{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:48:18Z","timestamp":1792759698287,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s11655-023-3738-x","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T14:03:15Z","timestamp":1683900195000},"page":"989-997","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inhibitory Effect of Jinkui Shenqi Pills on Glucocorticoid-Enhanced Axial Length Elongation in Experimentally Myopic Guinea Pigs"],"prefix":"10.1007","volume":"29","author":[{"given":"Qian","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-xiu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-xue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-dong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-sheng","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"3738_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","volume":"6","author":"PN Baird","year":"2020","unstructured":"Baird PN, Saw SM, Lanca C, Guggenheim JA, Smith III EL, Zhou X, et al. Myopia. Nat Rev Dis Primers 2020;6:99.","journal-title":"Nat Rev Dis Primers"},{"key":"3738_CR2","doi-asserted-by":"publisher","first-page":"6696234","DOI":"10.1155\/2021\/6696234","volume":"2021","author":"Y Zeng","year":"2021","unstructured":"Zeng Y, Li T, Zhang X, Ren Y, Huang Q, Wang J, et al. Effects of Haima Duobian Pill in a rat model of Kidney yang deficiency syndrome. Evid Based Complement Alternat Med 2021;2021:6696234.","journal-title":"Evid Based Complement Alternat Med"},{"key":"3738_CR3","doi-asserted-by":"publisher","first-page":"6132289","DOI":"10.1155\/2022\/6132289","volume":"2022","author":"W Ge","year":"2022","unstructured":"Ge W, Zhou BG, Zhong YB, Liu SQ, Huang JQ, Yuan WY, et al. Sishen Pill ameliorates dextran sulfate sodium (DSS)-induced colitis with Spleen-Kidney yang deficiency syndromes: role of gut microbiota, fecal metabolites, inflammatory dendritic cells, and TLR4\/NF-kappaB pathway. Evid Based Complement Alternat Med 2022;2022:6132289.","journal-title":"Evid Based Complement Alternat Med"},{"key":"3738_CR4","doi-asserted-by":"publisher","first-page":"7253240","DOI":"10.1155\/2018\/7253240","volume":"2018","author":"B Ji","year":"2018","unstructured":"Ji B, Li YY, Yang WJ, Zhang LZ, Fang MS, Fu HY, et al. Jinkui Shenqi Pills ameliorate asthma with \u201cKidney yang deficiency\u201d by enhancing the function of the hypothalamic-pituitary-adrenal axis to regulate T helper 1\/2 imbalance. Evid Based Complement Alternat Med 2018;2018:7253240.","journal-title":"Evid Based Complement Alternat Med"},{"key":"3738_CR5","doi-asserted-by":"publisher","first-page":"114044","DOI":"10.1016\/j.jep.2021.114044","volume":"276","author":"XY Cai","year":"2021","unstructured":"Cai XY, Zhang ZJ, Xiong JL, Yang M, Wang ZT. Experimental and molecular docking studies of estrogenlike and anti-osteoporosis activity of compounds in Fructus Psoraleae. J Ethnopharmacol 2021;276:114044.","journal-title":"J Ethnopharmacol"},{"key":"3738_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.steroids.2018.09.008","volume":"139","author":"M Ding","year":"2018","unstructured":"Ding M, Guo D, Wu J, Ye X, Zhang Y, Sha F, et al. Effects of glucocorticoid on the eye development in guinea pigs. Steroids 2018;139:1\u20139.","journal-title":"Steroids"},{"key":"3738_CR7","doi-asserted-by":"publisher","first-page":"579769","DOI":"10.3389\/fninf.2020.579769","volume":"14","author":"T Zhang","year":"2020","unstructured":"Zhang T, Jiang Q, Xu F, Zhang R, Liu D, Guo D, et al. Alternation of resting-state functional connectivity between visual cortex and hypothalamus in guinea pigs with experimental glucocorticoid enhanced myopia after the treatment of electroacupuncture. Front Neuroinform 2020;14:579769.","journal-title":"Front Neuroinform"},{"key":"3738_CR8","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1021\/acs.jproteome.6b00409","volume":"15","author":"L Zhao","year":"2016","unstructured":"Zhao L, Zhao A, Chen T, Chen W, Liu J, Wei R, et al. Global and targeted metabolomics evidence of the protective effect of Chinese patent medicine Jinkui Shenqi Pill on adrenal insufficiency after acute glucocorticoid withdrawal in rats. J Proteome Res 2016;15:2327\u20132336.","journal-title":"J Proteome Res"},{"key":"3738_CR9","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.ctim.2015.04.008","volume":"23","author":"X Xiong","year":"2015","unstructured":"Xiong X, Wang P, Li X, Zhang Y. Shenqi Pill, a traditional Chinese herbal formula, for the treatment of hypertension: a systematic review. Complement Ther Med 2015;23:484\u2013493.","journal-title":"Complement Ther Med"},{"key":"3738_CR10","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001;25:402\u2013408.","journal-title":"Methods"},{"key":"3738_CR11","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1093\/rheumatology\/keaa209","volume":"60","author":"RE Costello","year":"2021","unstructured":"Costello RE, Yimer BB, Roads P, Jani M, Dixon WG. Glucocorticoid use is associated with an increased risk of hypertension. Rheumatology (Oxford) 2021;60:132\u2013139.","journal-title":"Rheumatology (Oxford)"},{"key":"3738_CR12","doi-asserted-by":"publisher","first-page":"112734","DOI":"10.1016\/j.jep.2020.112734","volume":"255","author":"K Du","year":"2020","unstructured":"Du K, Gao XX, Feng Y, Li J, Wang H, Lv SL, et al. Integrated adrenal and testicular metabolomics revealed the protective effects of Guilingji on the Kidney-yang deficiency syndrome rats. J Ethnopharmacol 2020;255:112734.","journal-title":"J Ethnopharmacol"},{"key":"3738_CR13","doi-asserted-by":"crossref","first-page":"5952612","DOI":"10.1155\/2020\/5952612","volume":"2020","author":"L Zhang","year":"2020","unstructured":"Zhang L, Lang J, Jin L, Jin L, Cao B, Shao X, et al. Effect of Hirsutella sinensis Fungus on the hypothalamic-pituitary-adrenal axis in Lewis rats with Kidney-yang deficiency syndrome. Evid Based Complement Alternat Med 2020;2020:5952612.","journal-title":"Evid Based Complement Alternat Med"},{"key":"3738_CR14","doi-asserted-by":"publisher","first-page":"1517596","DOI":"10.1155\/2020\/1517596","volume":"2020","author":"Q Shang","year":"2020","unstructured":"Shang Q, Zhao W, Shen G, Yu X, Zhang Z, Huang X, et al. Jingui Shenqi Pills regulate bone-fat balance in murine ovariectomy-induced osteoporosis with Kidney yang deficiency. Evid Based Complement Alternat Med 2020;2020:1517596.","journal-title":"Evid Based Complement Alternat Med"},{"key":"3738_CR15","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1136\/bjophthalmol-2019-315636","volume":"105","author":"J Wang","year":"2021","unstructured":"Wang J, Cheng T, Zhang B, Xiong S, Zhao H, Li Q, et al. Puberty could regulate the effects of outdoor time on refractive development in Chinese children and adolescents. Br J Ophthalmol 2021;105:191\u2013197.","journal-title":"Br J Ophthalmol"},{"key":"3738_CR16","first-page":"2297","volume":"17","author":"ZT Chen","year":"2011","unstructured":"Chen ZT, Wang IJ, Liao YT, Shih YF, Lin LL. Polymorphisms in steroidogenesis genes, sex steroid levels, and high myopia in the Taiwanese population. Mol Vis 2011;17:2297\u20132310.","journal-title":"Mol Vis"},{"key":"3738_CR17","first-page":"3286583","volume":"2022","author":"T Yu","year":"2022","unstructured":"Yu T, Xie X, Wei H, Wu Q, Zhang X, Tian Q, et al. Electroacupuncture improves choroidal blood flow to inhibit the development of lens-induced myopia in guinea pigs. Evid Based Complement Alternat Med 2022;2022:3286583.","journal-title":"Evid Based Complement Alternat Med"},{"key":"3738_CR18","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/j.psyneuen.2013.01.013","volume":"38","author":"RJ Mocking","year":"2013","unstructured":"Mocking RJ, Ruhe HG, Assies J, Lok A, Koeter MW, Visser I, et al. Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. Psychoneuroendocrinology 2013;38:1607\u20131617.","journal-title":"Psychoneuroendocrinology"},{"key":"3738_CR19","doi-asserted-by":"publisher","first-page":"269","DOI":"10.2165\/00024677-200403050-00001","volume":"3","author":"D Richard","year":"2004","unstructured":"Richard D, Baraboi D. Circuitries involved in the control of energy homeostasis and the hypothalamic-pituitary-adrenal axis activity. Treat Endocrinol 2004;3:269\u2013277.","journal-title":"Treat Endocrinol"},{"key":"3738_CR20","doi-asserted-by":"publisher","first-page":"108758","DOI":"10.1016\/j.exer.2021.108758","volume":"212","author":"F Zhao","year":"2021","unstructured":"Zhao F, Zhou H, Chen W, Zhao C, Zheng Y, Tao Y, et al. Declines in PDE4B activity promote myopia progression through downregulation of scleral collagen expression. Exp Eye Res 2021;212:108758.","journal-title":"Exp Eye Res"},{"key":"3738_CR21","doi-asserted-by":"publisher","first-page":"4318","DOI":"10.1167\/iovs.17-224685","volume":"59","author":"N Srinivasalu","year":"2018","unstructured":"Srinivasalu N, Lu C, Pan M, Reinach PS, Wen Y, Hu Y, et al. Role of cyclic adenosine monophosphate in myopic scleral remodeling in guinea pigs: a microarray analysis. Invest Ophthalmol Vis Sci 2018;59:4318\u20134325.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3738_CR22","doi-asserted-by":"publisher","first-page":"8151","DOI":"10.1167\/iovs.14-14233","volume":"56","author":"RK Chun","year":"2015","unstructured":"Chun RK, Shan SW, Lam TC, Wong CL, Li KK, Do CW, et al. Cyclic adenosine monophosphate activates retinal apolipoprotein a1 expression and inhibits myopic eye growth. Invest Ophthalmol Vis Sci 2015;56:8151\u20138157.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3738_CR23","doi-asserted-by":"publisher","first-page":"108403","DOI":"10.1016\/j.abb.2020.108403","volume":"688","author":"S Wu","year":"2020","unstructured":"Wu S, Guo D, Wei H, Yin X, Zhang L, Guo B, et al. Disrupted potassium ion homeostasis in ciliary muscle in negative lens-induced myopia in guinea pigs. Arch Biochem Biophys 2020;688:108403.","journal-title":"Arch Biochem Biophys"},{"key":"3738_CR24","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.1167\/iovs.16-20941","volume":"58","author":"B Wang","year":"2017","unstructured":"Wang B, Liu Y, Chen S, Wu Y, Lin S, Duan Y, et al. A novel potentially causative variant of NDUFAF7 revealed by mutation screening in a Chinese family with pathologic myopia. Invest Ophthalmol Vis Sci 2017;58:4182\u20134192.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3738_CR25","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.cellsig.2004.09.009","volume":"17","author":"A Feliciello","year":"2005","unstructured":"Feliciello A, Gottesman ME, Avvedimento EV. cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases. Cell Signal 2005;17:279\u2013287.","journal-title":"Cell Signal"},{"key":"3738_CR26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/antiox10010021","volume":"10","author":"A Signorile","year":"2020","unstructured":"Signorile A, Ferretta A, Ruggieri M, Paolicelli D, Lattanzio P, Trojano M, et al. Mitochondria, oxidative stress, cAMP signalling and apoptosis: a crossroads in lymphocytes of multiple sclerosis, a possible role of nutraceutics. Antioxidants (Basel) 2020;10:21.","journal-title":"Antioxidants (Basel)"},{"key":"3738_CR27","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/164_2015_32","volume":"233","author":"K Ravnskjaer","year":"2016","unstructured":"Ravnskjaer K, Madiraju A, Montminy M. Role of the cAMP pathway in glucose and lipid metabolism. Handb Exp Pharmacol 2016;233:29\u201349.","journal-title":"Handb Exp Pharmacol"},{"key":"3738_CR28","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.jep.2014.02.011","volume":"152","author":"Y Tan","year":"2014","unstructured":"Tan Y, Liu X, Lu C, He X, Li J, Xiao C, et al. Metabolic profiling reveals therapeutic biomarkers of processed Aconitum carmichaeli Debx in treating hydrocortisone induced Kidney-yang deficiency syndrome rats. J Ethnopharmacol 2014;152:585\u2013593.","journal-title":"J Ethnopharmacol"},{"key":"3738_CR29","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1002\/ar.24718","volume":"304","author":"L Feng","year":"2021","unstructured":"Feng L, Lin L, Wang S, Zhao X, Dai Q, Wang L, et al. Clinical practice guidelines for the treatment of allergic rhinitis in children with traditional Chinese medicine. Anat Rec (Hoboken) 2021;304:2592\u20132604.","journal-title":"Anat Rec (Hoboken)"},{"key":"3738_CR30","doi-asserted-by":"publisher","first-page":"2049497","DOI":"10.1155\/2019\/2049497","volume":"2019","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Xu SY, Liu MN, Jia TY, Qu WJ, Han T, et al. Comparative studies on chemical contents and effect in Kidney-yang deficiency rats of salt-processed product and wine-processed product of Cuscutae Semen. Evid Based Complement Alternat Med 2019;2019:2049497.","journal-title":"Evid Based Complement Alternat Med"},{"key":"3738_CR31","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jchromb.2015.12.004","volume":"1026","author":"Y Nan","year":"2016","unstructured":"Nan Y, Zhou X, Liu Q, Zhang A, Guan Y, Lin S, et al. Serum metabolomics strategy for understanding pharmacological effects of Shenqi pill acting on Kidney yang deficiency syndrome. J Chromatogr B Analyt Technol Biomed Life Sci 2016;1026:217\u2013226.","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"3738_CR32","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/BF02835794","volume":"11","author":"WJ Che","year":"2005","unstructured":"Che WJ, He XZ, Jiang JP, Cai WY, Xie SJ. Preliminary study on treatment of partial androgen deficiency in aging males with Jingui Shenqi Pill. Chin J Integr Med 2005;11:300\u2013302.","journal-title":"Chin J Integr Med"},{"key":"3738_CR33","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1002\/jcp.30615","volume":"237","author":"SS Singh","year":"2022","unstructured":"Singh SS, Chauhan SB, Kumar A, Kumar S, Engwerda CR, Sundar S, et al. Amphiregulin in cellular physiology, health, and disease: potential use as a biomarker and therapeutic target. J Cell Physiol 2022;237:1143\u20131156.","journal-title":"J Cell Physiol"},{"key":"3738_CR34","first-page":"134","volume":"17","author":"WJ Jiang","year":"2017","unstructured":"Jiang WJ, Song HX, Li SY, Guo B, Wu JF, Li GP, et al. Amphiregulin antibody and reduction of axial elongation in experimental myopia. EBio Med 2017;17:134\u2013144.","journal-title":"EBio Med"},{"key":"3738_CR35","doi-asserted-by":"publisher","first-page":"e460","DOI":"10.1111\/aos.14080","volume":"97","author":"L Dong","year":"2019","unstructured":"Dong L, Shi XH, Kang YK, Wei WB, Wang YX, Xu XL, et al. Amphiregulin and ocular axial length. Acta Ophthalmol 2019;97:e460\u2013e470.","journal-title":"Acta Ophthalmol"},{"key":"3738_CR36","doi-asserted-by":"publisher","first-page":"5455","DOI":"10.1073\/pnas.0611647104","volume":"104","author":"L Ciarloni","year":"2007","unstructured":"Ciarloni L, Mallepell S, Brisken C. Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A 2007;104:5455\u20135460.","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-023-3738-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-023-3738-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-023-3738-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T08:33:47Z","timestamp":1729413227000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-023-3738-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,12]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["3738"],"URL":"https:\/\/doi.org\/10.1007\/s11655-023-3738-x","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,12]]},"assertion":[{"value":"8 February 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there are no conflicts of interest regarding the publication of this paper.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}