{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:38:46Z","timestamp":1789583926467,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s11655-025-3948-0","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T02:28:47Z","timestamp":1757384927000},"page":"1029-1036","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lu\u2019e Biyan Formula for Treatment of Allergic Rhinitis Patients with Fei (Lung)-Qi Deficiency-Coldness Syndrome: A Randomized, Double Blind, and Placebo-Controlled Trial"],"prefix":"10.1007","volume":"31","author":[{"given":"Ming-yue","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-yao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-sheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-ling","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"3948_CR1","first-page":"106","volume":"57","author":"Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery","year":"2022","unstructured":"Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association. Chinese guideline for diagnosis and treatment of allergic rhinitis (2022, revision). Chin J Otorhinolaryngol Head Neck Surg (Chin) 2022;57:106\u2013129.","journal-title":"Chin J Otorhinolaryngol Head Neck Surg (Chin)"},{"key":"3948_CR2","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1542\/pir.2022-005618","volume":"44","author":"B Cohen","year":"2023","unstructured":"Cohen B. Allergic rhinitis. Pediatr Rev 2023;44:537\u2013550.","journal-title":"Pediatr Rev"},{"key":"3948_CR3","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1016\/j.jaip.2024.03.023","volume":"12","author":"L Klimek","year":"2024","unstructured":"Klimek L, Mullol J, Ellis AK, Izquierdo-Dom\u00ednguez A, Hagemann J, Casper I, et al. Current management of allergic rhinitis. J Allergy Clin Immunol Pract 2024;12:1399\u20131412.","journal-title":"J Allergy Clin Immunol Pract"},{"key":"3948_CR4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2174\/1573396320666230912103108","volume":"20","author":"MA Tosca","year":"2024","unstructured":"Tosca MA, Trincianti C, Naso M, Nosratian V, Ciprandi G. Treatment of allergic rhinitis in clinical practice. Curr Pediatr Rev 2024;20:271\u2013277.","journal-title":"Curr Pediatr Rev"},{"key":"3948_CR5","first-page":"283","volume":"40","author":"M Lao-Araya","year":"2022","unstructured":"Lao-Araya M, Sompornrattanaphan M, Kanjanawasee D, Tantilipikorn P; the Allergy Asthma and Immunology Association of Thailand (AAIAT) Interesting Group on Immunotherapy. Allergen immunotherapy for respiratory allergies in clinical practice: a comprehensive review. Asian Pac J Allergy Immunol 2022;40:283\u2013294.","journal-title":"Asian Pac J Allergy Immunol"},{"key":"3948_CR6","first-page":"274","volume":"39","author":"X Zhao","year":"2023","unstructured":"Zhao X, Zhang J, Qin YH, Wang MQ, Li Q, Zhang BQ, et al. Guideline for the diagnosis and treatment of allergic rhinitis in children with integrated traditional Chinese and Western medicine. J Nanjing Univ Tradit Chin Med (Chin) 2023;39:274\u2013284.","journal-title":"J Nanjing Univ Tradit Chin Med (Chin)"},{"key":"3948_CR7","first-page":"368","volume":"65","author":"CF Liu","year":"2024","unstructured":"Liu CF, Wei DF, Yang W, Xie FB, Zheng DP, Xiang XH, et al. Discussion on the evidence value of textbooks in the formulation of traditional Chinese medicine diagnosis and treatment guidelines for allergic rhinitis. J Tradit Chin Med (Chin) 2024;65:368\u2013375.","journal-title":"J Tradit Chin Med (Chin)"},{"key":"3948_CR8","series-title":"dissertation","volume-title":"Analysis of the medication principles of Professor ZHANG Shu-nan in treating allergic rhinitis and the intervention mechanism of Lu\u2019e Biyan Formula","author":"MY Jia","year":"2021","unstructured":"Jia MY. Analysis of the medication principles of Professor ZHANG Shu-nan in treating allergic rhinitis and the intervention mechanism of Lu\u2019e Biyan Formula [dissertation]. Beijing: Beijing University of Chinese Medicine;2021."},{"key":"3948_CR9","series-title":"dissertation","volume-title":"Effect of Lu\u2019e Biyan Formula on Th1\/Th2 cells and related cytokines in allergic rhinitis model rats","author":"Y Yu","year":"2016","unstructured":"Yu Y. Effect of Lu\u2019e Biyan Formula on Th1\/Th2 cells and related cytokines in allergic rhinitis model rats [dissertation]. Beijing: Beijing University of Chinese Medicine;2016."},{"key":"3948_CR10","first-page":"575","volume":"44","author":"JX Yan","year":"2024","unstructured":"Yan JX, Zhang SN, Xiao SY, Fan JJ, Luo X, Jia MY. Effect of Lu\u2019e Rhinitis Formula on Th17\/Treg immune imbalance in mice with allergic rhinitis based on Notch1-Jagged1 signaling pathway. Chin J Integr Tradit West Med (Chin) 2024;44:575\u2013582.","journal-title":"Chin J Integr Tradit West Med (Chin)"},{"key":"3948_CR11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1177\/0194599814562166","volume":"152","author":"MD Seidman","year":"2015","unstructured":"Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, et al. Clinical practice guideline: allergic rhinitis executive summary. Otolaryngol Head Neck Surg 2015;152:197\u2013206.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"3948_CR12","first-page":"122","volume-title":"Traditional Chinese medicine otorhinolaryngology","year":"2007","unstructured":"Wang SZ, ed. Traditional Chinese medicine otorhinolaryngology. Beijing: China Traditional Chinese Medicine Press;2007:122\u2013126."},{"key":"3948_CR13","doi-asserted-by":"publisher","first-page":"301","DOI":"10.2500\/aap.2013.34.3676","volume":"34","author":"EO Meltzer","year":"2013","unstructured":"Meltzer EO. Pharmacotherapeutic strategies for allergic rhinitis: matching treatment to symptoms, disease progression, and associated conditions. Allergy Asthma Proc 2013;34:301\u2013311.","journal-title":"Allergy Asthma Proc"},{"key":"3948_CR14","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ctim.2019.05.018","volume":"45","author":"MH Kim","year":"2019","unstructured":"Kim MH, Hong SU, Kim HT, Seo HS, Kim K, Ko SG, et al. A multicenter study on the efficacy and safety of So-Cheong-Ryong-Tang for perennial allergic rhinitis. Complement Ther Med 2019;45:50\u201356.","journal-title":"Complement Ther Med"},{"key":"3948_CR15","first-page":"5116","volume":"14","author":"Z Ding","year":"2022","unstructured":"Ding Z, Yang N, Cui X, Zhou D. Therapeutic effect of Biyuan Tongqiao Granules combined with mometasone furoate nasal spray on clinical symptoms of children with allergic rhinitis. Am J Transl Res 2022;14:5116\u20135123.","journal-title":"Am J Transl Res"},{"key":"3948_CR16","first-page":"170","volume-title":"Guiding principles for clinical research of new traditional Chinese medicine","year":"2002","unstructured":"Zheng XY, ed. Guiding principles for clinical research of new traditional Chinese medicine. Beijing: China Medical Science and Technology Press;2002:170\u2013172."},{"key":"3948_CR17","first-page":"166","volume":"40","author":"Editorial Committee of Chinese Journal of Otorhinolaryngology HeadNeck Surgery","year":"2005","unstructured":"Editorial Committee of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association Otolaryngology Branch. Principles and recommended protocols for the diagnosis and treatment of allergic rhinitis (2004, Lanzhou). Chin J Otorhinolaryngol Head Neck Surg (Chin) 2005;40:166\u2013167.","journal-title":"Chin J Otorhinolaryngol Head Neck Surg (Chin)"},{"key":"3948_CR18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0254-6272(16)30024-3","volume":"36","author":"Y Bao","year":"2016","unstructured":"Bao Y, Gao JT, Sun JM, Zhang H. Research progress of traditional Chinese medicine Colla Corni Cervi. Jilin J Tradit Chin Med (Chin) 2016;36:173\u2013175.","journal-title":"Jilin J Tradit Chin Med (Chin)"},{"key":"3948_CR19","first-page":"516","volume":"44","author":"JL Song","year":"2024","unstructured":"Song JL, Zhang Z, Zhao ZD, Gao CY, Wang RJ, Pan XZ. Research progress of chemical constituents and pharmacological actions of Ebushicao (Centipeda minima). J Hunan Univ Chin Med (Chin) 2024;44:516\u2013530.","journal-title":"J Hunan Univ Chin Med (Chin)"},{"key":"3948_CR20","doi-asserted-by":"publisher","first-page":"644561","DOI":"10.3389\/fmolb.2021.644561","volume":"8","author":"G Wang","year":"2021","unstructured":"Wang G, Zhou B, Wang Z, Meng Y, Liu Y, Yao X, et al. Pharmacological mechanisms underlying the anti-asthmatic effects of Modified Guomin Decoction determined by network pharmacology and molecular docking. Front Mol Biosci 2021;8:644561.","journal-title":"Front Mol Biosci"},{"key":"3948_CR21","first-page":"194","volume":"25","author":"WH Zheng","year":"2019","unstructured":"Zheng WH, Qin LL. Anti-allergy effect of Guominjian and its components. Chin J Exp Tradit Med Form (Chin) 2019;25:194\u2013201.","journal-title":"Chin J Exp Tradit Med Form (Chin)"},{"key":"3948_CR22","doi-asserted-by":"publisher","first-page":"113989","DOI":"10.1016\/j.biopha.2022.113989","volume":"156","author":"S Yu","year":"2022","unstructured":"Yu S, Peng W, Qiu F, Zhang G. Research progress of astragaloside IV in the treatment of atopic diseases. Biomed Pharmacother 2022;156:113989.","journal-title":"Biomed Pharmacother"},{"key":"3948_CR23","doi-asserted-by":"publisher","first-page":"e22149","DOI":"10.1016\/j.heliyon.2023.e22149","volume":"9","author":"F Yuan","year":"2023","unstructured":"Yuan F, Yang Y, Liu L, Zhou P, Zhu Y, Chai Y, et al. Research progress on the mechanism of astragaloside IV in the treatment of asthma. Heliyon 2023;9:e22149.","journal-title":"Heliyon"},{"key":"3948_CR24","series-title":"dissertation","volume-title":"Study on the anti-allergic effect and mechanism of different extraction from Ramulus Cinnamomi","author":"ZQ Wu","year":"2015","unstructured":"Wu ZQ. Study on the anti-allergic effect and mechanism of different extraction from Ramulus Cinnamomi [dissertation]. Chengdu: Chengdu University of Traditional Chinese Medicine;2015."},{"key":"3948_CR25","first-page":"378","volume":"33","author":"P Wang","year":"2022","unstructured":"Wang P, Zhang HY, Liu YM, Zhong P, Ou W, Yang M. Research progress on chemical constituents, pharmacological effects and clinical application of volatile oil from Magnolia liliflora. China Pharm (Chin) 2022;33:378\u2013384.","journal-title":"China Pharm (Chin)"},{"key":"3948_CR26","first-page":"787","volume":"55","author":"HJ Zhang","year":"2024","unstructured":"Zhang HJ, Zhang MJ, Zhao LN, Mou XD. Analysis of inhaled allergen characteristics of adult patients with allergic asthma in Beijing. J New Med (Chin) 2024;55:787\u2013793.","journal-title":"J New Med (Chin)"},{"key":"3948_CR27","first-page":"951","volume":"42","author":"R Kong","year":"2021","unstructured":"Kong R, Li H, Zhao Y. Analysis of distributions of inhaled allergen and specific IgE levels in patients with allergic rhinitis\/asthma. Acad J Chin PLA Med Sch (Chin) 2021;42:951\u2013954.","journal-title":"Acad J Chin PLA Med Sch (Chin)"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-025-3948-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-025-3948-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-025-3948-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T19:02:50Z","timestamp":1761332570000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-025-3948-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["3948"],"URL":"https:\/\/doi.org\/10.1007\/s11655-025-3948-0","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"18 July 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest regarding the publication of this research article.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}