{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:05:45Z","timestamp":1784635545104,"version":"3.55.0"},"reference-count":116,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s11655-022-3724-3","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T15:03:43Z","timestamp":1661958223000},"page":"566-576","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mechanism Study on Chinese Medicine in Treatment of Nodular Goiter"],"prefix":"10.1007","volume":"29","author":[{"given":"Chang-lin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-zhou","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-ju","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-yu","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-qiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-mei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-qi","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"3724_CR1","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1097\/CAD.0000000000000617","volume":"29","author":"F Perri","year":"2018","unstructured":"Perri F, Giordano A, Pisconti S, et al. Thyroid cancer management: from a suspicious nodule to targeted therapy. Anticancer Drugs 2018;29:483\u2013490.","journal-title":"Anticancer Drugs"},{"key":"3724_CR2","doi-asserted-by":"publisher","first-page":"393","DOI":"10.4183\/aeb.2021.393","volume":"17","author":"W Jalloul","year":"2021","unstructured":"Jalloul W, Tibu R, Ionescu TM, et al. Personalized nuclear imaging protocol in cases with nodular goiter and parathyroid adenoma. Acta Endocrinol (Buchar) 2021;17:393\u2013398.","journal-title":"Acta Endocrinol (Buchar)"},{"key":"3724_CR3","doi-asserted-by":"publisher","first-page":"100","DOI":"10.4274\/mirt.48378","volume":"24","author":"H Saki","year":"2015","unstructured":"Saki H, Cengiz A, Yurekli Y. Effectiveness of radioiodine treatment for toxic nodular goiter. Mol Imag Radionucl Ther 2015;24:100\u2013104.","journal-title":"Mol Imag Radionucl Ther"},{"key":"3724_CR4","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.surg.2019.03.012","volume":"166","author":"AA Tam","year":"2019","unstructured":"Tam AA, Ozdemir D, Alkan A, et al. Toxic nodular goiter and thyroid cancer: is hyperthyroidism protective against thyroid cancer? Surgery 2019;166:356\u2013361.","journal-title":"Surgery"},{"key":"3724_CR5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.ecl.2018.10.008","volume":"48","author":"B Biondi","year":"2019","unstructured":"Biondi B, Cooper DS. Thyroid hormone suppression therapy. Endocrinol Metab Clin North Am 2019;48:227\u2013237.","journal-title":"Endocrinol Metab Clin North Am"},{"key":"3724_CR6","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/bjs.7824","volume":"99","author":"R Promberger","year":"2012","unstructured":"Promberger R, Ott J, Kober F, et al. Risk factors for postoperative bleeding after thyroid surgery. Br J Surg 2012;99:373\u2013379.","journal-title":"Br J Surg"},{"key":"3724_CR7","first-page":"81","volume":"59","author":"J Lukinovic","year":"2020","unstructured":"Lukinovic J, Bilic M. Overview of thyroid surgery complications. Acta Clin Croat 2020;59:81\u201386.","journal-title":"Acta Clin Croat"},{"key":"3724_CR8","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00330-014-3405-5","volume":"25","author":"HK Lim","year":"2015","unstructured":"Lim HK, Baek JH, Lee JH, et al. Efficacy and safety of radiofrequency ablation for treating locoregional recurrence from papillary thyroid cancer. Eur Radiol 2015;25:163\u2013170.","journal-title":"Eur Radiol"},{"key":"3724_CR9","first-page":"920","volume":"33","author":"SR Chung","year":"2017","unstructured":"Chung SR, Suh CH, Baek JH, et al. Safety of radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers: a systematic review and meta-analysis. Int J Hyperthermia 2017;33:920\u2013930.","journal-title":"Int J Hyperthermia"},{"key":"3724_CR10","first-page":"170","volume":"40","author":"LD Du","year":"2022","unstructured":"Du LD, Xu L, Zheng XD. Clinical effect of Xiaojin Pill combined with euthyrox on thyroid function and effect on nodular goiter. Chin Arch Tradit Chin Med (Chin) 2022;40:170\u2013173.","journal-title":"Chin Arch Tradit Chin Med (Chin)"},{"key":"3724_CR11","first-page":"601","volume":"7","author":"WX Zuo","year":"2017","unstructured":"Zuo WX, Zhang ZF, Liu ZM, et al. Review on molecular components participating negative feedback regulation in the hypothalamus-pituitary-thyroid axis. Curr Biotechnol 2017;7:601\u2013607.","journal-title":"Curr Biotechnol"},{"key":"3724_CR12","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s40618-015-0391-7","volume":"39","author":"M Knobel","year":"2016","unstructured":"Knobel M. Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters. J Endocrinol Invest 2016;39:357\u2013373.","journal-title":"J Endocrinol Invest"},{"key":"3724_CR13","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1001\/jamaoto.2020.0264","volume":"146","author":"J T Wu","year":"2020","unstructured":"Wu J. Thyroid nodules. JAMA Otolaryngol Head Neck Surg 2020;146:596.","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"3724_CR14","series-title":"Dissertation","volume-title":"Study on the ameliorative effects of resveratrol and quercetin on thyroid hormones function in obese mice induced by high-fat diet","author":"LY Hao","year":"2015","unstructured":"Hao LY. Study on the ameliorative effects of resveratrol and quercetin on thyroid hormones function in obese mice induced by high-fat diet [Dissertation]. Wuxi: Jiangnan University; 2015."},{"key":"3724_CR15","first-page":"120","volume":"14","author":"J Xie","year":"2018","unstructured":"Xie J, Li SL, Zhang W. Research progress on traditional Chinese in the treatment of nodular goiter. Asia-Pacific Tradit Med (Chin) 2018;14:120\u2013123.","journal-title":"Asia-Pacific Tradit Med (Chin)"},{"key":"3724_CR16","first-page":"1362","volume":"21","author":"MB Lin","year":"2010","unstructured":"Lin MB, Zhou Z. Protection effect of Fritillaria thunbergii against hyperthyroidism in rats and mice. China Pharm (Chin) 2010;21:1362\u20131363.","journal-title":"China Pharm (Chin)"},{"key":"3724_CR17","first-page":"853","volume":"33","author":"XX Tian","year":"2014","unstructured":"Tian XX, Wang R, Pan JY, et al. Effects of Huoxuexiaoying Tablet on the goiter model of rats. Herald Med (Chin) 2014;33:853\u2013857.","journal-title":"Herald Med (Chin)"},{"key":"3724_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000503575","volume":"29","author":"I Yildirim Simsir","year":"2020","unstructured":"Yildirim Simsir I, Cetinkalp S, Kabalak T. Review of factors contributing to nodular goiter and thyroid carcinoma. Med Princ Pract 2020;29:1\u20135.","journal-title":"Med Princ Pract"},{"key":"3724_CR19","series-title":"Dissertation","volume-title":"Effect and mechanism of antagonistic medicinal combination in addition and subtraction of anti-nodular goiter in Haizao Yuhu Decoction at a specific dose","author":"YM Lyu","year":"2020","unstructured":"Lyu YM. Effect and mechanism of antagonistic medicinal combination in addition and subtraction of anti-nodular goiter in Haizao Yuhu Decoction at a specific dose [Dissertation]. Beijing: Beijing University of Traditional Chinese Medicine; 2020."},{"key":"3724_CR20","first-page":"506","volume":"20","author":"FD Meng","year":"2017","unstructured":"Meng FD, Li W. Clinical efficacy observation of Pingxiao Capsules in the treatment of nodular goiter. China Pharm (Chin) 2017;20:506\u2013508.","journal-title":"China Pharm (Chin)"},{"key":"3724_CR21","series-title":"Dissertation","volume-title":"Jiedusanjie Decoction of tuberous strumous curative effect of correlation research","author":"XX Yan","year":"2011","unstructured":"Yan XX. Jiedusanjie Decoction of tuberous strumous curative effect of correlation research [Dissertation]. Jinan: Shandong University of Traditional Chinese Medicine; 2011."},{"key":"3724_CR22","series-title":"Dissertation","volume-title":"Analysis of risk factors for thyroid nodules in physical examination population and the value of TPO mRNA, TSHR mRNA and Tg mRNA expression levels in the diagnosis of benign and malignant nodular goiter","author":"W Ren","year":"2019","unstructured":"Ren W. Analysis of risk factors for thyroid nodules in physical examination population and the value of TPO mRNA, TSHR mRNA and Tg mRNA expression levels in the diagnosis of benign and malignant nodular goiter [Dissertation]. Hohhot: Inner Mongolia Medical University; 2019."},{"key":"3724_CR23","doi-asserted-by":"publisher","first-page":"795111","DOI":"10.3389\/fendo.2021.795111","volume":"12","author":"T Planck","year":"2021","unstructured":"Planck T, Lantz M, Perros P, et al. Use of thyroid hormones in hypothyrioid and euthyroid patients: a 2020 thesis questionnaire survey of members of the Swedish Endocrine Society. Front Endocrinol (Lausanne) 2021;12:795111.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3724_CR24","doi-asserted-by":"publisher","first-page":"777","DOI":"10.4158\/EP14425.OR","volume":"21","author":"A Aliyev","year":"2015","unstructured":"Aliyev A, Gupta M, Nasr C, et al. Circulating thyroid-stimulating hormone receptor messenger RNA as a marker of tumor aggressiveness in patients with papillary thyroid microcarcinoma. Endocr Pract 2015;21:777\u2013781.","journal-title":"Endocr Pract"},{"key":"3724_CR25","first-page":"661","volume":"49","author":"XH Yan","year":"2014","unstructured":"Yan XH, Sun CH, Na LS, et al. Mechanism of biological actions of quercetin based on biomolecular network. Acta Pharm Sin (Chin) 2014;49:661\u2013665.","journal-title":"Acta Pharm Sin (Chin)"},{"key":"3724_CR26","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1016\/j.bbagen.2012.07.015","volume":"1830","author":"U Schweizer","year":"2013","unstructured":"Schweizer U, Kohrle J. Function of thyroid hormone transporters in the central nervous system. Biochim Biophys Acta 2013;1830:3965\u20133973.","journal-title":"Biochim Biophys Acta"},{"key":"3724_CR27","first-page":"393","volume":"43","author":"YM Lv","year":"2020","unstructured":"Lv YM, Xiu LL, Liu HY, et al. Effect of Haizao Yuhu Decoction and its recipe removing antagonistic medicinal combination on the thyroid hormone level and tissue morphology in rats with nodular goiter. J Beijing Univ Tradit Chin Med (Chin) 2020;43:393\u2013401.","journal-title":"J Beijing Univ Tradit Chin Med (Chin)"},{"key":"3724_CR28","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1111\/gtc.12889","volume":"26","author":"T Ochiishi","year":"2021","unstructured":"Ochiishi T, Kaku M, Kajsongkram T, et al. Mulberry fruit extract alleviates the intracellular amyloid-beta oligomer-induced cognitive disturbance and oxidative stress in Alzheimer\u2019s disease model mice. Genes Cells 2021;26:861\u2013873.","journal-title":"Genes Cells"},{"key":"3724_CR29","doi-asserted-by":"publisher","first-page":"e13031","DOI":"10.1111\/acel.13031","volume":"18","author":"BG Trist","year":"2019","unstructured":"Trist BG, Hare DJ, Double KL. Oxidative stress in the aging substantia nigra and the etiology of Parkinson\u2019s disease. Aging Cell 2019;18:e13031.","journal-title":"Aging Cell"},{"key":"3724_CR30","doi-asserted-by":"publisher","first-page":"116416","DOI":"10.1016\/j.envpol.2020.116416","volume":"272","author":"M Zhang","year":"2021","unstructured":"Zhang M, Deng YL, Liu C, et al. Urinary phthalate metabolite concentrations, oxidative stress and thyroid function biomarkers among patients with nodular goiter. Environ Pollut 2021;272:116416.","journal-title":"Environ Pollut"},{"key":"3724_CR31","doi-asserted-by":"publisher","first-page":"e105669","DOI":"10.5812\/ijem.105669","volume":"19","author":"B Faam","year":"2021","unstructured":"Faam B, Ghadiri AA, Ghaffari MA, et al. Comparing oxidative stress status among Iranian males and females with malignant and non-malignant thyroid nodules. Int J Endocrinol Metab 2021;19:e105669.","journal-title":"Int J Endocrinol Metab"},{"key":"3724_CR32","doi-asserted-by":"publisher","first-page":"822","DOI":"10.3390\/cells11050822","volume":"11","author":"C Moscatello","year":"2022","unstructured":"Moscatello C, Di Marcantonio MC, Savino L, et al. Emerging role of oxidative stress on EGFR and OGG1-BER cross-regulation: implications in thyroid physiopathology. Cells 2022;11:822.","journal-title":"Cells"},{"key":"3724_CR33","doi-asserted-by":"publisher","first-page":"R31","DOI":"10.1530\/JOE-13-0588","volume":"221","author":"RS Fortunato","year":"2014","unstructured":"Fortunato RS, Ferreira AC, Hecht F, et al. Sexual dimorphism and thyroid dysfunction: a matter of oxidative stress? J Endocrinol 2014;221:R31\u2013R40.","journal-title":"J Endocrinol"},{"key":"3724_CR34","first-page":"749","volume":"16","author":"WL Liu","year":"2019","unstructured":"Liu WL, Liu WQ, Zhou SX. The correlation between serum superoxide dismutase, vitamin E and thyroid hormones in patients with thyroid disease. Lab Med Clin (Chin) 2019;16:749\u2013751.","journal-title":"Lab Med Clin (Chin)"},{"key":"3724_CR35","first-page":"2606","volume":"34","author":"C Li","year":"2019","unstructured":"Li C, Wang M, Wang X, et al. Effects of Astragali Radix preparation on oxidative stress in Wistar model rats with goiter injury induced by iodine deficiency. Acta Chin Med (Chin) 2019;34:2606\u20132611.","journal-title":"Acta Chin Med (Chin)"},{"key":"3724_CR36","first-page":"1211","volume":"30","author":"TC Qi","year":"2012","unstructured":"Qi TC, Gao TX. Comparative study on intervention mechanisms of iodine and Haizao Yuhu Decoction for goiter caused by iodine deficiency. Chin Arch Tradit Chin Med (Chin) 2012;30:1211\u20131214.","journal-title":"Chin Arch Tradit Chin Med (Chin)"},{"key":"3724_CR37","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.fertnstert.2010.12.011","volume":"95","author":"Z Soyman","year":"2011","unstructured":"Soyman Z, Noyan V, Tulmac M, et al. Serum paraoxonase 1 activity, asymmetric dimethylarginine levels, and brachial artery flow-mediated dilatation in women with polycystic ovary syndrome. Fertil Steril 2011;95:1067\u20131072.","journal-title":"Fertil Steril"},{"key":"3724_CR38","first-page":"365","volume":"52","author":"PP Shou","year":"2017","unstructured":"Shou PP, Pan TR, Zhong X, et al. Effect of catechin and levothyoxine on oxidative stress level in hypothyroidism rat. Acta Univ Med Anhui (Chin) 2017;52:365\u2013368.","journal-title":"Acta Univ Med Anhui (Chin)"},{"key":"3724_CR39","first-page":"843","volume":"34","author":"L Chunhua","year":"2021","unstructured":"Chunhua L, Zhixiong L, Dahua W, et al. The therapeutic effect and mechanism of Chinese medicine Xuan-Yun-Ding on posterior circulation ischemia with vertigo in a rabbit model. Pak J Pharm Sci 2021;34:843\u2013854.","journal-title":"Pak J Pharm Sci"},{"key":"3724_CR40","first-page":"e22729","volume":"14","author":"R Raj","year":"2022","unstructured":"Raj R, Paturi A, Ahmed MA, et al. Obstructive sleep apnea as a risk factor for venous thromboembolism: a systematic review. Cureus 2022;14:e22729.","journal-title":"Cureus"},{"key":"3724_CR41","doi-asserted-by":"publisher","first-page":"10591","DOI":"10.1039\/D1SM01212F","volume":"17","author":"AN Beris","year":"2021","unstructured":"Beris AN, Horner JS, Jariwala S, et al. Recent advances in blood rheology: a review. Soft Matter 2021;17:10591\u201310613.","journal-title":"Soft Matter"},{"key":"3724_CR42","first-page":"604","volume":"15","author":"Q Xie","year":"2015","unstructured":"Xie Q, Lu YY, Yi HF. Effect of prunella oral liquid on thryroid size in patients with different functional status of thyroid. Eval Anal Drug-Use Hosp China (Chin) 2015;15:604\u2013606.","journal-title":"Eval Anal Drug-Use Hosp China (Chin)"},{"key":"3724_CR43","series-title":"Dissertation","volume-title":"Clinical research on decoction of removing phlegm and activating blood circulation to eliminating goiter to treating the syndrome of turbid phlegm and blood stasis in nodular goiter","author":"KJ Pan","year":"2013","unstructured":"Pan KJ. Clinical research on decoction of removing phlegm and activating blood circulation to eliminating goiter to treating the syndrome of turbid phlegm and blood stasis in nodular goiter [Dissertation]. Nanjing: Nanjing University of Traditional Chinese Medicine; 2013."},{"key":"3724_CR44","series-title":"Dissertation","volume-title":"Expression and clinical significance of TGF-\u03b21 and IGF-1 in different thyroid nodules","author":"LL Zhang","year":"2018","unstructured":"Zhang LL. Expression and clinical significance of TGF-\u03b21 and IGF-1 in different thyroid nodules [Dissertation]. Zhengzhou: Zhengzhou University; 2018."},{"key":"3724_CR45","first-page":"409","volume":"21","author":"CH Zhao","year":"2015","unstructured":"Zhao CH, Song GY, Wei LM. Expression and significance of IGF-1 and IGF-1R in thyroid related diseases. Med Recapitul (Chin) 2015;21:409\u2013411.","journal-title":"Med Recapitul (Chin)"},{"key":"3724_CR46","doi-asserted-by":"publisher","first-page":"653627","DOI":"10.3389\/fendo.2021.653627","volume":"12","author":"TJ Smith","year":"2021","unstructured":"Smith TJ. Insulin-like growth factor pathway and the thyroid. Front Endocrinol (Lausanne) 2021;12:653627.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3724_CR47","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s12020-012-9864-z","volume":"44","author":"YJ Liu","year":"2013","unstructured":"Liu YJ, Qiang W, Shi J, et al. Expression and significance of IGF-1 and IGF-1R in thyroid nodules. Endocrine 2013;44:158\u2013164.","journal-title":"Endocrine"},{"key":"3724_CR48","doi-asserted-by":"publisher","first-page":"4039","DOI":"10.1210\/jc.2007-0816","volume":"92","author":"H Volzke","year":"2007","unstructured":"Volzke H, Friedrich N, Schipf S, et al. Association between serum insulin-like growth factor-1 levels and thyroid disorders in a population-based study. J Clin Endocrinol Metab 2007;92:4039\u20134045.","journal-title":"J Clin Endocrinol Metab"},{"key":"3724_CR49","doi-asserted-by":"publisher","first-page":"4899","DOI":"10.1096\/fj.13-231381","volume":"27","author":"S Ock","year":"2013","unstructured":"Ock S, Ahn J, Lee SH, et al. IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter. FASEB J 2013;27:4899\u20134908.","journal-title":"FASEB J"},{"key":"3724_CR50","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s12020-012-9864-z","volume":"44","author":"YJ Liu","year":"2013","unstructured":"Liu YJ, Qiang W, Shi J, et al. Expression and significance of IGF-1 and IGF-1R in thyroid nodules. Endocrine 2013;44:158\u2013164.","journal-title":"Endocrine"},{"key":"3724_CR51","series-title":"Dissertation","volume-title":"The clinical efficacy and Beimu Exiao Pills in treating nodular goiter and the influence of VEGF, IGF-1, TGF-\u03b21","author":"CL Zhang","year":"2015","unstructured":"Zhang CL. The clinical efficacy and Beimu Exiao Pills in treating nodular goiter and the influence of VEGF, IGF-1, TGF-\u03b21 [Dissertation]. Harbin: Heilongjiang University of Traditional Chinese Medicine; 2015."},{"key":"3724_CR52","first-page":"172","volume":"65","author":"KC Peres","year":"2021","unstructured":"Peres KC, Teodoro L, Amaral LHP, et al. Clinical utility of TGF\u03b21 and its receptors (TGF\u03b2 R1 and TGF\u03b2 R2) in thyroid nodules: evaluation based on single nucleotide polymorphisms and mRNA analysis. Arch Endocrinol Metab 2021;65:172\u2013184.","journal-title":"Arch Endocrinol Metab"},{"key":"3724_CR53","first-page":"1431","volume":"31","author":"Y Xu","year":"2017","unstructured":"Xu Y, Ma L, Zhang GA, et al. The clinicopathological associations between TGF-\u03b21 and papillary thyroid carcinoma: a meta-analysis. J Clin Otorhinol Head and Neck Surg (Chin) 2017;31:1431\u20131435.","journal-title":"J Clin Otorhinol Head and Neck Surg (Chin)"},{"key":"3724_CR54","first-page":"394","volume":"31","author":"SQ Wu","year":"2010","unstructured":"Wu SQ, Zuo XH, Chen RQ, et al. Therapeutic effect of Huoxuexiaoying Pills for nodular goiter. Med J Wuhan Univ (Chin) 2010;31:394\u2013397.","journal-title":"Med J Wuhan Univ (Chin)"},{"key":"3724_CR55","series-title":"Dissertation","volume-title":"Study on clinic effect of \u201cHuoxue Xiaoying\u201d priscription for nodular goiter and its therapeutic mechanism","author":"SQ Wu","year":"2010","unstructured":"Wu SQ. Study on clinic effect of \u201cHuoxue Xiaoying\u201d priscription for nodular goiter and its therapeutic mechanism [Dissertation]. Wuhan: Hubei University of Traditional Chinese Medicine; 2010."},{"key":"3724_CR56","first-page":"93","volume":"23","author":"LK Du","year":"2017","unstructured":"Du LK, Li N, Ma J, et al. Effects of Beimu Exiao Pills on the IGF-1 and TGF-\u03b21 in nodular goiter. J Basic Chin Med (Chin) 2017;23:93\u201394.","journal-title":"J Basic Chin Med (Chin)"},{"key":"3724_CR57","first-page":"6702","volume":"12","author":"WY Zou","year":"2012","unstructured":"Zou WY, Liu YY, Li S, et al. Study on the relationship between microvessel density in benign and malignant thyroid nodules. Prog Mod Biomed (Chin) 2012;12:6702\u20136704.","journal-title":"Prog Mod Biomed (Chin)"},{"key":"3724_CR58","first-page":"49","volume":"35","author":"T Jiang","year":"2019","unstructured":"Jiang T. Application of quantitative analysis of contrast ultrasound in measurement of microvessel density and regional blood volume in nodular goiter and thyroid cancer. J Baotou Med Coll (Chin) 2019;35:49\u201350.","journal-title":"J Baotou Med Coll (Chin)"},{"key":"3724_CR59","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s40618-019-01092-9","volume":"43","author":"A Molinaro","year":"2020","unstructured":"Molinaro A, Orlandi P, Niccolai F, et al. Genetic interaction analysis of VEGF-A rs3025039 and VEGFR-2 rs2071559 identifies a genetic profile at higher risk to develop nodular goiter. J Endocrinol Invest 2020;43:149\u2013155.","journal-title":"J Endocrinol Invest"},{"key":"3724_CR60","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1055\/s-0032-1327634","volume":"121","author":"P Malkomes","year":"2013","unstructured":"Malkomes P, Oppermann E, Bechstein WO, et al. Vascular endothelial growth factor\u2014marker for proliferation in thyroid diseases? Exp Clin Endocrinol Diabetes 2013;121:6\u201313.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"3724_CR61","first-page":"1977","volume":"37","author":"P Cui","year":"2019","unstructured":"Cui P, Wang XY. Effect of dispersing phlegm and resolving stasis method on expressions of related factors in goiter. Chin Arch Tradit Chin (Chin) 2019;37:1977\u20131980, 2063\u20132064.","journal-title":"Chin Arch Tradit Chin (Chin)"},{"key":"3724_CR62","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.3390\/cancers13061422","volume":"13","author":"FT Zahra","year":"2021","unstructured":"Zahra FT, Sajib MS, Mikelis CM. Role of bFGF in acquired resistance upon anti-VEGF therapy in cancer. Cancers (Basel) 2021;13:1422.","journal-title":"Cancers (Basel)"},{"key":"3724_CR63","doi-asserted-by":"publisher","first-page":"516","DOI":"10.12968\/jowc.2009.18.12.45609","volume":"18","author":"M Przybylski","year":"2009","unstructured":"Przybylski M. A review of the current research on the role of bFGF and VEGF in angiogenesis. J Wound Care 2009;18:516\u2013519.","journal-title":"J Wound Care"},{"key":"3724_CR64","series-title":"Dissertation","volume-title":"Study on effects and mechanism of \u201cHuoxue Xiaoying\u201d priscription on throid in rats of nodular goiter","author":"XK Tu","year":"2013","unstructured":"Tu XK. Study on effects and mechanism of \u201cHuoxue Xiaoying\u201d priscription on throid in rats of nodular goiter [Dissertation]. Wuhan: Hubei University of Traditional Chinese Medicine; 2013."},{"key":"3724_CR65","first-page":"93","volume":"32","author":"CY Liu","year":"2015","unstructured":"Liu CY, Ma J, Du LK, et al. Effect of Beimu Exiao Pills on serum VEGF level in patients with nodular goiter. Inf Tradit Chin Med (Chin) 2015;32:93\u201394.","journal-title":"Inf Tradit Chin Med (Chin)"},{"key":"3724_CR66","series-title":"Dissertation","volume-title":"The clinical efficacy of nodular goiter with Beimu Exiao Pills and its effect on bFGF and interferon B3","author":"XM Li","year":"2018","unstructured":"Li XM. The clinical efficacy of nodular goiter with Beimu Exiao Pills and its effect on bFGF and interferon B3; [Dissertation]. Harbin: Heilongjiang University of Traditional Chinese Medicine; 2018."},{"key":"3724_CR67","series-title":"Dissertation","volume-title":"Study on the mechanism of external application of Yingzhongxiao Ointment in the treatment of nodular goiter based on network pharmacology","author":"XY Chen","year":"2020","unstructured":"Chen XY. Study on the mechanism of external application of Yingzhongxiao Ointment in the treatment of nodular goiter based on network pharmacology [Dissertation]. Shenyang: Liaoning University of Traditional Chinese Medicine; 2020."},{"key":"3724_CR68","first-page":"705","volume":"8","author":"YL Shen","year":"2018","unstructured":"Shen YL, Wang SY, Lai YL, et al. The effects and mechanism of silenced PCNA gene expression on proliferation and apoptosis of thyroid carcinoma cells. Antitumor Pharm (Chin) 2018;8:705\u2013709.","journal-title":"Antitumor Pharm (Chin)"},{"key":"3724_CR69","first-page":"31","volume":"36","author":"F Lian","year":"2020","unstructured":"Lian F, Sun YK, Tang SF, et al. The diagnostic value of fine needle aspiration of thyroid nodules combined with contrast-enhanced ultrasonography in early stage thyroid microcarcinoma. Clin Med China (Chin) 2020;36:31\u201335.","journal-title":"Clin Med China (Chin)"},{"key":"3724_CR70","first-page":"963","volume":"28","author":"XK Tu","year":"2012","unstructured":"Tu XK, Chen RQ. Effect of Huoxue Xiaoying Priscription on proliferation and apoptosis of thyroid cells in rat model of nodular goiter. J Changchun Univ Chin Med (Chin) 2012;28:963\u2013965.","journal-title":"J Changchun Univ Chin Med (Chin)"},{"key":"3724_CR71","first-page":"809","volume":"18","author":"XL Liu","year":"2011","unstructured":"Liu XL, Zou XW, Sun H, et al. Investigation of succession model for goiter in iodine deficiency area. Chin J Bases Clin Gen Surg (Chin) 2011;18:809\u2013814.","journal-title":"Chin J Bases Clin Gen Surg (Chin)"},{"key":"3724_CR72","series-title":"Dissertation","volume-title":"Effects of Kang-Jia-Wan on angiogenesis and thyrocyte apoptosis induction and proliferation inhibition in rats of goiter","author":"Y Han","year":"2009","unstructured":"Han Y. Effects of Kang-Jia-Wan on angiogenesis and thyrocyte apoptosis induction and proliferation inhibition in rats of goiter [Dissertation]. Jinan: Shandong University; 2009."},{"key":"3724_CR73","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.3390\/cells10051228","volume":"10","author":"T Boczek","year":"2021","unstructured":"Boczek T, Mackiewicz J, Sobolczyk M, et al. The role of G protein-coupled receptors (GPCRs) and calcium signaling in schizophrenia. Focus on GPCRs activated by neurotransmitters and chemokines. Cells 2021;10:1228.","journal-title":"Cells"},{"key":"3724_CR74","first-page":"1769","volume":"12","author":"MH Wang","year":"2009","unstructured":"Wang MH, Hui Z, Wang GL et al. Expression of CXCR4 chemokine receptor in benign thyroid diseases. Chin Gen Pract (Chin) 2009;12:1769\u20131770.","journal-title":"Chin Gen Pract (Chin)"},{"key":"3724_CR75","doi-asserted-by":"publisher","first-page":"43","DOI":"10.23736\/S0391-1977.18.02709-8","volume":"45","author":"Z Wu","year":"2020","unstructured":"Wu Z, Cao Y, Jiang X, et al. Clinicopathological significance of chemokine receptor CXCR4 expression in papillary thyroid carcinoma: a meta-analysis. Minerva Endocrinol 2020;45:43\u201348.","journal-title":"Minerva Endocrinol"},{"key":"3724_CR76","first-page":"67","volume":"30","author":"PF Yin","year":"2010","unstructured":"Yin PF, Yu SP. PI3K\/Akt signal transduction pathway and thyroid nodules. Inter J Endocr Metab (Chin) 2010;30:67\u201369.","journal-title":"Inter J Endocr Metab (Chin)"},{"key":"3724_CR77","first-page":"27","volume":"4","author":"JK Yao","year":"2014","unstructured":"Yao JK, Hu CX, He WG, et al. Primary research expression profiles on correlated gene in nontoxic nodular goiter. China Med Pharm (Chin) 2014;4:27\u201330.","journal-title":"China Med Pharm (Chin)"},{"key":"3724_CR78","first-page":"206","volume":"16","author":"M Tian","year":"2021","unstructured":"Tian M, Qi ZL. Study on the mechanism of Liqi Xiaoying Recipe on rats with nodular goiter based on PI3K\/Akt signal pathway. China Pract Med (Chin) 2021;16:206\u2013208.","journal-title":"China Pract Med (Chin)"},{"key":"3724_CR79","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s12020-014-0380-1","volume":"48","author":"GI Manfredi","year":"2015","unstructured":"Manfredi GI, Dicitore A, Gaudenzi G, et al. PI3K\/Akt\/mTOR signaling in medullary thyroid cancer: a promising molecular target for cancer therapy. Endocrine 2015;48:363\u2013370.","journal-title":"Endocrine"},{"key":"3724_CR80","series-title":"Dissertation","volume-title":"Clinical study on the development of Yingzhongxiao Ointment and acupoint application in the treatment of nodular goiter","author":"YW Lai","year":"2019","unstructured":"Lai YW. Clinical study on the development of Yingzhongxiao Ointment and acupoint application in the treatment of nodular goiter [Dissertation]. Shenyang: Liaoning University of Traditional Chinese Medicine; 2019."},{"key":"3724_CR81","first-page":"436","volume":"44","author":"CR Ge","year":"2021","unstructured":"Ge CR, Wang X, Zhong GS, et al. Effect of Haizao Yuhu Decoction and its recipe removing antagonistic medicinal combination on mTOR-P70S6K\/4E-BP1 signal pathway in rats with goiter. J Beijing Univ Tradit Chin Med (Chin) 2021;44:436\u2013443.","journal-title":"J Beijing Univ Tradit Chin Med (Chin)"},{"key":"3724_CR82","doi-asserted-by":"publisher","first-page":"336","DOI":"10.7150\/thno.7851","volume":"4","author":"F Briest","year":"2014","unstructured":"Briest F, Grabowski P. PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms. Theranostics 2014;4:336\u2013365.","journal-title":"Theranostics"},{"key":"3724_CR83","first-page":"1348","volume":"23","author":"ZC Liu","year":"2016","unstructured":"Liu ZC, Zhao L. Expressions of PTEN and Ki-67 in primary thyroid cancer tissues and its clinical significances. Chin J Bases Clin Gen Surg (Chin) 2016;23:1348\u20131352.","journal-title":"Chin J Bases Clin Gen Surg (Chin)"},{"key":"3724_CR84","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1158\/0008-5472.CAN-06-3524","volume":"67","author":"N Yeager","year":"2007","unstructured":"Yeager N, Klein-Szanto A, Kimura S, et al. PTEN loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. Cancer Res 2007;67:959\u2013966.","journal-title":"Cancer Res"},{"key":"3724_CR85","series-title":"Dissertation","volume-title":"Research on clinical experience in the treatment of nodular goiter by using Huo Xue Xiao Ying Priscription and the mechanism in regulation of PI3K\/Akt signal pathway","author":"MX Zeng","year":"2017","unstructured":"Zeng MX. Research on clinical experience in the treatment of nodular goiter by using Huo Xue Xiao Ying Priscription and the mechanism in regulation of PI3K\/Akt signal pathway [Dissertation]. Wuhan: Hubei University of Traditional Chinese Medicine; 2017."},{"key":"3724_CR86","first-page":"1191","volume":"40","author":"HH Xiao","year":"2021","unstructured":"Xiao HH, Liu SM. Therapeutic efficacy of acupuncture combined with levothyroxine sodium for nodular goiter and its effects on serum TGF-\u03b1 and IFN-\u03b3. Shanghai J Acupunct Moxib (Chin) 2021;40:1191\u20131196.","journal-title":"Shanghai J Acupunct Moxib"},{"key":"3724_CR87","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3892\/ol.2015.3223","volume":"10","author":"D Chen","year":"2015","unstructured":"Chen D, Qi W, Zhang P, et al. Expression of the estrogen receptor \u03b1, progesterone receptor and epidermal growth factor receptor in papillary thyroid carcinoma tissues. Oncol Lett 2015;10:317\u2013320.","journal-title":"Oncol Lett"},{"key":"3724_CR88","first-page":"1352","volume":"22","author":"HP Cui","year":"2015","unstructured":"Cui HP, Dong JY, Yao L, et al. mTOR cooperating with ERK regulates the expression of cyclin D1 in Hep3B. Chin J Cancer Prevent Treat (Chin) 2015;22:1352\u20131356.","journal-title":"Chin J Cancer Prevent Treat (Chin)"},{"key":"3724_CR89","first-page":"1508","volume":"21","author":"HX Liu","year":"2014","unstructured":"Liu HX, Bai YF, Wu XX, et al. Expressions and clinical significance of protocadherin 9 and cyclin D1 in non-small cell lung cancer patients. Chin J Cancer Prevent Treat (Chin) 2014;21:1508\u20131512.","journal-title":"Chin J Cancer Prevent Treat (Chin)"},{"key":"3724_CR90","first-page":"325","volume":"46","author":"GM Wei","year":"2017","unstructured":"Wei GM, Zhou WB, Wu L, et al. Expression and significance of cyclin D1 and Bax in papillary thyroid microcarcinoma. Chongqing Med (Chin) 2017;46:325\u2013328.","journal-title":"Chongqing Med (Chin)"},{"key":"3724_CR91","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s12885-019-5452-4","volume":"19","author":"M Teshima","year":"2019","unstructured":"Teshima M, Tokita K, Ryo E, et al. Clinical impact of a cytological screening system using cyclin D1 immunostaining and genomic analysis for the diagnosis of nodular goiter. BMC Cancer 2019;19:245.","journal-title":"BMC Cancer"},{"key":"3724_CR92","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1038\/jid.2013.510","volume":"134","author":"J Kim","year":"2014","unstructured":"Kim J, Choi H, Cho EG, et al. FoxO3a is an antimelanogenic factor that mediates antioxidant-induced depigmentation. J Invest Dermatol 2014;134:1378\u20131388.","journal-title":"J Invest Dermatol"},{"key":"3724_CR93","first-page":"30","volume":"35","author":"LY Huang","year":"2013","unstructured":"Huang LY, Wang F, Cao Q, et al. Effects of silencing or overexpression of FOXO3a on the proliferation of endothelial progenitor cells. Chin J Cell Biol (Chin) 2013;35:30\u201335.","journal-title":"Chin J Cell Biol (Chin)"},{"key":"3724_CR94","doi-asserted-by":"publisher","first-page":"6608","DOI":"10.18632\/oncotarget.14245","volume":"8","author":"HJ Kim","year":"2017","unstructured":"Kim HJ, Lee SY, Kim CY, et al. Subcellular localization of FOXO3a as a potential biomarker of response to combined treatment with inhibitors of PI3K and autophagy in PIK3CA-mutant cancer cells. Oncotarget 2017;8:6608\u20136622.","journal-title":"Oncotarget"},{"key":"3724_CR95","first-page":"1651","volume":"29","author":"JW Yu","year":"2021","unstructured":"Yu JW, Liu YX, Shao MW, et al. Expression and subcellular location of FOXO3a in papillary thyroid cancer cells. J Mod Oncol (Chin) 2021;29:1651\u20131655.","journal-title":"J Mod Oncol (Chin)"},{"key":"3724_CR96","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.2174\/138945011796150299","volume":"12","author":"JY Yang","year":"2011","unstructured":"Yang JY, Hung MC. Deciphering the role of forkhead transcription factors in cancer therapy. Curr Drug Targets 2011;12:1284\u20131290.","journal-title":"Curr Drug Targets"},{"key":"3724_CR97","first-page":"148","volume":"12","author":"ZN Hao","year":"2015","unstructured":"Hao ZN, Zheng YB, Xiao GC, et al. Relationship between MAPK\/ERK signaling pathway and tumor angiogenesis. China Med Herald (Chin) 2015;12:148\u2013151.","journal-title":"China Med Herald (Chin)"},{"key":"3724_CR98","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.fsi.2022.02.036","volume":"123","author":"B Liu","year":"2022","unstructured":"Liu B, Li G, Yang J, et al. The mechanism of immune related signal pathway EGR2-FasL-Fas in transcription regulation and methylated modification of paralichthys olivaceus under acute hypoxia stress. Fish Shellfish Immunol 2022;123:152\u2013163.","journal-title":"Fish Shellfish Immunol"},{"key":"3724_CR99","first-page":"931","volume":"58","author":"MI Sheremet","year":"2017","unstructured":"Sheremet MI, Sydorchuk LP, Shidlovskyi VO, et al. Association of the blood serum cytokines\u2019 rate and lymphocytes\u2019 apoptosis with polymorphic variants of the BCL-2 (rs17759659), CTLA-4 (rs231775) and APO-1-FAS (rs2234767) genes in patients with nodular goiters in autoimmune thyroiditis and thyroid adenoma. Rom J Morphol Embryol 2017;58:931\u2013939.","journal-title":"Rom J Morphol Embryol"},{"key":"3724_CR100","doi-asserted-by":"publisher","first-page":"4264","DOI":"10.1210\/jc.2002-020111","volume":"87","author":"E Mezosi","year":"2002","unstructured":"Mezosi E, Yamazaki H, Bretz JD, et al. Aberrant apoptosis in thyroid epithelial cells from goiter nodules. J Clin Endocrinol Metab 2002;87:4264\u20134272.","journal-title":"J Clin Endocrinol Metab"},{"key":"3724_CR101","first-page":"555","volume":"32","author":"N Gul","year":"2018","unstructured":"Gul N, Temel B, Ustek D, et al. Association of pro-apoptotic bad gene expression changes with benign thyroid nodules. In Vivo 2018;32:555\u2013559.","journal-title":"In Vivo"},{"key":"3724_CR102","first-page":"179","volume":"15","author":"SQ Wu","year":"2020","unstructured":"Wu SQ, Chen YL, Cao CL, et al. Clinical observation of Huoxue Sanjie Priscription in the treatment of nodular goiter and its effect on serum sFas and sFasL. China Pract Med (Chin) 2020;15:179\u2013181.","journal-title":"China Pract Med (Chin)"},{"key":"3724_CR103","series-title":"Dissertation","volume-title":"Clinical observation on the therapeutic effect of Beimu Exiao Pills in the treatment of nodular goiter","author":"W Zhang","year":"2016","unstructured":"Zhang W. Clinical observation on the therapeutic effect of Beimu Exiao Pills in the treatment of nodular goiter [Dissertation]. Harbin: Heilongjiang University of Traditional Chinese Medicine; 2016."},{"key":"3724_CR104","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s12011-019-01825-0","volume":"195","author":"Y Liu","year":"2020","unstructured":"Liu Y, Chen H, Zhang L, et al. The association between thyroid injury and apoptosis, and alterations of Bax, Bcl-2, and Caspase-3 mRNA\/protein expression induced by nickel sulfate in Wistar rats. Biol Trace Elem Res (Chin) 2020;195:159\u2013168.","journal-title":"Biol Trace Elem Res (Chin)"},{"key":"3724_CR105","first-page":"304","volume":"42","author":"C Zhang","year":"2019","unstructured":"Zhang C, Zhong GS, Li N, et al. Effects of different species of Haizao in Haizao Yuhu Decoction with or without Gancao on the expressions of Bax, Bcl-2 mRNA in rats with goiter. J Beijing Univ Tradit Chin Med (Chin) 2019;42:304\u2013311.","journal-title":"J Beijing Univ Tradit Chin Med (Chin)"},{"key":"3724_CR106","first-page":"159","volume":"20","author":"GH Wang","year":"2014","unstructured":"Wang GH, Pan JY, Wang R, et al. Mechanism of Liqi Xiaoying Tablet on goiter of experimental rats. Chin J Exp Tradit Med Form (Chin) 2014;20:159\u2013163.","journal-title":"Chin J Exp Tradit Med Form (Chin)"},{"key":"3724_CR107","series-title":"Dissertation","volume-title":"Experimental study on Beimu Exiao effect of Chinese herbal compound on proliferation and apoptosis of FRTL-5 cells","author":"N Li","year":"2017","unstructured":"Li N. Experimental study on Beimu Exiao effect of Chinese herbal compound on proliferation and apoptosis of FRTL-5 cells [Dissertation]. Harbin: Heilongjiang University of Traditional Chinese Medicine; 2017."},{"key":"3724_CR108","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1002\/JPER.17-0716","volume":"90","author":"K Aral","year":"2019","unstructured":"Aral K, Aral CA, Kapila Y. The role of Caspase-8, Caspase-9, and apoptosis inducing factor in periodontal disease. J Periodontol 2019;90:288\u2013294.","journal-title":"J Periodontol"},{"key":"3724_CR109","first-page":"597","volume":"40","author":"YF Da","year":"2020","unstructured":"Da YF, Wang ZH, Zheng WK, et al. Research progress of inflammatory factors and signaling pathways in lumbar degenerative diseases. Chin J Orthop (Chin) 2020;40:597\u2013606.","journal-title":"Chin J Orthop (Chin)"},{"key":"3724_CR110","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1507\/endocrj.EJ16-0551","volume":"64","author":"N Inoue","year":"2017","unstructured":"Inoue N, Watanabe M, Nakaguchi A, et al. Functional polymorphisms affecting Th1 differentiation are associated with the severity of autoimmune thyroid diseases. Endocr J 2017;64:695\u2013703.","journal-title":"Endocr J"},{"key":"3724_CR111","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.imlet.2011.02.017","volume":"137","author":"H Kohara","year":"2011","unstructured":"Kohara H, Kitaura H, Fujimura Y, et al. IFN-\u03b3 directly inhibits TNF-\u03b1-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas\/Fas ligand interactions. Immunol Lett 2011;137:53\u201361.","journal-title":"Immunol Lett"},{"key":"3724_CR112","first-page":"1385","volume":"55","author":"AN Li","year":"2020","unstructured":"Li AN, Zhang XX, Ren CP, et al. Research on the mechanism of interleukin-1\u03b2 induced apoptosis of thyroid cells. Acta Univ Med Anhui (Chin) 2020;55:1385\u20131388.","journal-title":"Acta Univ Med Anhui (Chin)"},{"key":"3724_CR113","doi-asserted-by":"publisher","first-page":"R13","DOI":"10.1530\/ERC-13-0271","volume":"21","author":"F Morani","year":"2014","unstructured":"Morani F, Titone R, Pagano L, et al. Autophagy and thyroid carcinogenesis: genetic and epigenetic links. Endocr Relat Cancer 2014;21:R13\u2013R29.","journal-title":"Endocr Relat Cancer"},{"key":"3724_CR114","first-page":"153","volume":"35","author":"Y Li","year":"2018","unstructured":"Li Y, Gao WJ. Research progress on molecular regulation mechanism of autophagy. J Chengdu Med Univ (Chin) 2018;35:153\u2013156.","journal-title":"J Chengdu Med Univ (Chin)"},{"key":"3724_CR115","first-page":"45","volume":"51","author":"XX Lv","year":"2016","unstructured":"Lv XX, Hu ZW. New methods to detect autophagic flux. Acta Pharm Sin (Chin) 2016;51:45\u201351.","journal-title":"Acta Pharm Sin (Chin)"},{"key":"3724_CR116","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.biopha.2014.12.021","volume":"69","author":"N Zhang","year":"2015","unstructured":"Zhang N, Li L, Wang J, et al. Study of autophagy-related protein light chain 3 (LC3)-E expression levels in thyroid diseases. Biomed Pharmacother 2015;69:306\u2013310.","journal-title":"Biomed Pharmacother"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-022-3724-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-022-3724-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-022-3724-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T10:38:21Z","timestamp":1684924701000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-022-3724-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":116,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["3724"],"URL":"https:\/\/doi.org\/10.1007\/s11655-022-3724-3","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,31]]},"assertion":[{"value":"17 May 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}