{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:42:33Z","timestamp":1783107753705,"version":"3.54.6"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1007\/s11655-024-3756-y","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T11:02:18Z","timestamp":1721818938000},"page":"780-787","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and Safety of Sanjie Analgesic Capsule in Patients with Endometriosis-Associated Pain: A Multicenter, 3:1 Randomized, Double-Blind, Placebo-Controlled Trial"],"prefix":"10.1007","volume":"30","author":[{"given":"Jin-hua","family":"Leng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-fang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-hong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-fen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-qing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-he","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"3756_CR1","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","volume":"397","author":"HS Taylor","year":"2021","unstructured":"Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet 2021;397:839\u2013852.","journal-title":"Lancet"},{"key":"3756_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/ijgo.12521","volume":"142","author":"HS Taylor","year":"2018","unstructured":"Taylor HS, Adamson GD, Diamond MP, Goldstein SR, Horne AW, Missmer SA, et al. An evidence-based approach to assessing surgical versus clinical diagnosis of symptomatic endometriosis. Int J Gynaecol Obstet 2018;142:131\u2013142.","journal-title":"Int J Gynaecol Obstet"},{"key":"3756_CR3","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/ca.23270","volume":"32","author":"S Eid","year":"2019","unstructured":"Eid S, Loukas M, Tubbs RS. Clinical anatomy of pelvic pain in women: a gynecological perspective. Clin Anat 2019;32:151\u2013155.","journal-title":"Clin Anat"},{"key":"3756_CR4","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1056\/NEJMra1810764","volume":"382","author":"KT Zondervan","year":"2020","unstructured":"Zondervan KT, Becker CM, Missmer SA. Endometriosis. N Engl J Med 2020;382:1244\u20131256.","journal-title":"N Engl J Med"},{"key":"3756_CR5","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.fertnstert.2017.01.003","volume":"107","author":"RF Casper","year":"2017","unstructured":"Casper RF. Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills. Fertil Steril 2017;107:533\u2013536.","journal-title":"Fertil Steril"},{"key":"3756_CR6","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1080\/14656566.2017.1381086","volume":"18","author":"L Buggio","year":"2017","unstructured":"Buggio L, Somigliana E, Barbara G, Frattaruolo MP, Vercellini P. Oral and depot progestin therapy for endometriosis: towards a personalized medicine. Expert Opin Pharmacother 2017;18:1569\u20131581.","journal-title":"Expert Opin Pharmacother"},{"key":"3756_CR7","first-page":"CD004753","volume":"1","author":"J Brown","year":"2017","unstructured":"Brown J, Crawford TJ, Allen C, Hopewell S, Prentice A. Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis. Cochrane Database Syst Rev 2017;1:CD004753.","journal-title":"Cochrane Database Syst Rev"},{"key":"3756_CR8","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.ajog.2017.08.108","volume":"218","author":"FA Oladosu","year":"2018","unstructured":"Oladosu FA, Tu FF, Hellman KM. Nonsteroidal antiinflammatory drug resistance in dysmenorrhea: epidemiology, causes, and treatment. Am J Obstet Gynecol 2018;218:390\u2013400.","journal-title":"Am J Obstet Gynecol"},{"key":"3756_CR9","doi-asserted-by":"publisher","first-page":"e070750","DOI":"10.1136\/bmj-2022-070750","volume":"379","author":"AW Horne","year":"2022","unstructured":"Horne AW, Missmer SA. Pathophysiology, diagnosis, and management of endometriosis. BMJ 2022;379:e070750.","journal-title":"BMJ"},{"key":"3756_CR10","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","volume":"184","author":"PTK Saunders","year":"2021","unstructured":"Saunders PTK, Horne AW. Endometriosis: etiology, pathobiology, and therapeutic prospects. Cell 2021;184:2807\u20132824.","journal-title":"Cell"},{"key":"3756_CR11","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.fertnstert.2022.08.856","volume":"118","author":"H Yan","year":"2022","unstructured":"Yan H, Shi J, Li X, Dai Y, Wu Y, Zhang J, et al. Oral gonadotropin-releasing hormone antagonists for treating endometriosis-associated pain: a systematic review and network meta-analysis. Fertil Steril 2022;118:1102\u20131116.","journal-title":"Fertil Steril"},{"key":"3756_CR12","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1080\/14656566.2017.1359258","volume":"18","author":"A Perricos","year":"2017","unstructured":"Perricos A, Wenzl R. Efficacy of elagolix in the treatment of endometriosis. Expert Opin Pharmacother 2017;18:1391\u20131397.","journal-title":"Expert Opin Pharmacother"},{"key":"3756_CR13","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s11655-019-3208-2","volume":"26","author":"RH Zhao","year":"2020","unstructured":"Zhao RH, Liu Y, Lu D, Wu Y, Wang XY, Li WL, et al. Chinese medicine sequential therapy improves pregnancy outcomes after surgery for endometriosis-associated infertility: a multicenter randomized double-blind placebo parallel controlled clinical trial. Chin J Integr Med 2020;26:92\u201399.","journal-title":"Chin J Integr Med"},{"key":"3756_CR14","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s12978-018-0506-7","volume":"15","author":"Y Dai","year":"2018","unstructured":"Dai Y, Li X, Shi J, Leng J. A review of the risk factors, genetics and treatment of endometriosis in Chinese women: a comparative update. Reprod Health 2018;15:82.","journal-title":"Reprod Health"},{"key":"3756_CR15","doi-asserted-by":"publisher","first-page":"1110995","DOI":"10.3389\/fendo.2023.1110995","volume":"14","author":"R Guo","year":"2023","unstructured":"Guo R, Yi Z, Wang Y, Wang L. Network pharmacology and experimental validation to explore the potential mechanism of Sanjie Zhentong Capsule in endometriosis treatment. Front Endocrinol (Lausanne) 2023;14:1110995.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3756_CR16","doi-asserted-by":"publisher","first-page":"666","DOI":"10.3724\/SP.J.1009.2013.00666","volume":"11","author":"J Zou","year":"2013","unstructured":"Zou J, Guan Z, Zhang WY, Xiao W, Li YL. Beneficial effects of the Chinese herbal medicine Sanjie Zhentong Capsule on experimental endometriosis in rats. Chin J Nat Med 2013;11:666\u2013672.","journal-title":"Chin J Nat Med"},{"key":"3756_CR17","first-page":"748","volume":"27","author":"ZH Huang","year":"2007","unstructured":"Huang ZH. The clinical application of Sanjie Zhentong Capsules after laparoscopic surgery in the pelvic endometriosis. Chin J Integr Tradit West Med (Chin) 2007;27:748.","journal-title":"Chin J Integr Tradit West Med (Chin)"},{"key":"3756_CR18","doi-asserted-by":"publisher","first-page":"E10119","DOI":"10.1073\/pnas.1802166115","volume":"115","author":"M Kowanetz","year":"2018","unstructured":"Kowanetz M, Zou W, Gettinger SN, Koeppen H, Kockx M, Schmid P, et al. Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1). Proc Natl Acad Sci U S A 2018;115:E10119\u2013E10126.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3756_CR19","first-page":"645","volume":"42","author":"Cooperative Group of Endometriosis","year":"2007","unstructured":"Cooperative Group of Endometriosis, Chinese Society of Obstetrics and Gynecology, Chinese Medical Association. Norms for diagnosis and treatment of endometriosis. Chin J Obstetr Gynecol (Chin) 2007;42:645\u2013648.","journal-title":"Chin J Obstetr Gynecol (Chin)"},{"key":"3756_CR20","first-page":"CD003678","volume":"11","author":"I Chen","year":"2020","unstructured":"Chen I, Veth VB, Choudhry AJ, Murji A, Zakhari A, Black AY, et al. Pre- and postsurgical medical therapy for endometriosis surgery. Cochrane Database Syst Rev 2020;11:CD003678.","journal-title":"Cochrane Database Syst Rev"},{"key":"3756_CR21","first-page":"222","volume":"26","author":"N Song","year":"2010","unstructured":"Song Nan, Wang Yanyan, Leng Jinhua. Effect of Sanjie Analgesia Capsule on dysmenorrhea in endometriosis and adenomyosis. Chin J Appl Gynecol Obstetr (Chin) 2010;26:222\u2013223.","journal-title":"Chin J Appl Gynecol Obstetr (Chin)"},{"key":"3756_CR22","unstructured":"Shang Y, Zhao X, Li H, Xu Y, Zhao H, Zhao L. Clinical effect of rehabilitation new fluid combined with Sanjie Analgesic Capsules in the treatment of granulomatous mastitis and thyroiditis and impact on immune indexes of patients. Altern Ther Health Med 2023:AT9209."},{"key":"3756_CR23","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/1471-0528.14434","volume":"124","author":"MC Herman","year":"2017","unstructured":"Herman MC, Mak N, Geomini PM, Winkens B, Mol BW, Bongers MY. Is the Pictorial Blood Loss Assessment Chart (PBAC) score associated with treatment outcome after endometrial ablation for heavy menstrual bleeding? A cohort study. BJOG 2017;124:277\u2013282.","journal-title":"BJOG"},{"key":"3756_CR24","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/NNR.0000000000000477","volume":"70","author":"CX Chen","year":"2021","unstructured":"Chen CX, Carpenter JS, Ofner S, LaPradd M, Fortenberry JD. Dysmenorrhea symptom-based phenotypes: a replication and extension study. Nurs Res 2021;70:24\u201333.","journal-title":"Nurs Res"},{"key":"3756_CR25","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/j.fertnstert.2007.08.051","volume":"90","author":"T Harada","year":"2008","unstructured":"Harada T, Momoeda M, Taketani Y, Hoshiai H, Terakawa N. Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial. Fertil Steril 2008;90:1583\u20131588.","journal-title":"Fertil Steril"},{"key":"3756_CR26","first-page":"CD001019","volume":"3","author":"L Davis","year":"2007","unstructured":"Davis L, Kennedy SS, Moore J, Prentice A. Oral contraceptives for pain associated with endometriosis. Cochrane Database Syst Rev 2007;3:CD001019.","journal-title":"Cochrane Database Syst Rev"},{"key":"3756_CR27","doi-asserted-by":"publisher","first-page":"5913","DOI":"10.1038\/s41598-019-40694-4","volume":"9","author":"Y Sun","year":"2019","unstructured":"Sun Y, Yang J. A bioinformatics investigation into the pharmacological mechanisms of the effect of Fufang Danshen on pain based on methodologies of network pharmacology. Sci Rep 2019;9:5913.","journal-title":"Sci Rep"},{"key":"3756_CR28","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.3389\/fphar.2019.01578","volume":"10","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Zhang Y, Gao M, Cui X, Yang Y, van Duijn B, et al. Steamed Panax notoginseng attenuates anemia in mice with blood deficiency syndrome via regulating hematopoietic factors and JAK-STAT pathway. Front Pharmacol 2019;10:1578.","journal-title":"Front Pharmacol"},{"key":"3756_CR29","doi-asserted-by":"publisher","first-page":"745","DOI":"10.3389\/fphar.2017.00745","volume":"8","author":"Y Xiong","year":"2017","unstructured":"Xiong Y, Chen L, Hu Y, Cui X. Uncovering active constituents responsible for different activities of raw and steamed Panax notoginseng roots. Front Pharmacol 2017;8:745.","journal-title":"Front Pharmacol"},{"key":"3756_CR30","doi-asserted-by":"publisher","first-page":"9425963","DOI":"10.1155\/2017\/9425963","volume":"2017","author":"Y Jiang","year":"2017","unstructured":"Jiang Y, Zhang G, Yan D, Yang H, Ye Z, Ma T. Bioactivity-guided fractionation of the traditional Chinese medicine Resina Draconis reveals loureirin B as a PAI-1 inhibitor. Evid Based Complement Alternat Med 2017;2017:9425963.","journal-title":"Evid Based Complement Alternat Med"},{"key":"3756_CR31","doi-asserted-by":"publisher","first-page":"685092","DOI":"10.3389\/fphar.2021.685092","volume":"12","author":"S Shi","year":"2021","unstructured":"Shi S, Zhao Q, Ke C, Long S, Zhang F, Zhang X, et al. Loureirin B exerts its immunosuppressive effects by inhibiting STIM1\/Orai1 and KV1.3 channels. Front Pharmacol 2021;12:685092.","journal-title":"Front Pharmacol"},{"key":"3756_CR32","doi-asserted-by":"publisher","first-page":"112289","DOI":"10.1016\/j.fct.2021.112289","volume":"153","author":"SH Nile","year":"2021","unstructured":"Nile SH, Su J, Wu D, Wang L, Hu J, Sieniawska E, et al. Fritillaria thunbergii Miq. (Zhe Beimu): a review on its traditional uses, phytochemical profile and pharmacological properties. Food Chem Toxicol 2021;153:112289.","journal-title":"Food Chem Toxicol"},{"key":"3756_CR33","first-page":"136","volume":"5","author":"MF Toh","year":"2014","unstructured":"Toh MF, Mendonca E, Eddie SL, Endsley MP, Lantvit DD, Petukhov PA, et al. Kaempferol exhibits progestogenic effects in ovariectomized rats. J Steroids Horm Sci 2014;5:136.","journal-title":"J Steroids Horm Sci"},{"key":"3756_CR34","doi-asserted-by":"publisher","first-page":"4079","DOI":"10.3390\/nu13114079","volume":"13","author":"M Jinnouchi","year":"2021","unstructured":"Jinnouchi M, Miyahara T, Suzuki Y. Coix seed consumption affects the gut microbiota and the peripheral lymphocyte subset profiles of healthy male adults. Nutrients 2021;13:4079.","journal-title":"Nutrients"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-024-3756-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-024-3756-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-024-3756-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T12:07:44Z","timestamp":1724501264000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-024-3756-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,24]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["3756"],"URL":"https:\/\/doi.org\/10.1007\/s11655-024-3756-y","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,24]]},"assertion":[{"value":"13 January 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflicts of interest. This study was supported by Jiangsu Kanion Pharmaceutical Co., Ltd, China. Jiangsu Kanion Pharmaceutical Co., Ltd. did not participate in the research related work such as design and data analysis.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}