{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:07:21Z","timestamp":1776380841846,"version":"3.51.2"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s11655-024-3902-6","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T04:02:39Z","timestamp":1712203359000},"page":"675-683","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Naoxueshu Oral Liquid Accelerates Post-Craniotomy Hematoma Absorption in Patients: An Open-Label, Multicenter, and Randomized Controlled Trial"],"prefix":"10.1007","volume":"30","author":[{"given":"Qiu","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-xin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-ye","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-yun","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-chuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-cai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-gang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-wei","family":"Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-zhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-hua","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-xiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deng-liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-zhi","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"3902_CR1","doi-asserted-by":"publisher","first-page":"e294","DOI":"10.1016\/j.wneu.2018.07.136","volume":"119","author":"C Lopez Ramos","year":"2018","unstructured":"Lopez Ramos C, Brandel MG, Rennert RC, Wali AR, Steinberg JA, Santiago-Dieppa DR, et al. Clinical risk factors and postoperative complications associated with unplanned hospital readmissions after cranial neurosurgery. World Neurosurg 2018;119:e294\u2013e300.","journal-title":"World Neurosurg"},{"key":"3902_CR2","doi-asserted-by":"publisher","first-page":"e663","DOI":"10.1016\/j.wneu.2019.05.239","volume":"129","author":"C Wang","year":"2019","unstructured":"Wang C, Niu X, Ren Y, Lan Z, Zhang Y. Risk factors for postoperative intracranial hemorrhage after resection of intracranial tumor in 2259 consecutive patients. World Neurosurg 2019;129:e663\u2013e668.","journal-title":"World Neurosurg"},{"key":"3902_CR3","doi-asserted-by":"publisher","first-page":"499","DOI":"10.5603\/PJNNS.a2022.0074","volume":"56","author":"M Dobran","year":"2022","unstructured":"Dobran M, di Somma LGM, Paracino R. Haemostatic technique in malignant gliomas. Neurol Neurochir Pol 2022;56:499\u2013502.","journal-title":"Neurol Neurochir Pol"},{"key":"3902_CR4","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1161\/STROKEAHA.118.023766","volume":"50","author":"R Chen","year":"2019","unstructured":"Chen R, Wang X, Anderson CS, Robinson T, Lavados PM, Lindley RI, et al. Infratentorial intracerebral hemorrhage: relation of location to outcome. Stroke 2019;50:1257\u20131259.","journal-title":"Stroke"},{"key":"3902_CR5","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1093\/neuros\/nyx089","volume":"81","author":"HH Dasenbrock","year":"2017","unstructured":"Dasenbrock HH, Yan SC, Chavakula V, Gormley WB, Smith TR, Claus EB, et al. Unplanned reoperation after craniotomy for tumor: a national surgical quality improvement program analysis. Neurosurgery 2017;81:761\u2013771.","journal-title":"Neurosurgery"},{"key":"3902_CR6","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.wneu.2017.09.007","volume":"108","author":"K Lillem\u00e4e","year":"2017","unstructured":"Lillem\u00e4e K, J\u00e4rvi\u00f6 JA, Silvasti-Lundell MK, Antinheimo JJP, Hernesniemi JA, Niemi TT. Incidence of postoperative hematomas requiring surgical treatment in neurosurgery: a retrospective observational study. World Neurosurg 2017;108:491\u2013497.","journal-title":"World Neurosurg"},{"key":"3902_CR7","doi-asserted-by":"publisher","first-page":"E392","DOI":"10.1093\/neuros\/nyy429","volume":"84","author":"P Kerezoudis","year":"2019","unstructured":"Kerezoudis P, Glasgow AE, Alvi MA, Spinner RJ, Meyer FB, Bydon M, et al. Returns to operating room after neurosurgical procedures in a tertiary care academic medical center: implications for health care policy and quality improvement. Neurosurgery 2019;84:E392\u2013E401.","journal-title":"Neurosurgery"},{"key":"3902_CR8","doi-asserted-by":"publisher","first-page":"e348","DOI":"10.1016\/j.wneu.2018.11.171","volume":"123","author":"P Kerezoudis","year":"2019","unstructured":"Kerezoudis P, Alvi MA, Spinner RJ, Meyer FB, Habermann EB, Bydon M. Predictors of unplanned returns to the operating room within 30 days in neurosurgery: insights from a national surgical registry. World Neurosurg 2019;123:e348\u2013e370.","journal-title":"World Neurosurg"},{"key":"3902_CR9","doi-asserted-by":"publisher","first-page":"e01957","DOI":"10.1002\/brb3.1957","volume":"11","author":"J Song","year":"2021","unstructured":"Song J, Nie Y, Wang P, Lu H, Gao L. Naoxueshu relieves hematoma after clot removal in acute spontaneous intracerebral hemorrhage. Brain Behav 2021;11:e01957.","journal-title":"Brain Behav"},{"key":"3902_CR10","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1007\/s10072-021-05582-8","volume":"43","author":"J Song","year":"2022","unstructured":"Song J, Nie Y, Qin X, Wang P, Lu H, Gao L. Efficacy of Naoxueshu in acute spontaneous intracerebral hemorrhage: a multicenter observational study. Neurol Sci 2022;43:1885\u20131891.","journal-title":"Neurol Sci"},{"key":"3902_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jep.2018.12.010","volume":"232","author":"J Qiu","year":"2019","unstructured":"Qiu J, Wang LN, Hu JH, Zhang YQ. Oral administration of leeches (Shuizhi): a review of the mechanisms of action on antiplatelet aggregation. J Ethnopharmacol 2019;232:103\u2013109.","journal-title":"J Ethnopharmacol"},{"key":"3902_CR12","doi-asserted-by":"publisher","first-page":"660757","DOI":"10.3389\/fphar.2021.660757","volume":"12","author":"JR Chen","year":"2021","unstructured":"Chen JR, Xie XF, Zhang HQ, Li GM, Yin YP, Cao XY, et al. Pharmacological activities and mechanisms of hirudin and its derivatives\u2014a review. Front Pharmacol 2021;12:660757.","journal-title":"Front Pharmacol"},{"key":"3902_CR13","doi-asserted-by":"publisher","first-page":"154530","DOI":"10.1016\/j.phymed.2022.154530","volume":"108","author":"Y Li","year":"2023","unstructured":"Li Y, Tian C, Wei Y, Liu H, An N, Song K, et al. Exploring the pharmacological mechanism of Naoxueshu Oral Liquid in the treatment of intracerebral hemorrhage through weighted gene co-expression network analysis, network pharmacological and experimental validation. Phytomedicine 2023;108:154530.","journal-title":"Phytomedicine"},{"key":"3902_CR14","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1136\/svn-2020-000433","volume":"5","author":"Y Cao","year":"2020","unstructured":"Cao Y, Yu S, Zhang Q, Yu T, Liu Y, Sun Z, et al. Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of intracerebral haemorrhage. Stroke Vasc Neurol 2020;5:396\u2013402.","journal-title":"Stroke Vasc Neurol"},{"key":"3902_CR15","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1161\/STR.0000000000000069","volume":"46","author":"JC Hemphill","year":"2015","unstructured":"Hemphill JC, Greenberg SM, Anderson CS, Becker K, Bendok BR, Cushman M, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 2015;46:2032\u20132060.","journal-title":"Stroke"},{"key":"3902_CR16","doi-asserted-by":"publisher","first-page":"107309","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107309","volume":"32","author":"M Ali","year":"2023","unstructured":"Ali M, Maragkos GA, Yaeger KA, Schupper AJ, Hardigan TA, Vasan V, et al. Initial experience with minimally invasive endoscopic evacuation of intracerebral hemorrhage in the setting of radiographic herniation. J Stroke Cerebrovasc Dis 2023;32:107309.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"3902_CR17","first-page":"CD005951","volume":"10","author":"H Eilertsen","year":"2023","unstructured":"Eilertsen H, Menon CS, Law ZK, Chen C, Bath PM, Steiner T, et al. Haemostatic therapies for stroke due to acute, spontaneous intracerebral haemorrhage. Cochrane Database Syst Rev 2023;10:CD005951.","journal-title":"Cochrane Database Syst Rev"},{"key":"3902_CR18","first-page":"1","volume":"2017","author":"L Wu","year":"2017","unstructured":"Wu L, Li Y, Wang X, Ren X, Zhu H, Sun Y, et al. A systematic review and meta-analysis on the treatment of cerebral hemorrhage with Naoxueshu Oral Liquid. BioMed Res Int 2017;2017:1\u201311.","journal-title":"BioMed Res Int"},{"key":"3902_CR19","doi-asserted-by":"publisher","first-page":"933","DOI":"10.3389\/fphys.2018.00933","volume":"9","author":"J Song","year":"2018","unstructured":"Song J, Lyu Y, Wang P, Nie Y, Lu H, Gao L, et al. Treatment of Naoxueshu promotes improvement of hematoma absorption and neurological function in acute intracerebral hemorrhage patients. Front Physiol 2018;9:933.","journal-title":"Front Physiol"},{"key":"3902_CR20","doi-asserted-by":"publisher","first-page":"9121843","DOI":"10.1155\/2016\/9121843","volume":"2016","author":"H Jiang","year":"2016","unstructured":"Jiang H, Qin Y, Liu T, Zhang L, Wang M, Qin B, et al. Nao-Xue-Shu Oral Liquid protects and improves secondary brain insults of hypertensive cerebral hemorrhage. Evid Based Complement Altern Med 2016;2016:9121843.","journal-title":"Evid Based Complement Altern Med"},{"key":"3902_CR21","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3389\/fphar.2020.00349","volume":"11","author":"Y Zheng","year":"2020","unstructured":"Zheng Y, Ren W, Zhang L, Zhang Y, Liu D, Liu Y. A review of the pharmacological action of Astragalus polysaccharide. Front Pharmacol 2020;11:349.","journal-title":"Front Pharmacol"},{"key":"3902_CR22","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s11655-019-3032-8","volume":"27","author":"CH Zhang","year":"2021","unstructured":"Zhang CH, Yang X, Wei JR, Chen NMH, Xu JP, Bi YQ, et al. Ethnopharmacology, phytochemistry, pharmacology, toxicology and clinical applications of Radix Astragali. Chin J Integr Med 2021;27:229\u2013240.","journal-title":"Chin J Integr Med"},{"key":"3902_CR23","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s12272-022-01393-3","volume":"45","author":"CX Li","year":"2022","unstructured":"Li CX, Liu Y, Zhang YZ, Li JC, Lai J. Astragalus polysaccharide: a review of its immunomodulatory effect. Arch Pharm Res 2022;45:367\u2013389.","journal-title":"Arch Pharm Res"},{"key":"3902_CR24","doi-asserted-by":"publisher","first-page":"205873841986905","DOI":"10.1177\/2058738419869055","volume":"33","author":"R Pan","year":"2019","unstructured":"Pan R, Zhou M, Zhong Y, Xie J, Ling S, Tang X, et al. The combination of Astragalus membranaceus extract and ligustrazine to improve the inflammation in rats with thrombolytic cerebral ischemia. Int J Immunopathol Pharmacol 2019;33:205873841986905.","journal-title":"Int J Immunopathol Pharmacol"},{"key":"3902_CR25","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.intimp.2019.04.029","volume":"72","author":"X Li","year":"2019","unstructured":"Li X, Zhu Z, Gao S, Zhang L, Cheng X, Li S, et al. Inhibition of fibrin formation reduces neuroinflammation and improves long-term outcome after intracerebral hemorrhage. Int Immunopharmacol 2019;72:473\u2013478.","journal-title":"Int Immunopharmacol"},{"issue":"1S","key":"3902_CR26","first-page":"S75","volume":"22","author":"AD Kaye","year":"2019","unstructured":"Kaye AD, Manchikanti L, Novitch MB, Mungrue IN, Anwar M, Jones MR, et al. Responsible, safe, and effective use of antithrombotics and anticoagulants in patients undergoing interventional techniques: American Society of Interventional Pain Physicians (ASIPP) Guidelines. Pain Physician 2019;22(1S):S75\u2013128.","journal-title":"Pain Physician"},{"key":"3902_CR27","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1007\/s11655-014-2008-y","volume":"26","author":"S Huang","year":"2020","unstructured":"Huang S, Xu F, Wang YY, Shang MY, Wang CQ, Wang X, et al. Improvement and application of acute blood stasis rat model aligned with the 3Rs (Reduction, Refinement and Replacement) of humane animal experimentation. Chin J Integr Med 2020;26:292\u2013298.","journal-title":"Chin J Integr Med"},{"key":"3902_CR28","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00467-022-05668-1","volume":"38","author":"B B\u00fcy\u00fckkarag\u00f6z","year":"2023","unstructured":"B\u00fcy\u00fckkarag\u00f6z B, Bakkalo\u01e7lu SA. Serum osmolality and hyperosmolar states. Pediatr Nephrol Berl Ger 2023;38:1013\u20131025.","journal-title":"Pediatr Nephrol Berl Ger"},{"key":"3902_CR29","doi-asserted-by":"publisher","first-page":"e14290","DOI":"10.1016\/j.heliyon.2023.e14290","volume":"9","author":"Y Gong","year":"2023","unstructured":"Gong Y, Wang Y, Chen D, Teng Y, Xu F, Yang P. Predictive value of hyperglycemia on prognosis in spontaneous intracerebral hemorrhage patients. Heliyon 2023;9:e14290.","journal-title":"Heliyon"},{"key":"3902_CR30","first-page":"33","volume":"10","author":"WJ Tu","year":"2023","unstructured":"Tu WJ, Wang LD, Special Writing Group of China Stroke Surveillance Report. China stroke surveillance report 2021. Mil Med Res 2023;10:33.","journal-title":"Mil Med Res"},{"key":"3902_CR31","doi-asserted-by":"publisher","first-page":"818602","DOI":"10.3389\/fncel.2022.818602","volume":"16","author":"J Liu","year":"2022","unstructured":"Liu J, Zhu Z, Leung GKK. Erythrophagocytosis by microglia\/macrophage in intracerebral hemorrhage: from mechanisms to translation. Front Cell Neurosci 2022;16:818602.","journal-title":"Front Cell Neurosci"},{"key":"3902_CR32","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1084\/jem.20171905","volume":"215","author":"K Vaibhav","year":"2018","unstructured":"Vaibhav K, Braun M, Khan MB, Fatima S, Saad N, Shankar A, et al. Remote ischemic post-conditioning promotes hematoma resolution via AMPK-dependent immune regulation. J Exp Med 2018;215:2636\u20132654.","journal-title":"J Exp Med"},{"key":"3902_CR33","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41590-017-0006-x","volume":"19","author":"J Nikolich-\u017dugich","year":"2018","unstructured":"Nikolich-\u017dugich J. The twilight of immunity: emerging concepts in aging of the immune system. Nat Immunol 2018;19:10\u201319.","journal-title":"Nat Immunol"},{"key":"3902_CR34","doi-asserted-by":"publisher","first-page":"e2023216118","DOI":"10.1073\/pnas.2023216118","volume":"118","author":"Z Huang","year":"2021","unstructured":"Huang Z, Chen B, Liu X, Li H, Xie L, Gao Y, et al. Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis. Proc Natl Acad Sci 2021;118:e2023216118.","journal-title":"Proc Natl Acad Sci"},{"key":"3902_CR35","doi-asserted-by":"publisher","first-page":"604000","DOI":"10.3389\/fimmu.2020.604000","volume":"11","author":"R Shepherd","year":"2021","unstructured":"Shepherd R, Cheung AS, Pang K, Saffery R, Novakovic B. Sexual dimorphism in innate immunity: the role of sex hormones and epigenetics. Front Immunol 2021;11:604000.","journal-title":"Front Immunol"},{"key":"3902_CR36","doi-asserted-by":"publisher","first-page":"e039460","DOI":"10.1136\/bmjopen-2020-039460","volume":"10","author":"S Massicotte","year":"2020","unstructured":"Massicotte S, Lun R, Yogendrakumar V, Dewar B, Davies A, Fergusson DA, et al. Natural history of recovery after intracerebral haemorrhage: a scoping review protocol. BMJ Open 2020;10:e039460.","journal-title":"BMJ Open"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-024-3902-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-024-3902-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-024-3902-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T08:28:28Z","timestamp":1721896108000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-024-3902-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,4]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["3902"],"URL":"https:\/\/doi.org\/10.1007\/s11655-024-3902-6","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,4]]},"assertion":[{"value":"15 November 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors have declared that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}