{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:39:00Z","timestamp":1774496340188,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s11655-024-3903-5","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T07:02:43Z","timestamp":1727852563000},"page":"28-38","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Xiangshao Granules Ameliorate Post-stroke Depression by Inhibiting Activation of Microglia and IDO1 Expression in Hippocampus and Prefrontal Cortex"],"prefix":"10.1007","volume":"31","author":[{"given":"Cheng-gang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-shan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-hao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-chen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-nan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-xiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"3903_CR1","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1007\/s00415-021-10597-4","volume":"269","author":"J Guo","year":"2022","unstructured":"Guo J, Wang J, Sun W, Liu X. The advances of post-stroke depression: 2021 update. J Neurol 2022;269:1236\u20131249.","journal-title":"J Neurol"},{"key":"3903_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainresbull.2019.11.009","volume":"155","author":"QM Camargos","year":"2020","unstructured":"Camargos QM, Silva BC, Silva DG, Toscano ECB, Oliveira BDS, Bellozi PMQ, et al. Minocycline treatment prevents depression and anxiety-like behaviors and promotes neuroprotection after experimental ischemic stroke. Brain Res Bull 2020;155:1\u201310.","journal-title":"Brain Res Bull"},{"key":"3903_CR3","doi-asserted-by":"publisher","first-page":"871754","DOI":"10.3389\/fpsyt.2022.871754","volume":"13","author":"S Gu","year":"2022","unstructured":"Gu S, He Z, Xu Q, Dong J, Xiao T, Liang F, et al. The relationship between 5-hydroxytryptamine and its metabolite changes with post-stroke depression. Front Psychiatry 2022;13:871754.","journal-title":"Front Psychiatry"},{"key":"3903_CR4","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.pharmthera.2017.11.005","volume":"184","author":"RF Villa","year":"2018","unstructured":"Villa RF, Ferrari F, Moretti A. Post-stroke depression: mechanisms and pharmacological treatment. Pharmacol Ther 2018;184:131\u2013144.","journal-title":"Pharmacol Ther"},{"key":"3903_CR5","doi-asserted-by":"publisher","first-page":"821270","DOI":"10.3389\/fphar.2022.821270","volume":"13","author":"M Zhang","year":"2022","unstructured":"Zhang M, Bai X. Shugan Jieyu Capsule in post-stroke depression treatment: from molecules to systems. Front Pharmacol 2022;13:821270.","journal-title":"Front Pharmacol"},{"key":"3903_CR6","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.neubiorev.2018.04.005","volume":"90","author":"J Das","year":"2018","unstructured":"Das J, Rajanikant GK. Post stroke depression: the sequelae of cerebral stroke. Neurosci Biobehav Rev 2018;90:104\u2013114.","journal-title":"Neurosci Biobehav Rev"},{"key":"3903_CR7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jad.2023.10.037","volume":"344","author":"D Colita","year":"2024","unstructured":"Colita D, Burdusel D, Glavan D, Hermann DM, Colit\u01ce CI, Colita E, et al. Molecular mechanisms underlying major depressive disorder and post-stroke affective disorders. J Affect Disord 2024;344:149\u2013158.","journal-title":"J Affect Disord"},{"key":"3903_CR8","doi-asserted-by":"publisher","first-page":"798335","DOI":"10.3389\/fnagi.2021.798335","volume":"13","author":"L Wei","year":"2021","unstructured":"Wei L, Du Y, Xie Y, Yu X, Chen H, Qiu Y. Lipocalin-2 regulates hippocampal microglial activation in poststroke depression. Front Aging Neurosci 2021;13:798335.","journal-title":"Front Aging Neurosci"},{"key":"3903_CR9","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1002\/ptr.7616","volume":"37","author":"PY Ge","year":"2023","unstructured":"Ge PY, Qu SY, Ni SJ, Yao ZY, Qi YY, Zhao X, et al. Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism. Phytother Res 2023;37:342\u2013357.","journal-title":"Phytother Res"},{"key":"3903_CR10","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1515\/revneuro-2022-0047","volume":"34","author":"X Gong","year":"2022","unstructured":"Gong X, Chang R, Zou J, Tan S, Huang Z. The role and mechanism of tryptophan-kynurenine metabolic pathway in depression. Rev Neurosci 2022;34:313\u2013324.","journal-title":"Rev Neurosci"},{"key":"3903_CR11","doi-asserted-by":"publisher","first-page":"112675","DOI":"10.1016\/j.bbr.2020.112675","volume":"390","author":"B Carabelli","year":"2020","unstructured":"Carabelli B, Delattre AM, Waltrick APF, Araujo G, Suchecki D, Machado RB, et al. Fish-oil supplementation decreases indoleamine-2,3-dioxygenase expression and increases hippocampal serotonin levels in the LPS depression model. Behav Brain Res 2020;390:112675.","journal-title":"Behav Brain Res"},{"key":"3903_CR12","doi-asserted-by":"publisher","first-page":"7496","DOI":"10.3390\/ijms25137496","volume":"25","author":"Y Qin","year":"2024","unstructured":"Qin Y, Hu X, Zhao HL, Kurban N, Chen X, Yi JK, et al. Inhibition of indoleamine 2,3-dioxygenase exerts antidepressant-like effects through distinct pathways in prelimbic and infralimbic cortices in rats under intracerebroventricular injection with streptozotocin. Int J Mol Sci 2024;25:7496.","journal-title":"Int J Mol Sci"},{"key":"3903_CR13","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/164_2018_172","volume":"250","author":"D Lochmann","year":"2019","unstructured":"Lochmann D, Richardson T. Selective serotonin reuptake inhibitors. Handb Exp Pharmacol 2019;250:135\u2013144.","journal-title":"Handb Exp Pharmacol"},{"key":"3903_CR14","doi-asserted-by":"publisher","first-page":"116061","DOI":"10.1016\/j.jep.2022.116061","volume":"305","author":"S Li","year":"2023","unstructured":"Li S, Mu X, Ma S, Li X, Gao J, Liu X, et al. Xiangshao Granules reduce the aggressive behavior and hippocampal injury of premenstrual irritability in rats by regulating JIK\/JNK\/p38 signal pathway. J Ethnopharmacol 2023;305:116061.","journal-title":"J Ethnopharmacol"},{"key":"3903_CR15","doi-asserted-by":"publisher","first-page":"309262","DOI":"10.1155\/2013\/309262","volume":"2013","author":"Y Chen","year":"2013","unstructured":"Chen Y, Liu J, Wu X, Nice EC. Xiangshao Granule exerts antidepressive effects in a depression mouse model by ameliorating deficits in hippocampal BDNF and TrkB. Evid Based Complement Alternat Med 2013;2013:309262.","journal-title":"Evid Based Complement Alternat Med"},{"key":"3903_CR16","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1080\/13697137.2020.1820476","volume":"24","author":"R Chen","year":"2021","unstructured":"Chen R, Tang R, Zhang S, Wang Y, Wang R, Ouyang Y, et al. Xiangshao Granules can relieve emotional symptoms in menopausal women: a randomized controlled trial. Climacteric 2021;24:246\u2013252.","journal-title":"Climacteric"},{"key":"3903_CR17","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.bbr.2016.04.039","volume":"308","author":"W Tao","year":"2016","unstructured":"Tao W, Dong Y, Su Q, Wang H, Chen Y, Xue W, et al. Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K\/Akt\/mTOR mediated BDNF\/TrkB pathway. Behav Brain Res 2016;308:177\u2013186.","journal-title":"Behav Brain Res"},{"key":"3903_CR18","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1080\/01616412.2019.1576361","volume":"41","author":"MZ Hu","year":"2019","unstructured":"Hu MZ, Wang AR, Zhao ZY, Chen XY, Li YB, Liu B. Antidepressant-like effects of paeoniflorin on post-stroke depression in a rat model. Neurol Res 2019;41:446\u2013455.","journal-title":"Neurol Res"},{"key":"3903_CR19","doi-asserted-by":"publisher","first-page":"114962","DOI":"10.1016\/j.jep.2021.114962","volume":"287","author":"J Lu","year":"2022","unstructured":"Lu J, Li W, Gao T, Wang S, Fu C, Wang S. The association study of chemical compositions and their pharmacological effects of Cyperi Rhizoma (Xiangfu), a potential traditional Chinese medicine for treating depression. J Ethnopharmacol 2022;287:114962.","journal-title":"J Ethnopharmacol"},{"key":"3903_CR20","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/ame2.12179","volume":"4","author":"Y Li","year":"2021","unstructured":"Li Y, Zhang J. Animal models of stroke. Animal Model Exp Med 2021;4:204\u2013219.","journal-title":"Animal Model Exp Med"},{"key":"3903_CR21","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.brainresbull.2021.05.008","volume":"173","author":"X Hou","year":"2021","unstructured":"Hou X, Liu H, Ping Y, Zhang F, Zhi L, Jiang X, et al. CDDO-Im exerts antidepressant-like effects via the Nrf2\/ARE pathway in a rat model of post-stroke depression. Brain Research Bulletin 2021;173:74\u201381.","journal-title":"Brain Research Bulletin"},{"key":"3903_CR22","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1111\/cns.14207","volume":"29","author":"Y Chen","year":"2023","unstructured":"Chen Y, Zhang Y, Wang J, Li S, Wang Y, Zhang Z, et al. Anti-neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression-like behaviors via hypothalamic \u03b1 7nAchR\/JAK2\/STAT3\/NF- \u03ba B pathway in rats exposed to chronic unpredictable mild stress. CNS Neurosci Ther 2023;29:2634\u20132644.","journal-title":"CNS Neurosci Ther"},{"key":"3903_CR23","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.euroneuro.2023.08.496","volume":"77","author":"MJ Primo","year":"2023","unstructured":"Primo MJ, Fonseca-Rodrigues D, Almeida A, Teixeira PM, Pinto-Ribeiro F. Sucrose preference test: a systematic review of protocols for the assessment of anhedonia in rodents. Eur Neuropsychopharmacol 2023;77:80\u201392.","journal-title":"Eur Neuropsychopharmacol"},{"key":"3903_CR24","doi-asserted-by":"publisher","first-page":"105666","DOI":"10.1016\/j.yrtph.2024.105666","volume":"151","author":"ER Trunnell","year":"2024","unstructured":"Trunnell ER, Baines J, Farghali S, Jackson T, Jayne K, Smith R, et al. The need for guidance in antidepressant drug development: revisiting the role of the forced swim test and tail suspension test. Regul Toxicol Pharmacol 2024;151:105666.","journal-title":"Regul Toxicol Pharmacol"},{"key":"3903_CR25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/978-1-0716-3662-6_8","volume":"2761","author":"RCSR Danduga","year":"2024","unstructured":"Danduga RCSR, Kola PK. Elevated plus maze for assessment of anxiety and memory in rodents. Methods Mol Biol 2024;2761:93\u201396.","journal-title":"Methods Mol Biol"},{"key":"3903_CR26","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s11655-022-3677-6","volume":"29","author":"J Li","year":"2023","unstructured":"Li J, Chang JY, Jiang ZL, Yin YK, Chen JY, Jin W, et al. Network pharmacology and in vitro experimental verification on intervention of quercetin, present in Chinese medicine Yishen Qutong Granules, on esophageal cancer. Chin J Integr Med 2023;29:233\u2013243.","journal-title":"Chin J Integr Med"},{"key":"3903_CR27","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1111\/cns.13732","volume":"27","author":"Z Li","year":"2021","unstructured":"Li Z, Xu H, Xu Y, Lu G, Peng Q, Chen J, et al. Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation. CNS Neurosci Ther 2021;27:1570\u20131586.","journal-title":"CNS Neurosci Ther"},{"key":"3903_CR28","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1037\/bul0000096","volume":"143","author":"ML Dixon","year":"2017","unstructured":"Dixon ML, Thiruchselvam R, Todd R, Christoff K. Emotion and the prefrontal cortex: an integrative review. Psychol Bull 2017;143:1033\u20131081.","journal-title":"Psychol Bull"},{"key":"3903_CR29","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.biopsych.2019.01.011","volume":"85","author":"YI Sheline","year":"2019","unstructured":"Sheline YI, Liston C, McEwen BS. Parsing the hippocampus in depression: chronic stress, hippocampal volume, and major depressive disorder. Biol Psychiatry 2019;85:436\u2013438.","journal-title":"Biol Psychiatry"},{"key":"3903_CR30","doi-asserted-by":"publisher","first-page":"113138","DOI":"10.1016\/j.bbr.2021.113138","volume":"403","author":"AR Wang","year":"2021","unstructured":"Wang AR, Mi LF, Zhang ZL, Hu MZ, Zhao ZY, Liu B, et al. Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB\/BDNF pathway. Behav Brain Res 2021;403:113138.","journal-title":"Behav Brain Res"},{"key":"3903_CR31","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s11655-023-3596-1","volume":"29","author":"QL Hong","year":"2023","unstructured":"Hong QL, Ding YH, Chen JY, Shi SS, Liang RS, Tu XK. Schisandrin B protects against ischemic brain damage by regulating PI3K\/AKT signaling in rats. Chin J Integr Med 2023;29:885\u2013894.","journal-title":"Chin J Integr Med"},{"key":"3903_CR32","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1007\/s11655-019-3051-5","volume":"27","author":"B Zhang","year":"2021","unstructured":"Zhang B, Chang HS, Hu KL, Yu X, Li LN, Xu XQ. Combination of geniposide and eleutheroside B exerts antidepressant-like effect on lipopolysaccharide-induced depression mice model. Chin J Integr Med 2021;27:534\u2013541.","journal-title":"Chin J Integr Med"},{"key":"3903_CR33","doi-asserted-by":"publisher","first-page":"7872","DOI":"10.12998\/wjcc.v10.i22.7872","volume":"10","author":"Z Wang","year":"2022","unstructured":"Wang Z, Wu Q, Wang Q. Effect of celecoxib on improving depression: a systematic review and meta-analysis. World J Clin Cases 2022;10:7872\u20137882.","journal-title":"World J Clin Cases"},{"key":"3903_CR34","first-page":"413","volume":"11","author":"M Nozari","year":"2020","unstructured":"Nozari M, Nahavandi A, Zeinivand M, Eslami Gharaati M, Godarzi M, Ahmadi M, et al. Ibuprofen protection against restrained chronic stress-induced depression in male rats. Basic Clin Neurosci 2020;11:413\u2013422.","journal-title":"Basic Clin Neurosci"},{"key":"3903_CR35","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1007\/s00213-019-05210-6","volume":"236","author":"S Fu","year":"2019","unstructured":"Fu S, Wang J, Hao C, Dang H, Jiang S. Tetramethylpyrazine ameliorates depression by inhibiting TLR4-NLRP3 inflammasome signal pathway in mice. Psychopharmacology (Berl) 2019;236:2173\u20132185.","journal-title":"Psychopharmacology (Berl)"},{"key":"3903_CR36","doi-asserted-by":"publisher","first-page":"5224","DOI":"10.1111\/bph.15261","volume":"177","author":"X Xu","year":"2020","unstructured":"Xu X, Piao HN, Aosai F, Zeng XY, Cheng JH, Cui YX, et al. Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1\/TLR4\/NF- \u03ba B and TNF-\u03b1\/TNFR1\/NF-\u03ba B pathways. Br J Pharmacol 2020;177:5224\u20135245.","journal-title":"Br J Pharmacol"},{"key":"3903_CR37","doi-asserted-by":"publisher","first-page":"135292","DOI":"10.1016\/j.neulet.2020.135292","volume":"736","author":"J Wang","year":"2020","unstructured":"Wang J, Yang C, Liu Z, Li X, Liu M, Wang Y, et al. Association of the TLR4 gene with depressive symptoms and antidepressant efficacy in major depressive disorder. Neurosci Lett 2020;736:135292.","journal-title":"Neurosci Lett"},{"key":"3903_CR38","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s12575-023-00224-z","volume":"25","author":"Y Luo","year":"2023","unstructured":"Luo Y, Cheng J, Fu Y, Zhang M, Gou M, Li J, et al. D-allose inhibits TLR4\/PI3K\/AKT signaling to attenuate neuroinflammation and neuronal apoptosis by inhibiting Gal-3 following ischemic stroke. Biol Proced Online 2023;25:30.","journal-title":"Biol Proced Online"},{"key":"3903_CR39","doi-asserted-by":"publisher","first-page":"8493","DOI":"10.3390\/ijms23158493","volume":"23","author":"AS Correia","year":"2022","unstructured":"Correia AS, Vale N. Tryptophan metabolism in depression: a narrative review with a focus on serotonin and kynurenine pathways. Int J Mol Sci 2022;23:8493.","journal-title":"Int J Mol Sci"},{"key":"3903_CR40","doi-asserted-by":"publisher","first-page":"167","DOI":"10.14715\/cmb\/2022.68.8.30","volume":"68","author":"J Hwang","year":"2022","unstructured":"Hwang J, Park JS, Ramalingam M, Kim BC, Jeong HS, Jang S. Neuroprotective effects of a Wnt antagonist in quinolinic acid-induced excitotoxicity in N18D3 cells. Cell Mol Biol (Noisy-le-grand) 2022;68:167\u2013172.","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"3903_CR41","doi-asserted-by":"publisher","first-page":"175927","DOI":"10.1016\/j.ejphar.2023.175927","volume":"955","author":"CC Wu","year":"2023","unstructured":"Wu CC, Tzeng CY, Chang CY, Wang JD, Chen YF, Chen WY, et al. NMDA receptor inhibitor MK801 alleviated pro-inflammatory polarization of BV-2 microglia cells. Eur J Pharmacol 2023;955:175927.","journal-title":"Eur J Pharmacol"},{"key":"3903_CR42","doi-asserted-by":"publisher","first-page":"148","DOI":"10.36922\/an.v1i2.148","volume":"1","author":"QQ Li","year":"2022","unstructured":"Li QQ, Lin X, Shi YS. NMDA receptors: biological properties and their roles in neuropsychiatric disorders. Advanced Neurol 2022;1:148.","journal-title":"Advanced Neurol"},{"key":"3903_CR43","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jpsychires.2018.12.007","volume":"110","author":"HK Kim","year":"2019","unstructured":"Kim HK, Tyryshkin K, Elmi N, Dharsee M, Evans KR, Good J, et al. Plasma microRNA expression levels and their targeted pathways in patients with major depressive disorder who are responsive to duloxetine treatment. J Psychiatr Res 2019;110:38\u201344.","journal-title":"J Psychiatr Res"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-024-3903-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-024-3903-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-024-3903-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T10:12:15Z","timestamp":1735294335000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-024-3903-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,2]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["3903"],"URL":"https:\/\/doi.org\/10.1007\/s11655-024-3903-5","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,2]]},"assertion":[{"value":"7 June 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflicts of interest in this work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}