.","journal-title":"Chin a J Chin Mater Med (Chin)"},{"key":"3442_CR14","first-page":"80","volume":"38","author":"China Food and Drug Administration","year":"2017","unstructured":"China Food and Drug Administration. Be alert to the risk of liver damage caused by the oral preparation of Xianling Gubao. Shanghai Med (Chin) 2017;38:80.","journal-title":"Shanghai Med (Chin)"},{"key":"3442_CR15","first-page":"817","volume":"24","author":"R Jin","year":"2016","unstructured":"Jin R, Gu HY, Li LL, Sun LL. Current status of Chinese herbal preparations included in the Liver Tox database. Chin J Hepatol (Chin) 2016;24:817\u2013823.","journal-title":"Chin J Hepatol (Chin)"},{"key":"3442_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-018-2420-5","volume":"19","author":"A Li","year":"2019","unstructured":"Li A, Gao MH, Zhao N, Li P, Zhu JG, Li WF. Acute liver failure associated with Fructus Psoraleae: a case report and literature review. BMC Complem Altern M 2019;19:1\u20134.","journal-title":"BMC Complem Altern M"},{"key":"3442_CR17","unstructured":"World Health Organization (WHO), Uppsala Monitoring Centre. The use of the WHO-UMC system for standardised case causality assessment. Available at: http:\/\/www.who-umc.org\/Graphics\/26649.pdf 2018."},{"key":"3442_CR18","first-page":"810","volume":"23","author":"Drug-induced Liver Disease Study Group","year":"2015","unstructured":"Drug-induced Liver Disease Study Group, Chinese Society of Hepatology, Chinese Medical Association. Diagnosis and treatment guideline on drug-induced liver injury. Chin J Hepatol (Chin) 2015;23:810\u2013820.","journal-title":"Chin J Hepatol (Chin)"},{"key":"3442_CR19","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1007\/s11655-018-3000-8","volume":"24","author":"JB Wang","year":"2018","unstructured":"Wang JB, Zhu Y, Bai ZF, Wang FS, Li XH, Xiao XH. Guidelines for the diagnosis and management of herb-induced liver injury. Chin J Integr Med 2018;24:696\u2013706.","journal-title":"Chin J Integr Med"},{"key":"3442_CR20","unstructured":"China Food and Drug Administration. Measures for the reporting and monitoring of adverse drug reactions. Available at: http:\/\/samr.cfda.gov.cn\/WS01\/CL1031\/62621_7.html. Accessed 04 May 2011."},{"key":"3442_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s11684-019-0690-z","volume":"14","author":"Y Gao","year":"2020","unstructured":"Gao Y, Wang ZL, Tang JF, Liu XF, Shi W, Qin N, et al. New incompatible pair of TCM: Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions. Front Med (Chin) 2020;14:68\u201380.","journal-title":"Front Med (Chin)"},{"key":"3442_CR22","first-page":"4336","volume":"33","author":"JF Tang","year":"2018","unstructured":"Tang JF, Li WX, Wang XY, Li YH, Zhang HZ, Cao YJ, et al. Related biomarker screening of Zhuanggu Guanjie Pill induced idiosyncrasy liver injury based on metabolomics. China J Trait Chin Med Pharm (Chin) 2018;33:4336\u20134340.","journal-title":"China J Trait Chin Med Pharm (Chin)"},{"key":"3442_CR23","first-page":"574","volume":"53","author":"JF Tang","year":"2018","unstructured":"Tang JF, Wang XY, Yang W, Li WX, Li YH, Bai ZF, et al. Cytokine analysis of Zhuangguguanjie wan-induced idiosyncratic liver injury based on mathematical modeling. Acta Pharm Sin 2018;53:574\u2013584.","journal-title":"Acta Pharm Sin"},{"key":"3442_CR24","first-page":"1048","volume":"44","author":"FL Ge","year":"2019","unstructured":"Ge FL, Niu M, Han ZX, Zhang YF, Wang JB, Xiao XH, et al. Analysis of epidemiological characteristics of drug induced liver injury associated with Baixianpi preparations. China J Chin Mater Med (Chin) 2019;44:1048\u20131052.","journal-title":"China J Chin Mater Med (Chin)"},{"key":"3442_CR25","first-page":"77","volume":"12","author":"LT Xia","year":"2019","unstructured":"Xia LT, Rang C, Wang DY. Analysis on the standardization and rationality of the prescription of Chinese herbal decoction pieces. Chin J Clin Ration Drug Use (Chin) 2019;12:77\u201378.","journal-title":"Chin J Clin Ration Drug Use (Chin)"},{"key":"3442_CR26","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1053\/j.gastro.2019.02.002","volume":"156","author":"T Shen","year":"2019","unstructured":"Shen T, Liu YX, Shang J, Xie Q, Li J, Yan M, et al. Incidence and etiology of drug-induced liver injury in mainland China. Gastroenterology 2019;156:2230\u20132241.","journal-title":"Gastroenterology"},{"key":"3442_CR27","first-page":"984","volume":"118","author":"HJ Zimmerman","year":"1999","unstructured":"Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. Gastroenterology 1999;118:984\u2013985.","journal-title":"Gastroenterology"},{"key":"3442_CR28","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1001\/jama.1986.03370190120036","volume":"255","author":"JR O,Dell","year":"1986","unstructured":"O,Dell JR, Zetterman RK, Burnett DA. Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic. JAMA 1986;255:2636.","journal-title":"JAMA"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-021-3442-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-021-3442-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-021-3442-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T04:38:56Z","timestamp":1636087136000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-021-3442-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,8]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["3442"],"URL":"https:\/\/doi.org\/10.1007\/s11655-021-3442-2","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,8]]},"assertion":[{"value":"13 January 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}