{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:58:30Z","timestamp":1777485510618,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s11655-022-3729-y","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T08:49:02Z","timestamp":1672994942000},"page":"1007-1017","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Total Saponin Fraction of Dioscorea Nipponica Makino Improves Gouty Arthritis Symptoms in Rats via M1\/M2 Polarization of Monocytes and Macrophages Mediated by Arachidonic Acid Signaling"],"prefix":"10.1007","volume":"29","author":[{"given":"Qi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-juan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi-wu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"3729_CR1","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.jare.2017.04.008","volume":"8","author":"G Ragab","year":"2017","unstructured":"Ragab G, Elshahaly E, Bardin T. Gout: an old disease in new perspective\u2014a review. J Adv Res 2017;8:495\u2013511.","journal-title":"J Adv Res"},{"key":"3729_CR2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.7326\/M16-0570","volume":"166","author":"A Qaseem","year":"2017","unstructured":"Qaseem A, Harris RP, Forciea MA. Management of acute and recurrent gout: a clinical guideline from the American College of Physicians. Ann Inten Med 2017;166:58\u201368.","journal-title":"Ann Inten Med"},{"key":"3729_CR3","first-page":"639","volume":"13","author":"AK So","year":"2017","unstructured":"So AK, Martiono F. Inflammation in gout: mechanisms and therapeutic targets. Nat Rev 2017;13:639\u2013647.","journal-title":"Nat Rev"},{"key":"3729_CR4","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12974-017-0849-y","volume":"14","author":"HJ Liu","year":"2017","unstructured":"Liu HJ, Pan XX, Liu BQ, Gui X, Hu L, Jiang CY, et al. Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. J Neuroinflammation 2017;14:74.","journal-title":"J Neuroinflammation"},{"key":"3729_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/JLB.3HI0518-193R","volume":"105","author":"YZ Liu","year":"2019","unstructured":"Liu YZ, Tang HL, Liu XX, Chen HL, Feng N, Zhang J, et al. Frontline science: reprogramming COX2, 5-LOX, and CYP4A-mediated arachidonic acid metabolism in macrophages by salidroside alleviates gouty arthritis. J Leukoc Biol 2019;105:11\u201324.","journal-title":"J Leukoc Biol"},{"key":"3729_CR6","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.molmed.2017.06.005","volume":"23","author":"J Desai","year":"2017","unstructured":"Desai J, Steiger S, Anders HJ. Molecular pathophysiology of gout. Trends Mol Med 2017;23:756\u2013768.","journal-title":"Trends Mol Med"},{"key":"3729_CR7","first-page":"92","volume":"5","author":"XY Liu","year":"2018","unstructured":"Liu XY, Liu L. Research progress on the regulation of metabolism and pro-inflammation related macrophage polarization. E-J Transl Med 2018;5:92\u201396.","journal-title":"E-J Transl Med"},{"key":"3729_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/03007995.2017.1378502","volume":"33","author":"C Borghi","year":"2017","unstructured":"Borghi C. The management of hyperuricemia: back to the pathophysiology of uric acid. Curr Med Res Opin 2017;33:1\u20134.","journal-title":"Curr Med Res Opin"},{"key":"3729_CR9","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.talanta.2016.10.065","volume":"162","author":"N Wang","year":"2017","unstructured":"Wang N, Zhao X, Wang W, Peng Y, Bi K, Dai R. Targeted profiling of arachidonic acid and eicosanoids in rat tissue by UFLC-MS\/MS: application to identify potential markers for rheumatoid arthritis. Talanta 2017;162:479\u2013487.","journal-title":"Talanta"},{"key":"3729_CR10","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/med.21424","volume":"37","author":"C Pereira-Leite","year":"2017","unstructured":"Pereira-Leite C, Nunes C, Jamal SK, Cuccovia IM. Nonsteroidal anti-inflammatory therapy: a journal toward safety. Med Res Rev 2017;37:802\u2013859.","journal-title":"Med Res Rev"},{"key":"3729_CR11","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/JLB.3CE1018-384R","volume":"105","author":"Y Chen","year":"2019","unstructured":"Chen Y, Chen X. Ancient herbal component may be a novel therapeutic for gouty arthritis. J Leukoc Biol 2019;105:7\u20139.","journal-title":"J Leukoc Biol"},{"key":"3729_CR12","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s11655-019-3058-y","volume":"26","author":"X Wang","year":"2020","unstructured":"Wang X, Wang YG. Progress in the treatment of gout using Western and Chinese medicine. Chin J Integr Med 2020;26:8\u201313.","journal-title":"Chin J Integr Med"},{"key":"3729_CR13","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s11655-016-2741-5","volume":"25","author":"Q Zhou","year":"2019","unstructured":"Zhou Q, Yu DH, Zhang N, Liu SM. Anti-inflammatory effect of total saponins from Dioscorea nipponica Makino on gouty arthritis and its influence on NALP3 inflammasome. Chin J Integr Med 2019;25:663\u2013670.","journal-title":"Chin J Integr Med"},{"key":"3729_CR14","doi-asserted-by":"publisher","first-page":"2960","DOI":"10.1093\/rheumatology\/keaa018","volume":"59","author":"YF Huang","year":"2020","unstructured":"Huang YF, Xiao M, Ou JY, Lv Q, Wei QJ, Chen ZN, et al. Identification of the urine and serum metabolomics signature of gout. Rheumatology (Oxford) 2020;59:2960\u20132969.","journal-title":"Rheumatology (Oxford)"},{"key":"3729_CR15","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.jep.2017.04.024","volume":"206","author":"Q Zhou","year":"2017","unstructured":"Zhou Q, Lin FF, Liu SM, Sui XF. Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2\/4-IL-1R receptor signal pathway in rats of gouty arthritis. J Ethnopharmacol 2017;206:274\u2013282.","journal-title":"J Ethnopharmacol"},{"key":"3729_CR16","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1055\/s-0034-1383048","volume":"80","author":"Q Zhou","year":"2014","unstructured":"Zhou Q, Yu DH, Zhang C. Total saponins from Dioscorea nipponica ameliorate urate excretion in hyperuricemia mice. Planta Med 2014;80:1259\u20131268.","journal-title":"Planta Med"},{"key":"3729_CR17","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/s12906-020-03055-7","volume":"20","author":"Q Zhou","year":"2020","unstructured":"Zhou Q, Sun HJ, Liu SM, Jiang XH, Wang QY, Zhang S, et al. Anti-inflammation effects of the total saponin fraction from Dioscorea nipponica Makino on rats with gouty arthritis by influencing MAPK signaling pathway. BMC Complement Med Ther 2020;20:261.","journal-title":"BMC Complement Med Ther"},{"key":"3729_CR18","first-page":"55","volume":"44","author":"YX Su","year":"2013","unstructured":"Su YX, Chen BJ, Zhao FQ, Yan H, Zhou BH, Zhang Q, et al. Influence of Tong Feng Ning Granule on expressions of PGE-2, IL-8, I\u03ba B-\u03b1 and IKK-\u03b1 of knee joints of rats of acute gouty arthritis. Fujian J Tradit Chin Med (Chin) 2013;44:55\u201356.","journal-title":"Fujian J Tradit Chin Med (Chin)"},{"key":"3729_CR19","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.neuro.2019.06.001","volume":"74","author":"K Dec","year":"2019","unstructured":"Dec K, Lukomska A, Skonieczna-Zydecka K, Kolasa-Wolosiuk A, Tarnowski M, Baranowaka-Bosiacka I. Long-term exposure to fluoride as a factor promoting changes in the expression and activity of cyclooxygenases (COX1 and COX2) in various rat brain structures. Neurotoxicology 2019;74:81\u201390.","journal-title":"Neurotoxicology"},{"key":"3729_CR20","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/s12974-018-1247-9","volume":"15","author":"CM Drion","year":"2018","unstructured":"Drion CM, van Scheppingen J, Arena A, Geijtenbeek KW, Kooijman L, van Vliet EA, et al. Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo in search of potential anti-epileptogenic strategies for temporal lobe epilepsy. J Neuroinflammation 2018;15:212.","journal-title":"J Neuroinflammation"},{"key":"3729_CR21","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.4049\/jimmunol.1303188","volume":"194","author":"XX Kou","year":"2020","unstructured":"Kou XX, Li CS, He DQ, Wang XD, Hao T, Meng Z, et al. Estradiol promotes M1-like macrophage activation through cadherin-11 to aggravate temporomandibular joint inflammation in rats. J Immunol 2020;194:2810\u20132818.","journal-title":"J Immunol"},{"key":"3729_CR22","first-page":"120","volume":"20","author":"L Wang","year":"2020","unstructured":"Wang L, Xu P, Wang J, Tian J, Xiao XL. Effects of allogeneic bone marrow mesenchymal stem cells on the polarization of peritoneal macrophages in rats with acute necrotizing pancreatitis. Chin J Pancreatol 2020;20:120\u2013125.","journal-title":"Chin J Pancreatol"},{"key":"3729_CR23","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/pds.5127","volume":"30","author":"R Koto","year":"2020","unstructured":"Koto R, Nakajima A, Horiuchi H, Yamanaka H. Factors associated with achieving target serum uric acid level and occurrence of gouty arthritis: a retrospective observational study of Japanese health insurance claims data. Pharmacoepidemiol Drug Saf 2020;30:157\u2013168.","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"3729_CR24","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1080\/15384101.2021.1874696","volume":"20","author":"YF Liu","year":"2021","unstructured":"Liu YF, Xiang GL, Chen Z, Tu SH. Long non-coding RNA HOTAIR knockdown alleviates gouty arthritis through miR-20b upregulation and NLRP3 downregulation. Cell Cycle 2021;20:332\u2013344.","journal-title":"Cell Cycle"},{"key":"3729_CR25","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.apsb.2019.01.015","volume":"9","author":"F Zhou","year":"2019","unstructured":"Zhou F, Mei JT, Han XG, Li HJ, Yang SB, Wang MQ, et al. Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-\u03ba B\/MAPK signaling and protecting chondrocytes. Acta Pharm Sin B 2019;9:973\u2013985.","journal-title":"Acta Pharm Sin B"},{"key":"3729_CR26","doi-asserted-by":"crossref","unstructured":"Deng JP, Wu Z, Chen C, Zhao ZL, Li YF, Su ZQ, et al. Chinese medicine Huzhen Tongfeng Formula effectively attenuates gouty arthritis by inhibiting arachidonic acid. Mediators Inflamm 2020;6950206.","DOI":"10.1155\/2020\/6950206"},{"key":"3729_CR27","first-page":"265","volume":"4","author":"P Patrignani","year":"2003","unstructured":"Patrignani P, Capone ML, Tacconelli S. Clinical pharmacology of etoricoxib: a novel selective COX2 inhibitor. Expert Opin Pharmacother 2003;4:265\u2013284.","journal-title":"Expert Opin Pharmacother"},{"key":"3729_CR28","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1186\/s12906-016-1467-4","volume":"16","author":"YM Tabana","year":"2016","unstructured":"Tabana YM, AI-Suede FSR, Ahamed MBK, Dahham SS, Hassan LEA, Khalilpour S, et al. Cat\u2019s whiskers (Orthosiphon stamineus) tea modulates arthritis pathogenesis via the angiogenesis and inflammatory cascade. BMC Complement Altern Med 2016;16:480.","journal-title":"BMC Complement Altern Med"},{"key":"3729_CR29","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.jep.2010.11.003","volume":"133","author":"R Gautam","year":"2011","unstructured":"Gautam R, Jachak SM, Saklani A. Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth. mediated through cyclooxygenase (COX) inhibition. J Ethnopharmacol 2011;133:928\u2013930.","journal-title":"J Ethnopharmacol"},{"key":"3729_CR30","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.3390\/plants10061234","volume":"10","author":"JH Feng","year":"2021","unstructured":"Feng JH, Kim HY, Sim SM, Zuo GL, Jung JS, Hwang SH, et al. The anti-inflammatory and the antinociceptive effects of mixed Agrimonia pilosa Ledeb. and Salvia miltiorrhiza Bunge extract. Plants (Basel) 2021;10:1234.","journal-title":"Plants (Basel)"},{"key":"3729_CR31","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3892\/mmr.2021.11862","volume":"23","author":"XZ Zhang","year":"2021","unstructured":"Zhang XZ, Ding HD, Hu G, Lu Y. Simiaosan alleviates the symptoms of gouty arthritis via the NALP3\/IL-1\u03b2 pathway. Mol Med Rep 2021;23:223.","journal-title":"Mol Med Rep"},{"key":"3729_CR32","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3389\/fphar.2019.00229","volume":"10","author":"AC Rossaneis","year":"2019","unstructured":"Rossaneis AC, Longhi-Balbinot D, Bertozzi MM, Fattori V, Segato-Vendrameto CZ, Badaro-Garcia S, et al. [Ru(bpy)2(NO)SO3](PF6), a nitric oxide donating ruthenium complex, reduces gout arthritis in mice. Front Pharmacol 2019;10:229.","journal-title":"Front Pharmacol"},{"key":"3729_CR33","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1159\/000452567","volume":"40","author":"CH Luo","year":"2016","unstructured":"Luo CH, Lian XK, Hong LL, Zou JF, Li Z, Zhu YZ, et al. High uric acid activates the ROS-AMPK pathway, impairs CD68 expression and inhibits Ox-LDL-induced foam-cell formation in a human monocytic cell line, THP-1. Cell Physiol Biochem 2016;40:538\u2013548.","journal-title":"Cell Physiol Biochem"},{"key":"3729_CR34","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.3389\/fimmu.2017.01260","volume":"8","author":"JH Jeong","year":"2017","unstructured":"Jeong JH, Hong SC, Kwon OC, Ghang BZ, Hwang I, Kim YG, et al. CD14+ cells with the phenotype of infiltrated monocytes consist of distinct populations characterized by anti-inflammatory as well as pro-inflammatory activity in gouty arthritis. Front Immunol 2017;8:1260.","journal-title":"Front Immunol"},{"key":"3729_CR35","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s13075-016-1167-y","volume":"18","author":"L Liu","year":"2016","unstructured":"Liu L, Xue Y, Zhu ZF, Xuan DD, Yang X, Liang MR, et al. Interleukin 37 limits monosodium urate crystal-induced innate immune respionses in human and murine modles of gout. Arthritis Res Ther 2016;18:268.","journal-title":"Arthritis Res Ther"},{"key":"3729_CR36","doi-asserted-by":"publisher","first-page":"e1002937","DOI":"10.1371\/journal.pmed.1002937","volume":"16","author":"X Liu","year":"2019","unstructured":"Liu X, Meng XR, He YZ, Spiliopoulou A, Timofeeva M, Wei WQ, et al. Genetically determined serum urate levels and cardiovascular and other diseases in UK biobank cohort: a phenome-wide mendelian randomization study. Plos Med 2019;16:e1002937.","journal-title":"Plos Med"},{"key":"3729_CR37","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12883-018-1234-x","volume":"19","author":"JA Singh","year":"2019","unstructured":"Singh JA, Cleveland JD. Gout and the risk of Parkinson\u2019s disease in older adults: a study of U.S. medicare data. BMC Neurol 2019;19:4.","journal-title":"BMC Neurol"},{"key":"3729_CR38","doi-asserted-by":"publisher","unstructured":"Zhou Q, Sun HJ, Liu SM. Effects of total saponins from Dioscorea Nipponica Makino on monosodium urate-induced M1-polarized macrophages through arachidonic acid signaling pathway: an in vitro study. Chin J Integr Med 2022. doi: https:\/\/doi.org\/10.1007\/s11655-022-3721-6.","DOI":"10.1007\/s11655-022-3721-6"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-022-3729-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-022-3729-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-022-3729-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T06:19:03Z","timestamp":1698473943000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-022-3729-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,6]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["3729"],"URL":"https:\/\/doi.org\/10.1007\/s11655-022-3729-y","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,6]]},"assertion":[{"value":"20 December 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors report no declarations of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}